Bob van de Water
Professor of Drug safety science
- Name
- Prof.dr. B. van de Water
- Telephone
- +31 71 527 6223
- water_b@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-5839-2380
Prof. Dr. Bob van de Water is head of the Cancer Therapeutics and Drug Safety group at the Division of Drug Discovery & Safety.
More information about Bob van de Water
PhD Candidates
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Serkan Aslan -
Sibel Bahtiri -
Linda van den Berk -
Imke Bruns -
Gerhard Burger -
Tamara Danilyuk -
Britt Duijndam -
Hugo van Kessel -
Isoude Kuijper -
Hanneke Leegwater -
Elpida Lymperi
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Roshni Nair -
Mick van Schaick -
Johannes Schimming -
Kirsten Snijders -
Natasha Tahir -
Matthijs Vlasveld -
Nanette Vrijenhoek -
Lynn Wester -
Linglu Xu -
Fengjiao Zhang
News
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700,000 euros for the fight against aggressive breast cancer -
LACDR EMA Lunchtalk -
Safety testing of chemicals without laboratory animals -
NWO grant for research facility into the impact of environmental factors on health -
Animal-free chemical safety testing with new technology ToxProfiler -
Assessing the safety of chemicals and medicines without laboratory animals -
University invests extra funds in groundbreaking research -
The Cell Observatory just got upgraded, and here is why -
Nanoparticles: a wonder material with a downside? -
Ratification of High Troughput Microscopy Dutch Flagship Node as Euro-BioImaging Node Candidate
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Horizon2020 grant for toxicologist Bob van de Water -
Drug development: how can we make it more efficient? -
Leiden researchers discover genes that affect spread of breast cancer
Former PhD candidates
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Muriel Heldring
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Marije Niemeijer
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Lukas Wijaya
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Luc Bischoff
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Richard Beck
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Jichao He
-
Ronan McLaughlin
-
Thijmen Booij
-
Suzanna Huppelschoten
-
Michiel Fokkelman
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Zuzanna Baranski Madrigal
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Steven Hiemstra
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Hayri Balcıoğlu
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Steven Wink
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Sebastiaan ter Braak
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Sreenivasa Ramaiahgari
-
Marja Driessen
-
Zi Di
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Veerander Ghotra
-
Louise von Stechow
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Giulia Benedetti
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Whilhelmina van Roosmalen
-
Lisa Frederiksson
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Yu Qin
-
Sarah Verkoeijen
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Jordi Carreras Puigvert
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Hoa Truong
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Sylvia Le Dévédec
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Martine van Miltenburg
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Maria ban Nimwegen
-
Yafeng Ma
-
Marjo de Graauw
Projects
- Oncogenic protein tyrosine kinases and Annexin family members in breast cancer formation and metastasis
- Live cell imaging-based modelling of cellular toxicity pathways
- Identification of novel druggable targets for estrogen-receptor positive and triple negative breast cancers
- Novel Anticancer Targets for Killing Drug Resistant Triple Negative Breast Cancer
Courses
- Theme Effects of drugs III – Drug Safety Evaluation
- Signal transduction: from target discovery to therapy
- Post Doctoral Course "Cell Toxicology"
- Post-Doctoral: "Cellular Toxicology/Predictive Toxicology" - IMI-SafeSciMET Training Programme in Safety Sciences
Professor of Drug safety science
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Toxicology
- Bergonzini C., Gregori A., Hagens T.M.S., Noord V.E. van der, Water B. van de, Zweemer A.J.M., Coban B., Capula M., Mantini G., Botto A., Finamore F., Garajova I., McDonnell L.A., Schmidt T., Giovannetti E. & Danen E.H.J. (2024), ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells, Journal of Experimental & Clinical Cancer Research 43: 4.
- Wijaya L.S., Gabor A., Pot I.E., Have L. van de, Saez-Rodriguez J., Stevens J.L., Le Dévédec S.E., Callegaro G. & Water B. van de (2024), A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury, Toxicological Sciences 198(1): 14-30.
- Vlasveld M.P., Callegaro G., Fisher C., Eakins J., Walker P., Lok S., Oost S. van, Jong B. de, Pellegrino Coppola D., Burger G.A., Wink S. & Water B. van de (2024), The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability, Liver International 44(3): 760-775.
- Niemeijer M.C., Więcek W., Fu S., Huppelschoten S., Bouwman R.J.P., Baze A., Parmentier C., Richert L., Paules R.S., Bois F.Y. & Water B. van de (2024), Mapping interindividual variability of toxicodynamics using high-throughput transcriptomics and primary human hepatocytes from fifty donors, Environmental Health Perspectives 132(3): 37005.
- Zobl W., Bitsch A., Blum J., Boei J.J.W.A., Capinha L., Carta G., Castell J., Davoli E., Drake C., Fisher C.P., Heldring M.M., Islam B., Jennings P., Leist M., Pellegrino-Coppola D., Schimming J.P., Snijders K.E., Tolosa L., Water B. van de, Vugt-Lussenburg B.M.A. van, Walker P., Wehr M.M., Wijaya L.S. & Escher S.E. (2024), Protectiveness of NAM-based hazard assessment: which testing scope is required?, ALTEX - Alternatives to Animal Experimentation 41(2): 302-319.
- Kunnen S.J., Arnesdotter E., Willenbockel C.T., Vinken M. & Water B. van de (2024), Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment, ALTEX - Alternatives to Animal Experimentation 41(2): 213-232.
- Vadde R., Wijaya L.S., Beztsinna N., Griend C.J. van de, Water B. van de, Bonnet S.A. & Le Dévédec S.E. (2024), Cell viability imaging in tumor spheroids via DNA binding of a ruthenium(ii) light-switch complex, Chemical Communications 60(49): 6308-6311.
- Heldring M.M., Duijndam B., Kyriakidou A., Meer O.M. van der, Tedeschi M., Laan J.W. van der, Water B. van de & Beltman J.B. (2024), Interdependency of estradiol-mediated ERα activation and subsequent PR and GREB1 induction to control cell cycle progression, Heliyon 10(21): e38406.
- Veltman C.H.J., Pennings J.L.A., Water B. van de & Luijten M. (2023), An adverse outcome pathway network for chemically induced oxidative stress leading to (non)genotoxic carcinogenesis, Chemical Research in Toxicology 36(6): 805-817.
- Noord V.E. van der, Stel W. van der, Louwerens G., Verhoeven D., Kuiken H.J., Lieftink C., Grandits M., Ecker G.F., Beijersbergen R.L., Bouwman R.J.P., Le Dévédec S.E. & Water B. van de (2023), Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors, Breast Cancer Research 25(1): 51.
- Sanz F., Pognan F., Steger-Hartmann T., Díaz C., Asakura S., Amberg A., Bécourt-Lhote N., Blomberg N., Bosc N., Briggs K., Bringezu F., Brulle-Wohlhueter C., Brunak S., Bueters R., Callegaro G., Capella-Gutierrez S., Centeno E., Corvi J., Cronin M.T.D., Drew P., Duchateau-Nguyen G., Ecker G.F., Escher S., Felix E., Ferreiro M., Frericks M., Furlong L.I., Geiger R., George C., Grandits M., Ivanov-Draganov D., Kilgour-Christie J., Kiziloren T., Kors J.A., Koyama N., Kreuchwig A., Leach A.R., Mayer M.A., Monecke P., Muster W., Nakazawa C.M., Nicholson G., Parry R., Pastor M., Piñero J., Oberhauser N., Ramírez-Anguita J.M., Rodrigo A., Smajic A., Schaefer M., Schieferdecker S., Soininen I., Terricabras E., Trairatphisan P., Turner S.C., Valencia A., Water B. van de, Lei J.L. van de, Mulligen E.M. van, Vock E. & Wilkinson D. (2023), eTRANSAFE: data science to empower translational safety assessment, Nature Reviews Drug Discovery : .
- Audebert M., Assmann A.S., Azqueta A., Babica P., Benfenati E., Bortoli S., Bouwman R.J.P., Braeuning A., Burgdorf T., Coumoul X., Debizet K., Dusinska M., Ertych N., Fahrer J., Fetz V., Le Hégarat L., López de Cerain A., Heusinkveld H.J., Hogeveen K., Jacobs M.N., Luijten M., Raitano G., Recoules C., Rundén-Pran E., Saleh M., Sovadinová I., Stampar M., Thibol L., Tomkiewicz C., Vettorazzi A., Water B. van de, El Yamani N., Zegura B. & Oelgeschläger M. (2023), New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project, Frontiers in Toxicology 5: 1220998.
- Hosseini R., Vlasveld M.P., Willemse J.J., Water B. van de, Le Dévédec S.E. & Wolstencroft K.J. (2023), FAIR high content screening in bioimaging, Scientific Data 10(1): 462.
- Béquignon O.J.M., Gómez-Tamayo J.C., Lenselink E.B., Wink S., Hiemstra S.W., Lam C.C., Gadaleta D., Roncaglioni A., Norinder U., Water B. van de, Pastor M. & Westen G.J.P. van (2023), Collaborative SAR modeling and prospective in vitro validation of oxidative stress activation in human HepG2 cells, Journal of Chemical Information and Modeling 63(17): 5433-5445.
- Schmeisser S., Miccoli A., Bergen M. von, Berggren E., Braeuning A., Busch W., Desaintes C., Gourmelon A., Grafström R., Harrill J., Hartung T., Herzler M., Kass G.E.N., Kleinstreuer N., Leist M., Luijten M., Marx-Stoelting P., Poetz O., Ravenzwaay B. van, Roggeband R., Rogiers V., Roth A., Sanders P., Thomas R.S., Marie Vinggaard A., Vinken M., Water B. van de, Luch A. & Tralau T. (2023), New approach methodologies in human regulatory toxicology - Not if, but how and when!, Environment International 178: 108082.
- Holzer A.K., Dreser N., Pallocca G., Mangerich A., Stacey G., Dipalo M., Water B. van de, Rovida C., Wirtz P.H., Vugt B., Panzarella G., Hartung T., Terron A., Mangas I., Herzler M., Marx-Stoelting P., Coecke S. & Leist M. (2023), Acceptance criteria for new approach methods in toxicology and human health-relevant life science research - part I, ALTEX - Alternatives to Animal Experimentation 40(4): 706-712.
- Carta G., Stel W. van der, Scuric E.W.J., Capinha L., Delp J., Bennekou S.H., Forsby A., Walker P., Leist M., Water B. van de & Jennings P. (2023), Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells, Cell Biology and Toxicology 39: 3031-3059.
- Bergonzini C., Gregori A., Hagen T.M.S., Noord V.E. van der, Water B. van der, Zweemer A.J.M., Capula M., Mantini G., Botta A., Finamore F., Garajova I., McDonnell L.A., Schmidt T, Giovannetti E. & Danen E.H.J. (2023), ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells. Journal of Experimental & Clinical Cancer Research. [working paper].
- Danilyuk T.Y., Niemeijer M.C., Wijaya L.S., Snijders K., Berk L. van der, Braak S.J. ter, Callegaro G., Bouwman R.J.P., Le Dévédec S.E. & Water B. van de (2023), Human-induced pluripotent stem cell reporters for high-content screening of stress response activation identifying target organ-specific toxicities, Toxicology Letters 384: S192.
- Burgers E.J., Sharma R.P., Schildknecht S., Danilyuk T.Y., Wijaya L.S., Hincapie S., Ramirez Zickgraf F.M., Water B. van de & Beltman J.B. (2023), P06-09: Computational modelling of integrated stress response and oxidative stress response for cellular adversity predictions, Toxicology Letters 384: s108.
- Stel W. van der, Yang H., Le Dévédec S.E., Water B. van de, Beltman J.B. & Danen E.H.J. (2023), High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for oxphos complex I, III, and V inhibitors, Cell Biology and Toxicology 39: 415-433.
- Béquignon O.J.M., Bongers B.J., Jespers W., IJzerman A.P., Water B. van de & Westen G.J.P. van (2023), Papyrus: a large-scale curated dataset aimed at bioactivity predictions, Journal of Cheminformatics 15(1): 3.
- Liu Q., Liu N.S., Noord V.E. van der, Stel W. van der, Water B. van de, Danen E.H.J. & Le Dévédec S.E. (2023), Differential response of luminal and basal breast cancer cells to acute and chronic hypoxia, Breast Cancer Research and Treatment 198: 583-596.
- Callegaro G., Schimming J.P., Piñero González J., Kunnen S.J., Wijaya L.S., Trairatphisan P., Berk L. van den, Beetsma K., Furlong L.I., Sutherland J.J., Mollon J., Stevens J.L. & Water B. van de (2023), Identifying multiscale translational safety biomarkers using a network-based systems approach, iScience 26(3): 106094.
- Braak S.J. ter, Niemeijer M.C., Wolters L., Le Dévédec S.E., Bouwman R.J.P. & Water B. van de (2022), Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters, Mutagenesis 37(2): 130-142.
- Stel W. van der, Yang H., Vrijenhoek N.G., Schimming J.P., Callegaro G., Carta G., Darici S., Delp J., Forsby A., White A., Le Dévédec S.E., Leist M., Jennings P., Beltman J.B., Water B. van de & Danen E.H.J. (2022), Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation, Archives of Toxicology 96: 259-285.
- Vrijenhoek N.G., Wehr M.M., Kunnen S.J., Wijaya L.S., Callegaro G., Moné M.J., Escher S.E. & Water B. van de (2022), Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid, ALTEX - Alternatives to Animal Experimentation : .
- Grinberg M., Stöber R.M., Edlund K., Rempel E., Godoy P., Reif R., Widera A., Madjar K., Schmidt-Heck W., Marchan R., Sachinidis A., Spitkovsky D., Hescheler J., Carmo H., Arbo M.D., Water B. van de, Wink S., Vinken M., Rogiers V., Escher S., Hardy B., Mitic D., Apic G., Myatt G., Waldmann T., Mardinoglu A, Damm G., Seehofer D., Nüssler A., Weiss T.S., Oberemm A., Lampen A., Schaap M.M., Luijten M., Steeg H. van, Thasler W.E., Kleinjans J.C.S., Stierum R.H., Leist M., Rahnenführer J. & Hengstler J.G. (2022), Correction to: Toxicogenomics directory of chemically exposed human hepatocytes, Archives of Toxicology 96(3): 945-946.
- Burger G.A., Water B. van de, Le Dévédec S.E. & Beltman J.B. (2022), Density-dependent migration characteristics of cancer cells driven by pseudopod interaction, Frontiers in Cell and Developmental Biology 10: 854721.
- Tebby C., Gao W., Delp J., Carta G., Stel W. van der, Leist M., Jennings P., Water B. van de & Bois F.Y. (2022), A quantitative AOP of mitochondrial toxicity based on data from three cell lines, Toxicology In Vitro 81: 105345.
- Hiemstra S.W., Fehling-Kaschek M., Kuijper I.A., Bischoff L.J.M., Wijaya L.S., Rosenblatt M., Esselink J.J., Egmond A. van, Mos J., Beltman J.B., Timmer J., Water B. van de & Kaschek D. (2022), Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure, Scientific Reports 12(1): 7336.
- Duijndam B.H.A., Tedeschi M., Stel W. van der, Hoorn T. van den, Burg B. van der, Bouwman R.J.P., Laan J.W. van der & Water B. van der (2022), Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals, Toxicology In Vitro 81: 105348.
- Braak S.J. ter, Klip J.E., Wink S., Hiemstra S.W., Cooper S.L., Middleton A., White A. & Water B. van de (2022), Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses, Toxicology In Vitro 84: 105419.
- Pallocca G., Moné M.J., Kamp H., Luijten M., Water B. van de & Leist M. (2022), Next-generation risk assessment of chemicals – rolling out a human-centric testing strategy to drive 3R implementation: the RISK-HUNT3R project perspective, ALTEX - Alternatives to Animal Experimentation 39(3): 419-426.
- Heldring M.M., Wijaya L.S., Niemeijer M.C., Yang H., Lakhal T., Le Dévédec S.E., Water B. van de & Beltman J.B. (2022), Model-based translation of DNA damage signaling dynamics across cell types, PLoS Computational Biology 18(7): e1010264.
- Wester L., Venneker S., Hazenoot M., Pont C.M., Koedoot E., Timmermans A.M., Martens J.W.M., Jansen M.P.H.M., Kockx C.E.M., IJcken W.F.J. van, Meerman J.H.N., Zhang Y. & Water B. van de (2022), A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer, Biochemical Pharmacology 204: 115233.
- Llewellyn S.V., Kermanizadeh A., Ude V., Jacobsen N.R., Conway G.E., Shah U.K., Niemeijer M.C., Moné M.J., Water B. van de, Roy S., Moritz W., Stone V., Jenkins G.J.S. & Doak S.H. (2022), Assessing the transferability and reproducibility of 3D in vitro liver models from primary human multi-cellular microtissues to cell-line based HepG2 spheroids, Toxicology In Vitro 85: 105473.
- Driessen M., Plas-Duijvesteijn S. van der, Kienhuis A.S., Brandhof E.J. van den, Roodbergen M., Water B. van de, Spaink H.P., Palmblad M., Ven L.T.M. van der & Pennings J.L.A. (2022), Identification of proteome markers for drug-induced liver injury in zebrafish embryos, Toxicology 477: 153262.
- Noord V.E. van der, Water B. van de & Le Dévédec S.E. (2022), Targeting the heterogeneous genomic landscape in triple-negative breast cancer through inhibitors of the transcriptional machinery, Cancers 14(18): 4353.
- Capinha L., Zhang Y., Holzer A.K., Ückert A.K., Zana M., Carta G., Murphy C., Baldovini J., Mazidi Z., Grillari J., Dinnyes A., Water B. van de, Leist M., Commandeur J.N.M. & Jennings P. (2022), Transcriptomic-based evaluation of trichloroethylene glutathione and cysteine conjugates demonstrate phenotype-dependent stress responses in a panel of human in vitro models, Archives of Toxicology 97: 523-545.
- Sharma R.P., Wolters L., Braak B.T., Niemeijer M., Sparham C., Nicol B., White A., Water B. van de, Middleton A.M. & Beltman J.B. (2022), Deciphering the quantitative relationship between chemical kinetics and Nrf2 pathway dynamics, Toxicology Letters 368(Supplement 1): S288.
- Gupta R., Schrooders Y., Hauser D., Herwijnen M. van, Albrecht W., Braak B. ter, Brecklinghaus T., Castell J.V., Elenschneider L., Escher S., Guye P., Hengstler J.G., Ghallab A., Hansen T., Leist M., Maclennan R., Moritz W., Tolosa L., Tricot T., Verfaillie C., Walker P., Water B. van de, Kleinjans J. & Caiment F. (2021), Comparing in vitro human liver models to in vivo human liver using RNA-Seq, Archives of Toxicology 95: 573-589.
- Koedoot E., Wolters L., Smid M., Stoilov P., Burger G.A., Herpers B.H.A., Yan K., Price L.S., Martens J.W.M., Le Dévédec S.E. & Water B. van de (2021), Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy, Scientific Reports 11: 7529.
- Wijaya L.S., Trairatphisan P., Gabor A., Niemeijer M.C., Keet J., Alcalà Morera A., Snijders K.E., Wink S., Yang H., Schildknecht S., Stevens J.L., Bouwman R.J.P., Kamp H., Hengstler J., Beltman J.B., Leist M., Le Dévédec S.E., Saez-Rodriguez J. & Water B. van de (2021), Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury, Biochemical Pharmacology 190: 114591.
- Wijaya L.S., Rau C., Braun T.S., Marangoz S., Spegg V., Vlasveld M., Albrecht W., Brecklinghaus T., Kamp H., Beltman J.B., Hengstler J.G., Water B. van de, Leist M. & Schildknecht S. (2021), Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes, Cell Biology and Toxicology : .
- Llewellyn S.V., Niemeijer M., Nymark P., Moné M.J., Water B.van de, Conway G.E., Jenkins G.J.S. & Doak S.H. (2021), In vitro three-dimensional liver models for nanomaterial DNA damage assessment, Small 17(15): e2006055.
- Rovida C., Escher S.E., Herzler M., Bennekou S.H., Kamp H., Kroese D.E., Maslankiewicz L., Moné M.J., Patlewicz G., Sipes N., Aerts L. van, White A., Yamada T. & Water B. van de (2021), NAM-supported read-across: from case studies to regulatory guidance in safety assessment, ALTEX - Alternatives to Animal Experimentation 38(1): 140-150.
- Delp J., Cediel-Ulloa A., Cuciu I., Kranaster P., Vugt-Lussenburg B.M.A. van, Munic Kos V., Stel W. van der, Carta G., Hougaard Bennekou S., Jennings P., Water B. van de, Forsby A. & Leist M. (2021), Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors, Archives of Toxicology 95: 591-615.
- Stel W. van der, Carta G., Eakins J., Delp J., Suciu I., Forsby A., Cediel-Ulloa A., Attoff K., Troger F., Kamp H., Gardner I., Zdrazil B., Moné1 M.J., Ecker G.F., Pastor M., Gómez-Tamayo J.C., White A., Danen E.H.J., Leist M., Walker P., Jennings P., Hougaard Bennekou S. & Water B. van de (2021), New approach methods supporting read-across: two neurotoxicity AOP-based IATA case studies, ALTEX - Alternatives to Animal Experimentation 38(4): 615-635.
- Pognan F., Steger-Hartmann T., Díaz C., Blomberg N., Bringezu F., Briggs K., Callegaro G., Capella-Gutierrez S., Centeno E., Corvi J., Drew P., Drewe W.C., Fernández J.M., Furlong L.I., Guney E., Kors J.A.,Mayer M.A., Pastor M., Piñero J., Ramírez-Anguita J.M., Ronzano F., Rowell P., Saüch-Pitarch J., Valencia A., Water B. van de, Lei J. van der, Mulligen E. van & Sanz F. (2021), The eTRANSAFE project on translational safety assessment through Integrative knowledge management: achievements and perspectives, Pharmaceuticals 14(3): 237.
- Koedoot E., Steijn E. van, Vermeer M., González-Prieto R., Vertegaal A.C.O., Martens J.W.M., Le Dévédec S.E. & Water B. van de (2021), Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention, Journal of Experimental & Clinical Cancer Research 40: 82.
- Duijndam B., Goudriaan A., Hoorn T. van den, Stel W. van der, Le Dévédec S.E., Bouwman R.J.P., Laan J.W. van der & Water B. van de (2021), Physiologically relevant estrogen receptor alpha pathway reporters for single-cell imaging-based carcinogenic hazard assessment of estrogenic compounds, Toxicological Sciences 181(2): 187-198.
- Braak B. ter, Niemeijer M., Boon R., Parmentier C., Baze A., Richert. L., Huppelschoten S., Wink S., Verfaillie C. & Water B. van de (2021), Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes, Toxicology In Vitro 73: 105107.
- Liu T., Berk L. van den, Wondergem J.A.J., Tong C., Kwakernaak M.C., Braak B. ter, Heinrich D., Water B. van de & Kieltyka R.E. (2021), Squaramide‐based supramolecular materials Drive hepG2 spheroid differentiation, Advanced Healthcare Materials 10(11): 2001903.
- Tolosa L., Martínez-Sena T., Schimming J.P., Moro E., Escher S.E., Braak S.J. ter, Water B. van de, Miranda M.A., Vugt-Lussenburg B.M.A. van & Castell J.V. (2021), The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example, Archives of Toxicology 95(6): 2109-2121.
- Yang H., Stel W. van der, Lee R., Bauch C., Bevan S., Walker P., Water B. van de, Danen E.H.J. & Beltman J.B. (2021), Dynamic modeling of mitochondrial membrane potential upon exposure to mitochondrial inhibitors, Frontiers in Pharmacology 12: 679407.
- Snijders K.E., Fehér A., Táncos Z., Bock I., Téglási A., Berk L. van den, Niemeijer M., Bouwman P., Le Dévédec S.E., Moné M.J., Rossom R. van, Kumar M., Wilmes A., Jennings P., Verfaillie C.M., Kobolák J., Braak B. ter, Dinnyés A. & Water B. van de (2021), Fluorescent tagging of endogenous heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages, Archives of Toxicology 95(10): 3285-3302.
- Escher S.E., Aguayo-Orozco A., Benfenati E., Bitsch A., Braunbeck T., Brotzmann K., Bois F., Burg B. van der, Castel J., Exner T., Gadaleta D., Gardner I., Goldmann D., Hatley O., Golbamaki N., Graepel R., Jennings P., Limonciel A., Long A., Maclennan R., Mombelli E., Norinder U., Jain S., Capinha L.S., Taboureau O.T., Tolosa L., Vrijenhoek N.G., Vugt-Lussenburg B.M.A. van, Walker P., Water B. van de, Wehr M., White A., Zdrazil B. & Fisher C. (2021), Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action, Toxicology In Vitro 79: 105269.
- Callegaro G., Kunnen S.J., Trairatphisan P., Grosdidier S., Niemeijer M., Hollander W. den, Guney E., Piñero Gonzalez J., Furlong L., Webster Y.W., Saez-Rodriguez J., Sutherland J.J., Mollon J., Stevens J.L. & Water B. van de (2021), The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment, Archives of Toxicology 95(12): 3745-3775.
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- Jong Y. de, Oosterwijk J.G. van, Kruisselbrink A.B., Briaire I.H., Agrogiannis G., Baranski Madrigal Z., Cleven A.H., Cleton A.M., Water B. van de, Danen E.H.J. & Bovée J.V.M.G. (2016), Targeting survivin as a potential new treatment for chondrosarcoma of bone, Oncogenesis 5: e222.
- Wink S., Hiemstra S., Herpers B. & Water B. van de (2016), High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities, Archives of Toxicology : .
- Balcioglu H.E., Water B. van de & Danen E.H. (2016), Tumor-induced remote ECM network orientation steers angiogenesis, Scientific Reports 6: 22580.
- Rudolph J.D., Graauw M. de, Water B. van de, Geiger T. & Sharan R. (2016), Elucidation of Signaling Pathways from Large-Scale Phosphoproteomic Data Using Protein Interaction Networks, Cell Systems 3(6): 585-593.
- Sluis T.C. van der, Duikeren S. van, Huppelschoten S., Jordanova E.S., Nejad E.B., Sloots A., Boon L., Smit V.T.H.B.M., Welters M.J.P., Ossendorp F., Water B. van de, Arens R., Burg S.H. van der & Melief C.J.M. (2015), Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death, Clinical Cancer Research 21(4): 781-794.
- Sobral-Leite M., Wesseling J., Smit V.T., Nevanlinna H., Miltenburg M.H. van, Sanders J., Hofland I., Blows F.M., Coulson P., Patrycja G., Schellens J.H., Fagerholm R., Heikkilä P., Aittomäki K., Blomqvist C., Provenzano E., Ali H.R., Figueroa J., Sherman M., Lissowska J., Mannermaa A., Kataja V., Kosma V.M., Hartikainen J.M., Phillips K.A., Phillips K.A., Couch F.J., Olson J.E., Vachon C., Visscher D., Brenner H., Butterbach K., Arndt V., Holleczek B., Hooning M.J., Hollestelle A., Martens J.W., Deurzen C.H. van, Water B. van de, Broeks A., Chang-Claude J., Chenevix-Trench G., Easton D.F., Pharoah P.D., García-Closas M., Graauw M. de & Schmidt M.K. (2015), Annexin A1 expression in a pooled breast cancer series: association with tumor subtypes and prognosis, BMC Medicine 13: 156.
- Schaap M.M., Wackers P.F.K., Zwart E.P., Huijskens I., Jonker M.J., Hendriks G., Breit T.M., Steeg H. ten, Water B. van de & Luijten M. (2015), A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens, Archives of Toxicology 89(12): 2413-2427.
- Baranski Z., Booij T.H., Kuijjer M.L., Jong Y. de, Cleton-Jansen A.M., Price L.S., Water B. van de, Bovée J.V., Hogendoorn P.C. & Danen E.H. (2015), MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation, Genes and Cancer 6(11-12): 503-12.
- Baranski Z., Booij T.H., Cleton-Jansen A.M., Price L.S., Water B. van de, Bovee J.V.M.G., Hogendoorn P.C.W. & Danen E.H.J. (2015), Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma, Journal of Pathology 236(3): 348-359.
- Braak S.J. ter, Siezen C.L.E., Speksnijder E.N., Koedoot E., Steeg H. ter, Salvatori D.C.F., Water B. van de & Laan J.W. van der (2015), Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53(R270H/+)WAPCre mouse model, Breast cancer research 17: 14.
- Roosmalen W. van, Le Devedec S.E., Golani O., Smid M., Pulyakhina I., Timmermans A.M., Look M.P., Zi D., Pont C., Graauw M. de, Naffar-Abu-Amara S., Kirsanova C., Rustici G., Hoen P.A.C. 't, Martens J.W.M., Foekens J.A., Geiger B. & Water B.J. van de (2015), Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant, Journal of Clinical Investigation 125(4): 1648-1664.
- Ghotra V.P.S., He S., Horst G. van der, Nijhoff S., Bont H. de, Lekkerkerker A., Janssen R., Jenster G., Leenders G.J.L.H. van, Hoogland A., Marije M., Verhoef Esther I., Baranski Madrigal Z., Xiong J., Water B. van de, Pluijm G. van den, Snaar-Jagalska B.E. & Danen E.H.J. (2015), SYK is a candidate kinase target for the treatment of advanced prostate cancer, Cancer Research 75(1): 230-240.
- Driessen M., Vitins A.P., Pennings J.L.A., Kienhuis A.S., Water B. van de & Ven L.T.M. van der (2015), A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen, Toxicology Letters 232(2): 403-412.
- Stechow L. von, Typas D., Puigvert J.C., Oort L., Siddappa R., Pines A., Vrieling H., Water B. van de, Mullenders L.H.F. & Danen E.H.J. (2015), The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest, Molecular and Cellular Biology 35(7): 1254-1268.
- Baranski Madrigal Z., Booij T.H., Jong Y. de, Oosterwijk J. van, Cleton A.-M., Price L.S., Water B. van de, Bovee J.V.M.G., Hogendoorn P.C.W. & Danen E.H.J. (2015), Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in osteosarcoma cells, Cancer Research 75(15): 3780.
- Wink S. & Water B. van de (2015), A high throughput microscopy toxicity pathway reporter platform for chemical safety assessment , Toxicology Letters 238(2): S38-S38.
- Water B. van de (2015), Mechanistic insights in TNF signaling and drug-induced liver injury: towards a predictive preclinical toolbox, Toxicology Letters 238(2): S40-S40.
- Bronsveld H.K., Braak B. ter, Karlstad O., Vestergaard P., Starup-Linde J., Bazelier M.T., Bruin M.L. de, Boer A. de, Siezen C.L.E., Water B. van de, Laan J.W. van der & Schmidt M.K. (2015), Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence, Breast cancer research 17: 100.
- Braak B. ter, Wink S., Koedoot E., Pont C., Siezen C., Laan J.W. van der & Water B. van de (2015), Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells, Breast cancer research 17: 97.
- Baranski Madrigal Z., Jong Y. de, Ilkova T.I., Peterse E.F.P., Cleton-Jansen A.M., Water B. van de, Hogendoorn P.C.W., Bovée J.V.M.G. & Danen E.H.J. (2015), Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin, OncoTarget 6(34): 36113-36125.
- Peeters M.C., Fokkelman M., Boogaard B., Egerod K.L., Water B. van de, IJzerman A.P. & Schwartz T.W. (2015), The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration, Cellular Signalling 27(12): 2579-2588.
- Suter-Dick L., Alves P.M., Blaauboer B.J., Bremm K.-D., Brito C., Coecke S., Flick B., Fowler P., Hescheler J., Ingelman-Sundberg M., Jennings P., Kelm J.M., Manou I., Mistry P., Moretto A., Roth A., Stedman D., Water B. van de & Beilmann M. (2015), Stem cell-derived systems in toxicology assessment, Stem Cells and Development 24(11): 1284-1296.
- Di Z., Klop M.J.D., Rogkoti V.M., Le Dèvèdec S.E., Water B. van de, Verbeek F.J., Price L.S. & Meerman J.H.N. (2014), Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues, PLoS ONE 9(10): e109688.
- Yizhak K., Gaude E., Le Devedec S., Waldman Y.Y., Stein G.Y., Water B. van de, Frezza C. & Ruppin E. (2014), Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer, eLife 3: e03641.
- Wink S., Hiemstra S., Huppelschoten S., Danen E.H.J., Niemeijer M., Hendriks G., Vrieling H., Herpers B. & Water B. van de (2014), Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment, Chemical Research in Toxicology 27(3): 338-355.
- Water Bob van de (2014), Towards a High Throughput Microscopy Pathway in Toxicity Reporter Platform for Chemical Safety Assessment, Mutagenesis 29(6): 535-535.
- Moerkens M., Zhang Y., Wester L., Water B. van de & Meerman J.H.N. (2014), Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation, BMC Cancer 14: 283.
- Miltenburg M.H. van, Nimwegen M.J. van, Tijdens R.B., Lalai R.A., Kuiper R., Klarenbeek S., Schouten P.C., Vries A. de, Jonkers J.M.M. & Water B. van de (2014), Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation, British Journal of Cancer 110(11): 2747-2755.
- Yizhak K., Le Dévédec S.E., Rogkoti V.M., Baenke F., Boer V.C. de, Frezza C., Schulze A., Water B. van de & Ruppin E. (2014), A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration, Molecular Systems Biology 10(8): 744.
- Water B. van de, Klingmuller U. & Timmer J. (2014), A systems biology approach to unravel the drug-TNF alpha signaling synergy in idiosyncratic DILI, Toxicology Letters 229S: S39.
- Graauw M. de, Cao L., Winkel L., Miltenburg M.H.A.M. van, Dévédec S.E. le, Klop M., Yan K., Pont C.M., Rogkoti V.M., Tijsma A., Chaudhuri A., Lalai R.A., Price L.S., Verbeek F.J. & Water B. van de (2014), Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation, Oncogene 33(20): 2610-2619.
- Truong H.H., Xiong J., Ghotra V.P.S., Nirmala E., Haazen L., Le Dévédec S.E., Balcioglu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H.J. (2014), beta(1) Integrin Inhibition Elicits a Prometastatic Switch Through the TGF beta-miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer, Science Signaling 7(312): ra15.
- Ramaiahgari S.C., Braver M.W. den, Herpers B., Terpstra V., Commandeur J.N., Water B. van de & Price L.S. (2014), A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies, Archives of Toxicology 88(5): 1083-1095.
- Braak S.J. ter, Siezen C.L.E., Kannegieter N., Koedoot E., Water B. van de & Laan J.W. van der (2014), Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel, Archives of Toxicology 88(4): 953-966.
- Stokman G., Qin .Y., Booij T.H., Ramaiahgari S.C., Lacombe M., Dolman M.E., Dorenmalen K.M. van, Teske G.J., Florquin S., Schwede F., Water B. van de, Kok R.J. & Price L.S. (2014), Epac-Rap signaling reduces oxidative stress in the tubular epithelium, Journal of the American Society of Nephrology 25(7): 1474-1485.
- Truong H.H., Xiong J., Ghotra V.P, Nirmala .E, Haazen L.C.J.M., Dévédec S.E. le, Balcioğlu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H. (2014), β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer, Science Signaling 7(312): ra15.
- Fredriksson L., Wink S., Herpers B.H.A., Benedetti G., Hadi M., Bont H.J.G.M. de, Groothuis G., Luijten M., Danen E.H.J., Graauw M. de, Meerman J.H.N. & Water B. van de (2014), Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity, Toxicological Sciences 140(1): 144-159.
- Driessen M., Kienhuis A.S., Vitins A.P., Pennings J.L., Pronk T.E., Brandhof E.J. van den, Roodbergen M., Water B. van de & Ven L.T. van der (2014), Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans, Toxicology Letters 230(1): 48-56.
- Grinberg Marianna, Stoeber Regina M., Edlund Karolina, Rempel Eugen, Godoy Patricio, Reif Raymond, Widera Agata, Madjar Katrin, Schmidt-Heck Wolfgang, Marchan Rosemarie, Sachinidis Agapios, Spitkovsky Dimitry, Hescheler Jurgen, Carmo Helena, Arbo Marcelo D., Van de Water Bob, Wink Steven, Vinken Mathieu, Rogiers Vera, Escher Sylvia, Hardy Barry, Mitic Dragana, Myatt Glenn, Waldmann Tanja, Mardinoglu Adil, Damm Georg, Seehofer Daniel, Nuessler Andreas, Weiss Thomas S., Oberemm Axel, Lampen Alfons, Schaap Mirjam M., Luijten Mirjam, Van Steeg Harry, Thasler Wolfgang E., Kleinjans Jos C.S., Stierum Rob H., Leist Marcel, Rahnenfuehrer Joerg & Hengstler Jan G. (2014), Toxicogenomics directory of chemically exposed human hepatocytes, Archives of Toxicology 88(12): 2261-2287.
- Stechow L. von der, Water B. van de & Danen E.H.J. (2013), Unraveling DNA damage response-signaling networks through systems approaches, Archives of Toxicology 87(9): 1635-1648.
- Stechow L. von der, Ruiz-Aracama A., Water B. van de, Peijnenburg A., Danen E.H.J. & Lommen A. (2013), Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells, 8(10): e76476.
- Carreras Puigvert J., Stechow L. von der, Siddappa R., Pines A., Bahjat M., Haazen L.C., Olsen J.V., Vrieling H., Meerman J.H., Mullenders L.H., Water B. van de & Danen E.H.J. (2013), Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells, Science Signaling 6(259): ra5.
- Verissimo C.S., Elands R., Cheng S., Saaltink D.J., Horst J.P. ter, Alme M.N., Pont C.M., Water B. van der, Håvik B., Fitzsimons C.P. & Vreugdenhil E. (2013), Silencing of doublecortin-like (DCL) results in decreased mitochondrial activity and delayed neuroblastoma tumor growth, PLoS ONE 8(9): e75752.
- Hendriks G., Water B. van de, Schoonen W. & Vrieling H. (2013), Cellular-signaling pathways unveil the carcinogenic potential of chemicals, Journal of Applied Toxicology 33(6): 399-409.
- Benedetti G., Fredriksson L., Herpers B., Meerman J., Water B. van de & Graauw M. de (2013), TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells, Biochemical Pharmacology 85(2): 274-86.
- Benedetti G., Fokkelman M., Yan K., Fredriksson L., Herpers B., Meerman J., Water B. van de & Graauw M. de (2013), The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch, Molecular Pharmacology 84(1): 128-38.
- Driessen M., Kienhuis A.S., Pennings J.L., Pronk T.E., Brandhof E.J. van de, Roodbergen M., Spaink H.P., Water B. van de & Ven L.T. van der (2013), Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling. Arch.Toxicol. 87, no. 5:807-823, Archives of Toxicology 87: 807-823.
- Damiano L., Le Devedec S.E., Di Stefano P., Repetto D., Lalai R.A., Truong H., Xiong J.L., Danen E.H., Yan K., Verbeek F.J., De Luca E., Attanasio F., Buccione R., Turco E., Water B. van de & Defilippi P. (2012), p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation, Oncogene 31(5): 624-633.
- Truong H.H., Sonneville J. de, Ghotra V.P., Xiong J., Price L., Hogendoorn P.C., Spaink H.P., Water B. van de & Danen E.H. (2012), Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens, Biomaterials 33(1): 181-188.
- Le Dévédec S.E., Geverts B., Bont H.J.G.M. de, Yan K., Verbeek F.J., Houtsmuller A.B. & Water B. van de (2012), The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status, Journal of Cell Science 125(19): 4498-4506.
- Di Z., Herpers B.H.A., Fredriksson L., Yan K., Water B. van de, Verbeek F.J. & Meerman J.H.N. (2012), Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening, PLoS ONE 7(12): e52337.
- Ghotra V.P., He S., Bont H.J.G.M. de, Ent W. van der, Spaink H.P., Water B. van de, Snaar-Jagalska B.E. & Danen E.H.J. (2012), Automated whole animal bio-imaging assay for human cancer dissemination, 7(2): e31281.
- Hendriks G., Atallah M., Morolli B., Calléja F., Ras-Verloop N., Huijskens I., Raamsman M., Water B. van de & Vrieling H. (2012), The ToxTracker assay: novel GFP reporter systems that provide mechanistic insight into the genotoxic properties of chemicals, Toxicological Sciences 125(1): 285-298.
- Verissimo C.S., Cheng S., Puigvert J.C., Qin Y., Vroon A., Deutekom J. van, Price L.S., Danen E.H., Water B. van de, Fitzsimons C.P. & Vreugdenhil E. (2012), Combining doublecortin-like kinase silencing and vinca alkaloids results in a synergistic apoptotic effect in neuroblastoma cells, Journal of Pharmacology and Experimental Therapeutics 342(1): 119-130.
- Oosterwijk J.G. van, Herpers B.H.A., Meijer D., Briaire-Bruijn I.H. de, Cleton-Jansen A.M., Gelderblom H., Water B. van de & Bovée J.V.G.M. (2012), Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance, Annals of Oncology 23(6): 1617-1626.
- Verissimo C.S., Molenaar J.J., Meerman J., Puigvert J.C., Pont C., Danen E.H.J., Water B. van de, Versteeg R., Fitzsimons C.P. & Vreugdenhil E. (2012), DOUBLECORTIN-LIKE KINASE: A POTENTIAL THERAPEUTIC TARGET FOR NEUROBLASTOMA, Neuro-Oncology 14: 91-91.
- Qin Y., Stokman G., Yan K., Ramaiahgari S.C., Verbeek F.J., Graauw M. de, Water B. van de & Price L.S. (2012), cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac, British Journal of Pharmacology 165(4b): 1137-1150.
- Fredriksson Lisa, Herpers Bram, Benedetti Giulia, Matadin Quraisha, Puigvert Jordi C., De Bont Hans, Dragovic Sanja, Vermeulen Nico P.E., Commandeur Jan N.M., Danen E.H.J., De Graauw Marjo & Van de Water Bob (2011), Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis, Hepatology 53(6): 2027-2041.
- Pines A., Kelstrup C.D., Vrouwe M.G., Puigvert J.C., Typas D., Misovic B., De Groot A., Von Stechow L., Van de Water B., Danen E.H., Vrieling H., Mullenders L.H. & Olsen J.V. (2011), Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells, Molecular and Cellular Biology 31(24): 4964-4977.
- Yan K., Larios E., LeDevedec S., Water B. van de & Verbeek F.J. (2011), Automation in Cytomics: Systematic Solution for Image Analysis and Management in High Throughput Sequences, Proceedings IEEE Conference Engineering and Technology (CET 2011). 195-198.
- Zhang Y., Moerkens M., Ramaiahgari S., Bont H.J.G.M. de, Price L., Meerman J.H.N. & Water B. van de (2011), Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes, Breast cancer research 13(3): R52.
- Roosmalen W.P.E. van, Le Dévédec S.E., Zovko S., Bont H.J.G.M. & Water B. van de (2011), Functional screening with a live cell imaging-based random cell migration assay. In: Wells C. & Parsons M. (Eds.), Cell Migration. Methods in Molecular Biology no. 769: Humana Press. 435-448.
- Le Dévédec S.E., Roosmalen W. van, Pont C.M., Lalai R., Bont H.J.G.M. de & Water B. van de (2011), Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo. In: Wells C.M. & Parsons M. (Eds.), Cell Migration. Methods in Molecular Biology no. 769: Springer. 331-349.
- Hendriks G., Atallah M., Raamsman M., Morolli B., Putten H. van der, Jaadar H., Tijdens R.B., Esveldt-Van Lange R., Mullenders L., Water B. van de & Vrieling H. (2011), Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 709-710: 49-59.
- Qin Y., Alderliesten M.C., Stokman G., Pennekamp P., Bonventre J.V., Heer E. de, Ichimura T., De Graauw M., Price L.S. & Water B. van de (2011), Focal adhesion kinase signaling mediates acute renal injury induced by ischemia/reperfusion, The American Journal of Pathology 179(6): 2766-2778.
- Stokman G., Qin Y., Genieser H.G., Schwede F., Heer E. de, Bos J.L., Bajema I.M., Water B. van de & Price L.S. (2011), Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure, Journal of the American Society of Nephrology 22(5): 859-872.
- Le Devedec S.E., Lalai R., Pont C.M., Bont H.J.G.M. & Water B. van de (2011), Two-Photon Intravital Multicolor Imaging Combined with Inducible Gene Expression to Distinguish Metastatic Behavior of Breast Cancer Cells In Vivo, Molecular Imaging and Biology 13(1): 67-77.
- Le Dévédec S.E., Yan K., Bont H.J.G.M. de, Ghotra V.P., Truong H., Danen E.H., Verbeek F.J. & Water B. van de (2010), Systems microscopy approaches to understand cancer cell migration and metastasis, Cellular and Molecular Life Sciences 67(19): 3219-3240.
- Graauw M. de, Miltenburg M.H. van, Schmidt M.K., Pont C.M., Lalai R.A., Kartopawiro J., Pardali E., Le Dévédec S.E., Smit V.T., Wal A. van der, Veer L.J. van 't, Cleton-Jansen A.-M., Dijke P. ten & Water B. van de (2010), Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells, Proceedings of the National Academy of Sciences 107(14): 6340-6345.
- Verissimo C.S., Molenaar J.J., Meerman J.H.N., Puigvert J.C., Lamers F., Koster J., Danen E.H., Water B. van de, Versteeg R., Fitzsimons C.P. & Vreugdenhil E.H.J. (2010), Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells, Endocrine-Related Cancer 17(2): 399-414.
- Happe H., Leonhard W.N., Wal A. van der, Water B. van de, Lantinga-Van Leeuwen I.S., Breuning M.H., Heer E. de & Peters D.J.M. (2009), Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways, Human Molecular Genetics 18(14): 2532-2542.
- Puigvert J.C., Huveneers S., Fredriksson L., Veld M. op het, Water B. van de & Danen E.H.J. (2009), Cross-talk between integrins and oncogenes modulates chemosensitivity, Molecular Pharmacology 75(4): 947-55.
- Yan K., Le Devedec S., Water B. van de & Verbeek F.J. (2009), Cell Tracking and Data Analisys of in vitro Tumour Cells from Time--Lapse Image Sequences. Ranchordas A. & Araujo H. (Eds.), Proceedings of the Fourth International Conference on Computer Vision Theory and Applications, VISAPP. Fourth International Conference on Computer Vision Theory and Applications 5 February 2009 - 8 February 2009 no. Volume 1. Portugal: Scitepress. 281-286.
- Ma Y., Water B. van de & Le Dévédec S.E. (2009), Focal Adhesion Kinase (FAK) Inhibition as a potential strategy for anticancer therapies, Drugs of the Future 34(6): 477-483.
- Boesten L.S., Zadelaar A.S., Nieuwkoop A. van, Hu L., Teunisse A.F.A.S., Jochemsen A.G., Evers B., Water B. van de, Gijbels M.J., Vlijmen B.J. van, Havekes L.M. & Winther M.P. de (2009), Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice, Atherosclerosis 207(2): 399-404.
- Le Dévédec S.E., Roosmalen W.P.E. van, Maria N., Grimbergen M., Pont C.M., Lalai R.A. & Water B. van de (2009), An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gamma c(-/-) mouse, Clinical and Experimental Metastasis 26(7): 673-684.
- Miltenburg M.H. van, Lalai R.A., Bont H.J.G.M. de, Waaij E. van, Beggs H., Danen E.H.J. & Water B. van de (2009), Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility, The FASEB Journal 23(10): 3482-3493.
- Hamdi M., Popeijus H.E., Carlotti F., Janssen J.M., Burgt C. van der, Cornelissen-Steijger P.D.M., Water B. van de, Hoeben R.C., Matsuo K. & Dam H. van (2008), ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses, DNA Repair 7(3): 487-496.
- Graauw M. de, Tijdens I., Smeets M.B., Hensbergen P.J., Deelder A.M. & Water B. van de (2008), Annexin A2 Phosphorylation Mediates Cell Scattering and Branching Morphogenesis via Cofilin Activation, Molecular and Cellular Biology 28(3): 1029-1040.
- Heer P. de, Koudijs M.M., Velde C.J. van de, Aalbers R.I.J.M., Tollenaar R.A.E.M., Putter H., Morreau J., Water B. van de & Kuppen P.J.K. (2008), Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation, European Journal of Surgical Oncology 34(11): 1253-1261.
- Huveneers S., Arslan N., Water B. van de, Sonnenberg A. & Danen E.H.J. (2008), Integrins uncouple Src-induced morphological and oncogenic transformation, Journal of Biological Chemistry 283(19): 13243-13251.
- Graauw M. de, Le Devedec S., Tijdens R.B., Smeets M.B., Deelder A.M. & Water B. van de (2007), Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary rat renal proximal tubular cells, Journal of Pharmacology and Experimental Therapeutics 322(1): 89-100.
- Alderliesten M.C., Graauw M. de, Oldenampsen J., Qin Y., Pont C., Buren L. van & Water B. van de (2007), ERK Activation during Renal Ishcemia/Reperfusion Mediates Focal Adhesion Dissolution and Renal Injury, The American Journal of Pathology 171(2): 452-462.
- Nimwegen M.J. van & Water B. van de (2007), Focal adhesion kinase: A potential target in cancer therapy, Biochemical Pharmacology : .
- Alderliesten M., Graauw M. de, Oldenampsen J., Qin Y., Pont C.M., Buren L. van & Water B. van de (2007), Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury, The American Journal of Pathology 171(2): 452-462.
- Nimwegen M.J. van & Water B. van de (2007), Focal adhesion kinase: a potential target in cancer therapy, Biochemical Pharmacology 73(5): 597-609.
- Kruse J.J., Svensson J.P., Huigsloot M., Giphart-Gassler M., Schoonen W.G., Polman J.E., Jean Horbach G., Water B. van de & Vrieling H. (2007), A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 617(1-2): 58-70.
- Nimwegen M.J. van, Verkoeijen S., Kuppen P.J., Velthuis J.H. & Water B. van de (2007), An improved method to study NK-independent mechanisms of MTLn3 breast cancer lung metastasis, Clinical and Experimental Metastasis 24(5): 379-387.
- Water B. van de, Graauw M. de, Dévédec S.E. le & Alderliesten M.C. (2006), Cellular stress responses and molecular mechanisms of nephrotoxicity, Toxicology Letters 162: 83-93.
- Graauw M. de, Hensbergen P. & Water B. van de (2006), Phospho-proteomic analysis of cellular signaling, Electrophoresis 27(13): 2676-2686.
- Burg D., Riepsaame J., Pont C., Mulder G. & Water B. van de (2006), Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling, Biochemical Pharmacology 71(3): 268-277.
- Boesten L.S.M., Zadelaar A.S.M., Nieuwkoop A. van, Hu L, Jonkers J, Water B. van de, Gijbels M.J.J., Made I. van der, Winther M.P.J. de, Havekes L.M. & Vlijmen B.J.M. van (2006), Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice, The FASEB Journal 20(7): 953-955.
- Nimwegen M.J. van, Huigsloot M., Camier A., Tijdens R.B. & Water B. van de (2006), Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells, Molecular Pharmacology 70(4): 1330-1339.
- Lombaerts M., Wezel T. van, Philippo K., Dierssen J.W., Zimmerman R.M., Oosting J., Eijk R. van, Eilers P.H., Water B. van de, Cornelisse C.J. & Cleton A.M. (2006), E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines, British Journal of Cancer 94(5): 661-671.
- Water B. van de, Graauw M. de, Le Devedec S.E. & Alderliesten M. (2006), Cellular stress responses and molecular mechanisms of nephrotoxicity, Toxicology Letters 162(1): 83-93.
- Burg D., Riepsaame J., Mulder G.J. & Water B. van de (2006), Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling, Biochemical Pharmacology 71(3): 268-277.
- Boesten L.S.M., Zadelaar A.S., Nieuwkoop A. van, Hu L., Jonkers J., Water B. van de, Gijbels M.J., Made I. van der, Winther M.P.J. de, Havekes L.M. & Vlijmen B.J. van (2006), Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice, The FASEB Journal 20: 953-955.
- Boesten LS, Zadelaar A.S., Nieuwkoop A. van, Hu L., Jonkers J., Water B. van de, Gijbels M.J., Made I. van der, Winther M.P.J. de, Havekes L.M. & Vlijmen B.J. van (2006), Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice, The FASEB Journal 20(7): 953-955.
- Lombaerts M., Wezel T. van, Philippo K., Dierssen J.W., Zimmerman R., Oosting J., Eijk R. van, Eilers P.H.C., Water B. van de, Cornelisse C.J. & Cleton-Jansen A.M. (2006), E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines, British Journal of Cancer 94: 661-671.
- Boesten LS, Zadelaar A.S.M., Nieuwkoop A. van, Hu L., Jonkers J., Water B. van de, Gijbels M.J.J., Made I. van der, Winther M.P.J. de, Havekes L.M. & Vlijmen B.J.M. van (2006), Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice, The FASEB Journal 20(7): 953-955.
- Graauw M. de, Hensbergen P. & Water B. van de (2006), Phospho-proteomic analysis of cellular signaling, Electrophoresis 27: 2676-2686.
- Nimwegen M.J. van, Verkoeijen S., Buren L. van, Burg D. & Water B. van de (2005), Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation, Cancer Research 65(11): 4698-706.
- Nimwegen M.J. van, Verkoeijen S., Buren L. van, Burg D. & Water B. van de (2005), Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation, Cancer Research 65(11): 4698-4706.
- Imamdi R.M.A.A., Graauw M. de & Water B. van de (2004), Protein kinase C mediates cisplatin-induced loss of adherens junctions followed by apoptosis of renal proximal tubular epithelial cells, Journal of Pharmacology and Experimental Therapeutics 311(3): 892-903.
- Huigsloot M., Tijdens R.B. & Water B. van de (2003), Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2, Molecular Pharmacology 64(4): 965-973.
- Huigsloot M., Tijdens R.B., Mulder G.J. & Water B. van de (2002), Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary (MTLn3) cells, Journal of Biological Chemistry 277(39): 35869-35879.
- Leussink B.T., Nagelkerke J.F., Water B. van de, Slikkerveer A., Voet G.B. van der, Srinivasan A., Bruijn J.A., Wolff F.A. de & Heer E. de (2002), Pathways of proximal tubular cell death in busmuth nephrotoxicity, Toxicology and Applied Pharmacology 180: 100-109.
- Leussink B.T., Nagelkerke J.F., Water B. van de, Slikkerveer A., Voet G.B. van der, Srinivasan A., Bruijn J.A., Wolff F.A. de & Heer E. de (2002), Pathways of proximal tubular cell death in bismuth nephrotoxicity, Toxicology and Applied Pharmacology 180(2): 100-109.
- Nauta A.J., Daha M.R., Tijsma O., Water B. van de, Tedesco F. & Roos A. (2002), The membrane attack complex of complement induces caspase activation and apoptosis, European Journal of Immunology 32(3): 783-792.
- Nauta A.J., Daha M.R., Tijsma O.M.H., Water B. van de, Tedesco F. & Roos A. (2002), The membrane attack complex of complement induces caspase activation and apoptosis, European Journal of Immunology 32(3): 783-792.
- Leussink B.T., Nagelkerke J.F., Water B. van de, Slikkerveer A., Voet G.B. van der, Srinivasan A., Bruijn J.A., Wolff F.A. de & Heer E. de (2002), Pathways of proximal tubular cell death in bismuth nephrotoxicity, Toxicology and Applied Pharmacology 180: 100-109.
- Leussink B.T., Nagelkerke J.F., Water B. van de, Slikkerveer A., Voet G.B. van der, Srinivasan A., Bruijn J.A., Wolff F.A. de & Heer E. de (2002), Pathways of proximal tubular death in bismuth nephrotoxicity, Toxicology and Applied Pharmacology 180: 100-109.
- Huigsloot M., Tijdens R.B., Mulder G.J. & Water B. van de (2001), Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells, Biochemical Pharmacology 62(8): 1087-1097.
- Water B. van de, Houtepen F., Huigsloot M. & Tijdens R.B. (2001), Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury, Journal of Biological Chemistry 276(39): 36183-36193.
- Vlijmen B.J.M. van, Gerritsen G, Franken AL, Boesten L.S.M., Kockx M.M., Gijbels M.J.J., Vierboom M.P.M., Eck M. van, Water B. van de, Berkel T.J.C. van & Havekes L.M. (2001), Macrophage p53 deficiency leads to enhanced atherosclerosis in ApoE*3-Leiden transgenic mice, Circulation Research 88(8): 780-786.
- Water B. van de, Tijdens R.B., Verbrugge A., Huigsloot M., Dihal A.A., Stevens J.L., Jaken S. & Mulder G.J. (2000), Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells, Journal of Biological Chemistry 275(33): 25805-25813.
- Water B. van de, Nagelkerke J.F. & Stevens J.L. (1999), Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells, Journal of Biological Chemistry 274(19): 13328-13337.
- Liu H., Miller E., Water B. van de & Stevens J.L. (1998), Endoplasmic reticulum stress proteins block oxidant-induced Ca2+ increases and cell death, Journal of Biological Chemistry 273(21): 12858-12862.
- Water B. van de, Liu H. & Stevens J.L. (1998), ER stress response proteins in modulation of cell death. In: Nagelkerke J.F., Dierendonck J.H. van & Noteborn M.H.M. (Eds.), Pharmaceutical intervention in apoptotic pathways. Amsterdam: North-Holland. 113-126.
- Fowler L., Dong L., Bowes R., Water B. van de, Stevens J.L. & Jaken S. (1998), Transformation-sensitive changes in expression, localization and phosphorylation of adducins in renal proximal tubule epithelial cells, Cell Growth and Differentiation 9: 177-184.
- Kruidering M., Water B. van de, Zhan Y., Baelde J.J., Heer E., Mulder G.J., Stevens J.L. & Nagelkerke J.F. (1998), Cisplatin effects on F-actin and matrix proteins precede renal tubular cell detachment and apoptosis in vitro, Cell Death & Differentiation 5(7): 601-614.
- Kruidering M., Water B. van de, Heer E. de, Mulder G.J. & Nagelkerke J.F. (1997), Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain, Journal of Pharmacology and Experimental Therapeutics 280(2): 638-649.
- Kruidering M., Water B. van de & Nagelkerke J.F. (1996), Methods for studying renal toxicity. In: Seiler J.P., Kroftova O. & Eybl V. (Eds.), Toxicology - From Cells to Man. Archives of Toxicology : Supplement no. 18. Berlin Heidelberg: Springer. 173-183.
- Water B. van de, Zoeteweij J.P. & Nagelkerke J.F. (1996), Alkylation-induced oxidative cell injury of renal proximal tubular cells: involvement of glutathione redox-cycle inhibition, Archives of Biochemistry and Biophysics 327(1): 71-80.
- Andreadou I., Water B. van de, Commandeur J.N., Nagelkerke F.J. & Vermeulen N.P. (1996), Comparative cytotoxicity of 14 novel selenocysteine se-conjugates in rat renal proximal tubular cells, Toxicology and Applied Pharmacology 141(1): 278-287.
- Zoetewij J.P., Water B. van de, Bont H.J. de & Nagelkerke J.F. (1996), The role of a purinergic P2z receptor in calcium-dependent cell killing of isolated rat hepatocytes by extracellular adenosine triphosphate, Hepatology 23(4): 858-865.
- Water B. van de, Zoeteweij J.P., Bont H.J.G.M. de & Nagelkerke J.F. (1995), Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury, Molecular Pharmacology 48(5): 928-937.
- Water B. van de, Berkel T.J.C. van & Kuiper J. (1994), Activation of rat Kupffer cells to tumoricidal cells by the immunomodulator muramyl tripeptide-phosphatidylethanolamine incorporated into the novel drug carrier lactosylated low density lipoprotein, Molecular Pharmacology 45(5): 971-977.
- Water B. van de, Zoeteweij J.P., Bont H.J.G.M. de, Mulder G.J. & Nagelkerke J.F. (1994), Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine, Journal of Biological Chemistry 269(20): 14546-14552.
- Zoeteweij J.P., Water B. van de, Bont H.J.G.M. de & Nagelkerke J.F. (1994), Mitochondrial K+ as modulator of Ca(2+)-dependent cytotoxicity in hepatocytes. Novel application of the K(+)-sensitive dye PBFI (K(+)-binding benzofuran isophthalate) to assess free mitochondrial K+ concentrations, Biochemical Journal 299(2): 539-543.
- Zoeteweij J.P., Water B. van de, Bont H.J.G.M. de, Mulder G.J. & Nagelkerke J.F. (1993), Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium, Journal of Biological Chemistry 268(5): 3384-3388.
- Water B. van de, Zoetewey J.P., Bont H.J. de, Mulder G.J. & Nagelkerke J.F. (1993), The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine, Biochemical Pharmacology 45(11): 2259-2267.
- Zoeteweij J.P., Water B. van de, Bont H.J. de, Mulder G.J. & Nagelkerke J.F. (1992), Involvement of intracellular Ca2+ and K+ in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes, Biochemical Journal 288(1): 207-213.
- Nagelkerke J.F., Water B. van de, Twiss I.M., Zoetewey J.P., Bont H.J. de, Dogterom P. & Mulder G.J. (1991), Role of microtubuli in secretion of very-low-density lipoprotein in isolated rat hepatocytes: early effects of thiol reagents, Hepatology 14(6): 1259-1268.
- ad hoc advisor drug safety
- member of advisory board
- cursus coordinator cursus Toxicologie (1 dag) en cursus Carcinogeniciteit (1 dag)
- Editorial board member
- Lid van College