I earned my Bachelor's degree in Molecular Biology and Genetics from Bilkent University in Ankara, Turkey, followed by a Master of Science (MSc) degree in Advanced Biotechnology and Bioinformatics from the University of Milano. During my undergraduate years, I completed an internship at the Whitehead Institute at MIT, gaining valuable experience in in vivo studies. Subsequently, I embarked on my Ph.D. journey in the laboratory of Professor Bob van de Water, specializing in the development of human induced pluripotent stem cell (hiPSCs) based organ-specific drug toxicity screening platforms. Using the CRISPR/Cas9 technology, we endogenously tagged critical stress response pathways related genes with eGFP. Upon differentiation of the hiPSCs reporter lines into desired organ cell types, like hepatocyte-like cells (HLCs) of the liver, kidney proximal tubule like cells (PTCs), cardiomyocytes, we expose cells to chemicals and drugs to assess stress response activation, we monitor stress response activation and onset of cellular death using high throughput confocal microscopy. This innovative approach falls within the domain of New Approach Methodologies (NAMs), which aims to revolutionize human toxicity screening by reducing and eventually replacing animal testing.

More information about Tamara Danilyuk

Projects:

• RISKHUNT3R
• SysBioTop-moving

Publications