Adam Cohen
Professor Clinical Pharmacology
- Name
- Prof.dr. A.F. Cohen
- Telephone
- +31 71 526 9111
- ac@chdr.nl
- ORCID iD
- null
Adam Cohen in Professor of Clinical Pharmacology and was until 2018 CEO of the Foundation Centre for Human Drug Research (www.chdr.nl). CHDR is a leading institute involved in early drug research in collaboration with LUMC and Leiden University. He is a physician at the department of Nephrology of LUMC.
More information about Adam Cohen
Adam Cohen in Professor of Clinical Pharmacology and was until 2018 CEO of the Foundation Centre for Human Drug Research (www.chdr.nl). CHDR is a leading institute involved in early drug research in collaboration with LUMC and Leiden University. He is a physician at the department of Nephrology of LUMC.
He is Editor-in-Chief of the British Journal of Clinical Pharmacology. Between 1999 and 2011 he was vice-chairman of the Netherlands Competent Authority for Human Research (CCMO) and as such responsible for the formation of the regulatory policy for research in humans. He is a member of the supervisory Board of the Rotterdam Eye hospital and a member of the Scientific Advisory Council of the German Institute for Aerospace Research and active in several international committees for scientific advice. He is the current recipient of the Lilly Prize of the British Pharmacological Society. He is also active in several organizations for music and theater in Leiden.
Clinical Pharmacology
Clinical Pharmacologists study the effects of medicines in humans. All doctors no matter if they are surgeons or physicians use medicines when they treat patients so this knowledge is of importance in the whole field. Finding new medicines is necessary because there are still many diseases that are not treatable optimally. CHDR is involved in the study of medicines for virtually all therapeutic areas. Additionally methodology is required to measure the effects of medicines accurately. Studying new medicines and measuring their effects with innovative methodology are the hallmarks of the research at CHDR. New wearable devices allow these measurements to take place in the home of the patient and the Trial@home program is an important feature of the research at CHDR. Perhaps more important that the research is the education of undergraduate and postgraduate medical students who learn how medicines work and how they should usewith these potentially dangerous substances safely in patients.
Academic career
Adam Cohen studies pharmacy and medicine in Leiden and worked subsequently in the department of Clinical Pharmacology of the Wellcome Research Laboratories and the department of internal medicine of King’s College Hospital in Londen , UK. His PhD was in Leiden on May 29th with Professor Douwe Breimer. After his return to the Netherlands in 1987 he became CEO of the Centre for Human Drug Research which he led until 2018. During this period the organization grew to a size of 300 staff. His public lecture as Professor of Clinical Pharmacology was on March 31st 1995 and he will be in this position until November 9th 2018. From 1-1 2018 he is Director Innovation Services (InnoS) at CHDR involved in advice on drug development and innovative methods for evaluation of drug effects. He is one of the founders of the Leiden Paul Janssen FutureLab, an educational institute for researchers who aspire to develop health care interventions.
Professor Clinical Pharmacology
- Faculteit Geneeskunde
- Divisie 2
- Interne Geneeskunde
- Nierziekten
Professor of Clinical pharmacology
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Algemeen
Contact
- null
- Wall H.E.C. van der Doll R.J., Westen G.J.P. van, Niemeyer-van der Kolk T., Feiss G., Pinckaers H., Doorn M.B.A. van, Nijsten T., Sanders M.G.H., Cohen A.F., Burggraaf J., Rissmann R. & Pardo L.M. (2022), Discriminative machine learning analysis for skin microbiome: observing biomarkers in patients with seborrheic dermatitis, Journal of Artificial Intelligence for Medical Sciences 3(1-2): 1-7.
- Wall H.E.C. van der, Hassing G.J., Doll R.J., Westen G.J.P. van, Cohen A.F., Selder J.L., Kemme M., Burggraaf J. & Gal P. (2022), Cardiac age detected by machine learning applied to the surface ECG of healthy subjects: creation of a benchmark, Journal of Electrocardiology 72: 49-55.
- Wall, H.E.C. van der; Hassing, G.J.; Doll, R.J.; Westen, G.J.P. van; Cohen, A.F.; Selder, J.L.; Kemme, M.; Burggraaf, J. & Gal, P. (2022), Cardiac age detected by machine learning applied to the surface ECG of healthy subjects, Journal of Electrocardiology 72: 49-55.
- Wall H.E.C. van der, Doll R.J., Westen G.J.P. van, Koopmans I., Zuiker R.G., Burggraaf J. & Cohen A.F. (2021), Using machine learning techniques to characterize sleep-deprived driving behavior, Traffic Injury Prevention 22(5): 366-371.
- Wall H.E.C. van der, Doll R.J., Westen G.J.P. van der, Koopmans I., Zuiker R.G., Burggraaf J. & Cohen A.F. (2020), The use of machine learning improves the assessment of drug-induced driving behaviour, Accident Analysis and Prevention 148: 105822.
- Rijsbergen M., Niemeyer-van der Kolk T., Rijneveld R., Pinckaers J.H.F.M., Meshcheriakov I., Bavinck J.N.B., Doorn M.B.A. van, Hogendoorn G., Feiss G., Cohen A.F., Burggraaf J., Poelgeest M.I.E. van & Rissmann R. (2020), Mobile e-diary application facilitates the monitoring of patient-reported outcomes and a high treatment adherence for clinical trials in dermatology, Journal of the European Academy of Dermatology and Venereology 34(3): 633-639.
- Meer L. van, Moerland M., Gallagher J., Doorn M.B.A. van, Prens E.P., Cohen A.F., Rissmann R. & Burggraaf J. (2017), Injection site reactions after subcutaneous oligonucleotide therapy, British Journal of Clinical Pharmacology 82(2): 340-351.
- Goulooze S.C., Franson K.L., Cohen A.F. & Rissmann R. (2017), Clinical Pharmacology Research Internships at the Interface between Academia and Industry: Students' Perceptions and Scientific Output, Basic & Clinical Pharmacology & Toxicology 121(1): 22-28.
- Kanhai K.M.S., Goulooze S.C., Stevens J., Hay J.L., Dent G., Verma A., Hankemeier T., Boer T. de, Meijering H., Chavez J.C., Cohen A.F. & Groeneveld G.J. (2016), Quantifying Beta‐Galactosylceramide Kinetics in Cerebrospinal Fluid of Healthy Subjects Using Deuterium Labeling, CTS-Clinical and Translational Science 9(6): 321-327.
- Goulooze S.C., Cohen A.F. & Rissmann R. (2016), Olaparib, British Journal of Clinical Pharmacology 81(1): 171-173.
- Goulooze S.C., Cohen A.F. & Rissmann R. (2015), Bedaquiline, British Journal of Clinical Pharmacology 80(2): 182-184.
- Goulooze S.C., Cohen A.F. & Rissmann R. (2015), Lomitapide, British Journal of Clinical Pharmacology 80(2): 179-181.
- Goulooze S.C., Cohen A.F. & Rissmann R. (2015), Mirabegron, British Journal of Clinical Pharmacology 80(4): 762-764.
- Westra, A.E.; Sukhai, R.N.; Wit, J.M.; Beaufort, I.D. de & Cohen, A.F. (2010), Acceptable risks and burdens for children in research without direct benefit: a systematic analysis of the decisions made by the Dutch Central Committee, Journal of Medical Ethics 36(7): 420-424.
- Miley G.K., Carilli C.L., Taylor E.N., De Breuck C. & Cohen A.F. (2009), High Redshift Radio Galaxies: Laboratories for Massive Galaxy and Cluster Formation in the early Universe. [other].
- Jacobs G.E. & Cohen A.F. (2008), The South London and Maudsley NHS Foundation Trust and Oxleas NHS Foundation Trust Prescribing Guidelines, 9th edition, British Journal of Clinical Pharmacology : .
- Zuurman L., Roy C., Schoemaker R.C., Hazekamp A., Den Hartigh J., Bender J.C.M.E., Verpoorte R., Pinquier J., Cohen A.F. & Gerven J.M.A. van (2008), Effect of intrapulmonary tetrahydrocannabinol administration in humans, Journal of Psychopharmacology 22: 707-716.
- de Haas SL, de Visser SJ, van der Post JP, Schoemaker RC, van Dyck K, Murphy MG, de Smet M, Vessey LK, Ramakrishnan R, Xue L, Cohen AF & van Gerven JMA (2008), Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA(A) alpha(2,3) subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers, Journal of Psychopharmacology 22(1).
- Broeyer FJF, van Aken BE, Suzuki J, Kemme MJB, Schoemaker HC, Cohen AF, Mizushima Y & Burggraaf J (2008), The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man, British Journal of Clinical Pharmacology 65(1).
- Broeyer FJF, Osanto S, van Eck HJR, van Steijn AQMJ, Ballieux BEPB, Schoemaker RC, Cohen AF & Burggraaf J (2008), Evaluation of biomarkers for cardiotoxicity of anthracyclin-based chemotherapy, Journal of Cancer Research and Clinical Oncology 134(9).
- Zuurman L, Roy C, Schoemaker RC, Hazekamp A, den Hartigh J, Bender JCME, Verpoorte R, Pinquier JL, Cohen AF & van Gerven JMA (2008), Effect of intrapulmonary tetrahydrocannabinol administration in humans, Journal of Psychopharmacology 22(7).
- Strougo A, Zuurman L, Roy C, Pinquier JL, van Gerven JMA, Cohen AF & Schoemaker RC (2008), Modelling of the concentration-effect relationship of THC on central nervous system parameters and heart rate - insight into its mechanisms of action and a tool for clinical research and development of cannabinoids, Journal of Psychopharmacology 22(7).
- Liem-Moolenaar M, De Boer P, Zoethout RWM, Franson K, Cohen AF & Van Gerven JMA (2008), Study investigating R231857 effects on scopolamine-induced CNS impairment in healthy men, European Neuropsychopharmacology 18.
- Zoethout RWM, van Gerven JMA, Dumont GJH, Paltansing S, van Burgel ND, van der Linden M, Dahan A, Cohen AF & Schoemaker RC (2008), A comparative study of two methods for attaining constant alcohol levels, British Journal of Clinical Pharmacology 66(5).
- Haas S.L. de, Visser S.J. de, Kam M.L. de, Smet M. de, Murphy G., Vessey L., Cohen A.F. & Gerven J.M.A. van (2007), The selective central nervous system (CNS) effects of two different GABA-A Alpha 2,3 subtype selective agonists compared to lorazepam, Clinical Pharmacology & Therapeutics 81(S63): .
- zoethout R.W.M., Haas S.L. de, Duck K. van, Semt M. de, Rosen L.B., Murphy M.G., Gottesdiener K.M., Schoemaker R.C., Cohen A.F. & Gerven J.M.A. van (2007), A double-blind, double-dummy, randomized, placebo-controlled, crossover study to investigate the effects of ethanol and TPA023 on essential tremor, Basic & Clinical Pharmacology & Toxicology 101(Suppl 1): 91-92.
- Doorn M. van, Vogels J., Tas A., Hoogdalem E.J. van, Burggraaf J., Cohen A.F. & Greef J. van der (2007), Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers, British Journal of Clinical Pharmacology 63(5): 562-574.
- Boot J.D., Haas S. de, Tarasevych S., Roy C., Wang L., Amin D., Cohen J., Sterk P.J., Miller B., Paccaly A., Burggraaf J., Cohen A.F. & Diamant Z. (2007), Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma, American Journal of Respiratory and Critical Care Medicine 175(5): 450-457.
- Haas S. de, Otte A., Weerd A. de, Erp G. van, Cohen A.F. & Gerven J.M.A. van (2007), Exploratory polysomnographic evaluation of pregabalin on sleep disturbance in patients with epilepsy, Journal of clinical sleep medicine 3: 473-478.
- Haas S.L. de, Visser S.J. de, Post J.P. van der, Smet M. de, Schoemaker R.C., Rijnbeek B., Cohen A.F., Vega J.M., Agrawal N.G.B., Goel T.V., Simpson R.C., Pearson L.K., Li S., Hesney M., Murphy M.G. & Gerven J.M.A. van (2007), Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA a2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers, Journal of Psychopharmacology 21: 374-383.
- Haas S. de, Dingemanse J., Hoever P., Cohen A.F. & Gerven J.M.A. van (2007), Pseudo-hallucinations after zolpidem intake: A case report, 27: 728-730.
- Zuurman L., Roy C., Asset G., Amatsaleh A., Guimaraes L., Pinquier J., Cohen A.F. & Gerven J.M.A. van (2007), The effects of the novel CB1 antagonist AVE1625 on the THC-induced changes on central nervous system effects and heart rate, Clinical Pharmacology & Therapeutics 81(suppl 1:S4): .
- Zuurman L., Passier P.C., Kam M. de, Kleijn H.J., Cohen A.F. & Gerven J.M.A. van (2007), Pharmacokinetic and pharmacodynamic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers, Clinical Pharmacology & Therapeutics 81(S12): .
- Liem-Moolenaar M., Dunn M., Visser S.J. de, Schoemaker R.C., Cohen A.F., Bye A., Lowy M., Gray F. & Gerven J.M.A. van (2007), Psychomotor and cognitive effects of a single dose of SB223412 in healthy volunteers compared to placebo or haloperidol, Basic & Clinical Pharmacology & Toxicology 101(Suppl 1): 106.
- Bronswijk H. van, Dubois E.A., Zitman F.G. & Cohen A.F. (2007), New drugs; varenicline, Nederlands Tijdschrift voor Geneeskunde 151: 2503-2504.
- de Haas SL, de Visser SJ, de Kam ML, de Smet M, Murphy G, Vessey L, Cohen AF & van Gerven JM (2007), The selective central nervous system (CNS) effects of two different GABA(A) alpha(2, 3) subtype-selective agonists compared to lorazepam., Clinical Pharmacology and Therapeutics 81.
- Boot JD, de Haas SL, Tarasevych S, Roy C, Wang L, Amin D, Paccaly AJ, Sterk PJ, Miller B, Burggraaf J, Cohen AF & Diamant Z (2007), Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma., Clinical Pharmacology and Therapeutics 81.
- Zuurman L, Passier PC, de Kam M, Kleijn HJ, Cohen AF & van Gerven JM (2007), Pharmacokinetic and pharmacodynamic effects of the intravenously administered CB1 receptor agonist org 28611 in healthy male volunteers., Clinical Pharmacology and Therapeutics 81.
- Zuurman L, Roy C, Schoemaker RC, Asset G, Amatsaleh A, Guimaraes L, Pinquier J, Cohen AF & van Gerven JM (2007), The effects of the novel CB1 antagonist AVE1625 on THC-induced changes on central nervous system effects and heart rate., Clinical Pharmacology and Therapeutics 81.
- Cohen A, Rovelli A, Merlo DF, van Lint MT, Lanino E, Bresters D, Ceppi M, Bocchini V, Tichelli A & Socie G (2007), Risk for secondary thyroid carcinoma after hematopoietic stem-cell transplantation: An EBMT late effects working party study, Journal of Clinical Oncology 25(17).
- van der Vorst MMJ, Holthe JEKV, den Hartigh J, van der Heijden AJ, Cohen AF & Burggraaf J (2007), Absence of tolerance and toxicity to high-dose continuous intravenous furosemide in haemodynamically unstable infants after cardiac surgery, British Journal of Clinical Pharmacology 64(6).
- de Hass SL, de Visser SJ, van der Post JP, de Smet M, Schoemaker RC, Rijnbeek B, Cohen AF, Vega JM, Agrawal NGB, Goel TV, Simpson RC, Pearson LK, Li S, Hesney M, Murphy MG & van Gerven JMA (2007), Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA(A)alpha(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers, Journal of Psychopharmacology 21(4).
- Zuurman L, Roy C, Schoemaker RC, Asset G, Amatsaleh A, Guimaraes L, Pinquier JL, Cohen AF & van Gerven JMA (2007), Inhibition of THC-induced effects on central nervous system effects and heart rate by a novel CB1 receptor antagonist AVE1625, British Journal of Clinical Pharmacology 63(6).
- Boots I, Sukhai RN, Klein RH, Holl RA, Wit JM, Cohen AF & Burggraaf J (2007), Stimulation programs for pediatric drug research - do children really benefit?, European Journal of Pediatrics 166(8).
- Boot JD, de Haas S, Tarasevych S, Roy C, Wang L, Amin D, Cohen J, Sterk PJ, Miller B, Paccaly A, Burggraaf J, Cohen AF & Diamant Z (2007), Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma, American Journal of Respiratory and Critical Care Medicine 175(5).
- de Haas S, Dingemanse J, Hoever P, Cohen A & van Gerven J (2007), Pseudohallucinations after Zolpidem intake - A case report, Journal of Clinical Psychopharmacology 27(6).
- van Doorn M, Kemme M, Ouwens M, van Hoogdalem EJ, Jones R, Romijn H, de Kam M, Schoemaker R, Burggraaf K & Cohen A (2006), Evaluation of proinflammatory cytokines and inflammation markers as biomarkers for the action of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers, British Journal of Clinical Pharmacology 62(4).
- Twiss IM, van den Berk AHM, de Kam ML, Bosch JJ, Cohen AF, Vermeij P & Burggraaf J (2006), A comparison of the gastrointestinal effects of the nitrogen-containing Bisphosphonates pamidronate, alendronate, and olpadronate in humans, Journal of Clinical Pharmacology 46(4).
- Dumont G.J.H., Visser S.J. de, Cohen A.F. & Gerven J.M.A. van (2005), Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy volunteers, British Journal of Clinical Pharmacology 59: 495-510.
- Boot J.D., Tarasevych S., Sterk P.J., Schoemaker R.C., Wang L., Amin D., Cohen A.F. & Diamant Z. (2005), Reversal of the late asthmatic response increases exhaled nitric oxide, Respiratory Medicine 99: 1591-1594.
- Dumont G.J.H., Visser S.J. de, Cohen A.F. & Gerven J.M.A. van (2005), Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects, British Journal of Clinical Pharmacology 59: 495-510.
- Cohen J., Burggraaf J., Schoemaker R.C., Sterk P.J., Cohen A.F. & Diamant Z. (2005), Relationship between airway responsiveness to neurokinin A and methacholine in asthma, Pulmonary Pharmacology and Therapeutics 17: 171-176.
- Post J.P. van der, Visser S.J. de, Kam M.L. de, Woelfler M., Hilt D.C., Vornov J., Burak E.S., Bortey E., Slusher B.S., Limsakun T., Cohen A.F. & Gerven J.M.A. van (2005), The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693, British Journal of Clinical Pharmacology 60: 128-136.
- Cohen J, Burggraaf J, Schoemaker RC, Sterk PJ, Cohen AF & Diamant Z (2005), Relationship between airway responsiveness to neurokinin A and methacholine in asthma, Pulmonary Pharmacology and Therapeutics 18(3).
- van der Post JP, de Visser SJ, de Kam ML, Woelfler M, Hilt DC, Vornov J, Burak ES, Bortey E, Slusher BS, Limsakun T, Cohen AF & van Gerven JMA (2005), The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693, British Journal of Clinical Pharmacology 60(2).
- Zuurman L, Roy C, Hazekamp A, Schoemaker R, Hartigh JD, Bender JCME, Pinquier JL, Cohen AF & van Gerven JMA (2005), Effect of THC administration in humans: methodology study for further pharmacodynamic studies with cannabinoid agonist or antagonist, British Journal of Clinical Pharmacology 59(5).
- Dumont GJH, de Visser SJ, Cohen AF & van Gerven JMA (2005), Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects, British Journal of Clinical Pharmacology 59(5).
- van der Post JP, de Visser SJ, Schoemaker RC, Cohen AF & van Gerven JMA (2004), Pharmacokinetic/pharmacodynamic assessment of tolerance to central nervous system effects of a 3 mg sustained release tablet of rilmenidine in hypertensive patients, Journal of Psychopharmacology 18(2).
- Kamerling IMC, Van Haarst AD, De Kam ML, Cohen AF, Masclee AAM & Burggraaf J (2004), Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia, Alimentary Pharmacology and Therapeutics 19(7).
- Buijs MM, Romijn JA, Burggraaf J, de Kam ML, Frolich M, Ackermans MT, Sauerwein HP, Cohen AF, Meinders AE & Pijl H (2004), Glucose homeostasis in abdominal obesity: hepatic hyperresponsiveness to growth hormone action, AJP - Endocrinology and Metabolism 287(1).
- van der Post J, de Waal PP, de Kam ML, Cohen AF & van Gerven JMA (2004), No evidence of the usefulness of eye blinking as a marker for central dopaminergic activity, Journal of Psychopharmacology 18(1).
- Gijsman HJ, Cohen AF & van Gerven JMA (2004), The application of the principles of clinical drug development to pharmacological challenge tests of the serotonergic system, Journal of Psychopharmacology 18(1).
- Kamerling IMC, van Haarst AD, Burggraaf J, Schoemaker RC, de Kam ML, Heinzerling H, Cohen AF & Masclee AAM (2004), Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function, British Journal of Clinical Pharmacology 57(4).
- Socie G, Salooja N, Cohen A, Rovelli A, Carreras E, Locasciulli A, Korthof E, Weis J, Levy V & Tichelli A (2003), Nonmalignant late effects after allogeneic stem cell transplantation, Blood 101(9).
- Kamerling IMC, Burggraaf J, van Haarst AD, Oppenhuizen-Duinker MF, Schoemaker HC, Biemond I, Jones R, Heinzerling H, Cohen AF & Masclee AAM (2003), The effect of motilin on the rectum in healthy volunteers, British Journal of Clinical Pharmacology 55(6).
- Pieters MSM, van Steveninck AF, Schoemaker RC, Kroon JM, van Gerven JMA & Cohen AF (2003), The psychomotor effects of carbamazepine in epileptic patients and healthy volunteers, Journal of Psychopharmacology 17(3).
- Kamerling IMC, Van Haarst AD, Burggraaf J, Schoemaker RC, Biemond I, Heinzerling H, Jones R, Cohen AF & Masclee AAM (2003), Motilin effects on the proximal stomach in patients with functional dyspepsia and healthy volunteers, AJP - Gastrointestinal and Liver Physiology 284(5).
- Kemme MJB, Post JPV, Schoemaker RC, Straub M, Cohen AF & van Gerven JMA (2003), Central nervous system effects of moxonidine experimental sustained release formulation in patients with mild to moderate essential hypertension, British Journal of Clinical Pharmacology 55(6).
- Rijnbeek B, de Visser SJ, Franson KL, Cohen AF & van Gerven JMA (2003), REM sleep effects as a biomarker for the effects of antidepressants in healthy volunteers, Journal of Psychopharmacology 17(2).
- Buijs MM, Burggraaf J, Wijbrandts C, de Kam ML, Frolich M, Cohen AF, Romijn JA, Sauerwein HP, Meinders AE & Pijl H (2003), Blunted lipolytic response to fasting in abdominally obese women: evidence for involvement of hyposomatotropism, American Journal of Clinical Nutrition 77(3).
- Kamerling IMC, van Haarst AD, Burggraaf J, de Kam M, Biemond I, Jones R, Cohen AF & Masclee AAM (2002), Exogenous motilin affects postprandial proximal gastric motor function and visceral sensation, Digestive Diseases and Sciences 47(8).
- Schoemaker RC, Buijs MM, Pijl H, Burggraaf J & Cohen AF (2002), Modeling the influence of growth hormone on lipolysis, Journal of Pharmacokinetics and Pharmacodynamics 29(2).
- Kamerling IMC, Van Haarst AD, Burggraaf J, Schoemaker HC, Biemond I, Jones R, Cohen AF & Masclee AAM (2002), Dose-related effects of motilin on proximal gastrointestinal motility, Alimentary Pharmacology and Therapeutics 16(1).
- Buijs MM, Burggraaf J, Langendonk JG, Schoemaker RC, Frolich M, Arndt JW, Cohen AF, Romijn JA, Ackermans MT, Sauerwein HP, Meinders AE & Pijl H (2002), Hyposomatotropism blunts lipolysis in abdominally obese women, Journal of Clinical Endocrinology and Metabolism 87(8).
- Gijsman HJ, van Gerven JMA, Verkes RJ, Schoemaker RC, Pieters MSM, Pennings EJM, Hessing TJ & Cohen AF (2002), Saccadic peak velocity and EEG as end-points for a serotonergic challenge test, Human Psychopharmacology: Clinical and Experimental 17(2).
- Buijs MM, Romijn JA, Burggraaf J, De Kam ML, Cohen AF, Frolich M, Stellaard F, Meinders AE & Pijl H (2002), Growth hormone blunts protein oxidation and promotes protein turnover to a similar extent in abdominally obese and normal-weight women, Journal of Clinical Endocrinology and Metabolism 87(12).
- van der Post J, Noordzij LAW, de Kam ML, Blauw GJ, Cohen AF & van Gerven JMA (2002), Evaluation of tests of central nervous system performance after hypoxemia for a model for cognitive impairment, Journal of Psychopharmacology 16(4).
- Burggraaf J, Tulen JHM, Lalezari S, Schoemaker RC, De Meyer PHEM, Meinders AE, Cohen AF & Pijl H (2001), Sympathovagal imbalance in hyperthyroidism, AJP - Endocrinology and Metabolism 281(1).
- Twiss IM, Burggraaf J, Schoemaker RC, van Elburg RM, den Hartigh J, Cohen AF & Vermeij P (2001), The sugar absorption test in the evaluation of the gastrointestinal intolerance to bisphosphonates: Studies with oral pamidronate, Clinical Pharmacology and Therapeutics 69(6).
- Burggraaf J, Westendorp RGJ, in't Veen JCCM, Schoemaker RC, Sterk PJ, Cohen AF & Blauw GJ (2001), Cardiovascular side effects of inhaled salbutamol in hypoxic asthmatic patients, Thorax 56(7).
- Verkes RJ, Gijsman HJ, Pieters MSM, Schoemaker RC, de Visser S, Kuijpers M, Pennings EJM, de Bruin D, Van de Wijngaart G, Van Gerven JMA & Cohen AF (2001), Cognitive performance and serotonergic function in users of ecstasy, Psychopharmacology 153(2).
- Pijl H, Langendonk JG, Burggraaf J, Frolich M, Cohen AF, Veldhuis JD & Meinders AE (2001), Altered neuroregulation of GH secretion in viscerally obese premenopausal women, Journal of Clinical Endocrinology and Metabolism 86(11).
- Pijl H, de Meijer PHEM, Langius J, Coenegracht GIGM, van den Berk AHM, Shaw PKC, Boom H, Schoemaker RC, Cohen AF, Burggraaf J & Meinders AE (2001), Food choice in hyperthyroidism: Potential influence of the autonomic nervous system and brain serotonin precursor availability, Journal of Clinical Endocrinology and Metabolism 86(12).
- Langendonk JG, Veldhuis JD, Burggraaf J, Schoemaker RC, Cohen AF, Meinders AE & Pijl H (2001), Estimation of growth hormone secretion rate: impact of kinetic assumptions intrinsic to the analytical approach, AJP - Regulatory, Integrative and Comparative Physiology 280(1).
- Burggraaf J, Lalezari S, Emeis JJ, Vischer UM, de Meyer PHEM, Pijl H & Cohen AF (2001), Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol, Thyroid 11(2).
- Weijtens O, Schoemaker RC, Lentjes EGWM, Romijn FPHTM, Cohen AF & van Meurs JC (2000), Dexamethasone concentration in the subretinal fluid after a subconjunctival injection, a peribulbar injection, or an oral dose, Ophthalmology: Journal of The American Academy of Ophthalmology 107(10).
- de Roode A, van Gerven JMA, Schoemaker RC, Engbers FHM, Olieman W, Kroon JR, Cohen AF & Bovill JG (2000), A comparison of the effects of propofol and midazolam on memory during two levels of sedation by using target-controlled infusion, Anesthesia and Analgesia 91(5).
- Burggraaf J, Schoemaker RC, Lentjes EGWM & Cohen AF (2000), Sorbitol as a marker for drug-induced decreases of variable duration in liver blood flow in healthy volunteers, European Journal of Pharmaceutical Sciences 12(2).
- Kemme MJB, Burggraaf J, Schoemaker RC, Cohen AF & Blauw GJ (2000), No evidence for functional involvement of 5-HT2B receptors in serotonin-induced vasodilatation in the human forearm, Journal of Cardiovascular Pharmacology 36(6).
- Editor in Chief
- Wetenschappelijke adviesraad