Quantitative Clinical Pharmacology

Key publications

Key publications of the Quantitative Clinical Pharmacology group

Goulooze S.C., Zwep L.B., Vogt J.E., Krekels E.H.J., Hankemeier T., Anker J.N. van den & Knibbe C.A.J. (2019), Beyond the randomized clinical trial: innovative data science to close the pediatric evidence gap, Clinical Pharmacology and Therapeutics .
Smit C., Wasmann R.E., Goulooze S.C., Wiezer M.J., Dongen E.P.A. van , Mouton J.W., Brüggemann R.J.M. & Knibbe C.A.J. (2019), Population pharmacokinetics of vancomycin in obesity: finding the optimal dose for (morbidly) obese individuals, British Journal of Clinical Pharmacology 86(2): 303-317.
Calvier E.A.M., Krekels E.H.J., Yu H., Välitalo P.A.J., Johnson T.N., Rostami-Hodjegan A., Tibboel D., van der Graaf P.H., Danhof M., Knibbe C.A.J. (2018), Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments. CPT Pharmacometrics Syst Pharmacol.
Rongen A. van, Aa M.P van der, Matic M., Schaik R.H.N. van, Deneer V.H.M., Vorst M.M. van der & Knibbe C.A.J. (2018), Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial, Pediatric Drugs 20(4): 365-374.
Calvier E.A.M., Krekels E.H.J., Välitalo P.A.J., Rostami-Hodjegan A., Tibboel D., Danhof M., Knibbe C.A.J. (2017), Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?, Clinical Pharmacokinetics.
van Rongen A., Brill M.J.E., Vaughns J.D., Välitalo P.A.J., van Dongen E.P.A., van Ramshorst B., Barrett J.S., van den Anker J.N., Knibbe C.A.J. (2017), Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults. Clin Pharmacokinet.
Krekels E.H.J., van Hasselt J.G.C., van den Anker J.N., Allegaert K., Tibboel D., Knibbe C.A.J. (2017), Evidence-based drug treatment for special patient populations through model-based approaches. Eur J Pharm Sci. 109S: S22-S26.
Välitalo P.A., Krekels E.H., van Dijk M., Simons S., Tibboel D., Knibbe C.A. (2017), Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning. CPT Pharmacometrics Syst Pharmacol. 6(4): 239-248.
Brill M.J., Välitalo P.A., Darwich A.S., van Ramshorst B., van Dongen H.P., Rostami-Hodjegan A., Danhof M., Knibbe C.A. (2016), Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1-OH-midazolam in morbidly obese and weight loss surgery patients. CPT Pharmacometrics Syst Pharmacol. 5(1): 20-30.
Ahlers S.J., Välitalo P.A., Peeters M.Y., Gulik L.V, Dongen E.P. van, Dahan A., Tibboel D. & Knibbe C.A.J. (2015), Morphine Glucuronidation and Elimination in Intensive Care Patients: A Comparison with Healthy Volunteers., Anesthesia and analgesia 121(5): 1261-1273.
Knibbe C.A., Brill M.J., van Rongen A., Diepstraten J., van der Graaf P.H. & Danhof M. (2015), Drug disposition in obesity: toward evidence-based dosing, Annual Review of Pharmacology and Toxicolog 55: 149-67.
Brill M.J., Houwink A.P., Schmidt S., van Dongen E.P., Hazebroek E.J., van Ramshorst B., Deneer V.H., Mouton J.W., Knibbe C.A. (2014), Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis. J Antimicrob Chemother. 69(3): 715-23.
Krekels E.H.J., Tibboel D., Wildt S.N. de, Ceelie I., Dahan A. Dijk M. van, Danhof M. & Knibbe C.A.J. (2014), Evidence-based morphine dosing for postoperative neonates and infants., Clinical Pharmacokinetics 53(6): 553-563.