Key publications of the Cardiovascular Pharmacology group

• Hemme E., Biskop D., Depuydt M.A.C., Smit V., Delfos L., Bernabé Kleijn M.N.A., Foks A.C., Kuiper J. & Bot I. (2023), Bruton's Tyrosine Kinase inhibition by Acalabrutinib does not affect early or advanced atherosclerotic plaque size and morphology in Ldlr-/- mice, Vascul Pharmacol. 2023 Jun;150:107172
• Depuydt M.A.C., Schaftenaar F.H., Prange K.H.M. Boltjes A., Hemme E., Delfos L., de Mol J., de Jong M.J.M., Bernabé Kleijn M.N.A., Peeters J.A.H.M., Goncalves L., Wezel A., Smeets H.J., de Borst G.J., Foks A.C., Pasterkamp G., de Winther M.P.J., Kuiper J., Slütter B., & Bot I. (2023), Single-cell T cell Receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells, Nature Cardiovascular Research. 2023;2:112-125
• Depuydt M.A.C., Prange K.H.M., Slenders L., Örd T., Elbersen D., Boltjes A., de Jager S.C.A., Asselbergs F.W., de Borst G.J., Aavik E., Lönnberg T., Lutgens E., Glass C.K., den Ruijter H.M., Kaikkonen M.U., Slütter B., van der Laan S.W., Yla-Herttuala S., Mokry M., Kuiper J., de Winther M.P.J., Pasterkamp G. & Bot I. (2020), Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics, Circ Res. 2020 Nov 6;127(11):1437-1455
• Velden D.V., Bouwman M., Kröner M.J., Kuiper J., Quax P.H.A., de Vries M.R. & Bot I. (2020),Local Mast Cell Activation Promotes Neovascularization, Cells. 2020 Mar 12;9(3):701
• Kritikou E., Depuydt M.A.C., Vries M.R. de, Mulder K.E., Govaert A.M., Smit M.D., Duijn J. van, Foks A.C., Wezel A., Smeets H.J., Slütter B., Quax P.H.A., Kuiper J. & Bot I. (2019), Flow Cytometry-Based Characterization of Mast Cells in Human Atherosclerosis, Cells 8(4): 334.
• Kritikou E., Heijden T. van der, Swart M., Duijn J. van, Slütter B., Wezel A., Smeets H.J., Maffia P., Kuiper J. & Bot I. (2019), Hypercholesterolemia Induces a Mast Cell-CD4+ T Cell Interaction in Atherosclerosis, Journal of Immunology 202(5): 1531-1539.
• Indhirajanti S., Daele P.L.A. van, Bos S., Mulder M.T., Bot I. & Lennep J.E.R. van (2018), Systemic mastocytosis associates with cardiovascular events despite lower plasma lipid levels, Atherosclerosis 268: 152-156.
• Tsiantoulas D., Bot I., Ozsvar-Kozma M., Goederle L., Perkmann T., Hartvigsen K., Conrad D.H., Kuiper J., Mallat Z. & Binder C.J. (2017), Increased Plasma IgE Accelerate Atherosclerosis in Secreted IgM Deficiency, CIRCULATION RESEARCH 120(1): 78-84.
• Shi G.P., Bot I. & Kovanen P.T. (2015), Mast cells in human and experimental cardiometabolic diseases, Nature reviews. Cardiology 12: 643-658.