FitDis! is designed to ease the determination of binding energy and oligomeric state of coiled coil peptides. It allows direct fitting of concentration dependent thermal peptide unfolding curves measured for instance by CD–spectroscopy.

Models for any stoichiometry can be applied, that follow the general equilibrium:

A1_ϑ1 A2_ϑ2 … ↔ ϑ₁A1 + ϑ₂A2 + ...

More details can be found here.

FitDis! was programmed and tested using MatLab 2013a including the Curve Fitting Toolbox 3.0. If you have installed this software you can download the MatLab M-Files on the following pages.

In order to run FitDis! on Windows you first need to install the MatLab® Compiler Runtime (MCR):

1. Download the installer for MCR R2013a (8.1) at http://www.mathworks.com/products/compiler/mcr/ and execute it.
2. After the installation restart your computer.
3. For the installation of the FitDis! application download the most recent version here after filling out this form and unpack it in a folder of your choice. In this folder you will find a manual and a test dataset.
4. To start the application run the file "Fitdis.exe".

For questions and remarks, please contact: a.kros@chem.leidenuniv.nl.

The current version of FitDis! is made available by Leiden University under an Apache 2.0 license.

By sending information via this form you agree to the processing of the provided data. The data will only be processed for the purposes indicated in this form. Your consent can be withdrawn at any time by sending a message to a.kros@chem.leidenuniv.nl.

FitDis! download form