The Department of Biophysical Structural Chemistry studies how biological systems work at the molecular level through high-resolution structural analysis. Using state-of-the-art techniques in structural biology such as cryo-electron microscopy and X-ray crystallography we gain crucial insights into fundamental biochemical processes in atomic detail.

The group led by Sebastian Geibel delves into the world of pathogenic bacteria, focusing on mycobacteria, the culprits behind tuberculosis. Our research is dedicated to uncovering the mechanisms of transport across the cell envelopes of Mycobacteria and Corynebacteria. By mapping these pathways, we aim to reveal potential targets for therapeutic intervention. Additionally, we're exploring the role of bacterial lectins in cancer, seeking to understand their involvement in disease progression and potential as novel drug targets. 

Steffen Brünle's group investigates G protein-coupled receptors (GPCRs). These essential membrane proteins are prime targets for therapeutic drug development in disease and cancer treatment. The approach combines structural analysis via single-particle cryo-electron microscopy as well as classical and serial X-ray crystallography with functional study's to uncover the molecular basis of receptor activation and regulation. The group is part of the Leiden Early Drug Discovery & Development (LED3) network, providing structural biology expertise to support the hit and lead optimization pipeline.