Dissertation
The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
- Author
- Guillem Paniagua Soriano
- Date
- 11 February 2016
- Links
- Thesis in Leiden Repository
![](/binaries/content/gallery/ul2/main-images/science/lic/the-use-of-activity-based-protein-profiling-to-study-proteasome-biology.png/the-use-of-activity-based-protein-profiling-to-study-proteasome-biology.png/d300xvar)
The work described in this thesis focuses on the characterization of proteasome directed activity-based probes (ABPs) as well as on the adaptation mechanisms that make multiple myeloma derived cell lines resistant against proteasome inhibitors (PIs).