Expertise

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends across length scales facilitating an understanding of structure-function relationships at both the molecular and the cellular level. This naturally combines approaches from biochemistry, biophysics, cell biology, structural biology and genetics.

Structure and function of proteins, nucleic acids and protein-nucleic acid complexes

Atomic force microscopy
NMR
TIRF microscopy
Tethered Particle Motion
Magnetic tweezers
Optical tweezers
Topological analysis
Rigid base pair Monte Carlo simulations
Statistical physics modelling

Genomics and proteomics

ChIP-seq
RNA-seq
Chromosome Conformation Capture (3C, HiC)
Nanopore sequencing

Structure and morphology of cells, intracellular dynamics

TIRF microscopy
Confocal microscopy
PALM/STORM
Multi-focus 2-Photon microscopy
Fluorescence Correlation Spectroscopy