The recent COVID-19 outbreak has acted as a tipping-point, reminding us all of the pivotal role played by cities and their strategic position in an era of increasing uncertainty and complexity. That said, cities are not only the locus where the multiple impacts of COVID-19 have been most severe, but they also increasingly have become a fertile ground for a multitude of interventions that can be (re)configured and deployed to achieve a more sustainable future. One important lesson gleaned from this global pandemic is that cities with more sustainable and resilience capacities (no matter how these concepts are defined) have handled the crisis much better, so far.