Young Hae Choi
Associate professor
- Name
- Dr. Y.H. Choi
- Telephone
- +31 71 527 4510
- y.h.choi@biology.leidenuniv.nl
- ORCID iD
- 0000-0003-1484-1700
Currently, I have four research lines in which I am applying metabolomics and natural products chemistry skills: 1) Untargeted and targeted plant metabolomics and building a database of plants metabolome 2) Plant-microbial chemical interaction for symbiotic cooperation against plant pathogens 3) Investigation of the possibility of the existence of natural deep eutectic solvents in plant cells, organs or extracellular fluids 4) Development of natural drug formulations based on natural deep eutectic solvents and development of antibiotics and antifungal reagents targeting synergisms or potentiation
More information about Young Hae Choi
PhD Candidates
Postdocs
News
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30 years and Professor: the story of Changsheng Wu -
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Six million boost to search for new antibiotics -
Metabolomics Facility Leiden Featured in NWO Large-Scale Scientific Infrastructure website -
“Pulp Fraction”: Tackling the orange waste mountain
Support
I received my PhD degree from the College of Pharmacy, Seoul National University (Seoul, Korea) in 2000. After working for one year in a company, GreenTek 21, also in Seoul, I came to Division of Pharmacognosy, Section Metabolomics, Institute of Biology, Leiden University as a post-doc in 2002, (Seoul, Korea). In 2009 I became Assistant Professor and Associate Professor in 2014.
I have a long-standing interest in natural products and my current research topics are connected to fundamental scientific questions related to them.
- What kind of compounds are present in living organisms and how can such a huge number of metabolites be identified?
- Why do organisms produce these diverse metabolites?
- Which are the roles of these natural compounds in organisms
- How can we take advantage of all this wealth of resources provided by Nature to solve life science problems and develop useful products?
Associate professor
- Science
- Instituut Biologie Leiden
- IBL Plant Sciences
- Paulino Fernandez H., Choi Y.H., Vrieling K., Bresser M. de, Sewalt B.A. & Tonolo F. (2023), Cultivar-dependent phenotypic and chemotypic responses of drug-type Cannabis sativa L. to polyploidization, Frontiers in Plant Science 14: 1233191.
- Di Giulio C., Gonzalez Guzman J.M., Dutra Gomes J.V., Choi Y.H., Magalhães P.O., Fonseca-Bazzo Y.M., Silveira D. & EstradaO. (2023), A new lignan from Annona squamosa L. (Annonaceae) demonstrates vasorelaxant effects in vitro, Molecules 28(11): 4256.
- Al Fuhaid L., Nava-Ocampo M.F., Bucs S.S., Verpoorte R., Choi Y.H., Witkamp G.J. & Farinha A.S.F. (2023), Crystallization and time-dependent changes in betaine-urea-water natural deep eutectic solvents, Journal of Molecular Liquids 387: 122718.
- Choi Y.H., Jang P.Y. & Frederich M. (2023), Applications of metabolomics to the discovery of biomolecules from natural products, Frontiers in Molecular Biosciences 10: 1190730.
- Paulino Fernandes H., Salome-Abarca L.F., Pereira R.G., Seibert J.B., Silva-Junior G.J., Silva M.F.G.F. & Choi H.Y. (2022), Metabolomic investigation of citrus latifolia and the putative role of coumarins in resistance to black spot disease, Frontiers in Bioscience 9: 934401.
- Verpoorte R., Witkamp G.-J. & Choi Y.H. (2022), Preface: natural deep eutectic solvents: A third liquid phase in living organisms? Discovery, theory, biology and applications, Advances in Botanical Research 97: xv-xxii.
- Huberty M.D., Steinauer K., Heinen R., Jongen R., Hannula S.E., Choi Y.H. & Bezemer T.M. (2022), Temporal changes in plant soil feedback effects on microbial networks, leaf metabolomics and plant-insect interactions, Journal of Ecology 110(6): 1328-1343.
- Bayona Maldonado L.M., Voogd N.J. de & Choi Y.H. (2022), Metabolomics on the study of marine organisms, Metabolomics 18: 17.
- Salomé Abarca L.F., Hondel C.A.M.J.J. van den, Erol O., Klinkhamer P.G.L., Kim H.K. & Choi Y.H. (2021), HPTLC-based chemical profiling: an approach to monitor plant metabolic expansion caused by fungal endophytes, Metabolites 11(3): 174.
- Vailev H., Šmejkal K., Gronover C.S., Choi Y.H., Prüfer D., Jankovská D. & Ionkova I. (2021), Flavonol glycosides from aerial parts of Astragalus thracicus Griseb, Phytochemistry Letters 41: 119-122.
- Salome-Abarca L.F., Toorn T.J.C. van der, Vugt R.R. van, Klinkhamer P.G.L. & Choi Y.H. (2021), Chemical differentiation of plant latexes and their anti-herbivory activity against thrips Frankliniella occidentalis (#), Planta Medica 87(12/13): 1032-1044.
- Bayona Maldonado L.M., Kim M.S., Swierts T., Hwang G.-S., Voogd N.J. de & Choi Y.H. (2021), Metabolic variation in Caribbean giant barrel sponges: influence of age and sea-depth, Marine Environmental Research 172: 105503.
- Nava-Ocampo M.F., Al Fuhaid K., Santana A., Bucs S.S., Verpoorte R., Choi Y.H., Witkamp G.J., Vrouwenwelder J.S. & Farinha A.S.F. (2021), Structural properties and stability of the betaine-urea natural deep eutectic solvents, Journal of Molecular Liquids 343: 117655.
- Wahyuni D.S.C., Choi Y.H., Leiss K.A. & Klinkhamer P.G.L. (2021), Morphological and chemical factors related to Western Flower Thrips resistance in the ornamental gladiolus, Plants 10(7): 1384.
- Nava-Ocampo M.F., Al Fuhaid L., Verpoorte R., Choi Y.H., Loosdrecht M.C.M. van, Vrouwenvelder J.S., Witkamp G.J., Farinha A.S.F. & Bucs S.S. (2021), Natural deep eutectic solvents as biofilm structural breakers, Water Research 201: 117323.
- Mustafa N.R., Spelbos V.S., Witkamp G.-J., Verpoorte R. & Choi Y.H. (2021), Solubility and stability of some pharmaceuticals in natural deep eutectic solvents-based formulation, Molecules 26(9): 2645.
- Salome Abarca L.F., Godevac D., Kim M.S., Hwang G.-S., Parc S.C., Jang Y.P., Hondel C.A.M.J.J. van der, Verpoorte R., Klinkhamer P.G.L. & Choi Y.H. (2021), Latex metabolome of Euphorbia species: geographical and inter-species variation and its proposed role in plant defense against herbivores and pathogens, Journal of Chemical Ecology 47: 564–576.
- Yun N., Kim H.J., Park S.C., Park G., Kim M.K., Choi Y.H. & Jang Y.P. (2021), Localization of major ephedra alkaloids in whole aerial parts of Ephedrae Herba using direct analysis in real time-time of flight-mass spectrometry, Molecules 26(3): 580.
- Dai Y., Salome Abarca L.F., Jang Y.P. & Choi Y.H. (2021), A theme issue to celebrate professor Robert Verpoorte’s 75th birthday: “the past, current, and future of natural products”, Molecules 26(23): 7226.
- Dai Y., Varypataki E.M., Golovina E.A., Jiskoot W., Witkamp G.-J., Choi Y.H. & Verpoorte R. (2021), Natural deep eutectic solvents in plants and plant cells: In vitro evidence for their possible functions, Advances in Botanical Research 97: 159-184.
- Vanda H., Mustafa N.R., Verpoorte R., Klinkhamer P.G.L. & Choi Y.H. (2021), Natural deep eutectic solvents present in plant exudates? A case study on the saps of Droseraspecies, Advances in Botanical Research 97: 253-269.
- Dai Y., Choi Y.H. & Verpoorte R. (2021), Honey in traditional Chinese medicine: A guide to future applications of NADES to medicines, Advances in Botanical Research 97: 361-384.
- Zhang Z., Du C., De Barsy F., Liem M., Liakopoulos A., Wezel G.P. van, Choi Y.H., Claessen D. & Rozen D.E. (2020), Antibiotic production in Streptomyces is organized by a division of labor through terminal genomic differentiation, Science Advances 6(3): eaay5781.
- Huberty M.D., Martis B., Kampen J. van, Choi Y.H., Vrieling K., Klinkhamer P.G.L. & Bezemer T.M. (2020), Soil Inoculation Alters Leaf Metabolic Profiles in Genetically Identical Plants, Journal of Chemical Ecology 46: 745-755.
- Huberty M.D., Choi Y.H., Heinen R. & Bezemer T.M. (2020), Above-ground plant metabolomic responses to plant-soil feedbacks and herbivory, Journal of Ecology 108(4): 1703-1712.
- Suba R.B., Beveridge N.G.P., Kustiawan W., Snoo G.R. de, Iongh H.H. de, Wieren S.E. van, Choi Y.H. & Kim H.K. (2020), Food preference of the Bornean elephant (Elephas maximus borneensis) in North Kalimantan Province, Indonesia, and its conservation implications, Raffles Bulletin of Zoology 68: 791–802.
- Salomé-Abarca L.F., Mandrone M., Sanna C., Poli F., Hondel C.A.M.J.J. van der, Klinkhamer P.G.L. & Choi Y.H. (2020), Metabolic variation in Cistus monspeliensis L. ecotypes correlated to their plant-fungal interactions, Phytochemistry 176: 112402.
- Aydogan E.L., Budich O., Hardt M., Choi Y.H., Anweiler L., Jansen-Willems A B., Moser G., Müller C., Kämpfer P. & Glaeser S.P. (2020), Global warming shifts the composition of the abundant bacterial phyllosphere microbiota as indicated by a cultivation dependent and independent study of the grassland phyllosphere of a long-term warming field-experiment, FEMS Microbiology Ecology 96(8): fiaa087.
- Bayona L.M., Leeuwen G. van, Erol Ö., Swierts T., Ent E. van der, Voogd N.J. de & Choi Y.H. (2020), Influence of the geographical location on the metabolic production of giant barrel sponges (Xestospongia spp.) revealed by metabolomics tools, ACS Omega 5(21): 12398-12408.
- Bouguellid G., Russo C., Lavorgna M., Piscitelli C., Ayouni K., Wilson E., Kim H.K., Verpoorte R., Choi Y.H., Kilani-Atmani D., Atmani D. & Isidori M. (2020), Antimutagenic, antigenotoxic and antiproliferative activities of Fraxinus angustifolia Vahl. leaves and stem bark extracts and their phytochemical composition, PLoS ONE 15(4): e0230690.
- Oomen W.W., Begines P., Mustafa N.R., Wilson E.G., Verpoorte R. & Choi Y.H. (2020), Natural deep eutectic solvent extraction of flavonoids of Scutellaria baicalensis as a replacement for conventional organic solvents, Molecules 25(3): 617.
- Castellanos L., Naranjo-Gaybor S.J., Forero M., Morales G., Wilson E.G., Ramos F.A. & Choi Y.H. (2020), Metabolic fingerprinting of banana passion fruits and its correlation with quorum quenching activity, Phytochemistry 172: 112272.
- Salomé Abarca L.F., Klinkhamer P.G.L. & Choi Y.H. (2019), Plant latex, from ecological interests to bioactive chemical resources, Planta Medica 85(11-12): 856-868.
- Ma Y., Li Y., Ali S., Li P., Zhang W., Rauch M., Willot S., Ribitsch D., Choi Y.H., Alcalde M., Hollmann F. & Wang Y. (2019), Natural deep eutectic solvents as performance additives for peroxygenase catalysis, ChemCatChem 12(4): 989-994.
- Akhgari A., Laakso I., Maaheimo H., Choi Y.H., Seppänen-Laakso T. & Oksman-Caldentey K.-M. (2019), Methyljasmonate elicitation increases terpenoid indole alkaloid accumulation in Rhazya stricta hairy root cultures, Plants 8(12): 534.
- Le Hesran S., Groot T., Knapp M., Nugroho J.E., Beretta G., Salomé-Abarca L.F., Choi Y.H., Vancová M., Moreno-Rodenas A.M. & Dicke M. (2019), Mechanisms of drought resistance in Phytoseiulus persimilis eggs, Experimental and Applied Acarology 79(3-4): 279-298.
- Mišan A., Nađpal J., Stupar A., Pojić M., Mandić A., Verpoorte R. & Choi Y.H. (2019), The perspectives of natural deep eutectic solvents in agri-food sector, Critical Reviews in Food Science and Nutricion 60(15): 2564-2592.
- Ge Y., Chen X., Gođevac D., Bueno P.C.P., Salome Abarca L.F., Jang Y.P., Wang M. & Choi Y.H. (2019), Metabolic profiling of saponin-rich Ophiopogon japonicus roots based on 1H NMR and HPTLC platforms, Planta Medica 85(11/12): 917-924.
- Rozema E., Kierszniowska S., Almog-Gabai O., Wilson E.G., Choi Y.H., Verpoorte R., Hamo R., Chalifa-Caspi V., Assaraf Y.G. & Lubzens E. (2019), Metabolomics reveals novel insight on dormancy of aquatic invertebrate encysted embryos, Scientific Reports 9: 8878.
- López-Gresa M.P., Payá C., Rodrigo I., Bellés J.M., Barceló S., Choi Y.H., Verpoorte R. & Lisón P. (2019), Effect of benzothiadiazole on the metabolome of tomato plants infected by citrus exocortis viroid, Viruses 11(5): 437.
- Choi Y.H. & Verpoorte R. (2019), Green solvents for the extraction of bioactive compounds from natural products: from supercritical fluid extraction to ionic liquids and deep eutectic solvents, Current Opinion in Food Science 26: 87-93.
- Ma Y., Li P., Willot S.J.P., Zhang W., Ribitsch D., Choi Y.H., Verpoorte R., Zhang T., Hollmann F. & Wang Y. (2019), Natural deep eutectic solvents as multifuntional media for the valorization of agricultural wastes, ChemSusChem 12(7): 1310-1315.
- Freire R.T., Bero J., Beaufay C., Selegato D.M., Coqueiro A., Choi Y.H. & Quetin-Leclercq J. (2019), Identification of antiplosmodial triterpenes from Keetia species using NMR-based metabolic profiling, Metabolomics 15: 27.
- Wu C., Heul H.U. van der, Melnik A.V., Pannu N., Dorrestein P.C., Minnaard A.J., Choi Y.H. & Wezel G.P. van (2019), Lugdunomycin, an angucycline-derived molecule with unprecedented chemical architecture, Angewandte Chemie (International Edition) 58(9): 2809-2814.
- McAlpine J.B., Chen S.N., Kutateladze A., MacMillan J.B., Appendino G., Barison A., Beniddir M.A., Biavatti M.W., Bluml S., Boufridi A., Butler M.S., Capon R.J., Choi Y.H., Coppage D., Crews P., Crimmins M.T., Csete M., Dewapriya P., Egan J.M., Garson M.J., Genta-Jouve G., Gerwick W.H., Gross H., Harper M.K., Hermanto P., Hook J.M., Hunter L., Jeannerat D., Ji N.Y., Johnson T.A., Kingston D.G.I., Koshino H., Lee H.W., Lewin G., Li J., Linington R.G., Liu M., McPhail K.L., Molinski T.F., Moore B.S., Nam J.W., Neupane R.P., Niemitz M., Nuzilard J.M., Oberlies N.H., Ocampos F.M.M., Pan G., Quinn R.J., Reddy S.D., Renault J.H., Rivera-Chavez J., Robien W., Saunders C.M., Schmidt T.J., Seger C., Shen B., Steinbeck C., Stuppner H., Sturm S., Tagliatatela-Scafati O., Tantillo D.J., Verpoorte R., Wang B.G., Williams C.M., Williams P.G., Wist J., Yue J.M., Zhang C., Xu Z., Simmler C., Lankin D.C., Bisson J. & Pauli G.F. (2019), The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research, Natural Product Reports 36(1): 35-107.
- Mandrone M., Coqueiro A., Poli F., Antognoni F. & Choi Y.H. (2018), Identification of a collagenase-inhibiting flavonoid from alchemilla vulgaris using NMR-based metabolomics, Planta Medica 84(12-13): 941-946.
- Verpoorte R., Kim H.K. & Choi Y.H. (2018), Synergy: easier to say than to prove, Synergy 7: 34-35.
- Gonzalez C.G., Mustafa N.R., Wilson E.G., Verpoorte R. & Choi Y.H. (2018), Application of natural deep eutectic solvents for the "green" extraction of vanillin from vanilla pods, Flavour and Fragrance Journal 33(1): 91-96.
- Kim H.K., Kostidis S. & Choi Y.H. (2018), NMR Analysis of Fecal Samples. In: Giera M. (Ed.), Clinical Metabolomics: Methods and Protocols. Methods in Molecular Biology no. 1730. New York, NY, U.S.A.: Humana Press. 317-328.
- Liu X., Ahlgren S., Korthout H., Salomé Abarca L.F., Bayona Maldonado L.M., Verpoorte R. & Choi Y.H. (2018), Broad range chemical profiling of natural deep eutectic solvent extracts using a high performance thin layer chromatography-based method, Journal of Chromatography A 1532: 198-207.
- Salome Abarca L.F., Pas J. van der, Kim H.K., Uffelen G.A. van., Klinkhamer P.G.L. & Choi Y.H. (2018), Metabolic discrimination of pine resins using multiple analytical platforms, Phytochemistry 155: 37–44.
- Bayona Maldonado L., Videnova M. & Choi Y.H. (2018), Increasing metabolic diversity in marine sponges extracts by controlling extraction parameters, Marine Drugs 16(10): 393.
- Choi Y.H. (2018), Special issue dedicated to Prof. Dr. Robert Verpoorte, Planta Medica 84(12/13): 833.
- Mandrone M., Coqueiro A., Poli F., Antognoni F. & Choi Y.H. (2018), Identification of collagenase inhibiting flavonoid from Alchemilla vulgaris L. using NMR-based metabolomics, Planta Medica 84(12/13): 941-946.
- Ge Y., Sun M., Salome Abarca L.F., Wang M. & Choi Y.H. (2018), Investigation of species and environmental effects on Rhubarb roots metabolome using 1H NMR combined with high performance thin layer chromatography, Metabolomics 14: 137.
- Hennivanda H., Wilson E.G., Verpoorte R. & Choi Y.H. (2018), Green solvents from ionic liquids and deep eutectic solvents to natural deep eutectic solvents, Comptes Rendus Chimie 21(6): 628-638.
- Saiman M.Z., Miettinen K., Mustafa N.R., Choi Y.H., Verpoorte R. & Schulte A.E. (2018), Metabolic alteration of Catharanthus roseus cell suspension cultures overexpressing geraniol synthase in the plastids or cytosol, Plant Cell, Tissue and Organ Culture 134(1): 41-53.
- Khoyratty S., Choi Y.H., Dupont J., Verpoorte R. & Kodja H. (2017), Host and guest: vanilla inhabited by endophytes. In: Mérillon J.M. & Ramawat K.G. (Eds.), Fungal netabolites. Reference Series in Phytochemistry ((RSP)). Cham: Springer International Publishing. 191-217.
- Mouden S., Klinkhamer P.G.L., Choi Y.H. & Leiss K.A. (2017), Towards eco-friendly crop protection: natural deep eutectic solvents and defensive secondary metabolites, Phytochemistry Reviews 16(5): 935-951.
- Wu C., Ichinose K., Choi Y.H. & Wezel G.P. van (2017), Aromatic polyketide GTRI-02 is a previously unidentified product of the act gene cluster in Streptomyces coelicolor A3(2), ChemBioChem 18(14): 1428-1434.
- Wu C., Du C., Ichinose K., Choi Y.H. & Wezel G.P. van (2017), Discovery of C-glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a combined NMR-based metabolomics and bioinformatics workflow, Journal of Natural Products 80(2): 269-277.
- Kostidis S., Kokova D., Dementeva N., Saltykova I.V., Kim H.K., Choi Y.H. & Mayboroda O.A. (2017), 1H-NMR analysis of feces: new possibilities in the helminthes infections research, BMC Infectious Diseases 17: 275.
- Ralha de Abreu A.C., Coqueiro A., Sultan A.R., Lemmens N., Kim H.K., Verpoorte R., Warmel W.J.B. van, Simões M. & Choi Y.H. (2017), Looking to nature for a new concept in antimicrobial treatments: isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA, Scientific Reports 7: 3777.
- Chemat F., Cravotto G. & Choi Y.H. (Eds.) (2017), Special Issue "Green Extraction of Natural Product: Innovative Techniques, Alternative Solvents and Original Procedures". Molecules: MDPI AG.
- Dai Y., Rozema E., Verpoorte R. & Choi Y.H. (2016), Application of natural deep eutectic solvents to the extraction of anthocyanins from Catharanthus roseus with high extractability and stability replacing conventional organic solvent, Journal of Chromatography A 1434: 50-56.
- Krstić G., Anđelković B., Choi Y.H., Vajs V., Stević T., Tešević V. & Gođevac D. (2016), Metabolic changes in Euphorbia palusrtis latex after fungal infection of the plant, Phytochemistry 131: 17-25.
- Hovenkamp P., Yan S.-K. & Choi Y.H. (2016), Seasonal changes in starch content in trophopods of Matteuccia struthiopteris, American Fern Journal 106(3): 153-160.
- Schilthuizen M., Santos Pimenta L.P., Lammers Y., Steenbergen P.J., Flohil M., Beveridge N.G., Duijn P.T. van, Meulblok M.M., Sosef N., Ven R. van de, Werring R., Beentjes K.K., Meijer K., Vos R.A., Vrieling K., Gravendeel B., Choi Y.H., Verpoorte R., Smit C. & Beukeboom L.W. (2016), Incorporation of an invasive plant into a native insect herbivore food web, PeerJ 4: e1954.
- Leiss K.A., Choi Y.H. & Klinkhamer P.G.L. (2016), Application of eco-metabolomics in biological science, AIP Conference Proceedings 1744(1): 020033.
- Ralha de Abreu A.C., Paulet D., Coqueiro A., Malheiro J., Borge A., Saavedra M.J., Choi Y.H. & Simões M. (2016), Antibiotic adjuvants from Buxus sempervirens to promote effective treatment of drug-resistant Staphylococcus aureus including biofilms, RSC Advances 6(97): 95000-95009.
- Wu C., Choi Y.H. & Wezel G.P. van (2016), Metabolic profiling as a tool for prioritizing antimicrobial compounds, Journal of Industrial Microbiology and Biotechnology 43(2-3): 299-312.
- Wu C., Medema M.H., Läkamp R.M., Zhang L., Dorrestein P.C., Choi Y.H. & Wezel G.P. van (2016), Leucanicidin and endophenasides result from methyl-rhamnosylation by the same tailoring enzymes in Kitasatospora sp. MBT66, ACS Chemical Biology 11(2): 478-490.
- Akhtar M.T., Mushtaq M.Y., Verpoorte R., Richardson M.K. & Choi Y.H. (2016), Zebrafish as a model for systems medicine R&D: rethinking the metabolic effects of carrier solvents and culture buffers determined by (1)H NMR metabolomics, OMICS: A Journal of Integrative Biology 20(1): 42-52.
- Ayouni K., Berboucha M., Kim H.K., Atmani D., Verpoorte R. & Choi Y.H. (2016), Metabolomic tool to identify antioxidant compounds of Fraxinus angustifolia leaf and stem bark extracts, Industrial Crops and Products 88: 65-77.
- Goncalves A.L., Ralha de Abreu A.C., Coqueiro A., Gaspar A., Borges F., Choi Y.H., Pires J.C.M. & Simoes M. (2016), Co-cultivation of Synechocystis salina and Pseudokirchneriella subcapitata under varying phosphorus concentration is evidence of an allelopathic competition scenario, RSC Advances 6(61): 56091-56100.
- Coqueiro A., Choi Y.H., Verpoorte R., Gupta K.B.S.S., Mieri M. de, Hamburger M., Young M.C.M., Stapleton P., Gibbons S. & Bolzani V.D.S. (2016), Antistaphylococcal prenylated acylphloroglucinol and xanthones from Kielmeyera variabilis (Clusiaceae), Journal of Natural Products 79(3): 470-476.
- Ullrich S.F., Averesch N.J.H., Castellanos Hernandez L., Choi Y.H., Rothauer A. & Kayser O. (2016), Discrimination of wild types and hybrids of Duboisia myoporoides and Duboisia leichhardtii at different growth stages using 1H NM-based metabolite profiling and tropane alkaloids-tarted HPLC-MS analysis, Phytochemistry 131: 44-56.
- Wu C., Zhu H., Wezel G.P. van & Choi Y.H. (2016), Metabolomics-guided analysis of isocoumarin production by Streptomyces species MBT76 and biotransformation of flavonoids and phenylpropanoids, Metabolomics 12(5): 90.
- Angermayr S.A., Alphen P. van, Hasdemir D., Kramer G., Iqbal M., Grondelle W. van, Hoefsloot H.C., Choi Y.H. & Hellingwer K.J. (2016), Culturing of Synechocystis sp. PCC 6803 with N2 and CO2 in a diel regime reveals multi-phase glycogen dynamics with low maintenance costs, Applied and Environmental Microbiology 82(14): 4180-4189.
- Choi Y.H. (2016), Natural deep eutectic solvents: the missing link in understanding cellular metabolism in physiology (NWO).
- Geest G. van, Choi Y.H., Arens P., Post A. & Meeteren U. van (2016), Genotypic differences in metabolomics changes during storage induced-degreening of chrysanthemum disk florets, Postharvest Biology and Technology 115: 48-59.
- Akhtar M.T., Mushtaq M.Y., Verpoorte R., Richardson M.K. & Choi Y.H. (2016), Metabolic effects of cannabinoids in zebrafisch (Danio Rerio) embryos determined by 1HNMR metabolomics, Metabolomics 12(3): 44.
- Dai Y., Witkamp G.J., Verpoorte R. & Choi Y.H. (2015), Tailoring properties of natural deep eutectic solvents with water to facilitate their applications, Food Chemistry 187: 14-19.
- Khoyratty S., Dupont J., Lacoste S., Palama T.L., Choi Y.H., Kim H.K., Payet B., Grisoni M., Fouillaud M., Verpoorte R. & Kodja H. (2015), Fungal endophytes of Vanilla planifolia across Réunion Island: isolation, distribution and biotransformation, BMC Plant Biology 15: 142.
- Rozema E., Dam A.D. van, Sips H.C.M., Verpoorte R., Meijer O.C., Kooijman S. & Choi Y.H. (2015), Extending pharmacological dose-response curves for salsalate with natural deep eutectic solvents, RSC Advances 5(75): 61398-61401.
- Wu C., Wezel G.P. van & Choi Y.H. (2015), Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66, Journal of Antibiotics 68(7): 445-452.
- Wu C., Kim H.K., Wezel G.P. van & Choi Y.H. (2015), Metabolomics in the natural products field: a gateway to novel antibiotics, Drug Discovery Today: Technologies 13: 11-17.
- Kim H.K., Rutten N.B.M.M., Besseling-van der Vaart I., Niers L.E.M., Choi Y.H., Rijkers G.T. & Hemert S. van (2015), Probiotic supplementation influences faecal short chain fatty acids in infants at high risk for eczema, Beneficial Microbes 6(6): 783-790.
- Marin B., Frederich M., Tullio P. de, Wauters N., Choi Y.H. & Bodson M. (2015), Metabolomics analysis of Galium odoratum (L.) Scop.: Impact of the plant population origin an growth conditions, Current Metabolomics 3(2): 122-129.
- Mohd Zuwairi Bin Saiman M., Mustafa N.R., Pomahacova B., Verberne M.C., Verpoorte R., Choi Y.H. & Schulte A.E. (2015), Erratum to: Analysis of metabolites in the terpenoid pathway of Catharanthus roseus cell suspensions, Plant Cell, Tissue and Organ Culture 122(1): 257.
- Mohd Zuwairi Bin Saiman M., Mustafa N.R., Choi Y.H., Verpoorte R. & Schulte A.E. (2015), Metabolic alterations and distribution of five-carbon precursors in jasmonic acid-elicited Catharanthus roseus cell suspension cultures, Plant Cell, Tissue and Organ Culture 122: 351-362.
- Wu C., Du C., Gubbens J., Choi Y.H. & Wezel G.P. van (2015), Metabolomics-driven discovery of a prenylated isatin antibiotic produced by Streptomyces species MBT28, Journal of Natural Products 78(10): 2355–2363.
- Ali K., Verpoorte R., Wilson E.G. & Choi Y.H. (2015), Chemical Characterization of Marine Organisms Using e Metabolomic Approach. In: Baker B.J. (Ed.), Marine Biomedicine: From beach to Bedside. Boca Raton FL USA: CRC press. 23-42.
- Zheng L., Wang M., Ibarra Estrada E., Wu C., Wilson E.G., Verpoorte R., Klinkhamer P.G.L. & Choi Y.H. (2015), Investigation of chemomarkers of astragali radix of different ages and geographical origin by NMR profiling, Molecules 20(2): 3389-3405.
- Pan Q., Mustafa N.R., Tang K., Choi Y.H. & Verpoorte R. (2015), Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolites, Phytochemistry Reviews 15: 221-250.
- Wu C., Zacchetti B., Ram A.F.J., Wezel G.P. van, Claessen D. & Choi Y.H. (2015), Expanding the chemical space for natural products by Aspergillus-Streptomyces co-cultivation and biotransformation, Scientific Reports 2015(5): 10868.
- Scognamiglio M., Fiumano V., D'Abrosca B., Esposito A., Choi Y.H., Verpoorte R. & Fiorentino A. (2014), Chemical interactions between plants in Mediterranean vegetation: the influence of selected plant extracts on Aegilops geniculata metabolome, Phytochemistry 106: 69-85.
- Coqueiro A., Lee L.W., Silva Bolzani V. de, Verpoorte R. & Choi Y.H. (2014), Development of a temperature-pressure controlled extraction method for the alkaloids of Erythrina mulungu, Planta Medica 80(16): 1457-1458.
- Mushtaq M.Y., Marçal R.M., Champagne D.L., Kooy F. van der, Verpoorte R. & Choi Y.H. (2014), Effect of acute stresses on Zebra Fish (Danio rerio) metabolome measured by NMR-based metabolomics, Planta Medica 80(14): 1227-1233.
- Rachmania O., Choi Y.H., Arruabarrena I., Vermeulen B., Spronsen J. van, Verpoorte R. & Witkamp G.J. (2014), Environmentally benign supercritical CO2 extraction of galanthamine from floricultural crop waste of Narcissus pseudonarcissus, Journal of Supercritical Fluids 93: 7-19.
- Mushtaq M.Y., Choi Y.H., Verpoorte R. & Wilson E.G. (2014), Extraction for metabolomics: access to the metabolome, Phytochemical Analysis 25(4): 291-306.
- Yuliana N Rosa D Budijanto S Verpoorte R Choi Y (2014), Identification of adenosine A1 receptor ligands from Morus alba L. stem bark by NMR metabolomics approach, International Food Research Journal 21(3): 1103-1107.
- Jahangir M., Abdel-Farid I., Mahmood Z., Jamil M., Rey P., Choi Y.H. & Verpoorte R. (2014), Metabolomic approach: postharvest storage stability of red radish ( Raphanus sativus L.), Journal of the Chemical Society of Pakistan 36(5): 931-938.
- Choi Y.H. & Verpoorte R. (2014), Metabolomics: what you see is what you extract, Phytochemical Analysis 25(4): 289-290.
- Jahangir M., Abdel-Farid I.B., R.C.H. de Vos, Jonker H.H., Choi Y.H. & Verpoorte R. (2014), Metabolomic variation of brassica rapa var. rapa (var raapstelen) and raphanus sativus L. at different developmental stages, Pakistan Journal of Botany 46(4): 1445-1452.
- Bassey K., Viljoen A., Combrinck S. & Choi Y.H. (2014), New phytochemicals from the corms of medicinally important South African Hypoxis species, Phytochemistry Letters 10: lxix-lxxv.
- Verpoorte R. & Choi Y.H. (Eds.) (2014), Special Issue in Phytochemical Analysis, Pre-analytical methods in metabolomics: sample preparation and extraction: Wiley.
- Subedi A., Kunwar B., Choi Y.H., Dai Y., Andel T.R. van, Chaudhary R.P., Boer H.J. de & Gravendeel B. (2013), Collection and trade of wild-harvested orchids in Nepal, Journal of Ethnobiology and Ethnomedicine 9(1): 64.
- Pan Q., Dai Y., Nuringtyas T.R., Mustafa N.R., Schulte A.E., Verpoorte R. & Choi Y.H. (2013), Investigation of the chemomarkers correlated with flower colour in different organs of Catharanthus roseus using NMR‐based metabolomics, Phytochemical Analysis 25(1): 66-74.
- Lubbe A., Ali K., Verpoorte R. & Choi Y.H. (2013), NMR-based metabolomics analysis. In: Lämmerhofer M. & Weckwerth W. (Eds.), Metabolomics in Practice: Successful Strategies to Generate and Analyze Metabolic Data. Weinheim: Wiley-VCH. 209-238.
- Sar S van der., Kim H.K., Meissner A., Verpoorte R. & Choi Y.H. (2013), Nuclear magnetic resonance spectroscopy for plant metabolite profiling. In: Weckwerth W. & Kahl G. (Eds.), The Handbook of Plant Metabolomics. Weinheim: Wiley-VCH. 57-76.
- Lubbe A., Gude H., Verpoorte R. & Choi Y.H. (2013), Seasonal accumulation of major alkaloids in organs of pharmaceutical crop Narcissus Carlton, Phytochemistry 88: 43-53.
- Dai Y., Spronsen J. van, Witkamp G.J., Verpoorte R. & Choi Y.H. (2013), Natural deep eutectic solvents as new potential media for green technology, Analytica Chimica Acta 766: 61-68.
- Ali K., Iqbal M., Yuliana N.D., Lee Y.J., Park S., Han S., Lee J.W., Lee H.S., Verpoorte R. & Choi Y.H. (2013), Identification of bioactive metabolites against adenosine A1 receptor using NMR-based metabolomics, Metabolomics 9(4): 778-785.
- D’Abrosca B., Scognamiglio M., Fiumano V., Esposito A., Cho Y.H., Verpoorte R. & Fiorentino A. (2013), Plant bioassay to assess the effects of allelochemicals on the metabolome of the target species Aegilops geniculata by a NMR-based approach, Phytochemistry 93: 37-40.
- Charoonratana T., Pathompak P., Keawpradub H., Georgiev M.I., Choi Y.H., Verpoorte R. & Wungsintaweekul J. (2013), Limitation of mitragynine biosynthesis in mitragyna speciosa (Roxb.) Korth. through tryptamine availability, Zeitschrift fuer Naturforschung C : A Journal of Biosciences 68(9-10): 394-405.
- Ali K., Iqbal M., Fortes A.M., Pais M.S., Korthout H.A.A.J., Verpoorte R. & Choi Y.H. (2013), Red wines attenuate TNFα production in human histiocytic lymphoma cell line: An NMR spectroscopy and chemometrics based study, Food Chemistry 141: 3124-3130.
- Kim H.K., Choi Y.H. & Verpoorte R. (2013), Profiling the jasmonic acid responses by nuclear magnetic resonance-based metabolomics, Methods in Molecular Biology : 267-275.
- Dai L.Y., Witkamp G.J., Verpoorte R. & Choi Y.H. (2013), Natural deep eutectic solvents as a new extraction media for phenolic metabolites in Carthamus tinctorius, Analytical Chemistry 85(13): 6272-6278.
- Pimenta L.P.S., Kim H.K., Verpoorte R. & Choi Y.H. (2013), NMR-based metabolomics: a probe to utilize biodiversity. In: Rössner U. & Dias D.A. (Eds.), Metabolomics Tools for Natural Product Discovery. Methods in Molecular Biology. Totowa, NJ: Humana Press. 117-127.
- Goldhaber Pasillas G.D., Choi Y.H. & Verpoorte R. (2013), New methods of analysis and investigation of terpenoid indole alkaloids, Advances in Botanical Research 68: 233-272.
- Dai Y., Spronsen J. van, Witkamp G.J., Verpoorte R. & Choi Y.H. (2013), Ionic Liquids and Deep Eutectic Solvents in Natural Products Research: Mixtures of Solids as Extraction Solvents, Journal of Natural Products 76(11): 2162-2173.
- Yuliana N.D., Jahangir M., Verpoorte R. & Choi Y.H. (2013), Metabolomics for the rapid dereplication of bioactive compounds from natural sources, Phytochemistry Reviews 12(2): 293-304.
- Wolfender J.L., Rudaz S., Choi Y.H. & Kim H.K. (2013), Plant metabolomics: from holistic data to relevant biomarkers, Current Topics in Medicinal Chemistry 20: 1056-1090.
- Ali K., Maltese F., Figueiredo A., Rex M., Fortes A.M., Zyprian E., Pais M.S., Verpoorte R. & Choi Y.H. (2012), Alterations in grapevine leaf metabolism upon inoculation with Plasmopara viticola in different time-points, Plant Science 191-192: 100-107.
- Gao X.X., Cui J., Zhen X.Y., Li Z.Y., Choi Y.H., Zhou Y.Z., Tian J.S., Xing J., Tan X.J., Du G.H. & Qin X.M. (2012), An investigation of the antidepressant action of Xiaoyaosan in rats using ultra performance Liquid Chromatography–Mass Spectrometry combined with metabonomics, Phytotherapy Research 27(7): 1074-1085.
- Lubbe A., Verpoorte R. & Choi Y.H. (2012), Effects of fungicides on galanthamine and metabolite profiles in Narcissus bulbs, Plant Physiology and Biochemistry 58(11): 116-123.
- Jahangir M. Abdel-Farid I.B. Simoh S. Kim H.K. Verpoorte R. Choi Y.H. (2012), Investigation of Brassica biochemical status by NMR-based metabolomics, Acta Horticulturae 936: 163-172.
- Flores-Sanchez I.J., Choi Y.H. & Verpoorte R. (2012), Metabolite analysis of Cannabis sativa L. by NMR spectroscopy. In: Kaufmann M. & Klinger C. (Eds.), Functional genomics : methods and protocols. Methods in Molecular Biology no. 815. New York, N.Y., U.S.A.: Springer. 363-376.
- Mediani A., Abas F., Kahtib A., Maulidiani H., Shaari K., Choi Y.H. & Lajis N.H. (2012), 1H-NMR-based metabolomics approach to understanding the drying effects on the phytochemicals in Cosmos caudatus, Food Research International 49(2): 763-770.
- Ali K., Iqbal M., Korthout H.A.A.J., Maltese F., Fortes A.M., Pais M.S., Verpoorte R. & Choi Y.H. (2012), NMR spectroscopy and chemometrics as a tool for anti-TNFa activity screening in crude extracts of grapes and other berries, METABOLOMICS 8: 1148-1162.
- Kirk H.E., Cheng D., Choi Y.H., Vrieling K. & Klinkhamer P.G.L. (2012), Transgressive segregation of primary and secondary metabolites in F2 hybrids between Jacobaea aquatica and J. vulgaris, METABOLOMICS 8: 211-219.
- Pan Q., Wang Q., Yuan F., Xing S., Zhao J., Choi Y.H., Verpoorte R., Tian Y., Wang G. & Tang K. (2012), Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics, PLoS ONE 7(8): e43038.
- Qin X., Liu N.Q., Li Z., Liu X., Choi Y.H. & Verpoorte R. (2012), Metabolic fingerprinting by 1HNMR for discrimination of the two species used as radix bupleuri, Planta Medica 78(9): 926-933.
- Palama T.L., Grisoni M., Fock-Bastide I., Jade K., Barter L., Choi Y.H., Verpoorte R. & Kodja H. (2012), Metabolome of Vanilla planifolia (Orchidaceae) and related species under Cymbidium mosaic virus (CymMV) infection, Plant Physiology and Biochemistry 60: 25-34.
- Lopez-Gresa M.P., Lison P., Kim H.K., Choi Y.H., Verpoorte R., Rodrigo I., Conejero V. & Belles J.M. (2012), Metabolic fingerprinting of Tomato Mosaic Virus infected Solanum lycopersicum, Journal of Plant Physiology 169(16): 1586-1596.
- Sharma A., Cardoso-Taketa A., Choi Y.H., Verpoorte R. & Villarreal M.L. (2012), A comparison on the metabolic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca four years later, Journal of Ethnopharmacology 141(3): 964-974.
- Plischke A., Choi Y.H., Brakefield P.M., Klinkhamer P.G.L. & Bruinsma M. (2012), Metabolomic plasticity in GM and Non-GM potato leaves in response to Aphid Herbivory and virus infection, Journal of Agricultural and Food Chemistry 60(6): 1488-1493.
- Nuringtyas T.R., Choi Y.H., Verpoorte R., Klinkhamer P.G.L. & Leiss K.A. (2012), Differential tissue distribution of metabolites in Jacobaea vulgaris, Jacobaea aquatica and their crosses, Phytochemistry 78: 89-97.
- Mohd Zuwairi Bin Saiman M., Mustafa N.R., Schulte A.E., Verpoorte R. & Choi Y.H. (2012), Induction, characterization, and NMR-based metabolic profiling of adventitious root cultures from leaf explants of Gynura procumbens, Plant Cell, Tissue and Organ Culture 109: 465-475.
- Yuliana N.D., Khatib A., Verpoorte R. & Choi Y.H. (2011), Comprehensive extraction integrated with NMR metabolomics: a new way of bioactivity screening methods for plants, adenosine A1 receptor binding compounds in Orthosiphon stamineus Benth, Analytical Chemistry 83(17): 6902-6906.
- Chan W.T., Choi Y.H., Heijden R. van der, Lee M.S., Lin M.K., Kong H., Kim H.K., Verpoorte R., Hankemeier T. & Greef J. van der (2011), Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa Roots, Chemical and pharmaceutical bulletin 59: 546.
- Lubbe A., Choi Y.H., Vreeburg P. & Verpoorte R. (2011), Effect of fertilizers on galanthamine and metabolite profiles in Narcissus bulbs by 1H NMR, Journal of Agricultural and Food Chemistry 59(7): 3155-3161.
- Ali K., Maltese F., Fortes A.M., Pais M.S., Verpoorte R. & Choi Y.H. (2011), Pre-analytical method for NMR-based grape metabolic fingerprinting and chemometrics, Analytica Chimica Acta 703: 179.
- Palama T.L., Khatib A., Choi Y.H., Come B., Fock I., Verpoorte R. & Kodja H. (2011), Metabolic Characterization of Green Pods from Vanilla planifolia Accessions Grown in La Réunion, Onbekend 72: 258.
- Georgiev M., Ali K., Alipieva K., Verpoorte R. & Choi Y.H. (2011), Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics, Phytochemistry 72(16): 2045-2051.
- Kim H.K., Choi Y.H. & Verpoorte R. (2011), NMR-based plant metabolomics: where do we stand, where do we go?, Trends in Biotechnology 29: 267.
- Namdeo A., Sharma A., Yadav K., Gawande R., Mahadik K., Lopez-Gresa M., Kim H.K., Choi Y.H. & Verpoorte R. (2011), Metabolic characterization of Withania somnifera from different regions of India using NMR spectroscopy, Planta Medica 77(17): 1958-1964.
- Choi Y.H. (Ed.) (2011), . Phytochemical Analysis.
- Choi Y.H. (2011), Deconvolution of plant phenolic metabolism using multidimensional metabolomics (for Horizon Breakthrough Project). Netherlands: Netherlands Genomics Initiative.
- Spronsen J. van, Witkamp G.-J., Hollman F., Choi Y.H. & Verpoorte R. (15 December 2011), Process for extracting materials from biological material (patent no. PCT/NL2011/050407). Requested on 15 December 2011. [patent].
- Yuliana N.D., Khatib A., Choi Y.H. & Verpoorte R. (2011), Metabolomics for bioactivity assessment of natural products, Phytotherapy Research 25(2): 157-169.
- Yuliana N.D., Jahangir M., Korthout H.A., Choi Y.H., Kim H.K. & Verpoorte R. (2011), Comprehensive review on herbal medicine for energy intake suppression, Obesity Reviews 12(7): 499-514.
- Choi Y.H., Spronsen J. van, Dai Y., Verberne M., Hollmann F., Arends I.W.C.E., Witkamp G.-J. & Verpoorte R. (2011), Are natural deep eutectic solvents the missing link in understanding cellular metabolism and physiology?, Plant Physiology 156(4): 1701-1705.
- Grebenstein C., Choi Y.H., Rong J., Jong T.J. de & Tamis W.L.M. (2011), Metabolic fingerprinting reveals differences between shoots of wild and cultivated carrot (Daucus carota L.) and suggests maternal inheritance or wild trait dominance in hybrids, Phytochemistry 72(11-12): 1341-1347.
- Fortes A.M., Agudelo-Romero P., Silva M.S., Ali K., Sousa L., Maltese F., Choi Y.H., Grimplet J., Martinez-Zapater J.M. & Verpoorte R. (2011), Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening, BMC Plant Biology 11: 149.
- Maltese F., Ali K., Toepfer R., Choi Y.H. & Verpoorte R. (2011), Metabolic characterization of Palatinate German white wines according to sensory attributes, varieties, and vintages using NMR spectroscopy and multivariate data analyses, Journal of Biomolecular NMR 49: 255-266.
- Abreu I.N., Choi Y.H., Sawaya A.C.H.F., Eberlin M.N., Mazzafera P. & Verpoorte R. (2011), Metabolic alterations in different developmental stages of Pilocarpus microphyllus, Planta Medica 77(3): 293-300.
- Ali K., Maltese F., Fortes A.M., Pais M.S., Choi Y.H. & Verpoorte R. (2011), Monitoring biochemical changes during grape berry development in Portuguese cultivars by NMR spectroscopy, Food Chemistry 124(4): 1760-1769.
- Leiss K.A., Choi Y.H., Verpoorte R. & Klinkhamer P.G.L. (2011), An overview of NMR-based metabolomics to identify secondary plant compounds involved in host plant resistance, Phytochemistry Reviews 10(2): 205-216.
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- Verpoorte R., Choi Y.H. & Kim H.K. (2010), Metabolomics: will it stay?, Phytochemical Analysis 21(1): 2-3.
- Kim H.K., Saifullah S.K., Wilson E., Prat Kricun S.D., Meissner A., Goraler S., Deelder A.M., Choi Y.H. & Verpoorte R. (2010), Metabolic classification of South-American Ilex Species by NMR-based metabolomics, Phytochemistry 71(7): 773-784.
- Abdel-Farid B., Jahangir M., Mustafa N.R., Dam N. van, Kim H.K., Hondel C.A.M.J.J. van den, Choi Y.H. & Verpoorte R. (2010), Glucosinolate profiling of Brassica rapa cultivars after infection by Leptosphaeria maculans and Fusarium oxysporum, Biochemical Systematics and Ecology 38(4): 612-620.
- Palama T.L., Fock I., Choi Y.H., Verpoorte R. & Kodja H. (2010), Biological variation of Vanilla planifolia leaf metabolome, Phytochemistry 71(5-6): 567-573.
- Simoh S., Linthorst H.J.M., Lefeber A.W.M., Erkelens C., Kim H.K., Choi Y.H. & Verpoorte R. (2010), Metabolic changes of brassica rapa transformed with bacterial isochorismate synthase gene, Journal of Plant Physiology 167(18): 1525-1532.
- Shikov A.N., Kundracikova M., Palama T.L., Pozharitskaya O.N., Kosman V.M., Makarov V.G., Galambosi B., Kim H.K., Jang Y.P., Choi Y.H. & Verpoorte R. (2010), Phenolic constituents of Gnaphalium uliginosum, Phytochemistry Letters 3: 45-47.
- Liu N.Q., Cao M., Frédérich M., Choi Y.H., Verpoorte R. & Kooy F. van der (2010), Metabolomic investigation of the ethnopharmacological use of Artemisia afra with NMR Spectroscopy and Multivariate Data Analysis, Journal of Ethnopharmacology 128(1): 230-235.
- Lubbe A., Pomahacova B., Choi Y.H. & Verpoorte R. (2010), Analysis of metabolic variation and galanthamine content in Narcissus bulbs by 1H NMR, Phytochemical Analysis 21(1): 66-72.
- Palama T.L., Menard P., Fock I., Choi Y.H., Bourdon E., Govinden-Soulange J., Bahut M., Payet B., Verpoorte R. & Kodja H. (2010), Shoot differentiation from protocorm callus cultures of Vanilla planifolia (Orchidaceae): proteomic and metabolic responses at early stage, Onbekend 10: 82.
- Pec J., Flores-Sanchez I.J., Choi Y.H. & Verpoorte R. (2010), Metabolic analysis of elicited cell suspension cultures of cannabis sativa L. by 1H-NMR spectroscopy, Biotechnology Letters 32(7): 935-941.
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- Kim H.K., Choi Y.H. & Verpoorte R. (2010), NMR-based metabolomic analysis of plants, Nature Physics 5: 536-549.
- Kim H.K., Wilson E., Choi Y.H. & Verpoorte R. (2010), Metabolomics: a tool for anticancer leadfinding from natural products, Planta Medica 76(11): 1094-1102.
- López-Gresa M.P., Maltese F., Bellés J.M., Conejero V., Kim H.K., Choi Y.H. & Verpoorte R. (2010), Metabolic response of tomato leaves upon different plant-pathogen interactions, Phytochemical Analysis 21(1): 89-94.
- Liu N.-Q., Choi Y.H., Verpoorte R. & Kooy F. van der (2010), Comparative quantitative analysis of artemisinin with chromatography and qNMR, Phytochemical Analysis 21(5): 451-456.
- Fischedick J.T., Hazekamp A., Erkelens T., Choi Y.H. & Verpoorte R. (2010), Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes, Phytochemistry 71(17-18): 2058-2073.
- Kim H.K., Verpoorte R. & Choi Y.H. (Eds.) (2010), Special Issue of Phytochemical Analysis, Metabolomics in Natural Products: Wiley.
- Verpoorte R., Choi Y.H. & Kim H.K. (2010), Metabolomics: what is new?, Flavour and Fragrance Journal 25(3): 128-131.
- Leiss K.A., Choi Y.H., Abdel-Farid I.B., Verpoorte R. & Klinkhamer P.G.L. (2009), NMR metabolomics of thrips resistance in Senecio hybrid, Journal of Chemical Ecology 35: 219-229.
- Simoh S., Quintana N., Kim H.K., Choi Y.H. & Verpoorte R. (2009), Metabolic changes in agrobacterium tumefaciens-infected Brassica rapa, Journal of Plant Physiology 166(10): 1005-1014.
- Arany A.M., Jong T.J. de, Kim H.K., Dam N.M. van, Choi Y.H., Mil H.G.J. van, Verpoorte R. & Meijden E. van der (2009), Genotype-environment interactions affect flower and fruit herbivory and plant chemistry of Arabidopsis thaliana in a transplant experiment, Ecological Research 24(5): 1161-1171.
- Maltese F., Erkelens C., Kooy F. van der, Choi Y.H. & Verpoorte R. (2009), Identification of natural enantiomeric flavanone glycosides by NMR spectroscopy, Food Chemistry 116(2): 575-579.
- Yuliana N.D., Khatib A., Link-Struensee A.M.R., IJzerman A.P., Rungkat-Zakari F., Choi Y.H. & Verpoorte R. (2009), Adenosine A1 receptor antagonist activity of methoxy flavonoids from Orthosiphon stamineus, Planta Medica 75(2): 132-136.
- Kooy F. van der, Maltese F., Choi Y.H., Kim H.K. & Verpoorte R. (2009), Quality control of herbal material and phytopharmaceuticals with the use of MS and NMR based metabolic fingerprinting, Planta Med. 75: 763-775.
- Palama T.L., Khatib A., Choi Y.H., Fock I., Payet B., Verpoorte R. & Kodja H. (2009), Metabolic changes in different developmental stages of vanilla planifolia pods, Journal of Agricultural and Food Chemistry 57(17): 7651-7658.
- Dayakar V., Badri N., Quintana N., El Kassis E., Kim H.K., Choi Y.H., Suguyama A., Verpoorte R., Martinoia E., Manter D.K. & Vivanco Jorge M. (2009), An ABC transporter mutation alters in root exudation of phytochemicals that provoke an overhaul of natural soil microbiota, Plant Physiology 151(4): 2006-2017.
- Ali K., Maltese F., Choi Y.H. & Verpoorte R. (2009), Metabolic constituents of grapevine and grape-derived products, Phytochemistry Reviews 9: 357–378.
- Flores-Sanchez I.J., Peč J., Fei J., Choi Y.H., Dusek J. & Verpoorte R. (2009), Elicitation studies in cell suspension cultures of Cannabis sativa L, Plant Biotechnology Journal 143(2): 157-168.
- Abdel-Farid I.B., Jahangir M., Hondel C.A.M.J.J. van den, Kim H.K., Choi Y.H. & Verpoorte R. (2009), Fungal infection-induced metabolites in Brassica rapa, Plant Science 176(5): 608-615.
- Lira T., Yariwake J.H., Choi Y.H., Kim H.K. & Verpoorte R. (2009), Metabonomic study of transgenic and non-transgenic sugarcane leaves based on NMR profile, Planta Medica 75(09): PB3.
- Mustafa N.R., Kim H.K., Choi Y.H., Erkelens C., Lafeber A.W.M., Spijksma G.K., Heijden R. van der & Verpoorte R. (2009), Biosynthesis of salicylic acid in fungus elicited Catharanthus roseus cells, Phytochemistry 70(4): 532-539.
- Fortes A.M., Batista D., Santos F., Figueiredo A., Serrazina S., Choi Y.H., Miersch O., Lange P., Wasternack C., Verpoorte R. & Pais M.S. (2009), Deciphering morphogenesis for hop improvement. A transcriptomic and metabolomic perspective, Proceedings of the Scientific Commission International Hop Growers' Convention (I.H.G.C.). Scientific Commission International Hop Growers' Convention. Leon 35-40.
- Ali K., Maltese F., Zyprian E., Rex M., Choi Y.H. & Verpoorte R. (2009), NMR metabolic fingerprinting based identification of grapevine metabolites associated with downy mildew resistance, J. Agricult. Food Chem. 57: 9599-9606.
- Leiss K.A., Maltese F., Choi Y.H., Verpoorte R. & Klinkhamer P.G.L. (2009), Identification of chlorogenic acid as a resistance factor for thrips in chrysanthemum, Plant Physiology 150(3): 1567-1575.
- Jahangir M., Kim H.K., Choi Y.H. & Verpoorte R. (2009), Health affecting compounds in Brassicaceae, Comprehensive Reviews in Food Science and Food Safety 8(2): 31-43.
- Jahangir M., Abdel-Farid I.B., Kim H.K., Choi Y.H. & Verpoorte R. (2009), Healthy and unhealthy plants: the effect of stress on the metabolism of Brassicaceae, Environmental and Experimental Botany 67(1): 23-33.
- Mustafa N.R., Kim H.K., Choi Y.H. & Verpoorte R. (2009), Metabolic changes of salicylic acid-elicited catharanthus roseus cell suspension cultures monitored by NMR-based metabolomics, Biotechnology Letters 31: 1967-1974.
- Mustafa N.K., Kim H.K., Choi Y.H. & Verpoorte R. (2008), Single step purification of salicylic acid from Catharanthus roseus cell culture (plant material) by anion exchange for NMR analysis, Journal of Liquid Chromatography and Related Technologies 31: 702-713.
- Taketa A.T.C., Pereda-Miranda R., Choi Y.H., Verpoorte R. & Villarreal M.L. (2008), Metabolomic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca using nuclear magnetic resonance spectroscopy and multivariate data analysis, Planta Medica 74(10): 1295-1301.
- Jahangir M., Abdel-Farid I.B., Choi Y.H. & Verpoorte R. (2008), Metal ions-inducing metabolites accumulation in Brassica rapa, Journal of Plant Physiology 165(14): 1429-1437.
- Mosleh Arany A., Jong T.J. de, Kim H.K., Dam N. van, Choi Y.H., Verpoorte R. & Meijden E. van der (2008), Glucosinolates and other metabolites in the leaves of Arabidopsis thaliana from natural populations and their effects on a generalist and a specialist herbivore, Chemoecology: Evolution and mechanisms of the chemical base of ecological interactions 18: 65-71.
- Fortes A., Santos F., Choi Y.H., Figueiredo A.C., Silva M.S., Sousa L., Pessoa F., Acioli B., Sebastiana M., Palme K., Malhó R., Verpoorte R. & Pais M.S. (2008), Organogenic nodule development in hop (Humulus lupulus L.): transcript and metabolic responses, BMC Genomics 9: 445.
- Chang W.T., Choi Y.H., Heijden R. van der, Kong H., Kim H.K., Verpoorte R., Xu G., Hankemeier T., Greef J. van der & Wang M. (2008), Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa Roots, : .
- Kooy F. van der, Maltese F., Choi Y.H., Kim H.K. & Verpoorte R. (2008), Quality control of herbal material and phytopharmaceuticals with the use of MS and NMR based metabolic fingerprinting, Planta Medica : .
- Figueiredo A.C., Fortes M., Ferreira S., Sebastiana M., Choi Y.H., Sousa L., Acioli-Santos B., Pessoa F., Verpoorte R. & Salomé Pais M. (2008), Transcriptional and metabolic profiling of grape (Vitis vinifera L.) leaves unravel possible innate resistance against pathogenic fungi, J. Exp. Bot. 59: 3371-3381.
- Leiss K.A., Choi Y.H., Abdel-Farid I.B., Verpoorte R. & Klinkhamer P.G.L. (2008), NMR metabolomics of thrips resistance in Senecio hybrid, Journal of Chemical Ecology : .
- Cardoso-Taketa A., Pereda-Miranda R., Choi Y.H., Verpoorte R. & Villarreal M. (2008), Metabolic profiling of the Mexican anxiolytic and sedative plant Galphimia glauca using nuclear magnetic resonance spectroscopy and multivariate data analysis, Planta Medica 74(10): 1295-1301.
- Verpoorte R., Choi Y.H., Mustafa N.K. & Kim H.K. (2008), Metabolomics: back to basics, Phytochemistry Reviews 7: 525-537.
- Jahangir M., Kim H.K., Choi Y.H. & Verpoorte R. (2008), Metabolomic response of Brassica rapa submitted to pre-harvest bacterial contamination, Food Chemistry 107(1): 362-368.
- Jahangir M., Bayoumi I., Abdel-Farid I.B., Kim H.K., Choi Y.H. & Verpoorte R. (2008), Stress induced metabolic responses in food plants of Brassicaceae, Mol. Biosystem. : .
- Karlsson P., Pettersson J., Choi Y.H., Verpoorte R., Bohlin L. & Rafter J.J. (2008), NMR metabolomic analysis of fecal water from subjects on a vegetarian diet, Biological and Pharmaceutical Bulletin 31(6): 1192-1198.
- Angelova N.S., Kong H.W., Heijden R. van der, Yang S.Y., Choi Y.H., Kim H.K., Wang M., Hankemeier T., Greef J. van der, Xu X. & Verpoorte R. (2008), Recent methodology in the phytochemical analysis of ginseng, Phytochemical Analysis 19: 2-16.
- Fraccaroli M., Nicoletti S., Maltese F., Choi Y.H., Guzzo F., Levi M. & Verpoorte R. (2008), Preanalytical method for metabolic profiling of plant cell cultures of Passiflora garckei, Biotechnology Letters 30: 2031-2035.
- Dao T.H.H., Puig R.C., Kim H.K., Erkelens C., Lefeber A.W.M., Linthorst H.J.M., Choi Y.H. & Verpoorte R. (2008), Effect of benzothiadiazole on the metabolome of Arabidopsis thaliana, Plant Physiology and Biochemistry 47(2): 146-152.
- Sanchez-Sampredo A., Kim H.K., Choi Y.H., Verpoorte R. & Corchete P. (2007), Metabolomic alterations in elicitor treated Silybum marianum suspension cultures monitored by nuclear magnetic resonance spectroscopy, Journal of Biotechnology 130(2): 133-142.
- Khatib A., Wilson E.G., Kim H.K., Supardi M., Choi Y.H. & Verpoorte R. (2007), NMR assignment of iso--acids from isomerised extracts of Humulus lupulus L. cones, Phytochemical Analysis 18: 371-377.
- Verpoorte R., Choi Y.H. & Kim H.K. (2007), NMR-based metabolomics at work in phytochemistry, 6: 3-14.
- Abdel-Farid I.B., Kim H.K., Choi Y.H. & Verpoorte R. (2007), Metabolic characterization of Brasica rapa leaves by NMR-spectroscopy, Journal of Agricultural and Food Chemistry 55(19): 7936-7943.
- Widarto H.T., Meijden E. van der, Lefeber A.W.M., Erkelens C., Kim H.K., Choi Y.H. & Verpoorte R. (2006), Metabolomic differentiation of Brassica rapa following herbivory by different insect instars using two dimensional nuclear magnetic resonance spectroscopy, Journal of Chemical Ecology 32(11): 2417-2428.
- Sumthong P., Damveld R.A., Choi Y.H., Arentshorst M., Ram A.F.J., Hondel C.A.M.J.J. van den & Verpoorte R. (2006), Activity of quinones from teak (Tectona grandis) on fungal cell wall stress, Planta Medica 72(10): 943-944.
- Choi Y.H., Kim H.K., Verpoorte R., Linthorst H.J.M., Hollander J., Lefeber A.W.M., Erkelens C. & Nuzillard J.-M. (2006), NMR metabolomics to revisit the tobacco mosaic virus infection in Nicotiana tabacum leaves, 69: 742-742.
- Petterson J., Huss U., Karlsson P.C., Choi Y.H., Verpoorte R., Rafter J.J. & Bohlin L. (2006), Natural COX-2 inhibitors and effects on colon cancer cells, Planta Medica 72(11): 1066-1067.
- Choi Y.H., Kim H.K. & Verpoorte R. (2006), Metabolomics. In: Kayser O. & Quax W. (Eds.), Medicinal Plant Biotechnology: From Basic Research to Industrial Applications. Weinheim: Wiley-VCH. 9-28.
- Kim H.K., Choi Y.H. & Verpoorte R. (2006), Metabolomic analysis of Catharanthus roseus using NMR and principal component analysis. Biotechnology. In: Saito K., Dixon R. & Willmitzer L. (Eds.), Plant Metabolomics. Biotechnology in Agriculture and Forestry. Biotechnology in Agriculture and Forestry no. 57. Heidelberg: Springer. 261-276.
- Abdel-Farid I.B., Choi Y.H., Kim H.K., Hondel C.A.M.J.J. van den, Meijden E. van der & Verpoorte R. (2006), The role of secondary metabolites in Arabidopsis and Brassica in the interaction with fungi, Current Topics in Microbiology and Immunology 7: 47-73.
- Yang S.Y., Kim H.K., Lefeber A.W.M., Erkelens C., Angelova N.S., Choi Y.H. & Verpoorte R. (2006), Application of two-dimensional nuclear magnetic resonance spectroscopy to quality control of ginseng commercial products, Planta Medica 72(4): 364-369.
- Liang Y.-S., Choi Y.H., Kim H.K., Linthorst H.J.M. & Verpoorte R. (2006), Metabolomic analysis of methyl jasmonate treated Brassica rapa leaves by 2-dimensional NMR spectroscopy, Phytochemistry 67(22): 2503-2511.
- Khatib A., Kim H.K., Wilson E.G., Choi Y.H. & Verpoorte R. (2006), High performance liquid chromatographic method for Iso‐α‐Acids, Journal of Liquid Chromatography and Related Technologies 29(2): 293-302.
- Khatib A., Wilson E.G., Kim H.K., Lefeber A.W.M., Erkelens C., Choi Y.H. & Verpoorte R. (2006), Application of two dimensional J-resolved nuclear magnetic resonance spectrum to differentiation of beer, Analytica Chimica Acta 559(2): 264-270.
- Liang Y.-S., Lefeber A.W.M., Erkelens C., Kim H.K., Choi Y.H. & Verpoorte R. (2006), Identification of phenylpropanoids in Brassica rapa leaves treated with methyl jasmonate using two-dimensional nuclear magnetic resonance spectroscopy, Journal of Chromatography A 1112: 148-155.
- Hendrawati O., Yao Q., Choi Y.H., Kim H.K., Linthorst H.J.M., Erkelens C., Lefeber A.W.M. & Verpoorte R. (2006), Metabolic differentiation of Arabidopsis treated with methyl jasmonate using nuclear magnetic resonance spectroscopy, Plant Science 170(6): 1118-1124.
- Verpoorte R., Kim H.K. & Choi Y.H. (2005), New perspectives of medicinal plants in a globalized world. Mukherjee P.K. (Ed.), Proceedings International Conference on Botanicals. . Kolkata, India: Allied Book Agency. 11-18.
- Choi Y.H., Sertic S., Kim H.K., Wilson E.G., Michopoulosa F., Lefeber A.W.M., Erkelens C., Kricun S.D.P. & Verpoorte R. (2005), Classification of Ilex species based on metabolomic fingerprinting using nuclear magnetic resonance and multivariate data analysis, Journal of Agricultural and Food Chemistry 53(4): 1237-1245.
- Kirk H.E., Choi Y.H., Kim H.K., Verpoorte R. & Meijden E. van der (2005), Comparing metabolomes: the chemical consequences of hybridization in plants, New Phytologist 167(2): 613-622.
- Iren F. van, Winter W. de, Roytrakul S., Choi Y.H., Verpoorte R. & Suhartono L. (2005), Metabolic comparison of cryopreserved and normal cells from Tabernaemontana divaricata suspension cultures, Plant Cell, Tissue and Organ Culture 83: 59-66.
- Rauter A.P., Martins A., Borges C., Ferreira J., Justino J., Bronze M.R., Coelho A.V., Choi Y.H. & Verpoorte R. (2005), Liquid Chromatography-diode array detection-electronspray ionisation mass spectrometry/nuclear magentic resonance analyses of the anti-hyperglemic flavonoid extract of Genista tenera: structure elucidation of a flavonoid-C-glycoside, Journal of Chromatography A 1089(1-2): 59-64.
- Kim H.K., Choi Y.H., Erkelens C., Lefeber A.W.M. & Verpoorte R. (2005), Metabolic fingerprinting of Ephedra species using 1H-NMR spectroscopy and principle component analysis, Chemical and pharmaceutical bulletin 53(1): 105-109.
- Choi Y.H., Choi H.-K., Peltenburg-Looman A.M.G., Lefeber A.W.M. & Verpoorte R. (2004), Quantitative analysis of ginkgolic acids from Ginkgo leaves and products using 1HNMR, Phytochemical Analysis 15: 325-330.
- Choi H.-K., Choi Y.H., Verberne M., Lefeber A.W.M., Erkelens C. & Verpoorte R. (2004), Metabolic fingerprinting of wild type and transgenic tobacco plants by 1H NMR and multivariate analysis technique, Phytochemistry 65(7): 857-864.
- Choi Y.H., Kim H.K., Wilson E., Erkelens C., Trijzelaar B. & Verpoorte R. (2004), Quantitative analysis of retinol and retinol palmitate in vitamin tablets using 1H-nuclear magnetic resonance spectroscopy, Analytica Chima Acta 512: 141-147.
- Choi Y.H., Hazekamp A., Peltenburg-Looman A.M.G., Frederich M., Erkelens C., Lefeber A.W.M. & Verpoorte R. (2004), NMR Assignment of major cannabinoids and cannbiflavonoids isolated from Cannabis sativa flowers, Phytochemical Analysis 15: 345-354.
- Choi Y.H., Kim H.K., Hazekamp A., Erkelens C., Lefeber A.W.M. & Verpoorte R. (2004), Metabolomic differentiation of Cannabis sativa cultivars using 1H-NMR and principal component analysis, Journal of Natural Products 67(6): 953-957.
- El-Sayed M., Choi Y.H., Frédérich M., Roytrakul S. & Verpoorte R. (2004), Alkaloid accumulation in Catharanthus roseus cell suspension cultures fed with stemmadenine, Biotechnology Letters 26(10): 793-798.
- Kim H.K., Choi Y.H., Luijendijk T.J.C., Rocha R.A.V. & Verpoorte R. (2004), Comparison of extraction methods for secologanin and the quantitative analysis of secologanin from symphoricarpos albus using 1H‐NMR, Phytochemical Analysis 15(4): 257-261.
- Frederich M., Cristino A., Choi Y.H., Verpoorte R., Tits M., Angenot L. & Zeches-Hanrot M. (2004), Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves, Planta Medica 70(1): 72-76.
- Choi Y.H., Casas Tapias E., Kim H.K., Lefeber A.W.M., Erkelens C., Verhoeven J.TH.J., Brzin J., Zel J. & Verpoorte R. (2004), Metabolic discrimination of Catharanthus roseus leaves infected by phytoplasma using 1HNMR spectroscopy and multivariate data analysis, Plant Physiology 135(4): 2398-2410.
- Frederich M., Choi Y.H., Angenot L., Harnischfeger G., Lefeber A.W.M., Erkelens C. & Verpoorte R. (2004), Metabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by 1 H nuclear magnetic resonance spectrometry and multivariate analysis techniques, Phytochemistry 65(13): 1993-2001.
- Raharjo T.J., Chang W.T., Choi Y.H., Peltenburg-Looman A.M.G. & Verpoorte R. (2004), Olivetol as product of a polyketide synthase (PKS) in Cannabis sativa, Plant Science 166: 381-385.
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- Choi Y.H., Choi H.-K., Hazekamp A., Bermejo P., Schilder Y.D.C., Erkelens C. & Verpoorte R. (2003), Quantitative analysis of bilobalide and ginkgolides from Ginkgo biloba leaves and Ginkgo products using H-1-NMR, Chemical and pharmaceutical bulletin 51: 158-161.
- Frederich M., Choi Y.H. & Verpoorte R. (2003), Quantitative analysis of strychnine and brucine in Strychnos nux-vomica using H-1-NMR, Planta Medica 69: 1169-1171.
- Kim H.K., Choi Y.H., Wen-Te Chang R. & Verpoorte R. (2003), Quantitative analysis of ephedrine analogues from Ephedra species using H-1-NMR, Chemical and pharmaceutical bulletin 51: 1382-1385.
- Choi Y.H., Kim J., Kim J.Y., Joung S.N., Yoo K. & Chang Y.S. (2000), Modifier effects on supercritical CO2 extraction efficiency of cephalotaxine fromCephalotaxus wilsoniana leaves, Archives of Pharmacal Research 23(2): 163-166.