Xuesong Wang
Postdoc
- Name
- Dr. X. Wang
- Telephone
- 071 5276225
- x.wang@lacdr.leidenuniv.nl
I am a postdoc at the Division of Drug Discovery and Safety. I obtained my PhD under the supervision of Prof. dr. Laura Heitman, Prof. dr. Gerard van Westen, and Prof. dr. Ad IJzerman, focusing on the characterization of cancer-related somatic mutations in adenosine receptors. Currently, my work focuses on identifying the role of G protein-coupled receptors (GPCRs) in triple-negative breast cancer (TNBC) by performing the phenotypic screening on a GPCR compound library. Meanwhile, I'm also working on the establishment of stably expressing FRET biosensor TNBC cell lines to further investigate GPCR signaling pathways in TNBC cells.
More information about Xuesong Wang
Postdoc
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Toxicology
- Beerkens B.L. H., Andrianopoulou V., Wang X., Liu R., Westen G.J. P. van, Jespers W., IJzerman A.P., Heitman L.H. & Es D van der (2024), N-Acyl-N-alkyl sulfonamide probes for ligand-directed covalent labeling of GPCRs: the adenosine A2B receptor as case study, ACS Chemical Biology 19(7): 1554-1562.
- Feng C., Liu R., Brooks R.D.B., Wang X., Jespers W., Gorostiola González M., Westen G.J. P. van, Danen E.H.J. & Heitman L.H. (2024), The effect of cancer-associated mutations on ligand binding and receptor function: a case for the 5-HT2C receptor, European Journal of Pharmacology 985: 177081.
- Hollander L.S. den, Béquignon O.J.M., Wang X., Wezel K. van, Broekhuis J.D., Gorostiola Gonzalez M., Visser K.E. de, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2023), Corrigendum to "Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism" [Biochem. Pharmacol. 208 (2023) 115399], Biochemical Pharmacology 209: 115540 (115450).
- Wang X., Jespers W., Waal J.J. de, Wolff K.A.N., Uden L. van, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2022), Cancer-related somatic mutations alter adenosine A1 receptor pharmacology: a focus on mutations in the loops and C- terminus, The FASEB Journal 36(6): e22358.
- Wang X., Jespers W., Wolff K.A.N., Buytelaar J., IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2022), Cancer-related somatic mutations in transmembrane helices alter adenosine A1 receptor pharmacology, Molecules 27(12): 3742.
- Beerkens B.L.H., Wang X., Avgeropoulou M., Adistia L.N., Veldhoven J.P.D. van, Jespers W., Liu R., Heitman L.H., IJzerman A.P. & Es D. van der (2022), Development of subtype-selective covalent ligands for the adenosine A2B receptor by tuning the reactive group, RSC Medicinal Chemistry 13(7): 850-856.
- Wang X. (20 September 2022), The good? The bad? The mutant! : Characterization of cancer-related somatic mutations and identification of a selectivity hotspot in adenosine receptor (Dissertatie. Leiden Academic Centre for Drug Research (LADCR), Faculty of Science, Leiden University). Supervisor(s): IJzerman A.P., Heitman L.H. & Westen G.J.P. van.
- Feng C.L., Wang X., Jespers W., Liu R., Zamarbide Losada S.D., Gorostiola Gonzalez M., Westen G.J.P. van, Danen E.H.J. & Heitman L.H. (2022), Cancer-associated mutations of the adenosine A2A receptor have diverse influences on ligand binding and receptor functions, Molecules 27(15): 4676.
- Bongers B.J., Gorostiola González M., Wang X., Vlijmen H. van, Jespers W., Gutiérrez-de-Terán H., Ye K., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2022), Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors, Scientific Reports 12(1): 21534.
- Wang X., Westen G.J.P. van, IJzerman A.P. & Heitman L.H. (2022), G protein-coupled receptors and their mutations in cancer: a focus on adenosine receptors. In: Gilchrist A. (Ed.), GPCRs as therapeutic targets: John Wiley & Sons. 631-676.
- Hollander L.S. den, Béquignon O.J.M., Wang X., Wezel K. van, Broekhuis J., Gorostiola González M., Visser K.E. de, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2022), Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism, Biochemical Pharmacology 208: 115399.
- Wang X., Westen G.J.P. van, Heitman L.H. & IJzerman A.P. (2021), G protein-coupled receptors expressed and studied in yeast. The adenosine receptor as a prime example, Biochemical Pharmacology 187: 114370.
- Wang X., Jespers W., Prieto-Díaz R., Majellaro M., IJzerman A.P., Westen G.J.P. van, Sotelo E. & Heitman L.H. (2021), Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition, Scientific Reports 11: 14171.
- Wang X. Jespers W. Bongers B.J. Habben Jansen M.C.C. Stangenberger C.M. Dilweg M.A. Gutiérrez-de-Terán H. IJzerman A.P. Heitman L.H. Westen G.J.P. van (2020), Characterization of cancer-related somatic mutations in the adenosine A2B receptor, European Journal of Pharmacology 880: 173126.
- Doornbos M.L.J., Wang X., Vermond S.C., Peeters L., Pérez-Benito L., Trabanco A.A., Lavreysen H., Cid J.M., Heitman L.H., Tresadern G. & IJzerman A.P. (2019), Covalent Allosteric Probe for the Metabotropic Glutamate Receptor 2: Design, Synthesis, and Pharmacological Characterization, Journal of Medicinal Chemistry 62(1): 223-233.