Willy Spaan
Professor emeritus Medical Microbiology, in particular fundamental virology
- Name
- Prof.dr. W.J.M. Spaan
- w.j.m.spaan@lumc.nl
- ORCID iD
- 0000-0001-9430-6622
Professor emeritus Medical Microbiology, in particular fundamental virology
- Faculteit Geneeskunde
- Divisie 4
- Medische Microbiologie
Contact
- Groeneveld, G.H.; Spaan, W.J.; Hoek, W. van der & Dissel, J.T. van (2018), Het intensieve griepseizoen van 2018, Nederlands Tijdschrift voor Geneeskunde 162(D3323).
- Zlateva, K.T.; Coenjaerts, F.E.J.; Crusio, K.M.; Lammens, C.; Leus, F.; Viveen, M.; Ieven, M.; Spaan, W.J.M.; Claas, E.C.J. & Gorbalenya, A.E. (2013), No novel coronaviruses identified in a large collection of human nasopharyngeal specimens using family-wide CODEHOP-based primers, Archives of Virology 158(1): 251-255.
- Slobodskaya, O.; Snijder, E.J. & Spaan, W.J.M. (2012), Organ tropism of murine coronavirus does not correlate with the expression levels of the membrane-anchored or secreted isoforms of the carcinoembryonic antigen-related cell adhesion molecule 1 receptor.
- Posthuma, C.C.; Beek, M.T. van der; Blij-de Brouwer, C.S. van der; Heiden, P.L.J. van der; Marijt, E.W.A.; Spaan, W.J.M.; Claas, E.C.J.; Nederstigt, C.; Vossen, A.C.T.M.; Snijder, E.J. & Kroes, A.C.M. (2011), Mass spectrometry-based comparative sequencing to detect ganciclovir resistance in the UL97 gene of human cytomegalovirus., Journal of Clinical Virology 51(1): 25-30.
- Zlateva, K.T.; Crusio, K.M.; Leontovich, A.M.; Lauber, C.; Claas, E.; Kravchenko, A.A.; Spaan, W.J.M. & Gorbalenya, A.E. (2011), Design and validation of consensus-degenerate hybrid oligonucleotide primers for broad and sensitive detection of corona- and toroviruses, Journal of Virological Methods 177(2): 174-183.
- Liefhebber, J.M.P.; Hensbergen, P.J.; Deelder, A.M.; Spaan, W.J.M. & Leeuwen, H.C. van (2010), Characterization of hepatitis C virus NS3 modifications in the context of replication, Journal of General Virology 91: 1013-1018.
- Liefhebber, J.M.P.; Punt, S.; Spaan, W.J.M. & Leeuwen, H.C. van (2010), The human collagen beta(1-O)galactosyltransferase, GLT25D1, is a soluble endoplasmic reticulum localized protein, BMC Cell Biology 11.
- Silva, P.A.G.C.; Pereira, C.F.; Dalebout, T.J.; Spaan, W.J.M. & Bredenbeek, P.J. (2010), An RNA Pseudoknot Is Required for Production of Yellow Fever Virus Subgenomic RNA by the Host Nuclease XRN1, Journal of Virology 84(21): 11395-11406.
- Corver J, Broer R, van Kasteren P & Spaan W (2009), Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entry, Virology Journal 6.
- Liefhebber JMP, Brandt BW, Broer R, Spaan WJM & van Leeuwen HC (2009), Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain, Virology Journal 6.
- Slobodskaya O, Laarman A & Spaan WJM (2008), Intracellular restriction of a productive noncytopathic coronavirus infection, Journal of Virology 82(1).
- Versteeg GA, van de Nes PS, Bredenbeek PJ & Spaan WJM (2007), The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations, Journal of Virology 81(20).
- Versteeg GA, Bredenbeek PJ, van den Worm SHE & Spaan WJM (2007), Group 2 coronaviruses prevent immediate early interferon induction by protection of viral RNA from host cell recognition, Virology 361(1).
- Silva PAGC, Molenkamp R, Dalebout TJ, Charlier N, Neyts JH, Spaan WJM & Bredenbeek PJ (2007), Conservation of the pentanucleotide motif at the top of the yellow fever virus 17D 3 ' stem-loop structure is not required for replication, Journal of General Virology 88.
- Bredenbeek PJ, Molenkamp R, Spaan WJM, Deubel V, Marianneau P, Salvato MS, Moshkoff D, Zapata J, Tikhonov C, Patterson J, Carrion R, Ticer A, Brasky K & Lukashevich IS (2006), A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins, Virology 345(2).
- Versteeg GA, Slobodskaya O & Spaan WJM (2006), Transcriptional profiling of acute cytopathic murine hepatitis virus infection in fibroblast-like cells, Journal of General Virology 87.
- Pasternak AO, Spaan WJM & Snijder EJ (2006), Nidovirus transcription: how to make sense ... ?, Journal of General Virology 87.
- Schinkel J, Spaan WJM & Kroes ACM (2004), Meta-analysis of mutations in the NS5A gene and hepatitis C virus resistance to interferon therapy: uniting discordant conclusions, Antiviral Therapy 9(2).
- Pasternak AO, Spaan WJM & Snijder EJ (2004), Regulation of relative abundance of Arterivirus subgenornic rnRNAs, Journal of Virology 78(15).
- van Leeuwen HC, Reusken CBEM, Roeten M, Dalebout TJ, Riezu-Boj JI, Ruiz J & Spaan WJM (2004), Evolution of naturally occurring 5 ' non-translated region variants of hepatitis C virus genotype 1b in selectable replicons, Journal of General Virology 85.
- Zevenhoven-Dobbe JC, Greve S, van Tol H, Spaan WJM & Snijder EJ (2004), Rescue of disabled infectious single-cycle (DISC) Equine arteritis virus by using complementing cell lines that express minor structural glycoproteins.
- Gorbalenya AE, Snijder EJ & Spaan WJM (2004), Severe acute respiratory syndrome coronavirus phylogeny: toward consensus, Journal of Virology 78(15).
- Feltkamp MCW, Broer R, di Summa FM, Struijk L, van der Meijden E, Verlaan BPJ, Westendorp RGJ, ter Schegget J, Spaan WJM & Bavinck JNB (2003), Seroreactivity to epidermodysplasia verruciformis-related human papillomavirus types is associated with nonmelanoma skin cancer, Cancer Research 63(10).
- Bredenbeek PJ, Kooi EA, Lindenbach B, Huijkman N, Rice CM & Spaan WJM (2003), A stable full-length yellow fever virus cDNA clone and the role of conserved RNA elements in flavivirus replication, Journal of General Virology 84.
- Schinkel J, de Jong MD, Bruning B, van Hoek B, Spaan WJM & Kroes ACM (2003), The potentiating effect of ribavirin on interferon in the treatment of hepatitis C: lack of evidence for ribavirin-induced viral mutagenesis, Antiviral Therapy 8(6).
- Molenkamp R, Kooi EA, Lucassen MA, Greve S, Thijssen JCP, Spaan WJM & Bredenbeek PJ (2003), Yellow fever virus replicons as an expression system for hepatitis C virus structural proteins, Journal of Virology 77(2).
- Reusken CBEM, Dalebout TJ, Eerligh P, Bredenbeek PJ & Spaan WJM (2003), Analysis of hepatitis C virus/classical swine fever virus chimeric 5 ' NTRs: sequences within the hepatitis C virus IRES are required for viral RNA replication, Journal of General Virology 84.
- Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LLM, Guan Y, Rozanov M, Spaan WJM & Gorbalenya AE (2003), Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage, Journal of Molecular Biology 331(5): 991-1004.
- Snijder EJ, Dobbe JC & Spaan WJM (2003), Heterodimerization of the two major envelope proteins is essential for arterivirus infectivity, Journal of Virology 77(1).
- Pasternak AO, van den Born E, Spaan WJM & Snijder EJ (2003), The stability of the duplex between sense and antisense transcription-regulating sequences is a crucial factor in arterivirus subgenomic mRNA synthesis, Journal of Virology 77(2): 1175-1183.
- Brown CS, DiSumma FM, Rommelaere J, Dege AY, Cornelis JJ, Dinsart C & Spaan WJM (2002), Production of recombinant H1 parvovirus stocks devoid of replication-competent viruses, Human Gene Therapy 13(18).
- Schinkel J, Spaan WJM & Kroes ACM (2001), Mutations in the NS5A gene and hepatitis C virus resistance to interferon: Solving the controversy, Journal of Hepatology 34: 119-120.
- Rijnbrand R, Bredenbeek PJ, Haasnoot PC, Keift JS, Spaan WJM & Lemon SM (2001), The influence of downstream protein-coding sequence on internal ribosome entry on hepatitis C virus and other flavivirus RNAs, RNA 7(4).
- Dobbe JC, van der Meer Y, Spaan WJM & Snijder EJ (2001), Construction of chimeric arteriviruses reveals that the ectodomain of the major glycoprotein is not the main determinant of equine arteritis virus tropism in cell culture, Virology 288(2).
- Pasternak AO, van den Born E, Spaan WJM & Snijder EJ (2001), Sequence requirements for RNA strand transfer during nidovirus discontinuous subgenomic RNA synthesis, EMBO Journal 20(24).
- Molenkamp R, Rozier BCD, Greve S, Spaan WJM & Snijder EJ (2001), Characterization of an arterivirus defective interfering RNA - Replication and homologous recombination, NIDOVIRUSES (CORONAVIRUSES AND ARTERIVIRUSES) 494: 519-525.
- Molenkamp R, van Tol H, Rozier BCD, van der Meer Y, Spaan WJM & Snijder EJ (2000), The arterivirus replicase is the only viral protein required for genome replication and subgenomic mRNA transcription, Journal of General Virology 81.
- Pasternak AO, Gultyaev AP, Spaan WJM & Snijder EJ (2000), Genetic manipulation of arterivirus alternative mRNA leader-body junction sites reveals tight regulation of structural protein expression, Journal of Virology 74(24).
- Molenkamp R, Greve S, Spaan WJM & Snijder EJ (2000), Efficient homologous RNA recombination and requirement for an open reading frame during replication of equine arteritis virus defective interfering RNAs, Journal of Virology 74(19).
- Denison MR, Spaan WJM, van der Meer Y, Gibson CA, Sims AC, Prentice E & Lu XT (1999), The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis, Journal of Virology 73(8): 6862-6871.
- Kroes ACM, Leendertse D & Spaan WJM (1999), Access to treatment for HIV in developing countries, Lancet 353(9147): 153-153.
- van der Meer Y, Snijder EJ, Dobbe JC, Schleich S, Denison MR, Spaan WJM & Krijnse Locker J (1999), Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication, Journal of Virology 73(9): 7641-7657.
- van Marle G, van Dinten LC, Spaan WJM, Luytjes W & Snijder EJ (1999), Characterization of an equine arteritis virus replicase mutant defective in subgenomic mRNA synthesis, Journal of Virology 73(7): 5274-5281.
- van Marle G, Dobbe JC, Gultyaev AP, Luytjes W, Spaan WJM & Snijder EJ (1999), Arterivirus discontinuous mRNA transcription is guided by base pairing between sense and antisense transcription-regulating sequences, Proceedings of the National Academy of Sciences 96(21): 12056-12061.
- Molenkamp R & Spaan WJM (1997), Identification of a specific interaction between the coronavirus mouse hepatitis virus A59 nucleocapsid protein and packaging signal, Virology 239(1): 78-86.
- Brian DA & Spaan WJM (1997), Recombination and coronavirus defective interfering RNAs, Seminars in virology 8(2): 101-111.
- Bos ECW, Luytjes W & Spaan WJM (1997), The function of the spike protein of mouse hepatitis virus strain A59 can be studied on virus-like particles: Cleavage is not required for infectivity, Journal of Virology 71(12): 9427-9433.
- Bos ECW, Dobbe JC, Luytjes W & Spaan WJM (1997), A subgenomic mRNA transcript of the coronavirus mouse hepatitis virus strain A59 defective interfering (DI) RNA is packaged when it contains the DI packaging signal, Journal of Virology 71(7): 5684-5687.
- Grunberg K, Timmers MC, Smits HH, deKlerk EPA, Dick EC, Spaan WJM, Hiemstra PS & Sterk PJ (1997), Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo, Clinical and Experimental Allergy 27(1): 36-45.
- Wassenaar ALM, Spaan WJM, Gorbalenya AE & Snijder EJ (1997), Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: Evidence that nsp2 acts as a cofactor for the nsp4 serine protease, Journal of Virology 71(12): 9313-9322.
- van Dinten LC, den Boon JA, Wassenaar ALM, Spaan WJM & Snijder EJ (1997), An infectious arterivirus cDNA clone: Identification of a replicase point mutation that abolishes discontinuous mRNA transcription, Proceedings of the National Academy of Sciences 94(3): 991-996.
- Rijnbrand R, vanderStraaten T, vanRijn PA, Spaan WJM & Bredenbeek PJ (1997), Internal entry of ribosomes is directed by the 5' noncoding region of classical swine fever virus and is dependent on the presence of an RNA pseudoknot upstream of the initiation codon, Journal of Virology 71(1): 451-457.
- Franssila R, Soderlund M, Brown CS, Spaan WJM, Seppala I & Hedman K (1996), IgG subclass response to human parvovirus B19 infection, Clinical and diagnostic virology 6(1): 41-49.
- Luytjes W, Gerritsma H & Spaan WJM (1996), Replication of synthetic defective interfering RNAs derived from coronavirus mouse hepatitis virus-A59, Virology 216(1): 174-183.
- vanElsackerNiele AMW, Kroon FP, vanderEnde ME, Salimans MMM, Spaan WJM & Kroes ACM (1996), Prevalence of parvovirus B19 infection in patients infected with human immunodeficiency virus, Clinical Infectious Diseases 23(6): 1255-1260.
- Bos ECW, Luytjes W, VanderMeulen H, Koerten HK & Spaan WJM (1996), The production of recombinant infectious DI-particles of a murine coronavirus in the absence of helper virus, Virology 218(1): 52-60.
- vanDinten LC, Wassenaar ALM, Gorbalenya AE, Spaan WJM & Snijder EJ (1996), Processing of the equine arteritis virus replicase ORF1b protein: Identification of cleavage products containing the putative viral polymerase and helicase domains, Journal of Virology 70(10): 6625-6633.
- denBoon JA, Kleijnen MF, Spaan WJM & Snijder EJ (1996), Equine arteritis virus subgenomic mRNA synthesis: Analysis of leader-body junctions and replicative-form RNAs, Journal of Virology 70(7): 4291-4298.
- Snijder EJ, Wassenaar ALM, vanDinten LC, Spaan WJM & Gorbalenya AE (1996), The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases, Journal of Biological Chemistry 271(9): 4864-4871.
- Rijnbrand RCA, Abbink TEM, Haasnoot PCJ, Spaan WJM & Bredenbeek PJ (1996), The influence of AUG codons in the hepatitis C virus 5' nontranslated region on translation and mapping of the translation initiation window, Virology 226(1): 47-56.
- CHEUNG D, DICK EC, TIMMERS MC, DEKLERK EPA, SPAAN WJM & STERK PJ (1995), RHINOVIRUS INHALATION CAUSES LONG-LASTING EXCESSIVE AIRWAY NARROWING IN RESPONSE TO METHACHOLINE IN ASTHMATIC SUBJECTS IN-VIVO, American Journal of Respiratory and Critical Care Medicine 152(5): 1490-1496.
- Bos ECW, Heunen L, Luytjes W & Spaan WJM (1995), Mutational analysis of the murine coronavirus spike protein: Effect on cell-to-cell fusion, Virology 214(2): 453-463.
- HEEMSKERK MHM, SCHOEMAKER HM, SPAAN WJM & BOOG CJP (1995), PREDOMINANCE OF MHC CLASS II-RESTRICTED CD4(+) CYTOTOXIC T-CELLS AGAINST MOUSE HEPATITIS-VIRUS A59, Immunology 84(4): 521-527.
- VANMARLE G, LUYTJES W, VANDERMOST RG, VANDERSTRAATEN T & SPAAN WJM (1995), REGULATION OF CORONAVIRUS MESSENGER-RNA TRANSCRIPTION, Journal of Virology 69(12): 7851-7856.
- VANDERMOST RG, LUYTJES W, RUTJES S & SPAAN WJM (1995), TRANSLATION BUT NOT THE ENCODED SEQUENCE IS ESSENTIAL FOR THE EFFICIENT PROPAGATION OF THE DEFECTIVE INTERFERING RNAS OF THE CORONAVIRUS MOUSE HEPATITIS-VIRUS, Journal of Virology 69(6): 3744-3751.
- HEEMSKERK MHM, SCHILHAM MW, SCHOEMAKER HM, SPIERENBURG G, SPAAN WJM & BOOG CJP (1995), ACTIVATION OF VIRUS-SPECIFIC MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II-RESTRICTED CD8+ CYTOTOXIC T-CELLS IN CD4-DEFICIENT MICE, European Journal of Immunology 25(4): 1109-1112.
- HEEMSKERK MHM, SCHOEMAKER HM, DEJONG I, SCHIJNS VECJ, SPAAN WJM & BOOG CJP (1995), DIFFERENTIAL ACTIVATION OF MOUSE HEPATITIS VIRUS-SPECIFIC CD4(+) CYTOTOXIC T-CELLS IS DEFINED BY PEPTIDE LENGTH, Immunology 85(4): 517-522.
- SODERLUND M, BROWN CS, SPAAN WJM, HEDMAN L & HEDMAN K (1995), EPITOPE TYPE-SPECIFIC IGG RESPONSES TO CAPSID PROTEINS VP1 AND VP2 OF HUMAN PARVOVIRUS B19, Journal of Infectious Diseases 172(6): 1431-1436.
- RIJNBRAND R, BREDENBEEK P, VANDERSTRAATEN T, WHETTER L, INCHAUSPE G, LEMON S & SPAAN W (1995), ALMOST THE ENTIRE 5' NON-TRANSLATED REGION OF HEPATITIS-C VIRUS IS REQUIRED FOR CAP-INDEPENDENT TRANSLATION, FEBS Letters 365(2-3): 115-119.
- Snijder EJ, Wassenaar ALM, Spaan WJM & Gorbalenya AE (1995), The arterivirus nsp2 protease - An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases, Journal of Biological Chemistry 270(28): 16671-16676.
- den Boon JA, Spaan WJM & Snijder EJ (1995), Equine arteritis virus subgenomic RNA transcription - UV inactivation and translation inhibition studies, Virology 213(2): 364-372.
- VANGRUNSVEN WMJ, SPAAN WJM & MIDDELDORP JM (1994), LOCALIZATION AND DIAGNOSTIC APPLICATION OF IMMUNODOMINANT DOMAINS OF THE BFRF3-ENCODED EPSTEIN-BARR-VIRUS CAPSID PROTEIN, Journal of Infectious Diseases 170(1): 13-19.
- VANDERMOST RG, DEGROOT RJ & SPAAN WJM (1994), SUBGENOMIC RNA-SYNTHESIS DIRECTED BY A SYNTHETIC DEFECTIVE INTERFERING RNA OF MOUSE HEPATITIS-VIRUS - A STUDY OF CORONAVIRUS TRANSCRIPTION INITIATION, Journal of Virology 68(6): 3656-3666.
- CAVANAGH D, BRIEN DA, BRINTON M, ENJUANES L, HOLMES KV, HORZINEK MC, LAI MMC, LAUDE H, PLAGEMANN PGW, SIDDELL S, SPAAN WJM, TAGUCHI F & TALBOT PJ (1994), REVISION OF THE TAXONOMY OF THE CORONAVIRUS, TOROVIRUS AND ARTERIVIRUS GENERA, Archives of Virology 135(1-2): 227-237.
- BOOG CJP, HEEMSKERK MHM, SCHOENMAKER H & SPAAN WJM (1994), PREDOMINANCE OF MHC CLASS II-RESTRICTED CD4+ CYTOTOXIC T-CELLS AGAINST MHV-A59 MIGHT BE DUE TO THE REDUCTION OF MHC CLASS-I SURFACE EXPRESSION ON VIRUS-INFECTED CELLS, Journal of Cellular Biochemistry: 351-351.
- Snijder EJ, Wassenaar ALM & Spaan WJM (1994), Proteolytic processing of the replicase ORF1a protein of equine arteritis virus, Journal of Virology 68(9): 5755-5764.
- BROWN CS, WELLINGWESTER S, FEIJLBRIEF M, VANLENT JWM & SPAAN WJM (1994), CHIMERIC PARVOVIRUS B19 CAPSIDS FOR THE PRESENTATION OF FOREIGN EPITOPES, Virology 198(2): 477-488.
- HEEMSKERK MHM, SCHOEMAKER HM, SPAAN WJM & BOOG CJP (1993), MOUSE HEPATITIS-VIRUS INFECTION INFLUENCES THE ANTIGEN RECOGNITION BY CD8+ CYTOTOXIC T-CELLS, Journal of Cellular Biochemistry: 66-66.
- VENNEMA H, HEIJNEN L, ROTTIER PJM, HORZINEK MC & SPAAN WJM (1993), A NOVEL GLYCOPROTEIN OF FELINE INFECTIOUS PERITONITIS CORONAVIRUS CONTAINS A KDEL-LIKE ENDOPLASMIC-RETICULUM RETENTION SIGNAL, Advances in Experimental Medicine and Biology 342: 209-214.
- VANGRUNSVEN WMJ, VANHEERDE EC, DEHAARD HJW, SPAAN WJM & MIDDELDORP JM (1993), GENE-MAPPING AND EXPRESSION OF 2 IMMUNODOMINANT EPSTEIN-BARR-VIRUS CAPSID PROTEINS, Journal of Virology 67(7): 3908-3916.
- VANDERMOST RG, DEGROOT RJ, LUYTJES W & SPAAN WJM (1993), CORONAVIRUS DI RNAS - A TOOL TO STUDY REPLICATION, TRANSCRIPTION AND RECOMBINATION, Journal of Cellular Biochemistry: 4-4.
- HEEMSKERK MHM, SCHOEMAKER HM, ALPHEN HE, VANDERZEE R, JOOSTEN I, SPAAN WJM & BOOG CJP (1993), DETERMINATION OF THE CYTOTOXIC T-CELL EPITOPES OF MOUSE HEPATITIS-VIRUS, USING ELUTION OF VIRAL PEPTIDES FROM CLASS-I MHC MOLECULES AS AN APPROACH, Advances in Experimental Medicine and Biology 342: 407-412.
- DANIEL C, ANDERSON R, BUCHMEIER MJ, FLEMING JO, SPAAN WJM, WEGE H & TALBOT PJ (1993), IDENTIFICATION OF AN IMMUNODOMINANT LINEAR NEUTRALIZATION DOMAIN ON THE S2 PORTION OF THE MURINE CORONAVIRUS SPIKE GLYCOPROTEIN AND EVIDENCE THAT IT FORMS PART OF A COMPLEX TRIDIMENSIONAL STRUCTURE, Journal of Virology 67(3): 1185-1194.
- BROWN CS, JENSEN T, MELOEN RH, PUIJK W, SUGAMURA K, SATO H & SPAAN WJM (1992), LOCALIZATION OF AN IMMUNODOMINANT DOMAIN ON BACULOVIRUS-PRODUCED PARVOVIRUS B19-CAPSIDS - CORRELATION TO A MAJOR SURFACE REGION ON THE NATIVE VIRUS PARTICLE, Journal of Virology 66(12): 6989-6996.
- SALIMANS MMM, VANBUSSEL MJAWM, BROWN CS & SPAAN WJM (1992), RECOMBINANT PARVOVIRUS B19-CAPSIDS AS A NEW SUBSTRATE FOR DETECTION OF B19-SPECIFIC IGG AND IGM ANTIBODIES BY AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY, Journal of Virological Methods 39(3): 247-258.
- DEGROOT RJ, VANDERMOST RG & SPAAN WJM (1992), THE FITNESS OF DEFECTIVE INTERFERING MURINE CORONAVIRUS-DI-A AND ITS DERIVATIVES IS DECREASED BY NONSENSE AND FRAMESHIFT MUTATIONS, Journal of Virology 66(10): 5898-5905.
- VANDERMOST RG, HEIJNEN L, SPAAN WJM & DEGROOT RJ (1992), HOMOLOGOUS RNA RECOMBINATION ALLOWS EFFICIENT INTRODUCTION OF SITE-SPECIFIC MUTATIONS INTO THE GENOME OF CORONAVIRUS MHV-A59 VIA SYNTHETIC COREPLICATING RNAS, Nucleic Acids Research 20(13): 3375-3381.
- Snijder EJ, Wassenaar ALM & Spaan WJM (1992), The 5' end of the equine arteritis virus replicase gene encodes a papain-like cysteine protease, Journal of Virology 66(12): 7040-7048.
- BROWN CS, VANLENT JWM, VLAK JM & SPAAN WJM (1991), ASSEMBLY OF EMPTY CAPSIDS BY USING BACULOVIRUS RECOMBINANTS EXPRESSING HUMAN PARVOVIRUS-B19 STRUCTURAL PROTEINS, Journal of Virology 65(5): 2702-2706.
- HOGERVORST EJM, SCHOULS L, WAGENAAR JPA, BOOG CJP, SPAAN WJM, VANEMBDEN JDA & VANEDEN W (1991), MODULATION OF EXPERIMENTAL AUTOIMMUNITY - TREATMENT OF ADJUVANT ARTHRITIS BY IMMUNIZATION WITH A RECOMBINANT VACCINIA VIRUS, Infection and Immunity 59(6): 2029-2035.
- VANDERMOST RG, BREDENBEEK PJ & SPAAN WJM (1991), A DOMAIN AT THE 3' END OF THE POLYMERASE GENE IS ESSENTIAL FOR ENCAPSIDATION OF CORONAVIRUS DEFECTIVE INTERFERING RNAS, Journal of Virology 65(6): 3219-3226.
- den Boon JA, Snijder EJ, Chirnside ED, de Vries AAF, Horzinek MC & Spaan WJM (1991), Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily, Journal of Virology 65(6): 2910-2920.
- Snijder EJ, den Boon JA, Horzinek MC & Spaan WJM (1991), Comparison of the genome organization of toroviruses and coronaviruses - evidence for 2 nonhomologous RNA recombination events during Berne virus evolution, Virology 180(1): 448-452.
- Snijder EJ, den Boon JA, Horzinek MC & Spaan WJM (1991), Characterization of defective interfering RNAs of Berne virus.
- CHIRNSIDE ED & SPAAN WJM (1990), REVERSE TRANSCRIPTION AND CDNA AMPLIFICATION BY THE POLYMERASE CHAIN-REACTION OF EQUINE ARTERITIS VIRUS (EAV), Journal of Virological Methods 30(2): 133-140.
- Snijder EJ, Horzinek MC & Spaan WJM (1990), A 3'-coterminal nested set of independently transcribed messenger RNAs is generated during Berne virus replication, Journal of Virology 64(1): 331-338.
- Snijder EJ, den Boon JA, Bredenbeek PJ, Horzinek MC, Rijnbrand R & Spaan WJM (1990), The carboxyl-terminal part of the putative Berne virus polymerase is expressed by ribosomal frameshifting and contains sequence motifs which indicate that toro-viruses and coronaviruses are evolutionarily related, Nucleic Acids Research 18(15): 4535-4542.
- DEVRIES AAF, CHIRNSIDE ED, BREDENBEEK PJ, GRAVESTEIN LA, HORZINEK MC & SPAAN WJM (1990), ALL SUBGENOMIC MESSENGER-RNAS OF EQUINE ARTERITIS VIRUS CONTAIN A COMMON LEADER SEQUENCE, Nucleic Acids Research 18(11): 3241-3247.
- Snijder EJ, den Boon JA, Spaan WJM, Verjans GMGM & Horzinek MC (1989), Identification and primary structure of the gene encoding the Berne virus nucleocapsid protein.
- Snijder EJ, Ederveen J, Spaan WJM, Weiss M & Horzinek MC (1988), Characterization of Berne virus genomic and messenger RNAs.
- Lid
- Voorzitter
- Voorzitter
- Lid
- Voorzitter
- Voorzitter
- Voorzitter commissie Veiligheid in de Zorg
- Voorzitter programmacommissie Kwaliteit van Zorg