Theodorus van Berkel
Professor emeritus of Biopharmacy, in particular drug targeting
- Name
- Prof.dr. T.J.C. van Berkel
- Telephone
- +31 71 527 2727
- t.berkel@lacdr.leidenuniv.nl
Professor emeritus of Biopharmacy, in particular drug targeting
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Biopharmaceutics
- Singh A., Kraaijeveld A.O., Curaj A., Wichapong K., Hammerich L., Jager S.C.A. de, Bot I., Atamas S.P., Berkel T.J.C. van, Jukema J.W., Comerford I., McColl S.R., Mees B., Heemskerk J.W.M., Nicolaes G.A.F., Hackeng T., LiehnE.A., Tacke F. & Biessen E.A.L. (2024), CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization, Frontiers in Immunology 15: 1327051.
- Medina Rodriguez Indira, Wieland E.B., Temmerman L., Otten J.J.T., Bermudez B., Bot I., Rademakers T., WijnandsE., Schurgers L., Mees B., Berkel T.J.C. van, Goossens P. & Biessen E.A.L. (2024), Colony stimulating factor 1 receptor (Csf1r) expressing cell ablation in mafia (macrophage-specific Fas-induced apoptosis) mice alters monocyte landscape and atherosclerotic lesion characteristics, European Journal of Immunology 54(11): 2350943.
- Hoekstra M., Eck M. van & Berkel T.J.C. van (2023), Perspective : hepatocyte-directed base editing as novel treatment for human dyslipidemia-current status and remaining challenges, Arteriosclerosis, Thrombosis, and Vascular Biology 43(6): 832-835.
- Segers F.M.E., Ruder A.V., Westra M.M., Lammers T., Dadfar S.M., Roemhild K., Lam T.S., Kooi M.E., Cleutjens K.B.J.M., Verheyen F.K., Schurink G.W.H., Haenen, G.W.H., Berkel T.J.C. van, Bot I., Halvorsen B., Sluimer J.C. & Biessen E.A.L. (2023), Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis, Cardiovascular Research 118(17): 3346-3359.
- Ouweneel A.B., Zhao Y., Calpe-Berdiel L., Lammers B., Hoekstra M., Berkel T.J.C. van & Eck M. van (2021), Impact of bone marrow ATP-binding cassette transporter A1 deficiency on atherogenesis is independent of the presence of the low-density lipoprotein receptor, Atherosclerosis 319: 79-85.
- Hoekstra M., Sluis R.J. van der, Hildebrand R.B., Lammers B., Zhao Y., Praticò D., Berkel T.J.C. van, Rensen P.C.N., Kooijman S., Jauhiainen M. & Eck M. van (2020), Disruption of PLTP (phospholipid transfer protein)-mediated HDL (high-density lipoprotein) maturation reduces SR-BI (scavenger receptor BI) deficiency-driven atherosclerosis susceptibility despite unexpected metabolic complications, Arteriosclerosis, Thrombosis, and Vascular Biology 40(3): 611-623.
- Korporaal S.J.A., Molenaar T.J.M., Lutters B.C.H., Meurs I., Drost-Verhoef S., Kuiper J., Berkel T.J.C. van & Biessen E.A.L. (2019), Peptide Antagonists for P-selectin Discriminate between Sulfatide-Dependent Platelet Aggregation and PSGL-1-Mediated Cell Adhesion, Journal of Clinical Medicine 8(8): 1266.
- Fontaine M.A.C., Westra M.M., Bot I., Jin H., Franssen A.J.P.M., Bot M., Jager S.C.A. de, Dzhagalov I., He Y.W., Vlijmen B.J.M. van, Gijbels M.J.J., Reutelingsperger C.P., Berkel T.J.C. van, Sluimer J.C., Temmerman L. & Biessen E.A.L. (2019), Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells, Scientific Reports 9(1): 14547.
- Snip O.S.C., Hoekstra M., Zhao Y., Calpe-Berdiel L., Vulve J., Carles Escola-Gil J., Foks A., Sluis R.J. van der, Blanco-Vaca F., Berkel T.J.C. van, Kuivenhoven J. & Eck M. van (2018), Reduced systemic inflammation and increased reverse cholesterol transport together drive leukocyte ABCA1-mediated protection against atherosclerosis, Atherosclerosis 275: e43-e44.
- Ren B., Kampen E.E.M. van, Berkel T.J.C. van, Cruickshank S.M. & Eck M. van (2017), Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis, Atherosclerosis 256: 35-46.
- Temmerman L., Westra M.M., Bot I., Vlijmen B.J.M. van, Bree N. van, Bot M., Habets K.L.L., Keulers T.G.H., Vlag J. van der, Cotter T.G., Berkel T.J.C. van & Biessen E.A.L. (2017), Leukocyte Bim deficiency does not impact atherogenesis in ldlr(-/-) mice, despite a pronounced induction of autoimmune inflammation, Scientific Reports 7: 3086.
- Hoekstra M. & Berkel T.J.C. van (2016), Functionality of High-Density Lipoprotein as Antiatherosclerotic Therapeutic Target, Arteriosclerosis, Thrombosis, and Vascular Biology 36(11): E87-E94.
- Louwe M.C., Lammers B., Frias M.A., Foks A.C., Leeuw L.R. de., Hildebrand R.B., Kuiper J., Smit J.W.A., Berkel T.J.C. van, James R.W., Geerling J.J., Rensen P.C.N. & Eck M. van (2016), ABCA1 deficiency protects the heart against myocardial infarction-induced injury, Atherosclerosis 251: 159-163.
- Medina I., Cougoule C., Drechsler M., Bermudez B., Koenen R.R., Sluimer J., Wolfs I., Döring Y., Herias V., Gijbels M., Bot I., De Jager S.C., Weber C., Cleutjens J., Van Berkel T.J.C., Sikkink K.J., Mócsai A., Maridonneau-Parini I., Soehnlein O. & Biessen E.A. (2015), Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility, Circulation 132(6): 490-501.
- Kampen E. van, Beaslas O., Hildebrand R.B., Lammers B., Berkel T.J.C. van, Olkkonen V.M. & Eck M. van (2014), Orp8 Deficiency in Bone Marrow-Derived Cells Reduces Atherosclerotic Lesion Progression in LDL Receptor Knockout Mice, PLoS ONE 9(10): e109024.
- Bot I., Daissormont I.T., Zernecke A., Puijvelde G.H.M. van, Kramp B., Jager S.C. de, Sluimer J.C., Manca M., Hérias V., Westra M.M., Bot M., Santbrink P.J. van, Berkel T.J.C. van, Su L., Skjelland M., Gullestad L., Kuiper J., Halvorsen B., Aukrust P., Koenen R.R., Weber C. & Biessen E.A. (2014), CXCR4 blockade induces atherosclerosis by affecting neutrophil function, Journal of Molecular and Cellular Cardiology 74: 44-52.
- Hoekstra M., Sluis R.J. van der, Eck M. van & Berkel T.J.C. van (2013), Adrenal-Specific Scavenger Receptor BI Deficiency Induces Glucocorticoid Insufficiency and Lowers Plasma Very-Low-Density and Low-Density Lipprotein Levels in Mice, Arteriosclerosis, Thrombosis, and Vascular Biology 33(2): e39-46.
- Stoep M. van der, Li Z., Calpe-Berdiel L., Sluis R.J. van der, McKinnon H.J., Smit M.J., Berkel T.J.C. van, Van Eck M., Hoekstra M. & Korporaal S.J.A. (2013), Liver X receptor (LXR) agonist T0901317 induces regression of early and advanced atherosclerotic lesions under normolipidemic conditions in mice: PB 1.32-1, Journal of Thrombosis and Haemostasis 11(s2): 520-520.
- Stoep M. van der, Li Z., Sluis R.J. van der, Berkel T.J.C. van, Eck M. van, Hoekstra M. & Korporaal S.J.A. (2013), Liver X receptor (LXR) activation influences murine platelet count only under normolipidemic conditions, Journal of Thrombosis and Haemostasis 11: 910-910.
- Bot M., Jager S.C., MacAleese L., Lagraauw H.M., Berkel T.J.C. van, Quax P.H.A., Kuiper J., Heeren R.M., Biessen E.A. & Bot I. (2013), Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation, Journal of Lipid Research 54(5): 1265-1274.
- Bot M., Veldhoven P.P. van, Jager S.C.A. de., Johnson J., Nijstad N., Santbrink P.J. van, Westra M.M., Hoeven G. van der, Gijbels M.J., Mueller-Tidow C., Varge G., Tietge U.J.F., Kuiper J., Berkel T.J.C. van, Nofer J.R., Bot I. & Biessen E.A.L. (2013), Hematopoietic Sphingosine 1-Phosphate Lyase Deficiency Decreases Atherosclerotic Lesion Development in LDL-Receptor Deficient Mice, PLoS ONE 8(5): e63360.
- Hoekstra M., Sluis R.J. van der, Li Z., Oosterveer M.H., Groen A.K. & Berkel T.J.C. van (2012), FXR agonist GW4064 increases plasma glucocorticoid levels in C57BL/6 mice, Molecular and Cellular Endocrinology 362(1-2): 69-75.
- Vrins C.L.J., Ottenhoff R., Oever K. van den, Waart D.R. de, Kruyt J.K., Zhao Y., Berkel T.J.C. van, Havekes L.M., Aerts J.M., Eck M. van, Rensen P.C.N. & Groen A.K. (2012), Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein, Journal of Lipid Research 53(10): 2017-2023.
- Calpe-Berdiel L., Zhao Y., Graauw M. de, Ye D., Santbrink P.J. van, Mommaas A.M., Foks A., Bot M., Meurs I., Kuiper J., Mack J.T., Eck M. van, Tew K.D. & Berkel T.J.C. van (2012), Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice, Atherosclerosis 223(2): 332-341.
- Calpe-Berdiel L., Zhao Y., Graauw M. de, Ye D., Santbrink P.J. van, Mommaas A.M., Foks A.C., Bot M., Meurs I., Kuiper J., Mack J.T., Eck M. van, Tew K.D. & Berkel T.J.C. van (2012), Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice, Atherosclerosis 223(2): 332-341.
- Meurs I., Lammers B., Zhao Y., Out R., Hildebrand R.B., Hoekstra M., Berkel T.J.C. van & Eck M. van (2012), The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherogenesis, Atherosclerosis 221(1): 41-47.
- Bot I., Vries H. de, Korporaal S.J.A., Foks A.C., Bot M., Veldhoven J.P.D., Borg M.N.D. ter, Santbrink P.J. van, Berkel T.J. van.C., Kuiper J. & Ijzerman A.P. (2012), Adenosine A(2B) Receptor Agonism Inhibits Neointimal Lesion Development After Arterial Injury in Apolipoprotein E-Deficient Mice, Arteriosclerosis, Thrombosis, and Vascular Biology 32(9): 2197-2205.
- Li Z., Wang Y., Sluis R.J. van der, Hoorn J.W.A. van der, Princen H.M.G., Eck M. van, Berkel T.J.C. van, Rensen P.C.N. & Hoekstra M. (2012), Niacin reduces plasma CETP levels by diminishing liver macrophage content in CETP transgenic mice, Biochemical Pharmacology 84(6): 821-829.
- Sluis Ronald J. van der, Puijvelde G.H. van, Berkel T.J.C. van & Hoekstra M. (2012), Adrenalectomy stimulates the formation of initial atherosclerotic lesions: Reversal by adrenal transplantation, Atherosclerosis 221(1): 76-83.
- Jager S.C. de, Bermudez B., Bot I., Koenen R.R., Bot M., Kavelaars A., Waard V. de, Heijnen C.J., Muriana F.J., Weber C., Berkel T.J.C. van, Kuiper J., Lee S.J., Abia R. & Biessen E.A. (2011), Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis, The Journal of Experimental Medicine 208(2): 217-225.
- Ye D., Zhao Y., Hildebrand R.B., Singaraja R.R., Hayden M.R., Berkel T.J.C. van & Eck M. van (2011), The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in LDL receptor knockout mice, The American Journal of Pathology 178(1): 413-422.
- Karuna R., Holleboom A.G., Motazacker M.M., Kuivenhoven J.A., Frikke-Schmidt R., Tybjaerg-Hansen A., Georgopoulos S., Eck M. van, Berkel T.J.C. van, Eckardstein A. von der & Rentsch K.M. (2011), Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism, Atherosclerosis 214(2): 448-455.
- Lammers B., Zhao Y., Hoekstra M., Hildebrand R.B., Ye D., Meurs I., Berkel T.J.C. van & Eck M. van (2011), Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1and ApoE, PLoS ONE 6(10): e26095.
- Zhao Y., Ye D., Wang J., Calpe-Berdiel L., Azzis S.B., Berkel T.J. van & Eck M. van (2011), Stage-Specific Remodeling of Atherosclerotic Lesions on Cholesterol Lowering in LDL Receptor Knockout Mice, The American Journal of Pathology 179(3): 1522-1532.
- Lammers B., Chandak P.G., Aflaki E., Puijvelde G.H.M. van, Radovic B., Hildebrand R.B., Meurs I., Out R., Kuiper J., Berkel T.J.C. van, Kolb D., Haemmerle G., Zechner R., Levak-Frank S., Eck M. van & Kratky D. (2011), Macrophage adipose triglyceride lipase deficiency attenuates atherosclerotic lesion development in LDL receptor knockout mice, Arteriosclerosis, Thrombosis, and Vascular Biology 31(1): 67-73.
- Wang Y., Li Z., Hoekstra M., Bieghs V., Shiri-Sverdlov R., Berkel T.J.C. van, Smit J.W.A., Princen H.M.G., Romijn J.A., Havekes L.M. & Rensen P.C.N. (2011), Niacin, atorvastatin and fenofibrate decrease plasma CETP by reduction of the hepatic macrophage content in APOE*3-Leiden.CETP mice, Atherosclerosis Supplements 12(1): 38-38.
- Korporaal S.J.A., Meurs I., Hauer A.D., Hildebrand R.B., Hoekstra M., Ten Cate H., Pratico D., Akkerman J.W.N., Berkel T.J.C. van, Kuiper J. & Eck M. van (2011), Deletion of the HDL receptor SR-BI in mice modulates thrombosis susceptibility and indirectly affects platelet function by elevation of plasma free cholesterol, Arteriosclerosis, Thrombosis, and Vascular Biology 31(1): 34-42.
- Jennemann R., Rothermel U., Wang S., Sandhoff R., Kaden S., Out R., Berkel T.J.C. van, Aerts J.M.F.G., Ghauharali K., Sticht C. & Groene H.J. (2010), Hepatic Glycosphingolipid Deficiency and Liver Function in Mice, Hepatology 51(5): 1799-1809.
- Habets K.L., Puijvelde G.H.M. van, Duivenvoorde L.M. van, Wanrooij E.J. van, Vos P. de, Tervaert J.W., Berkel T.J.C. van, Toes R.E. & Kuiper J. (2010), Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice, Cardiovascular Research 85(3): 622-630.
- Hoekstra M., Korporaal S.J., Li Z., Zhao Y., Eck M. van & Berkel T.J. van (2010), Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice, AJP - Endocrinology and Metabolism 299(6): E1038-1043.
- Meurs I., Eck M. van & Berkel T.J.C. van (2010), Key Molecule in Cholesterol Efflux and the Prevention of Atherosclerosis, Current Pharmaceutical Design 16(13): 1445-1467.
- Hildebrand R.B., Lammers B., Meurs I., Korporaal S.J., De Haan W., Zhao Y., Kruijt J.K., Pratico D., Schimmel A.W., Holleboom A.G., Hoekstra M., Kuivenhoven J.A., Van Berkel T.J., Rensen P.C. & Van Eck M. (2010), Restoration of High-Density Lipoprotein Levels by Cholesteryl Ester Transfer Protein Expression in Scavenger Receptor Class B Type I (SR-BI) Knockout Mice Does not Normalize Pathologies Associated with SR-BI Deficiency, Arteriosclerosis, Thrombosis, and Vascular Biology 30(7): 1439-39.
- Hoekstra M., Ye D., Hildebrand R.B., Zhao Y., Lammers B., Stitzinger M., Kuiper J., Berkel T.J.C. van & Eck M. van (2009), Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production, Journal of Lipid Research 50(6): 1039-1046.
- Jager S.C. de, Canté-Barrett K., Bot I., Husberg C., Puijvelde G.H.M. van, Santbrink P.J. van, Yndestad A., Oever J.M. van den, Kuiper J., Berkel T.J.C. van, Lipp M., Zwaginga J.J., Fibbe W.E., Aukrust P. & Biessen E.A. (2009), Impaired effector memory T-cell regulation facilitates graft versus host disease in CCR7-deficient bone marrow transplant chimeras, Transplantation 88(5): 631-639.
- Puijvelde G.H.M. van, Wanrooij E.J. van, Hauer A.D., Vos P. de, Berkel T.J.C. van & Kuiper J. (2009), Effect of natural killer T cell activation on the initiation of atherosclerosis, Thrombosis and Haemostasis 102(2): 223-230.
- Hoekstra M., Meurs I., Koenders M., Out R., Hildebrand R.B., Kruijt J.K., Eck M. van & Berkel T.J.C. van (2008), Absence of HDL cholesteryl ester uptake in mice via SR-BI impairs an adequate adrenal glucocorticoid-mediated stress response to fasting, Journal of Lipid Research 49: 738-745.
- Eck M. van, Hoekstra M., Out R., Ros I.X., Kruijt J.K., Hildebrand R.B. & Berkel T.J.C. van (2008), Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo, 49(1): 136-146.
- Wanrooij E.J.A. van, Jager S.C.A. de, Es T. van, Vos P., Birch H.L., Owen D.A., Watson R.J., Biessen E.A.L., Chapman G.A. & Berkel T.J.C. van (2008), CXCR3 antagonist NBI-74330 attenuates atherosclerotic plaque formation in LDL receoptor-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 28(2): 251-257.
- Wanrooij E.J.A. van, Vos P. de, Bixel M.G., Vestweber D., Berkel T.J.C. van & Kuiper J. (2008), Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein, Cardiovascular Research 78(3): 590-596.
- Hauer A.D., Habets K.L., Wanrooij E.J.A. van, Vos P. de, Krueger J., Reisfeld R.A., Berkel T.J.C. van & Kuiper J. (2008), Vaccination against TIE2 reduces atherosclerosis, Atherosclerosis : .
- Out R., Jessup W., Goff L.J., Hoekstra M., Gelissen I.C., Zhao Y., Kritharides L., Chimini G., Kuiper J., Chapman M.J., Huby T., Berkel T.J.C. van & Eck M. van (2008), Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC, Circulation Research 102(1): 113-120.
- Guo J., Bot I., Nooijer R. de, Hoffman S.J., Stroup G.B., Biessen E.A.L., Benson G.M., Groot P.H., Eck M. van & Berkel T.J.C. van (2008), Leukocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in LDL-receptor deficient mice, Cardiovascular Research : .
- Ye D., Kraaijeveld A.O., Grauss R.W., Willems S.M., Vark-van der Zee L.C. van, Jager S.C.A. de, Jauhiainen M., Kuivenhoven J.A., Dalling-Thie G.M., Atsma D.E., Hogendoorn P.C., Biessen E.A.L., Berkel T.J.C. van, Jukema J.W. & Eck M. van (2008), Reduced leucocyte cholesteryl ester transfer protein expression in acute coronary syndromes, Journal of Internal Medicine 264(6): 571-585.
- Haan W. de, Out R., Berbée J.F., Hoogt C.C. van der, Dijk K.W. van, Berkel T.J.C. van, Romijn J.A., Havekes L.M. & Rensen P.C.N. (2008), Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo, Biochemical and Biophysical Research Communications 377(4): 1294-1298.
- Kraaijeveld A.O., Jager S.C.A. de, Daissormont I., Bot I.M., Segers F., Mccoll S.R., Atamas S.P., Berkel T.J.C. van, Jukema J.W. & Biessen E.A.L. (2008), CC chemokine ligand-18 enhances atherogenesis and induces accumulation of T-cells in atherosclerotic plaques of ApoE-/- mice, European Heart Journal 29(Suppl_1): 524-524.
- Puijvelde G.H.M. van, Es T. van, Habets K.L., Hauer A.D., Berkel T.J.C. van & Kuiper J. (2008), A vaccine against atherosclerosis: myth or reality?, Future Cardiology 4(2): 125-33.
- Hu L., Hoogt C.C. van der, Espirito Santo S.M.S., Out R., Kypreos K.E., Vlijmen B.L. van, Berkel T.J.C. van, Romijn J.A., Havekes L.M., Willems van Dijk K. & Rensen P.C.N. (2008), The hepatic uptake of VLDL in absence off the three major apoE-recognizing receptors is regulated by LPL activity and involves heparan sulfate proteoglycans and scavenger receptor BI, : .
- Out R., Hoekstra M., Habets K.L., Meurs I., Waard V. de, Hildebrand R.B., Wang Y., Chimini G., Kuiper J., Berkel T.J.C. van & Eck M. van (2008), Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophagesand distinct atherosclerosis at relatively low plasma cholesterol levels, Arteriosclerosis, Thrombosis, and Vascular Biology 28(2): 258-264.
- Hu L., Hoogt C.C. van der, Espirito Santo S.M.S., Out R., Kypreos K.E., Vlijmen B.J.M. van, Berkel T.J.C. van, Romijn J.A., Havekes L.M., Dijk K.W. van & Rensen P.C.N. (2008), The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL, 49(7): 1553-1561.
- Jager S.C.A. de, Kraaijeveld A.O., Grauss R.W., Jager W. de, Liem S.S., Hoeven B.L. van der, Prakken B.J., Putter H., Berkel T.J.C. van, Atsma D.E., Schalij M.J., Jukema J.W. & Biessen E.A.L. (2008), CCL3 (MIP-1alpha) levels are elevated during acute coronary syndromes and show strong prognostic power for future ischemic events, Journal of Molecular and Cellular Cardiology 45(3): 446-452.
- Herczenik E., Bouma B., Korporaal S.J.A., Strangi R., Zeng Q., Gros P., Eck M. van, Berkel T.J.C. van, Gebbink M.F. & Akkerman J.W. (2007), Activation of human platelets by misfolded proteins, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 1657-1665.
- Out R., Hoekstra M., Meurs I., Vos P. de, Kuiper J., Eck M. van & Berkel T.J.C. van (2007), Total body ABCG1 expression protects against early atherosclerotic lesion development in mice, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 594-599.
- Eck M. van, Hoekstra M., Hildebrand R.B., Yaong Y., Stengel D., Kruijt J.K., Sattler W., Tietge U.J., Ninio E., Berkel T.J.C. van & Praticò D. (2007), Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 2413-2419.
- Nofer J.R., Bot M., Brodde M., Taylor P.J., Salm P.H., Brinkmann V., Berkel T.J.C. van, Assmann G. & Biessen E.A.L. (2007), FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice, Circulation 115: 501-508.
- Pennings M., Hildebrand R.B., Ye D., Kunne C., Berkel T.J.C. van, Groen A.K. & Eck M. van (2007), Bone marrow-derived multidrug resistance protein ABCB4 protects against atherosclerotic lesion development in LDL receptor knockout mice, Cardiovascular Research 76: 175-183.
- Fledderus J.O., Thienen J.V. van, Boon R.A., Dekker R.J., Rohlena J., Volger O.L., Bijnen A.B., Daemen M.J., Kuiper J., Berkel T.J.C. van, Pannekoek H. & Horrevoets A.J.G. (2007), Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2, Blood 109: 4249-4257.
- Korporaal S.J.A., Eck M. van, Adelmeijer J., Ijsseldijk M.J., Out R., Lisman T., Lenting P.J., Berkel T.J.C. van & Akkerman J.W. (2007), Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 2476-2483.
- Yu H., Berkel T.J.C. van & Biessen E.A.L. (2007), Therapeutic potential of VIVIT, a selective peptide inhibitor of nuclear factor of activated T cells, in cardiovascular disorders, Cardiovascular Drugs and Therapy 25: 175-187.
- Hauer A.D., Puijvelde G.H.M. van, Peterse N., Vos P. de, Weel V. van, Wanrooij E.J.A. van, Biessen E.A.L., Quax P.H., Niethammer A.G., Reisfeld R.A., Berkel T.J.C. van & Kuiper J. (2007), Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 2050-2057.
- Vikstedt R., Ye D., Metso J., Hildebrand R.B., Berkel T.J.C. van, Ehnholm C., Jauhiainen M. & Eck M. van (2007), Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 578-586.
- Kraaijeveld A.O., Jager S.C.A. de, Jager W.J. de, Prakken B.J., McColl S.R., Haspels I., Putter H., Berkel T.J.C. van, Nagelkerken L., Jukema J.W. & Biessen E.A.L. (2007), CC Chemokine Ligand-5 (CCL5/RANTES) and CC Chemokine Ligand-18 (CCL18/PARC) Are Specific Markers of Refractory Unstable Angina Pectoris and Are Transiently Raised During Severe Ischemic Symptoms, Circulation 116: 1931-1941.
- Puijvelde G.H.M. van, Es T. van, Wanrooij E.J.A. van, Habets K.L., Vos P. de, Zee R. van der, Eden W. van, Berkel T.J.C. van & Kuiper J. (2007), Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology 27: 2677-2683.
- Bot I., Berkel T.J.C. van & Biessen E.A.L. (2007), Viral serine protease inhibitors as anti-atherosclerotic therapy, Current Opinion in Investigational Drugs 8: 729-735.
- Kuiper J., Puijvelde G.H.M. van, Wanrooij E.J.A. van, Es T. van, Habets K.L., Hauer A.D. & Berkel T.J.C. van (2007), Immunomodulation of the inflammatory response in atherosclerosis, Current Opinion in Lipidology 18: 521-526.
- Kraaieveld A.O., Jager S.C.A. de, Jager W.J. de, Prakken B.J., McColl S.R., Haspels I., Putter H., Berkel T.J.C. van, Nagelkerken L., Jukema J.W. & Biessen E.A.L. (2007), CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms, Circulation 116: 1931-1941.
- Wanrooij E.J. van, Puijvelde G.H. van, Vos P. de, Yagita H., Berkel T.J.C. van & Kuiper J. (2007), Interruption of the Tnfrsf4/Tnfsf4 (OX40/)X40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 27(1): 204-210.
- Eck M. van, Ye D., Hildebrand R.B., Kruijt J.K., Haan W. de, Hoekstra M., Rensen P.C.N., Ehnholm C., Jauhiainen M. & Berkel T.J.C. van (2007), Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice, Circulation Research 100: 678-685.
- Kuiper J., Puijvelde G.H.M. van, Wanrooij E.J. van, Es T. van, Habets K., Hauer A.D. & Berkel T.J.C. van (2007), Immunomodulation of the inflammatory response in atherosclerosis, Current Opinion in Lipidology 18(5): 521-526.
- Wanrooij E.J. van, Puijvelde G.H.M. van, Vos P. de, Yagita H., Berkel T.J.C. van & Kuiper J. (2007), Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 27(1): 204-210.
- Hauer A.D., Puijvelde G.H.M. van, Peterse N., Vos P. de, Weel V. van, Wanrooij E.J. van, Biessen E.A., Quax P.H., Niethammer A.G., Reisfeld R.A., Berkel T.J.C. van & Kuiper J. (2007), Vaccination against VEGFR2 attenuates initiation and progression of atherosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology 27(9): 2050-2057.
- Ye D., Hoekstra M., Out R., Meurs I., Kruijt J.K., Hildebrand R.B., Berkel T.J.C. van & Eck M. van (2007), Hepatic cell-specific atp-binding cassette (ABC) transporter profiling identifies putative novel candidates for macrophage cholesterol homeostasis in mice, Atherosclerosis Supplements 8(1): 24-24.
- Lucerna M., Zernecke A., Nooijer R. de, Jager S.C.A. de, Bot I., Lans C. van der, Kholova I., Liehn E.A., Berkel T.J.C. van, Yla-Herttuala S., Weber C. & Biessen E.A.L. (2007), Vascular endothelial growth factor-A induces plaque expansion in Apo Eknockout mice by promoting de novo leukocyte recruitment, Blood 109: 122-129.
- Triesscheijn M., Ruevekamp M., Out R., Berkel T.J.C. van, Schellens J.H., Baas P. & Stewart F.A. (2007), The pharmacokinetic behavior of the photosensitizer meso-tetra-hydroxyphenyl-chlorin in mice and men, Cancer Chemotherapy and Pharmacology 60: 113-122.
- Westerterp M., Eck M. van, Haan W. de, Offerman E.H., Berkel T.J.C. van, Havekes L.M. & Rensen P.C.N. (2007), Apolipoprotein CI aggravates atherosclerosis development in apoE-knockout mice despite mediating cholesterol efflux from macrophages, Atherosclerosis 195(1): E9-E16.
- Volger O.L., Fledderus J.O., Kisters N., Fontijn R.D., Moerland P.D., Kuiper J., Berkel T.J.C. van, Bijnens A.P., Daemen M.J., Pannekoek H. & Horrevoets A.J.G. (2007), Distinctive expression of chemokines and transforming growth factor-β signaling in human arterial endothelium during atherosclerosis, The American Journal of Pathology 171: 326-337.
- Bot I., Jager S.C. de, Zernecke A., Weber C., Berkel T.J.C. van & Biessen E.A. (2007), Mast cell activation promotes leukocyte recruitment and adhesion to the atherosclerotic plaque, Circulation 116(16): 242-242.
- Hoekstra M., Stitzinger M., Out R., Van Eck M., Van Berkel T.J. & Kuiper J. (2007), Nutrition-induced changes in adiponutrin gene expression implicate a role for adiponutrin in hepatic lipogenesis, Atherosclerosis Supplements 8(1): 211-211.
- Yu H., Sliedregt-Bol K.M., Overkleeft H.S., Marel G.A. van der, Berkel T.J.C. van & Biessen E.A.L. (2007), Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agent, Arteriosclerosis, Thrombosis, and Vascular Biology 26(7): 1531-1537.
- Hawinkels L.J.A.C., Rossenberg S.M.W. van, Jonge-Muller E.S.M. de, Molenaar T.J.M., Appeldoorn C.C.M., Berkel T.J.C. van, Sier C.F.M. & Biessen E.A.L. (2007), Efficient degradation-aided selection of protease inhibitors by phage display, Biochemical and Biophysical Research Communications 364(3): 549-555.
- Bot I., Jager S.C.A. de, Zernecke A., Lindstedt K., Berkel T.J.C. van, Weber C. & Biessen E.A.L. (2007), Perivascular mast cells promote atherogenesis and induce plaque destabilization in apolipoprotein E-deficient mice, Circulation 115: 2516-2525.
- Kruit J.K., Groen A.K., Berkel T.J.C. van & Kuipers F. (2006), Emerging roles of the intestine in control of cholesterol metabolism, World Journal of Gastroenterology 28: 6429-6439.
- Eck M. van, Singaraja R., Ye D., Hildebrand R.B., James E.R., Hayden M.R. & Berkel T.J.C. van (2006), Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 929-954.
- Pennings M., Meurs I., Ye D., Out R., Hoekstra M., Berkel T.J.C. van & Eck M. van (2006), Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development, 580: 5588-5596.
- Singaraja R., Eck M. van, Bissada N., Zimetti F., Collins H.L., Hildebrand RB, Hayden A., Brunham L.R., Kang M.H., Fruchart JC, Berkel T.J.C. van, Parks J.S., Staels B., Rothblat G.H., Fievet C. & Hayden M.R. (2006), Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo, Circulation 19: 1301-1309.
- Bot M., Bot I., Jager S.C. de, Berkel T.J.C. van & Biessen E.A. (2006), Lysophosphatidic acid: a two-faced key actor in atherogenesis, Circulation 114(18): 341-341.
- Out R., Hoekstra M., Hildebrand RB, Kruit J.K., Meurs I., Li Z., Kuipers F., Berkel T.J.C. van & Eck M. van (2006), Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 2295-2300.
- Snoey J., Mertens G., Lievens J., Berkel T.J.C. van, Collen D., Biessen E.A.L. & Geest B. van der (2006), Lipid Emulsions Potently Increase Transgene Expression in Hepatocytes after Adenoviral Transfer, Molecular Therapy 13: 98-107.
- Puijvelde G.H.M. van, Hauer A.D., Vos P. de, Heuvel R. van den, Herwijnen M.J. van, Zee R. van der, Eden W. van, Berkel T.J.C. van & Kuiper J. (2006), Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis, Circulation 114(18): 1968-1976.
- Hoekstra M., Stitzinger M., Wanrooij E.J.A. van, Michon I.N., Kruijt J.K., Kamphorst J.T., Eck M. van, Vreugdenhil E., Berkel T.J.C. van & Kuiper J. (2006), Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet, Journal of Lipid Research 47: 2198-2207.
- Bot l., Eefting D., Vries M.R. de, Bockel H. van, Berkel T.J.C. van, Biessen E.A. & Quax P.H. (2006), Local lentiviral ShRNA mediated silencing of CCR2 inhibits intimal hyperplasia in ApoE3Leiden mice, Circulation 114(18): 122-123.
- Eefting D., Bot I., Vries M.R. de, Bockel J.H. van, Berkel T.J.C. van, Biessen E.A.L. & Quax P.H.A. (2006), Local lentiviral shRNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic ApoE3Leiden mice, European Heart Journal 27(suppl_1): 5.
- Rensen P.C., Sliedregt L.A.J.M., Santbrink P.J. van, Ferns M., Schifferstein H.N.J., Leeuwen S.H., Souverein J.H., Berkel T.J.C. van & Biessen E.A. (2006), Stimulation of liver-directed cholesterol flux in mice by novel N-acetylgalactosamine-terminated glycolipids with high affinity for the asialoglycoprotein receptor, Arteriosclerosis, Thrombosis, and Vascular Biology : .
- Nooijer R. de, Verkleij C.J.N., Thusen J.H. von der, Jukema J.W., Wall E.E. van der, Berkel T.J.C. van, Baker A.H. & Biessen E.A.L. (2006), Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage in advanced lesions but not at earlier stages of atherogenesis, Arteriosclerosis, Thrombosis, and Vascular Biology 26(2): 340-346.
- Bot M., Bot I., Berkel T.J.C. van & Biessen E.A.L. (2006), Atherosclerotic lesion progression changes lysophosphatidic acid homeostasis to favor its accumulation, Atherosclerosis Supplements 7(3): 230-230.
- Rensen P.C.N., Sliedregt L.A.J.M., Santbrink P.J. van, Ferns M., Schifferstein H.N.J., Leeuwen S.H., Souverijn J.H.M., Berkel T.J.C. van & Biessen E.A.L. (2006), Stimulation of liver-directed cholesterol flux in mice by novel N-acetylgalactosamine-terminated glycolipids with high affinity for the asialoglycoprotein receptor, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 169-175.
- Rensen P.C.N., Gras J.C.E., Lindfors EK, Willems van Dijk K., Jukema J.W., Berkel T.J.C. van & Biessen E.A.L. (2006), Selective targeting of liposomes to macrophages using a ligand with high affinity for the macrophage scavenger receptor class A, Current drug discovery technologies 3: 135-144.
- Nooijer R. de, Verkleij C.J.N., Thüsen J.H. von der, Jukema J.W., Wall E.E. van der, Berkel T.J.C. van, Baker A.H. & Biessen E.A.L. (2006), Lesional Overexpression of Matrix Metalloproteinase-9 Promotes Intraplaque Hemorrhage in Advanced Lesions But Not at Earlier Stages of Atherogenesis, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 340-346.
- Hauer A.D., Vos P. de, Peterse N., Cate H. ten, Berkel T.J.C. van, Stassen F.R. & Kuiper J. (2006), Delivery of Chlamydia pneumoniae to the vessel wall aggravates atherosclerosis in LDLr(-/-) mice, Cardiovascular Research 69: 280-288.
- Vikstedt R., Ye D., Metso J, Hildebrand RB, Berkel T.J.C. van, Ehnholm C., Jauhiainen M. & Eck M. van (2006), Macrophage PLTP contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development, Arteriosclerosis, Thrombosis, and Vascular Biology : .
- Gras J.C.E., Verkuijlen P., Frants R.R., Havekes L.M., Berkel T.J.C. van, Biessen E.A.L. & Dijk K.W. van (2006), Specific and efficient targeting of adenovirus vectors to macrophages: Application of a fusion protein between an adenovirus-binding fragment and avidin, linked to a biotinylated oligonucleotide, Journal of Gene Medicine 8(6): 668-678.
- Puijvelde G.H.M. van, Hauer A.D., Vos P. de, Heuvel R. van den, Herwijnen M.J., Zee R. van der, Eden W. van, Berkel T.J.C. van & Kuiper J. (2006), Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis, Circulation 31: 1968-1976.
- Wanrooij E.J.A. van, Puijvelde G.H.M. van, Vos P. de, Yagita H., Berkel T.J.C. van & Kuiper J. (2006), Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology : .
- Rensen P.C.N., Sliedregt L.A.J.M., Santbrink P.J. van, Ferns M., Schifferstein H.N.J., Leeuwen SH van, Souverijn J.H.M., Berkel T.J.C. van & Biessen E.A.L. (2006), Stimulation of liver-directed cholesterol flux in mice by novel N-acetylgalactosamine-terminated glycolipids with high affinity for the asialoglycoprotein receptor, Arteriosclerosis, Thrombosis, and Vascular Biology 26: 169-175.
- Kraaijeveld A., Nooijer R. de, Meijboom B., Wall E. van der, Jukema W., Berkel T.J.C. van & Biessen E. (2005), Increased atherosclerotic burden in young versus aged LDLr-/- mice, Journal of Vascular Research 42(Supplement 2): 87-87.
- Zadelaar A.S.M., Thusen J.H. von der, Boesten L.S.M., Hoeben R.C., Kockx M.M., Versnel M.A., Berkel T.J.C. van, Havekes L.M., Biessen E.A.L. & Vlijmen B.J.M. van (2005), Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer, Atherosclerosis 183(2): 244-250.
- Eck M. van, Oost J., Goudriaan J.R., Hoekstra M., Hildebrand M., Bos IST, Willems Van Dijk K. & Berkel T.J.C. van (2005), Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development, Atherosclerosis 83: 230-237.
- Nooijer R. de, Verkleij C.J.N., Thusen J.H. von der, Jukema J.W., Wall E.E. van der, Berkel T.J.C. van, Baker A.H. & Biessen E.A. (2005), Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage in advanced lesions but not at earlier stages of atherogenesis, Arteriosclerosis, Thrombosis, and Vascular Biology 26(2): 340-346.
- Eck MV, Oost J., Goudriaan J.R., Hoekstra M, Hildebrand RB, Bos IS, Willems Van Dijk J.A.P. & Berkel T.J.C. van (2005), Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development, Atherosclerosis 183: 230-237.
- Out R., Hoekstra M., Jager S.C.A. de, Vos P. de, Westhuyzen D.R. van der, Webb N.R., Eck M. van, Biessen E.A.L. & Berkel T.J.C. van (2005), Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice, 46: 1172-1181.
- Berkel T.J.C. van, Out R., Hoekstra M., Kuiper J., Biessen E.A.L. & Eck M. van (2005), Scavenger receptors: friend or foe in atherosclerosis?, Current Opinion in Lipidology 16: 525-535.
- Dekker R.J., Thienen J.V. van, Rohlena J., Jager S.C.A. de, Elderkamp Y.W., Seppen J., Vries C.J. de, Biessen E.A.L., Berkel T.J.C. van, Pannekoek H. & Horrevoets A.J.G. (2005), Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes, The American Journal of Pathology 67: 609-618.
- Hoekstra M., Out R., Kruijt J.K., Eck M. van & Berkel T.J.C. van (2005), Diet induced regulation of genes involved in cholesterol metabolism in rat liver parenchymal and Kupffer cells, Journal of Hepatology 42: 400-407.
- Hauer A.D., Uyttenhove C., Vos P. de, Stroobant V., Renauld J.C., Berkel T.J.C. van, Snick J. van & Kuiper J. (2005), Blockade of interleukin-12 function by protein vaccination attenuates atherosclerosis, Circulation 112: 1054-1062.
- Guo J., Waard V. de, Eck M. van, Hildebrand RB, Wanrooij E.J.A. van, Kuiper J., Maeda N., Benson M.H., Groot P.H.E. & Berkel T.J.C. van (2005), Repopulation of apolipoprotein E knockout mice with CCR2-deficient progenitor cells does not inhibit ongoing atherosclerotic lesion development, Arteriosclerosis, Thrombosis, and Vascular Biology 25: 1014-1019.
- Wanrooij E.J.A. van, Happe H., Hauer A.D., Vos P., Imanishi T., Fujiwara H., Berkel T.J.C. van & Kuiper J. (2005), HIV Entry Inhibitor TAK-779 Attenuates Atherogenesis in Low-Density Lipoprotein Receptor-Deficient Mice, Arteriosclerosis, Thrombosis, and Vascular Biology 25: 2642-2647.
- Tietge U.J., Pratico D., Ding T., Funk C.D., Hildebrand RB, Berkel T.J.C. van & Eck M. van (2005), Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress, 46: 1604-1614.
- Meurs I., Hoekstra M., Wanrooij E.J.A. van, Hildebrand RB, Kuiper J., Kuipers F., Hardeman M.R., Berkel T.J.C. van & Eck M. van (2005), HDL cholesterol levels are an important factor for determining the lifespan of erythrocytes, Experimental Hematology 33: 1309-1319.
- Eck M. van, Pennings M., Hoekstra M., Out R. & Berkel T.J.C. van (2005), Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis, Current Opinion in Lipidology 16: 307-315.
- Donners M.M., Bot I., Windt L.J. de, Berkel T.J.C. van, Daemen M.J., Biessen E.A.L. & Heeneman S. (2005), Low-dose FK506 blocks collar-induced atherosclerotic plaque development and stabilizes plaques in ApoE-/- mice, American Journal of Transplantation 5: 1204-1215.
- Willekens F.L., Werre J.M., Kruijt J.K., Roerdinkholder-Stoelwinder B., Groenen-Dopp Y.A., Bos A.G. van den, Bosman G.L. & Berkel T.J.C. van (2005), Liver Kupffer cells rapidly remove red blood cell-derived vesicles from the circulation by scavenger receptors, Blood 105: 2141-2145.
- Appeldoorn C.G., Bonnefoy A., Lutters B.C.H., Daenens K., Berkel T.J.C. van, Hoylaerts M.F. & Biessen E.A.L. (2005), Gallic acid antagonizes P-selectin-mediated platelet-leukocyte interactions: implications for the French paradox, Circulation 111: 106-112.
- Guo J., Eck M. van, Waard V. de, Maeda N., Benson G.N., Groot P.H. & Berkel T.J.C. van (2005), The presence of leukocyte CC-chemokine receptor 2 in CCR2 knockout mice promotes atherogenesis, Biochimica et Biophysica Acta 1740: 543-459.
- Bot I., Guo J., Eck M. van, Santbrink P.J. van, Groot P.H., Hildebrand RB, Seppen J., Berkel T.J.C. van & Biessen E.A.L. (2005), Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to persistent knockdown of CCR2 function in vivo, Blood 106: 1147-1153.
- Hauer A.D., Vos P. de, Peterse N., Weel V., Quax P.H., Puijvelde G.H.M. van, Berkel T.H.J. van, Reisfeld R.A. & Kuiper J. (2005), Vaccination against VEGF receptor 2 blocks initiation and progression of atherosclerosis, Atherosclerosis Supplements 6(1): 68-68.
- Zadelaar A.S.M., Thusen J.H. von der, Boesten L.S., Hoeben R.C., Kockx M.M., Versnel M.A., Berkel T.J.C. van, Havekes L.M., Biessen E.A. & Vlijmen B.J.M. van (2005), Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus mediated Fas ligand gene transfer, Atherosclerosis 183(2): 244-250.
- Lucerna M., Nooijer R. de, Zernecke A., Bot I., Jager S. de, Berkel T. van, Weber C. & Biessen E. (2005), Adenoviral mediated overexpression of VEGF leads to a vulnerable plaque phenotype in ApoE-deficient mice, Journal of Vascular Research 42(Supplement 2): 111-112.
- Berkel T. van, Out R., Hoekstra M., Hildebrand R.B., Kruijt K., Singaraja R., Kaminski W.E., Schmitz G., Hayden M. & Eck M. van (2005), W10 regulation of plasma HDL levels and metabolism, Atherosclerosis Supplements 6(1): 46-46.
- Krom Y.D., Gras J.C.E., Frants R.R., Havekes L.M., Berkel T.J.C. van, Biessen E.A.L. & Willems van Dijk K. (2005), Efficient targeting of adenoviral vectors to integrin positive vascular cells utilizing a CAR-cyclic RGD linker protein, Biochemical and Biophysical Research Communications 338: 847-854.
- Krom Y.D., Gras J.C.E., Frants R.R., Havekes L.M., Berkel T.J.C. van, Biessen E.A.L. & Willems van Dijk K. (2005), Efficient targeting of adenoviral vectors to integrin positive vascular cells utilizing a CAR-cyclic RGD linker protein, Biochemical and Biophysical Research Communications 338: 847-854.
- Krom Y.D., Gras J.C.E., Frants R.R., Havekes L.M., Berkel T.J.C. van, Biessen E.A. & Willems van Dijk J.A.P. (2005), Efficient targeting of adenoviral vectors to integrin positive vascular cells utilizing a CAR-cyclic RGD linker protein, Biochemical Biophysical Research Communications 338: 847-854.
- Zadelaar A.S.M., Thusen J.H. von der, Boesten L.S.M., Hoeben R.C., Kockx M.M., Versnel M.A., Berkel T.J.C. van, Havekes L.M., Biessen E.A.L. & Vlijmen B.J.M. van (2005), Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer, Atherosclerosis 183: 244-250.
- Out R., Hoekstra M., Spijkers J.A., Kruijt J.K., Eck M. van, Bos I.S.T., Twisk J. & Berkel T.J.C. van (2004), Scavenger receptor class B type I is solely reponsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice, 45: 2088-2095.
- Korporaal S.J.A., Relou I.A., Eck M. van, Strasser V., Bezemer M., Gorter G., Berkel T.J.C. van, Nimpf J., Akkerman J.W. & Lenting P.J. (2004), Binding of Low Density Lipoprotein to Platelet Apolipoprotein E Receptor 2' results in phosphorylation of p38MAPK, Journal of Biological Chemistry 279(50): 52526-52534.
- Willekens F.L., Werre J.M., Kruijt J.K., Roerdinkholder-Stoelwinder B., Groenen-Dopp Y.A., Bos A.G. van den, Bosman G.J. & Berkel T.J.C. van (2004), Liver Kupffer cells rapidly remove red blood cell-derived vesicles from the circulation by scavenger receptors, Blood 18: 2141-2145.
- Lutters B.C.H., Leeuwenburgh M.A., Appeldoorn C.C.M., Molenaar T.J.M., Berkel T.J.C. van & Biessen E.A.L. (2004), Blocking endothelial adhesion molecules: a potential therapeutic strategy to combat atherogenesis, Current Opinion in Lipidology 15: 545-552.
- Eck M. van, Bos I.S., Hildebrand R.B., Rij B.T. & Berkel T.J.C. van (2004), Dual role for scavenger receptor class B, type I on bone marrow-derived cells in atherosclerotic lesion development, The American Journal of Pathology 165: 785-794.
- Puijvelde G. van, Vos P. de, Zee R. van der, Eden W. van, Berkel T.J.C. van & Kuiper J. (2004), Oral tolerance with oxidized LDL reduces atherogenesis, Atherosclerosis Supplements 5(1): 43-43.
- Rossenberg S.M.W. van, Keulen A.C.I. van, Drijfhout J.W., Vasto S., Koerten H.K., Spies F., Noordende J.M. van 't, Berkel T.J.C. van & Biessen E.A. (2004), Stable polyplexes based on arginine-containing oligopeptides for in vivo gene delivery, Gene Therapy 11: 457-464.
- Donners M., Heeneman S., Bot I., Hooff J. van, Windt L. de, Berkel T.J.C. van, Daemen M. & Biessen E. (2004), FK506 immunosuppression inhibits collar-induced atherosclerotic plaque development in ApoE deficient mice, American Journal of Transplantation 4(s8): 192-193.
- Rensen P.C.N., Leeuwen S.H., Sliedregt L.A.J.M., Berkel T.J.C. van & Biessen E.A.L. (2004), Design and synthesis of novel N-acetylgalactosamine-terminated glycolipids for targeting of lipoproteins to the hepatic asialoglycoprotein receptor, Journal of Medicinal Chemistry 4: 5798-5808.
- Thüsen J.H. von der, Fekkes M.L., Passier R., Zonneveld A.J. van, Manfroid V., Berkel T.J.C. van & Biessen E.A.L. (2004), Adenoviral transfer of endothelial nitric oxide synthase attenuates lesion formation in a novel murine model of postangioplasty restenosis, Arteriosclerosis, Thrombosis, and Vascular Biology 24: 357-362.
- Nooijer R. de, Thüsen J.H. von der, Verkleij C.J.N., Kuiper J., Jukema J.W., Wall E.E. van der, Berkel T.J.C. van & Biessen E.A.L. (2004), Overexpression of IL-18 decreases intimal collagen content and promotes a vulnerable plaque phenotype in apolipoprotein-E-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 24: 2313-9.
- Rensen P.C.N., Berbee J.F.P., Schippers E.F., Dissel J.T. van, Bakker-Woudenberg A.J.M., Leeuwen H.J. van, Haas C.J.C., Kessel K.P.M., Berkel T.J.C. van, Kuiper J., Kooistra T. & Havekes L.M. (2004), Apolipoproteins modulate inflammatory responses in rodents and humans: implications for sepsis, Shock 21: 153.
- Hauer A., Uyttenhove C., Vos P. de, Stroobant V., Renauld J., Berkel T.J.C. van, Snick J. van & Kuiper J. (2004), Vaccination against interleukin 12 attenuates atherosclerosis in LDL receptor deficient mice, Atherosclerosis Supplements 5(1): 41-42.
- Lutters B., Molenaar T., Korporaal S., Akkerman J., Berkel T.J.C. van, Kuiper J. & Biessen E. (2004), Peptide antagonists specifically inhibit the interaction between P-selectin and platelet-exposed sulfatides and reduce platelet aggregation, Atherosclerosis Supplements 5(1): 12-12.
- Berkel T.J.C. van, Thüsen J.H. von der, Kuiper J., Biessen E. & Eck M. van (2004), Genetic manipulation of macrophage and vascular genes in mouse models of atherosclerosis, International Congress Series 1262: 384-387.
- Out R., Kruijt J.K., Rensen P.C.N., Hildebrand R.B., Vos P. de, Eck M. van & Berkel T.J.C. van (2004), Scavenger receptor BI plays a role in facilitating chylomicron metabolism, Journal of Biological Chemistry 279(18): 18401-18406.
- Amersfoort E.S. van, Berkel T.J.C. van & Kuiper J. (2003), Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock, Clinical Microbiology Reviews 16: 379-414.
- Guo J., Eck M. van, Twisk J., Maeda N., Benson G.N., Groot P.H. & Berkel T.J.C. van (2003), Transplantation of monocyte CC-chemokine receptor 2-deficient bone marrow into ApoE3-Leiden mice inhibits atherogenesis, Arteriosclerosis, Thrombosis, and Vascular Biology 23: 447-453.
- Hoen P.A.C. 't, Lans C. van der, Eck M. van, Bijsterbosch M.K., Berkel T.J.C. van & Twisk J. (2003), Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes, Circulation Research 93: 262-269.
- Appeldoorn C.C.M., Molenaar T.J.M., Bonnefoy A., Leeuwen S.H. van., Vandervoort P.A., Hoylaerts M.F., Berkel T.J.C. van & Biessen E.A.L. (2003), Rational optimization of a short human P-selectin-binding peptide leads to nanomolar affinity antagonists, Journal of Biological Chemistry 278(12): 10201-10207.
- Eck M. van, Twisk J., Hoekstra M., Rij B.T., Lans C. van der, Bos I.S., Kruijt J.K., Kuipers F. & Berkel T.J.C. van (2003), Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver, Journal of Biological Chemistry 278(26): 23699-23705.
- Rossenberg S.M.W. van, Sliedregt-Bol K.M., Prince P.C., Berkel T.J.C. van, Boom J.H. van, Marel G.A. van der & Biessen E.A.L. (2003), A targeted peptide nucleic acid to down-regulate mouse microsomal triglyceride transfer protein expression in hepatocytes, Bioconjugate Chemistry 14: 1077-1082.
- Molenaar T.J.M., Twisk J., Haas S.A. de, Peterse N., Vogelaar B.J., Leeuwen S.H., Michon I.N., Berkel T.J.C. van, Kuiper J. & Biessen E.A.L. (2003), P-selectin as a candidate target in athero-sclerosis, Biochemical Pharmacology 66: 859-866.
- Thüsen J.H. von der, Kuiper J., Berkel T.J.C. van & Biessen E.A.L. (2003), Interleukins in atherosclerosis: molecular pathways and therapeutic potential, Pharmacological Reviews 55: 133-166.
- Rossenberg S.M.W. van, Sliedregt-Bol K.M., Koning G., Elst H. van den, Berkel T.J.C. van, Boom J.H. van, Marel G.A. van der & Biessen E.A.L. (2003), Improvement of hepatocyte-specific gene expression by a targeted colchicine prodrug, ChemBioChem 4: 633-639.
- Florea B.I., Molenaar T.J.M., Bot I., Michon I.N., Kuiper J., Berkel T.J.C. van, Junginger H.E., Biessen E.A.L. & Borchard G. (2003), Identification of an internalising peptide in differentiated Calu-3 cells by phage display technology; application to gene delivery to the airways, Journal of Drug Targeting 11(7): 383-390.
- Nooijer R. de, Thusen J.H. von der, Kuiper J., Verkleij C.J., Berkel T.J.C. van, Levy S. & Biessen E.A. (2003), Overexpression of interleukin-18 decreases plaque stability apolipoprotein-E deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 108(17): 224-224.
- Hoen P.A.C. 't, Out R., Commandeur J.N.M., Vermeulen N.P.E., Batenburg F.H.D. van, Manoharan M., Berkel T.J.C. van, Biessen E.A.L. & Bijsterbosch M.K. (2003), Selection of antisense oligodeoxynucleotides against Glutathione S-transferease Mu, RNA 8: 1572-1583.
- Bot I., Thüsen J.H. von der, Donners M.M., Lucas A., Fekkes M.L., Jager S.C.A. de, Kuiper J., Daemen M.J., Berkel T.J.C. van, Heeneman S. & Biessen E.A.L. (2003), Serine protease inhibitor Serp-1 strongly impairs atherosclerotic lesion formation and induces a stable plaque phenotype in ApoE-/-mice, Circulation Research 93: 464-471.
- Michon I.N., Penning L.C., Molenaar T.J.M., Berkel T.J.C. van & Kuiper J. (2002), The effect of TGF-beta receptor binding peptides on smooth muscle cells, Biochemical and Biophysical Research Communications 293: 1279-1286.
- Hoen P.A.C. 't, Out R., Commandeur J.N.M., Vermeulen N.P.E., Batenburg F.H.D. van, Manoharan M., Berkel T.J.C. van, Biessen E.A.L. & Bijsterbosch M.K. (2002), Selection of antisense oligodeoxynucleotides against glutathions S-transerase Mu, RNA 8: 1572-1583.
- Bot I., Thüsen J.H. von der, Donners M.M., Lucas A.R., Berkel T.J.C. van, Kuiper J., Heeneman S. & Biessen E.A.L. (2002), The serine protease inhibitor Serp-1 strongly impairs de novo atherosclerotic lesion formation in ApoE -/- mice, Circulation 106: II-300.
- Hoen P.A.C. 't, Out R., Commandeur J.N.M., Vermeulen N.P.E., Batenburg F.H.D. van, Manoharan M., Berkel T.J.C. van, Biessen E.A.L. & Bijsterbosch M.K. (2002), Selection of antisense oligodeoxynucleotides against glutathione S-transferase Mu, RNA 8: 1572-1583.
- Hoen P.A.C. 't, Rooseboom M., Bijsterbosch M.K., Berkel T.J.C. van, Vermeulen N.P.E. & Commandeur J.N.M. (2002), Induction of glutathione-S-transferase mRNA levels by chemopreventive selenocysteine Se-conjugates, Biochemical Pharmacology 63: 1843-1849.
- Bijsterbosch M.K., Manoharan M., Dorland R., Veghel R. van, Biessen E.A.L. & Berkel T.J.C. van (2002), Bis-Cholesteryl-conjugated phosphorothioate oligodeoxynucleotides are highly selectively taken up by the liver, 302: 619-626.
- Hoen P.A.C. 't, Rosema S.W., Commandeur J.N.M., Vermeulen J.J., Manoharan M., Berkel T.J.C. van & Biessen E.A.L. (2002), Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression, 269: 2574-2583.
- Thüsen J.H. von der, Berkel T.J.C. van, Biessen E.A.L., Hoeben R.C., Vlijmen B.J.M. van, Havekes L.M. & Kocks M.M. (2002), Unraveling the mechanism of plaque rupture in marine models. Response, Circulation 106: 186-187.
- Thüsen J.H. von der, Nooijer R. de, Wanrooij E.J.A. van, Berkel T.J.C. van, Lai M.C. & Biessen E.A.L. (2002), Cathepsin S expression level is critical in atherosclerotic lesion homeostasis, Circulation 106: II-43.
- Molenaar T.J.M., Korporaal S.J.A., Akkerman J.W., Berkel T.J.C. van, Kuiper J. & Biessen E.A.L. (2002), Peptide antagonists inhibit the interaction of P-selectin with sulfatide-containing liposomes and reduce platelet aggregation, Circulation 106: II-120.
- Michon I.N., Hauer A.D., Thüsen J.H. von der, Molenaar T.J.M., Berkel T.J.C. van & Kuiper J. (2002), Targeting of peptides to restenotic vascular smooth muscle cells using phage display in vitro and in vivo, Biochimica et Biophysica Acta 1591: 87-97.
- Appeldoorn C.C.M., Molenaar T.J.M., Leeuwen SH van, Berkel T.J.C. van & Biessen E.A.L. (2002), Rational optimization of P-selectin binding peptide leads to nanomolar affinity for the use in anti-atherothrombotic therapy, Circulation 106: II-84.
- Eck M. van, Twisk J., Rij B. van, Lans C. van der, Hoekstra M., Bos S., Kuipers F. & Berkel T.J.C. van (2002), Differential effects of scavenger receptor BI (SRBI) deficiency on the arterial wall and the liver, Circulation 106: II-77.
- Thüsen J.H. von der, Berkel T.J.C. van, Biessen E.A.L., Hoeben R.C., Vlijmen B.J.M. van, Havekes L.M. & Kockx M.M. (2002), Unraveling the mechanisms of plaque rupture in murine models, Circulation 106: 186.
- Eck M. van, Bos I.S., Kaminski W.E., Orso E., Rothe G., Twisk J., Bottcher A., Amersfoort E.S. van, Christiansen-Weber T.A., Fung-Leung W.P., Berkel T.J.C. van & Schmitz G. (2002), Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues, 99: 6298-6303.
- Molenaar T.J.M., Appeldoorn C.C.M., Haas S.A. de, Michon I.N., Bonnefoy A., Hoylarts M.F., Pannekoek H., Berkel T.J.C. van, Kuiper J. & Biessen E.A.L. (2002), Specific inhibition of P-selectin-mediated cell adhesion by phage display-derived peptide antagonists, Blood 100: 3570-3577.
- Rijken D.C., Kaaden M.E. van der, Groeneveld E., Barrett-Bergshoeff M.M., Berkel T.J.C. van & Kuiper J. (2002), Characterization of the binding of urokinase-type plasminogen activator to the asialoglycoprotein receptor, Thrombosis and Haemostasis 88: 83-88.
- Hoen P.A.C. 't, Rosema B.-S., Commandeur J.N.M., Vermeulen N.P.E., Manoharan M., Berkel T.J.C. van, Biessen E.A.L. & Bijsterbosch M.K. (2002), Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of GST-Mu expression, 269: 2574-2583.
- Rossenberg S.M.W. van, Sliedregt-Bol K.M., Meeuwenoord N.J., Berkel T.J.C. van, Boom J.H. van, Marel G.A. van der & Biessen E.A.L. (2002), Targeted lysosome disruptive elements for improvement of parenchymal liver cell-specific gene delivery, Journal of Biological Chemistry 277(48): 45803-45810.
- Molenaar T.J.M., Berkel T.J.C. van, Kuiper J., Mayadas-Norton T. & Biessen E.A.L. (2002), Specific binding and cleavage of P-selectin by μ-calpain is mediated by a highly conserved pentapeptide motif, Circulation 106: II-150.
- Thüsen J.H. von der, Vlijmen B.J.M. van, Hoeben R.C., Kockx M.M., Havekes L.M., Berkel T.J.C. van & Biessen E.A.L. (2002), Induction of atherosclerotic plaque rupture in apolipoprotein E - / - mice after adenovirus-mediated transfer of p53, Circulation : 2064-2070.
- Biessen E.A.L., Sliedregt-Bol K.M., Hoen P.A.C. 't, Prince P., Bilt E. van de, Valentijn A.R.P.M., Meeuwenoord N.J., Princen H., Bijsterbosch M.K., Marel M.A. van der, Boom J.H. van & Berkel T.J.C. van (2002), Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes, Bioconjugate Chemistry 13: 295-300.
- Thüsen J.H. von der, Vlijmen B.J.M. van, Hoeben R.C., Kockx M., Havekes A.M., Berkel T.J.C. van & Biessen E.A. (2002), Induction of atherosclerotic plaque rupture in apolipoprotein E -/- mice after adenovirus-mediated transfer of p53, Circulation 105(17): 2064-2070.
- Biessen E.A.L., Sliedregt-Bol K.M., Hoen P.A.C. 't, Prince P., Bilt E. van de, Valentijn A.R.P.M., Meeuwenoord N.J., Princen H., Bijsterbosch M.K., Marel G.A. van der, Boom J.H. van & Berkel T.J.C. van (2002), Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsal triglyceride transfer protein expression in hepatocytes, Bioconjugate Chemistry 13: 295-302.
- Eck M. van, Bos S. & Berkel T.J.C. van (2002), Macrophage scavenger receptor B1 (SRBI) deficiency promotes atherosclerotic lesion development, Circulation 106: II-77.
- Molenaar T.J.M., Michon I.N., Haas S.A. de, Berkel T.J.C. van & Biessen E.A.L. (2002), Uptake and processing of modified bacteriophage M13 in mice: implications for phage display, Virology 293: 182-191.
- Jong M.C., Rensen P.C.N., Dahlmans V.E.H., Boom H van der, Berkel T.J.C. van & Havekes L.M. (2001), Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice, 42(10): 1578-1585.
- Sliedregt L.A.J.M., Rossenberg S.M.W. van, Autar R., Valentijn A.R.P.M., Marel G.A. van der, Boom J.H. van, Piperi C., Merwe P.A. van der, Kuiper J., Berkel T.J.C. van & Biessen E.A. (2001), Design and synthesis of multivalent homing device for targeting to murine CD22, Bioorganic & Medicinal Chemistry 9(1): 85-97.
- Eck-Smaling M.M. van, Willems Van Dijk J.A.P., Herijgers N., Hofker M.H., Groot P.H. & Berkel T.J.C. van (2001), Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis, Atherosclerosis 154: 103-112.
- Vlijmen B.J.M. van, Gerritsen G, Franken AL, Boesten L.S.M., Kockx M.M., Gijbels M.J.J., Vierboom M.P.M., Eck M. van, Water B. van de, Berkel T.J.C. van & Havekes L.M. (2001), Macrophage p53 deficiency leads to enhanced atherosclerosis in ApoE*3-Leiden transgenic mice, Circulation Research 88(8): 780-786.
- Eck M. van, Herijgers N., Dijk K.W. van, Havekes A.M., Hofker M.H., Groot P.H. & Berkel T.J.C. van (2000), Effect of macrophage-derived mouse ApoE, human ApoE3, human ApoE2 (Arg155-Cys) on cholesterol levels and atherosclerosis in ApoE-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 20(1): 119-127.
- Eck-Smaling M.M. van, Winther M.P.J. de, Herijgers N., Havekes L.M., Hofker M.H., Groot P.H. & Berkel T.J.C. van (2000), Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in apoE-deficient mice, Arteriosclerosis, Thrombosis, and Vascular Biology 20: 2600-2606.
- Herijgers N., Winther M.P.J. de, Eck-Smaling M.M. van, Havekes L.M., Hofker M.H., Hoogerbrugge P.M. & Berkel T.J.C. van (2000), Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice, 41: 1402-1409.
- Tacken P.J., Teusink B, Jong M.C., Harats D, Havekes L.M., Hofker M.H., Koffeman L.J. & Berkel T.J.C. van (2000), LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice, 41: 2055-2062.
- Herijgers N., Winther M.P.J. de, Eck M. van, Havekes A.M., Hofker M.H., Koffeman L.J. & Berkel T.J.C. van (2000), Effect of human scavenger receptor class A oerexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice, 41(9): 1402-1409.
- Biessen E.A.L., Valentijn A.R.P.M., De Vrueh R.L., Bilt E. van de, Sliedregt L.A.J.M., Prince P.C., Bijsterbosch M.K., Boom J.H. van, Marel G.A. van der, Mulder F.E. & Berkel T.J.C. van (2000), Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl) adenine with improved pharmokinetics and antiviral activity, The FASEB Journal 14: 1784-1792.
- Rensen P.C.N., Jong M.C., Vark LC, Boom H van der, Hendriks W.L., Berkel T.J.C. van, Biessen E.A.L. & Havekes A.M. (2000), Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo. Evidence for retroendocytosis, Journal of Biological Chemistry 275(12): 8564-8571.
- Vlijmen B.J.M. van, Willems van Dijk K., Hof B.H. van 't, Zee A. van der, Santamarina-Fojo S., Berkel T.J.C. van, Havekes L.M. & Hofker M.H. (1999), In LDL receptor-deficient mice, catabolism of remnant lipoproteins requires a high level of apoE but is inhibited by excess apoE, 40: 336-344.
- Fluiter K., Sattler W., Beer M.C. de, Connel P.M., Westhuyzen D.R. van der & Berkel T.J.C. van (1999), Scavenger receptor BI mediates the selective uptake of oxidized cholesterol esters by rat liver, Journal of Biological Chemistry 274(13): 8893-8899.
- Versluis J., Rump E.T., Rensen P.C.N., Berkel T.J.C. van & Bijsterbosch M.K. (1999), The stable incorporation of a lipophilic daunorubicin prodrug into apolipoprotein E-exposing liposomes induces uptake of the prodrug via the LDL receptor in vivo, Journal of Pharmacology and Experimental Therapeutics 289: 1-7.
- Vlijmen B.J.M. van, Rohlmann A., Page S.T., Bensadoun A., Bos I.S.T., Berkel T.J.C. van, Havekes A.M. & Hertz J. (1999), An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoprotein, Journal of Biological Chemistry 274(49): 35219-35226.
- Biessen E.A.L., Bilt E. van de, Prince P., Valentijn A.R.P.M., Marel G.A. van der, Boom J.H. van & Berkel T.J.C. van (1999), Tissue specific down-regulation of microsomal triglyceride tranfer protein by glycoconjugated PNA, Circulation 100: 4305-4310.
- Vries H.E., Moor A.C.E., Dubbelman T.M.A.R., Berkel T.J.C. van & Kuiper J. (1999), Oxidized low-density lipoprotein as a delivery system for photosensitizers: implications for photodynamic therapy of atherosclerosis, Journal of Pharmacology and Experimental Therapeutics 289: 528-534.
- Vries H.E., Buchner B., Berkel T.J.C. van & Kuiper J. (1999), Specific interaction of oxidized low density lipoprotein with macrophage-derived foam cells isolated from rabbit atherosclerotic lesions, Arteriosclerosis, Thrombosis, and Vascular Biology 19: 638-645.
- Sliedregt L.A.J.M., Rensen P.C.N., Rump E.T., Santbrink P.J. van, Bijsterbosch M.K., Valentijn A.R.P.M., Marel G.A. van der, Boom J.H. van, Berkel T.J.C. van & Biessen E.A.L. (1999), Design and synthesis of novel amphiphilic dendritic galactosides for selective targeting of liposomes to the hepatic asialoglycoprotein receptor, Journal of Medicinal Chemistry 42: 609-618.
- Eck M. van, Zimmerman R., Zechner R., Groot P.H.E. & Berkel T.J.C. van (1998), Role of macrophage-derived LPL in lipoprotein metabolism, Circulation 98: I-663.
- Biessen E.A.L. & Berkel T.J.C. van (1998), Receptor-dependent cell specific delivery of antisense oligonucleotides. In: , Cardiovascular specific gene expression. Dordrecht, The Netherlands: Kluwer Academic Publishers.
- Oosten M. van, Bilt E. van de, Berkel T.J.C. van & Kuiper J. (1998), New scavenger receptor-like receptors for the binding of lipopolysaccharide to liver endothelial and Kupffer cells, Infection and Immunity 66: 5107-5112.
- Versluis J., Rump E.T., Rensen P.C.N., Berkel T.J.C. van & Bijsterbosch M.K. (1998), Synthesis of a lipophilic daunorubicin derivative and its incorporation into lipidic carriers developed for LDL receptor-mediated tumor therapy, PHARMACEUTICAL RESEARCH 15: 531-537.
- Bijsterbosch M.K., Smeijsters L.J.J.W. & Berkel T.J.C. van (1998), Disposition of the acyclic nucleoside phosphonate (s)-9-(3-hydroxy-2-phosphonylmethoxypropyl) adenine [(s)-HPMPA], Antimicrobial Agents and Chemotherapy 42: 1146-1150.
- Fluiter K., Westhuijzen D.R. van der & Berkel T.J.C. van (1998), In vivo regulation of scavenger receptor BI and the selective uptake of HDL cholesteryl esters in rat liver parenchymal and Kupffer cells, Journal of Biological Chemistry 273(14): 8434-8438.
- Fluiter K., Sattler W., Westhuijzen D.R. van der & Berkel T.J.C. van (1998), Scavenger receptor BI mediates the selective uptake of oxidized cholesterol esters by rat liver, Circulation 98: I-202.
- Berkel T.J.C. van, Velzen A.G. van, Kruijt J.K., Suzuki H. & Kodama T. (1998), Uptake and catabolism of modified LDL in scavenger-receptor class A type I/II knock-out mice, Biochemical Journal 331: 29-35.
- Versluis J., Rensen P.C.N., Rump E.T., Berkel T.J.C. van & Bijsterbosch M.K. (1998), LDL receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes, British Journal of Cancer 78: 1607-1614.
- Vries H.E., Ronke E., Reinders J.H., Berkel T.J.C. van & Kuiper J. (1998), Acute effects of oxidized low density lipoprotein on the metabolic responses of macrophages, The FASEB Journal 12: 111-118.
- Biessen E.A.L., Vietsch H., Kuiper J. & Berkel T.J.C. van (1998), Liver uptake of phosphodiester oligodeoxynucleotides is mediated by scavenger receptor type binding sites, Molecular Pharmacology 53: 262-269.
- Rensen P.C.N., Oosten M. van, Amersfoort E.S. van, Eck M. van, Kuiper J. & Berkel T.J.C. van (1998), Apolipoprotein E is increased by bacterial LPS in vivo and protects against LPS-induced lethality, Circulation 98: I-305.
- Kuiper J., Vries H.E., Moor A.C.E., Dubbelman T.M.A.R. & Berkel T.J.C. van (1998), Arteriosclerosis and photodynamic therapy: oxidatively modified LDL as a delivery system for photosensitizer, Circulation 98: I-635.
- Herijgers N., Eck M. van, Korporaal S.J.A., Groot P.H.E., Hoogerbrugge P.M. & Berkel T.J.C. van (1998), Crucial role of the macrophage low density receptor (LDLr) in foam cell formation and the development of atherosclerosis, Circulation 98: I-385.
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- Rump E.T., Vrueh R.L.A. de, Sliedregt L.A.J.M., Biessen E.A.L., Berkel T.J.C. van & Bijsterbosch M.K. (1998), Preparation of conjugates of oligodeoxynucleotides and lipid structures, and their interaction with low-density lipoprotein, Bioconjugate Chemistry 9: 341-349.
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- Rensen P.C.N., Sliedregt L.A.J.M., Santbrink P.J. van, Berkel T.J.C. van & Biessen E.A.L. (1998), Novel glycolipids with high affinity for the hepatic asialoglycoprotein receptor are potent cholesterol-lowering agents, Circulation 98: I-451.
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