Sylvia Le Dévédec
Assistant Professor
- Name
- Dr. S.E. Le Dévédec
- Telephone
- +31 71 527 4285
- s.e.ledevedec@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-0615-9616
Dr. Sylvia Le Dévédec is Assistant Professor at the Drug Discovery & Safety division.
More information about Sylvia Le Dévédec
PhD Candidates
News
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Dutch Research Council Open Science Fund grants for five Leiden projects -
How oxygen deprivation causes cancer cells to spread -
Joining hands to advance Dutch microscopy -
700,000 euros for the fight against aggressive breast cancer -
NWO grant for research facility into the impact of environmental factors on health -
The Cell Observatory just got upgraded, and here is why -
Ratification of High Troughput Microscopy Dutch Flagship Node as Euro-BioImaging Node Candidate
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Leiden researchers discover genes that affect spread of breast cancer
Cell biologist from education, light microscopist from experience, I have acquired significant experience in drug discovery and safety using imaging as a key technology to get mechanistic insight in disease development. Manager of our High-Content imaging platform at the Cell Observatory and team player in our research division, I am also a fervent advocate of Open Science and very active in the FAIRification process of our imaging core facility.
Light microscopy has been the guiding theme in my academic career. During my master at the University of Amsterdam in the lab of Prof. R. van Driel (under supervision of Dr. PJ Verschure), I used confocal microscopy to determine the functional organization of nuclear bodies in cancer cells. After a break of few years working in the industry and traveling around the world on a bike, I decided to return to my first interest: look how fascinating are cells when studied through a microscope. During my PhD project in the lab of Prof. B. van de Water at the University of Leiden, I have been interested in how adhesion to the extracellular matrix regulates the behaviour of normal and cancer cells. I used various microscopy techniques including FRAP, FLIP, FRET, TIRF and intravital imaging. In recent years, I have helped for the expansion of the microscopy infrastructure of the Division of Toxicology. Nowadays, all the microscopes are housed at the Cell Observatory, a stimulating environment where bio-imaging and bioinformatics are integrated in a shared facility for Life Science at Leiden University.
Research Interests: all kind of light microscopy techniques (functional high-content imaging), image analysis and data management, assay development for 2D and 3D phenotypic screening, integration of Multi-Omics data. Actively involved in the development of an optical metabolic imaging platform for understanding further cancer metabolism. We also aim at using this metabolic imaging for safety assessment in dedicated cell models such as kidney organoids.
Research Management: ‘it is all about metadata and well annotated data’. FAIR data management with a special focus on large bio-imaging datasets (lab data management/SOP writing/Database OMERO/data life cycle/standards for FAIR data).
Teaching: actively involved in the Bachelor and Master Bio-Pharmaceutical program as well as PhD program of Leiden University. As a teacher and supervisor, I value and enjoy my work in helping young students developing in bright scientists.
Coordinator of the third year BSc course ‘Functional genomics: from Genotype to Phenotype’ (minor ‘Disease, Signaling and Drug Targets' (DSDT))
Assistant Professor
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Toxicology
- Schmied C., Nelson M.S., Avilov S., Bakker G.J., Bertocchi C., Bischof J., Boehm U., Brocher J., Carvalho M.T., Chiritescu C., Christopher J., Cimini B.A., Conde-Sousa E., Ebner M., Ecker R., Eliceiri K., Fernandez-Rodriguez J., Gaudreault N., Gelman L., Grunwald D., Gu T., Halidi N., Hammer M., Hartley M., Held M., Jug F. Kapoor V., Koksoy A.A., Lacoste J., Le Dévédec S.E., Le Guyader S., Liu P., Martins G.G., Mathur A., Miura K., Montero Llopis P., Nitschke R., North A., Parslow A.C., Payne-Dwyer A., Plantard L., Ali R., Schroth-Diez B., Schütz L., Scott R.T., Seitz A., Selchow O., Sharma V.P., Spitaler M., Srinivasan S., Strambio-De-Castillia C., Taatjes D., Tischer C. & Jambor H.K. (2024), Community-developed checklists for publishing images and image analyses, Nature Methods 21: 170-181.
- Bretin L.R., Husiev Y., Vadde R., Zhang L., Hakkennes M.L.A., Abyar S., Johns A.C., Le Dévédec S.E., Betancourt T., Kornienko A. & Bonnet S.A. (2024), Red‐light activation of a microtubule polymerization inhibitor via amide functionalization of the ruthenium photocage, Angewandte Chemie (International Edition) 63(5): e202316425.
- Wijaya L.S., Gabor A., Pot I.E., Have L. van de, Saez-Rodriguez J., Stevens J.L., Le Dévédec S.E., Callegaro G. & Water B. van de (2024), A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury, Toxicological Sciences 198(1): 14-30.
- Abyar S., Huang L., Husiev Y., Bretin L.R., Chau B., Vadde R., Wildeman J.H., Belfor K., Wijyay L.S., Noord V.E. van der, Harms A.C., Siegler M.A., Le Dévédec S.E. & Bonnet S.A. (2024), Oxygen-dependent interactions between the ruthenium cage and the photoreleased inhibitor in NAMPT-targeted photoactivated chemotherapy, Journal of Medicinal Chemistry 67(13): 11086–11102.
- Vadde R., Wijaya L.S., Beztsinna N., Griend C.J. van de, Water B. van de, Bonnet S.A. & Le Dévédec S.E. (2024), Cell viability imaging in tumor spheroids via DNA binding of a ruthenium(ii) light-switch complex, Chemical Communications 60(49): 6308-6311.
- Yin J., Forn-Cuní G., Surendran A.M., Lopes-Bastos B., Pouliopoulou N., Jager M.J., Le Dévédec S.E., Chen Q. & Snaar-Jagalska B.E. (2024), Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts, Angiogenesis : .
- Noord V.E. van der, Stel W. van der, Louwerens G., Verhoeven D., Kuiken H.J., Lieftink C., Grandits M., Ecker G.F., Beijersbergen R.L., Bouwman R.J.P., Le Dévédec S.E. & Water B. van de (2023), Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors, Breast Cancer Research 25(1): 51.
- Zhang L., Wang P., Zhou X.Q., Bretin L.R., Zeng X., Husiev Y., Polanco Rivas E.A., Zhao G., Wijaya L.S., Biver T., Le Dévédec S.E., Sun W. & Bonnet S. (2023), Cyclic ruthenium-peptide conjugates as integrin-targeting phototherapeutic prodrugs for the treatment of brain tumors, Journal of the American Chemical Society 145(27): 14963-14980.
- Zhang C., Le Dévédec S.E., Ali A.M.A.M. & Hankemeier T. (2023), Single-cell metabolomics by mass spectrometry: ready for primetime?, Current Opinion in Biotechnology 82: 102963.
- Beerkens B.L.H., Snijders I.M., Snoeck J., Liu R., Tool A.T.J., Le Dévédec S.E., Jespers W., Kuijpers T.W., Westen G.J.P. van, Heitman L.H., IJzerman A.P. & Es D. van der (2023), Development of an affinity-based probe to profile endogenous human adenosine A3 receptor expression, Journal of Medicinal Chemistry 66(16): 11399-11413.
- Hosseini R., Vlasveld M.P., Willemse J.J., Water B. van de, Le Dévédec S.E. & Wolstencroft K.J. (2023), FAIR high content screening in bioimaging, Scientific Data 10(1): 462.
- Danilyuk T.Y., Niemeijer M.C., Wijaya L.S., Snijders K., Berk L. van der, Braak S.J. ter, Callegaro G., Bouwman R.J.P., Le Dévédec S.E. & Water B. van de (2023), Human-induced pluripotent stem cell reporters for high-content screening of stress response activation identifying target organ-specific toxicities, Toxicology Letters 384: S192.
- Stel W. van der, Yang H., Le Dévédec S.E., Water B. van de, Beltman J.B. & Danen E.H.J. (2023), High-content high-throughput imaging reveals distinct connections between mitochondrial morphology and functionality for oxphos complex I, III, and V inhibitors, Cell Biology and Toxicology 39: 415-433.
- Liu Q., Liu N.S., Noord V.E. van der, Stel W. van der, Water B. van de, Danen E.H.J. & Le Dévédec S.E. (2023), Differential response of luminal and basal breast cancer cells to acute and chronic hypoxia, Breast Cancer Research and Treatment 198: 583-596.
- Braak S.J. ter, Niemeijer M.C., Wolters L., Le Dévédec S.E., Bouwman R.J.P. & Water B. van de (2022), Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters, Mutagenesis 37(2): 130-142.
- Stel W. van der, Yang H., Vrijenhoek N.G., Schimming J.P., Callegaro G., Carta G., Darici S., Delp J., Forsby A., White A., Le Dévédec S.E., Leist M., Jennings P., Beltman J.B., Water B. van de & Danen E.H.J. (2022), Mapping the cellular response to electron transport chain inhibitors reveals selective signaling networks triggered by mitochondrial perturbation, Archives of Toxicology 96: 259-285.
- Lerink L.J.S., Kok M.J.C., Mulvey J.F., Le Dévédec S.E., Markovski A.A., Wüst R.C.I., Alwayn I.P.J., Ploeg R.J., Schaapherder A.F.M., Bakker J.A. & Lindeman J.H.N. (2022), Preclinical models versus clinical renal ischemia reperfusion injury: a systematic review based on metabolic signatures, American Journal of Transplantation 22(2): 344-370.
- Burger G.A., Water B. van de, Le Dévédec S.E. & Beltman J.B. (2022), Density-dependent migration characteristics of cancer cells driven by pseudopod interaction, Frontiers in Cell and Developmental Biology 10: 854721.
- Tong. C., Wondergem A.J., Brink M. van den, Kwakernaak M.C., Chen Y., Hendrix M.M.R.M., Voets I.K., Danen E.H.J., Le Dévédec S., Heinrich D.M. & Kieltyka R.E. (2022), Spatial and temporal modulation of cell instructive cues in a filamentous supramolecular biomaterial, ACS Applied Materials and Interfaces 14(15): 17042-17054.
- Sijben H.J., Dall’ Acqua L., Liu R., Jarret A., Christodoulaki E., Onstein S., Wolf G., Verburgt S.J., Le Dévédec S.E., Wiedmer T., Superti-Furga G., IJzerman A.P. & Heitman L.H. (2022), Impedance-based phenotypic readout of transporter function: a case for glutamate transporters, Frontiers in Pharmacology 13: 872335.
- Heldring M.M., Wijaya L.S., Niemeijer M.C., Yang H., Lakhal T., Le Dévédec S.E., Water B. van de & Beltman J.B. (2022), Model-based translation of DNA damage signaling dynamics across cell types, PLoS Computational Biology 18(7): e1010264.
- Liu Q., Stel W. van der, Noord V.E. van der, Leegwater H., Coban B., Elbertse K., Pruijs J.T.M., Béquignon O.J.M., Westen G.J.P. van, Dévédec S.E. le & Danen E.H.J. (2022), Hypoxia triggers TAZ phosphorylation in basal a triple negative breast cancer cells, International Journal of Molecular Sciences 23(17): 10119.
- Liu Q., Palmgren V.A.C., Danen E.H.J. & Le Dévédec S.E. (2022), Acute vs. chronic vs. intermittent hypoxia in breast cancer: a review on its application in in vitro research, Molecular Biology Reports 49(11): 10961-10973.
- Dekker Y., Le Dévédec S.E., Danen E.H.J. & Liu Q. (2022), Crosstalk between hypoxia and extracellular matrix in the tumor microenvironment in breast cancer, Genes 13(9): 1585.
- Noord V.E. van der, Water B. van de & Le Dévédec S.E. (2022), Targeting the heterogeneous genomic landscape in triple-negative breast cancer through inhibitors of the transcriptional machinery, Cancers 14(18): 4353.
- Beerkens B.L.H., Koc C., Liu R., Florea B.I., Le Dévédec S.E., Heitman L.H., IJzerman A.P. & Es D. van der (2022), A chemical biological approach to study G protein-coupled receptors: labeling the adenosine A1 receptor using an electrophilic covalent probe, ACS Chemical Biology 17(11): 3131-3139.
- Hoekstra M., Liu Q., Zhang Y.H., Wel E.J. van der, Le Devedec S.E. & Eck M. van (2022), Hypocholesterolemic phospholipid transfer protein knockout mice exhibit a normal glucocorticoid response to food deprivation, American Journal of Translational Research 14(3): 1884-1891.
- Koedoot E., Wolters L., Smid M., Stoilov P., Burger G.A., Herpers B.H.A., Yan K., Price L.S., Martens J.W.M., Le Dévédec S.E. & Water B. van de (2021), Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy, Scientific Reports 11: 7529.
- Wijaya L.S., Trairatphisan P., Gabor A., Niemeijer M.C., Keet J., Alcalà Morera A., Snijders K.E., Wink S., Yang H., Schildknecht S., Stevens J.L., Bouwman R.J.P., Kamp H., Hengstler J., Beltman J.B., Leist M., Le Dévédec S.E., Saez-Rodriguez J. & Water B. van de (2021), Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury, Biochemical Pharmacology 190: 114591.
- Koedoot E., Steijn E. van, Vermeer M., González-Prieto R., Vertegaal A.C.O., Martens J.W.M., Le Dévédec S.E. & Water B. van de (2021), Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention, Journal of Experimental & Clinical Cancer Research 40: 82.
- Duijndam B., Goudriaan A., Hoorn T. van den, Stel W. van der, Le Dévédec S.E., Bouwman R.J.P., Laan J.W. van der & Water B. van de (2021), Physiologically relevant estrogen receptor alpha pathway reporters for single-cell imaging-based carcinogenic hazard assessment of estrogenic compounds, Toxicological Sciences 181(2): 187-198.
- Kok M.J.C. de, Schaapherder A.F., Wüst R.C.I., Zuiderwijk M., Bakker J.A., Lindeman J.H.N. & Le Dévédec S.E. (2021), Circumventing the crabtree effect in cell culture: a systematic review, Mitochondrion 59: 83-95.
- Snijders K.E., Fehér A., Táncos Z., Bock I., Téglási A., Berk L. van den, Niemeijer M., Bouwman P., Le Dévédec S.E., Moné M.J., Rossom R. van, Kumar M., Wilmes A., Jennings P., Verfaillie C.M., Kobolák J., Braak B. ter, Dinnyés A. & Water B. van de (2021), Fluorescent tagging of endogenous heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages, Archives of Toxicology 95(10): 3285-3302.
- Liu S., González Prieto R., Zhang M., Geurink P.P., Kooij R., Iyengar P.V., Dinther M. van, Bos E., Zhang X., Le Dévédec S.E., Water B. van de, Koning R.I., Zhu H.J., Mesker W.E., Vertegaal A., Ovaa H., Zhang L., Martens J.W.M. & Dijke P. ten (2020), Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis, Clinical Cancer Research 26(6): 1460-1473.
- Leone M.L., Romeijn S.G., Du G., Dévédec S.E. Le, Vrieling H., O'Mahony C., Bouwstra J.A. & Kersten G.F.A. (2020), Diphtheria toxoid dissolving microneedle vaccination: Adjuvant screening and effect of repeated-fractional dose administration, International Journal of Pharmaceutics 580: 119182.
- Lindeman J.H., Wijermars L.G., Kostidis S., Mayboroda O.A., Harms A.C., Hankemeier T., Bierau J., Sai Sankar Gupta K.B., Giera M., Reinders M.E., Zuiderwijk M.C., Le Dévédec S.E., Schaapherder A.F. & Bakker J.A. (2020), Results of an explorative clinical evaluation suggest immediate and persistent post-reperfusion metabolic paralysis drives kidney ischemia reperfusion injury, Kidney International 98(6): 1476-1488.
- Gonzalez-Beltran A.N., Masuzzo P., Ampe C., Bakker G.J., Besson S., Eibl R.H., Friedl P., Gunzer M., Kittisopikul M., Devedec S.E. le, Leo S., Moore J., Paran Y., Prilusky J., Rocca-Serra P., Roudot P., Schuster M., Sergeant G., Stromblad S., Swedlow J.R., Erp M. van, Troys M. van, Zaritsky A., Sansone S.A. & Martens L. (2020), Community standards for open cell migration data, GigaScience 9(5): giaa041.
- Koedoot E., Smid M., Foekens J.A., Martens J.W.M., Le Dévédec S.E. & Water B. van de (2019), Co-regulated gene expression of splicing factors as drivers of cancer progression, Scientific Reports 9(1): 5484.
- Nair N.U., Das A., Rogkoti V.M., Fokkelman M., Marcotte R., Jong C.G. de, Koedoot E., Lee J.S., Meilijson I., Hannenhalli S., Neel B.G., Water B. van de, Le Dévédec S.E. & Ruppin E. (2019), Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival, Scientific Reports 9: 10989.
- Koedoot E., Fokkelman M., Rogkoti V.M., Smid M., Sandt I. van de, Bont H.J.G.M. de, Pont C.M., Klip J.E., Wink S., Timmermans M.A., Wiemer E.A.C., Stoilov P., Foekens J.A., Le Dévédec S.E., Martens J.W.M. & Water B. van de (2019), Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes, Nature Communications 10(1): 2983.
- Verkoeijen S., Ma Y.F., Roosmalen W. van, Lalai R., Miltenburg M.H.A.M. van, Graauw M. de, Water B. van de & Le Dévédec S.E. (2019), Paxillin serine 178 phosphorylation in control of cell migration and metastasis formation through regulation of EGFR expression in breast cancer, Journal of Cancer Metastasis and Treatment 5: 51.
- He J., Wink S., Bont H. de, Le Dévédec S., Zhang Y. & Water B. van de (2019), FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells, Biochemical Pharmacology 169: 113640.
- Koedoot E., Wolters L., Water B. van de & Dévédec S.E.L. (2019), Splicing regulatory factors in breast cancer hallmarks and disease progression, OncoTarget 10(57): 6021-6037.
- Koenders S.T.A., Wijaya L.S., Erkelens M.N., Bakker A.T., Noord V.E. van der, Rooden E.J. van, Burggraaff L., Putter P.C., Botter E., Wals K., Elst H. van den, Dulk H. den, Florea B.I., Water B. van de, Westen G.J.P. van, Mebius R.E., Overkleeft H.S., Le Dévédec S.E. & Stelt M. van der (2019), Development of a Retinal-Based Probe for the Profiling of Retinaldehyde Dehydrogenases in Cancer Cells, ACS Central Science 5(12): 1965-1974.
- Rixel V.H.S. van, Ramu V., Auyeung A.B., Beztsinna N., Leger D.Y., Lameijer L.N., Hilt S.T., Le Devedec S.E., Yildiz T., Betancourt T., Gildner M.B., Hudnall T.W., Sol V., Liagre B., Kornienko A. & Bonnet S. (2019), Photo-Uncaging of a Microtubule-Targeted Rigidin Analogue in Hypoxic Cancer Cells and in a Xenograft Mouse Model, Journal of the American Chemical Society 141(46): 18444-18454.
- Buijs J.T., Laghmani E., Akker R.F.P. van den, Tieken C., Vletter E.M., Molen K.M. van der, Crooijmans J.J., Kroone C., Le Devedec S.E., Pluijm G. van der & Versteeg H.H. (2019), The direct oral anticoagulants rivaroxaban and dabigatran do not inhibit orthotopic growth and metastasis of human breast cancer in mice, Journal of Thrombosis and Haemostasis 17(6): 951-963.
- Buijs J.T., Laghman E.H., Akker R.F.P. van den, Tieken C., Vletter E., Molen K. van der, Crooijmans J., Kroone C., Pluijm G. van der, Le Devedec S.E. & Versteeg H.H. (2018), Direct oral anticoagulants do not inhibit growth and metastasis of human triple negative breast cancer in immunodeficient mice, Thrombosis Research 164(1): S221-S222.
- Lameijer L.N., Ernst D., Hopkins S.L., Meijer M.S., Askes S.H.C., Le Dévédec S.E. & Bonnet S.A. (2017), A Red-Light-Activated Ruthenium-Caged NAMPT Inhibitor Remains Phototoxic in Hypoxic Cancer Cells, Angewandte Chemie (International Edition) 56(38): 11549-11553.
- Roosmalen W. van, Le Devedec S.E., Golani O., Smid M., Pulyakhina I., Timmermans A.M., Look M.P., Zi D., Pont C., Graauw M. de, Naffar-Abu-Amara S., Kirsanova C., Rustici G., Hoen P.A.C. 't, Martens J.W.M., Foekens J.A., Geiger B. & Water B.J. van de (2015), Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant, Journal of Clinical Investigation 125(4): 1648-1664.
- Di Z., Klop M.J.D., Rogkoti V.M., Le Dèvèdec S.E., Water B. van de, Verbeek F.J., Price L.S. & Meerman J.H.N. (2014), Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues, PLoS ONE 9(10): e109688.
- Yizhak K., Gaude E., Le Devedec S., Waldman Y.Y., Stein G.Y., Water B. van de, Frezza C. & Ruppin E. (2014), Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer, eLife 3: e03641.
- Yizhak K., Le Dévédec S.E., Rogkoti V.M., Baenke F., Boer V.C. de, Frezza C., Schulze A., Water B. van de & Ruppin E. (2014), A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration, Molecular Systems Biology 10(8): 744.
- Graauw M. de, Cao L., Winkel L., Miltenburg M.H.A.M. van, Dévédec S.E. le, Klop M., Yan K., Pont C.M., Rogkoti V.M., Tijsma A., Chaudhuri A., Lalai R.A., Price L.S., Verbeek F.J. & Water B. van de (2014), Annexin A2 depletion delays EGFR endocytic trafficking via cofilin activation and enhances EGFR signaling and metastasis formation, Oncogene 33(20): 2610-2619.
- Truong H.H., Xiong J., Ghotra V.P.S., Nirmala E., Haazen L., Le Dévédec S.E., Balcioglu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H.J. (2014), beta(1) Integrin Inhibition Elicits a Prometastatic Switch Through the TGF beta-miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer, Science Signaling 7(312): ra15.
- Truong H.H., Xiong J., Ghotra V.P, Nirmala .E, Haazen L.C.J.M., Dévédec S.E. le, Balcioğlu H.E., He S., Snaar-Jagalska B.E., Vreugdenhil E., Meerman J.H.N., Water B. van de & Danen E.H. (2014), β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer, Science Signaling 7(312): ra15.
- Damiano L., Le Devedec S.E., Di Stefano P., Repetto D., Lalai R.A., Truong H., Xiong J.L., Danen E.H., Yan K., Verbeek F.J., De Luca E., Attanasio F., Buccione R., Turco E., Water B. van de & Defilippi P. (2012), p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation, Oncogene 31(5): 624-633.
- Larios E., Zhang Yanju, Yan K., Di Z., Le Dévédec S., Groffen F. & Verbeek F.J. (2012), Automation in cytomics: a modern RDBMS based platform for image analysis and management in high-throughput screening experiments. He J., Liu X., Krupinski E.A. & Xu G. (Eds.), Health Information Science. HIS 2012. HIS 2012: Health Information Science 8 April 2012 - 10 April 2012. Berlin, Heidelberg: Springer. 76-87.
- Le Dévédec S.E., Geverts B., Bont H.J.G.M. de, Yan K., Verbeek F.J., Houtsmuller A.B. & Water B. van de (2012), The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status, Journal of Cell Science 125(19): 4498-4506.
- Yan K., Larios E., LeDevedec S., Water B. van de & Verbeek F.J. (2011), Automation in Cytomics: Systematic Solution for Image Analysis and Management in High Throughput Sequences, Proceedings IEEE Conference Engineering and Technology (CET 2011). 195-198.
- Roosmalen W.P.E. van, Le Dévédec S.E., Zovko S., Bont H.J.G.M. & Water B. van de (2011), Functional screening with a live cell imaging-based random cell migration assay. In: Wells C. & Parsons M. (Eds.), Cell Migration. Methods in Molecular Biology no. 769: Humana Press. 435-448.
- Le Dévédec S.E., Roosmalen W. van, Pont C.M., Lalai R., Bont H.J.G.M. de & Water B. van de (2011), Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo. In: Wells C.M. & Parsons M. (Eds.), Cell Migration. Methods in Molecular Biology no. 769: Springer. 331-349.
- Le Devedec S.E., Lalai R., Pont C.M., Bont H.J.G.M. & Water B. van de (2011), Two-Photon Intravital Multicolor Imaging Combined with Inducible Gene Expression to Distinguish Metastatic Behavior of Breast Cancer Cells In Vivo, Molecular Imaging and Biology 13(1): 67-77.
- Le Dévédec S.E., Yan K., Bont H.J.G.M. de, Ghotra V.P., Truong H., Danen E.H., Verbeek F.J. & Water B. van de (2010), Systems microscopy approaches to understand cancer cell migration and metastasis, Cellular and Molecular Life Sciences 67(19): 3219-3240.
- Graauw M. de, Miltenburg M.H. van, Schmidt M.K., Pont C.M., Lalai R.A., Kartopawiro J., Pardali E., Le Dévédec S.E., Smit V.T., Wal A. van der, Veer L.J. van 't, Cleton-Jansen A.-M., Dijke P. ten & Water B. van de (2010), Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells, Proceedings of the National Academy of Sciences 107(14): 6340-6345.
- Yan K., Le Devedec S., Water B. van de & Verbeek F.J. (2009), Cell Tracking and Data Analisys of in vitro Tumour Cells from Time--Lapse Image Sequences. Ranchordas A. & Araujo H. (Eds.), Proceedings of the Fourth International Conference on Computer Vision Theory and Applications, VISAPP. Fourth International Conference on Computer Vision Theory and Applications 5 February 2009 - 8 February 2009 no. Volume 1. Portugal: Scitepress. 281-286.
- Ma Y., Water B. van de & Le Dévédec S.E. (2009), Focal Adhesion Kinase (FAK) Inhibition as a potential strategy for anticancer therapies, Drugs of the Future 34(6): 477-483.
- Le Dévédec S.E., Roosmalen W.P.E. van, Maria N., Grimbergen M., Pont C.M., Lalai R.A. & Water B. van de (2009), An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gamma c(-/-) mouse, Clinical and Experimental Metastasis 26(7): 673-684.
- Graauw M. de, Le Devedec S., Tijdens R.B., Smeets M.B., Deelder A.M. & Water B. van de (2007), Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary rat renal proximal tubular cells, Journal of Pharmacology and Experimental Therapeutics 322(1): 89-100.
- Water B. van de, Graauw M. de, Le Devedec S.E. & Alderliesten M. (2006), Cellular stress responses and molecular mechanisms of nephrotoxicity, Toxicology Letters 162(1): 83-93.