Somayah Elsayed
Assistant professor
- Name
- Dr. S.S.M.A. Elsayed Ph.D.
- Telephone
- +31 71 527 4561
- s.elsayed@biology.leidenuniv.nl
- ORCID iD
- 0000-0003-3837-6137
I am a natural products chemist (MSc and PhD), with a bachelor degree in pharmaceutical sciences. My research mainly focuses on the identification and structure elucidation of new natural products, with unusual skeletons and strong biological activities, which can be useful as potential drug leads.
PhD Candidates
News
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1 million euros grant for smart antibiotic combinations – tackling resistant infections and antimicrobial resistance -
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‘Polarisation is good. Much better than an uneasy silence’ -
High priority of banks and tax authorities in bankruptcies proves outdated -
Learning from the Experts: Dutch Negotiators on Climate diplomacy -
Antibodies against rheumatic diseases tested directly on patients -
Gianclaudio Malgieri moderates panel at IAPP Data Protection Congress 2024 -
H2OLAW conference: Law-science interfaces within the law of the sea and fresh water law -
College of Europe postgraduate programmes presented by Pierre Bachelier -
Europe Hub hosts first edition of Stockholm Explorative Talks in the Netherlands
Assistant professor
- Science
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Machushynets V., Al Ayed K., Terlouw R., Du C., Buijs P., Willemse J., Elsayed S., Schill J., Trebosc V.: Pieren M., Alexander F.M., Cochrane S.A., Liles M.R., Medema M.H., Martin N.I. & Wezel G.P. van (2024), Discovery and derivatization of tridecaptin antibiotics with altered host specificity and enhanced bioactivity, ACS Chemical Biology 19(5): 1106-1115.
- Nuutila A., Xiao X., Heul H.U. van der, Wezel G.P. van Dinis P., Elsayed S.S.M.A. & Metsä-Ketelä M. (2024), Divergence of classical and C-Ring-Cleaved Angucyclines: Elucidation of early tailoring steps in Lugdunomycin and Thioangucycline biosynthesis, ACS Chemical Biology 19(5): 1131-1141.
- Al Ayed U.K., Zamarbide Losada S.D., Machushynets N.V., Terlouw B., Elsayed S.S.M.A., Shill J., Trebos V., Pieren M., Medema M.H., Wezel G.P. van & Martin N.I. (2023), Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability, ACS infectious diseases 9(4): 739-748.
- Elsayed S.S.M.A., Heul H.U. van der, Xiao X., Nuutila A., Baars L.R., Wu C., Metsä-Ketelä M. & Wezel G.P. van (2023), Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis, Communications Chemistry 6: 281.
- Meij A. van der, Elsayed S.S.M.A., Willemse J.J., Du C., Wood T.M., Martin N.I., Raaijmakers J.M. & Wezel G.P. van (2023), The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes, Applied and Environmental Microbiology 89(11): e01239-23.
- Jansma J., Thome N.U., Schwalbe M., Chrysovalantou Chatziioannou A., Elsayed S.S.M.A., Wezel G.P. van, Abbeele P. van den, Hemert S. van & El Aidy S. (2023), Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach, Gut Microbes 15(1): 2232506.
- Bergeijk D.A. van, Elsayed S.S.M.A., Du C., Nuñez Santiago I., Roseboom A.M., Zhang L., Carrion Bravo V.J., Spaink H.P. & Wezel G.P. van (2022), The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces, Communications Chemistry 5: 14.
- Machushynets N.V., Elsayed S.S.M.A., Du C., Siegler M.A., Cruz M. de la, Genillou O., Hankemeier T. & Wezel G.P. van (2022), Discovery of actinomycin L, a new member of the actinomycin family of antibiotics, Scientific Reports 12: 2813.
- Elsayed S.S., Genta-Jouve G., Carrion V.J., Nibbering P.H., Siegler M.A., Boer W., Hankemeier T. & Wezel G.P. van (2020), Atypical spirotetronate polyketides identified in the underexplored genus streptacidiphilus, Journal of Organic Chemistry (JOC) 85(16): 10648-10657.
- Xiao X., Elsayed S.S.M.A., Wu C., Heul H.U. van der, Metsä-Ketelä M., Du C., Prota A.E., Chen C.C., Liu W., Guo R.T., Abrahams J.P. & Wezel G.P. van (2020), Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway, ACS Chemical Biology 15(9): 2529-2538.
- Kloosterman A.M., Cimermancic P., Elsayed S.S.M.A., Du C., Hadjithomas M., Donia M.S., Fischbach M.A., Wezel G.P. van & Medema M.H. (2020), Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides, PLoS Biology 18(12): e3001026.
- Machushynets N.V., Wu C., Elsayed S.S., Hankemeier T. & Wezel G.P. van (2019), Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27, Journal of Industrial Microbiology and Biotechnology 46(3-4): 483-492.
- Carrión V.J., Perez-Jaramillo J., Cordovez V., Tracanna V., Hollander M. de, Ruiz-Buck D., Mendes L.W., Ijcken W.F.J. van, Gomez-Exposito R., Elsayed S.S., Mohanraju P., Arifah A., Oost J. van der, Paulson J.N., Mendes R., Wezel G.P. van, Medema M.H. & Raaijmakers J.M. (2019), Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome, Science 366(6465): 606-612.
- Huang S., Tabudravu J., Elsayed S.S.M.A., Travert J., Peace D., Tong M.G., Kyeremeh K., Kelly S.M., Trembleau L., Ebel R., Jaspars M., Yu Y. & Deng H. (2015), Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins, Angewandte Chemie (International Edition) 54(43): 12697-12701.
- Elsayed S.S.M.A., Trusch F., Deng H., Raab A., Prokes I., Busarakam K., Asenjo J.A., Andrews B.A., West P. van, Bull A.T., Goodfellow M., Yu Y., Ebel R., Jaspars M. & Rateb M.E. (2015), Chaxapeptin, a Lasso Peptide from Extremotolerant Streptomyces leeuwenhoekii Strain C58 from the Hyperarid Atacama Desert, Journal of Organic Chemistry (JOC) 80(20): 10252-10260.
- Huang S., Elsayed S.S.M.A., Lv M., Tabudravu J., Rateb M.E., Gyampoh R., Kyeremeh K., Ebel R., Jaspars M., Deng Z., Yu Y. & Deng H. (2015), Biosynthesis of Neocarazostatin A Reveals the Sequential Carbazole Prenylation and Hydroxylation in the Tailoring Steps, Chemistry & Biology 22(12): 1633-1642.
- Hamdy A.A., Aboutabl E.A., Elsayed S.S.M.A., Hussein A.A., Díaz-Marrero A.R., Darias J. & Cueto M. (2009), 3-Keto-22-epi-28-nor-cathasterone, a brassinosteroid-related metabolite from Cystoseira myrica, Steroids 74(12): 927-930.