Sjaak Neefjes
Professor of Chemical immunology
- Name
- Prof.dr. J.J.C. Neefjes
- Telephone
- +31 71 527 2727
- j.j.c.neefjes@umail.leidenuniv.nl
- ORCID iD
- null
Neefjes is professor in Chemical Immunology and chair of the department of Cell and Chemical Biology (CCB) at the LUMC in Leiden. His is also chair of the LUMC Research Counsel and a member of the LUMC Research Board. In addition, he is member of the Board of KNAW and of FEAM. Neefjes is an elected member of the Norwegian Academy of Sciences and Letters, EMBO, Academia Europaea and KNHW. For his work, Neefjes received various awards including the KNCV Golden Medal, the Nefkens award and the Spinoza Advanced award (twice).
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Former PhD candidates
Neefjes is professor in Chemical Immunology and chair of the department of Cell and Chemical Biology (CCB) at the LUMC in Leiden. His is also chair of the LUMC Research Counsel and a member of the LUMC Research Board. In addition, he is member of the Board of KNAW and of FEAM.
Neefjes is an elected member of the Norwegian Academy of Sciences and Letters, EMBO, Academia Europaea and KNHW.
For his work, Neefjes received various awards including the KNCV Golden Medal, the Nefkens award and the Spinoza Advanced award (twice).
Cell and Chemical Biology
Neefjes applies chemical tools and inhibitors to study biological processes. These are related to the mechanism of antigen presentation by MHC molecules and how these move through cells, the way bacteria contribute to cancer formation and the way an important class of cancer drugs work. Neefjes detoxified these drugs and is currently busy preparing these for clinical studies.
Academic career
Sjaak Neefjes absolved the study Chemistry at the Free University Amsterdam. He absolved his doctoral research at the Netherlands Cancer Institute (NKI) in Amsterdam. The title of his doctoral thesis (November 1990, cum laude) reads ‘Cell Biological Aspect of MHC class I and II molecules’. His career later on was as follows.
Post Graduate Education and Training
1991 Post-doctoral research with prof. dr. H.L. Ploegh, Division of Cellular Biochemistry, the Netherlands Cancer Institute, Amsterdam
1991-1992 Visiting scientist at the laboratory of drs. C. Benoit and D. Mathis at the Institut de Chimie Biologique, Strassbourg
1992-1993 EMBO long-term fellowship, laboratory of prof. dr. G Hämmerling at the Deutsche Krebs Forschungs Zentrum (DKFZ), Heidelberg
Academic Appointments
1993 – 1997 Staff member, Division of Cellular Biochemistry, the Netherlands Cancer Institute, Amsterdam
1998 – 2008 Head Division of Tumor Biology, the Netherlands Cancer Institute, Amsterdam
1999 – 2014 Extraordinary professor at Leiden University, chair of 'Antigen Presentation and Processing'
2000 – 2003 Dean Graduate School Oncology Amsterdam (OOA)
2007 – 2011 Deputy Scientific Director, the Netherlands Cancer Institute, Amsterdam
2009 – 2016 Head Division of Cell Biology II, the Netherlands Cancer Institute, Amsterdam
2009 – 2011 Visiting professor at the Centre for Immune Regulation of the University of Oslo, Norway
2009 – present Ombudsman for Sanquin Amsterdam
2014 – 2016 Extraordinary professor at Leiden University, chair 'Chemical Immunology'
2016 – 2017 Head Division of Chemical Immunology, LUMC, Leiden NL
2018 – present Head Department of Cell and Chemical Biology, LUMC, NL
Prizes and honourable appointments
Neefjes studied chemistry at the VU and moved to the NKI to the new lab of Hidde Ploegh for his PhD research on the question how MHC molecules work. His PhD thesis is named Çell Biological aspects of MHC class I and II molecules (VU Amsterdam, cum laude).
After a post-doc at the DKFZ in Heidelberg, he started as a group leader at the NKI in Amsterdam where he has be acting chair of various departments and acting vice-director. He moved with the group of Huib Ovaa in 2016 to the LUMC where Neefjes is currently acting Chair of the Department CCB. Neefjes accepting speech was named ‘Over leven en overleven’ (About life and survival).
Professor of Chemical immunology
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Bio-organic Synthesis
Professor Chemical Immunology
- Faculteit Geneeskunde
- Divisie 4
- Cel en Chemische biologie
Contact
- Scywacyk V., Slaats R.H., Cofino-Fabres C., Den S.A. ten, Rivera-Arbeláez J.M., Dannenberg M., Boheemen C. van, Ribeiro M.C., Zanden S.Y. van der, Nollet E.D., Velden J., Neefjes J.J.C. & Cao L. (2024), A safety screening platform for individualized cardiotoxicity assessment, iScience 27(3): 109139.
- Hulst M.B., Zhang L., Heul H.U. van der, Du C., Elsayed S.S.M.A., Koroleva A., Grocholski T., Wander D.P.A., Metsä-Ketelä M., Neefjes J.J.C. & Wezel G.P. (2024), Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines, Frontiers in Bioengineering and Biotechnology 12: 1363803.
- Gelder M.A. van, Li Y., Wander D.P.A., Berlin I., Overkleeft H.S., Zanden S.Y. van der & Neefjes J.J.C. (2024), Novel N,N-dimethyl-idarubicin analogues are effective cytotoxic agents for ABCB1-overexpressing, doxorubicin-resistant cells, Journal of Medicinal Chemistry 67(16): 13802-13812.
- Schwach, V.; Slaats, R.H.; Cofino-Fabres, C.; , S.A.T. den; Rivera-Arbelaez, J.M.; Dannenberg, M.; Boheemen, C. van; Ribeiro, M.C.; Zanden, S.Y.V.; Nollet, E.E.; Velden, J. van der; Neefjes, J.; Cao, L. & Passier, R. (2024), A safety screening platform for individualized cardiotoxicity assessment, iScience 27(3).
- Emmerik, C.L. van; Lobbia, V.; Neefjes, J.; Nelissen, F.H.T. & Ingen, H. van (2024), Monitoring Anthracycline Cancer Drug-Nucleosome Interaction by NMR Using a Specific Isotope Labeling Approach for Nucleosomal DNA, ChemBioChem 25(9).
- Hulst, M.B.; Zhang, L.; Heul, H.U. van der; , C. du; Elsayed, S.S.; Koroleva, A.; Grocholski, T.; Wander, D.P.A.; Metsä-Ketelä, M.; Neefjes, J.J.C. & Wezel, G.P. van (2024), Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines, Frontiers in Bioengineering and Biotechnology 12.
- Wang, Y.M.; Beurden, A.W. van; Tersteeg, M.M.H.; Michel, S.; Kastelein, A.; Neefjes, J.; Rohling, J.H.T.; Meijer, J.H. & Deboer, T. (2024), Internal circadian misallignment in a mouse model of chemotherapy induced fatigue, Brain, Behavior, and Immunity 115: 588-599.
- Qiao, X.H.; Zanden, S.Y. van der; Li, X.Y.; Tan, M.K.; Zhang, Y.X.; Song, J.Y.; Gelder, M.A. van; Hamoen, F.L.; Janssen, L.; Zuur, C.L.; Pang, B.X.; Tellingen, O. van; Li, J.M. & Neefjes, J. (2024), Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients, Molecular Cancer 23(1).
- Schoufour, T.A.W.; Duijn, A.V. van; Derksen, I.; Melgers, M.; Veenendaal, J.M.F. van; Lensen, C.; Heemskerk, M.H.M.; Neefjes, J.; Wijdeven, R.H.M. & Scheeren, F.A. (2024), CRISPR-Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition, iScience 27(6).
- Jongsma, M.L.M.; Bakker, N.; Voortman, L.M.; Koning, R.I.; Bos, E.; Akkermans, J.J.L.L.; Janssen, L. & Neefjes, J. (2024), Systems mapping of bidirectional endosomal transport through the crowded cell, Current Biology 34(19).
- Marlieke L M Jongsma 1, Nina Bakker 2, Lenard M Voortman 2, Roman I Koning 3, Erik Bos 3, Jimmy J L L Akkermans 2, Lennert Janssen 2 & Jacques Neefjes 4 (2024), Systems mapping of bidirectional endosomal transport through the crowded cell.
- Neefjes, J.; Gurova, K.; Sarthy, J.; Szabó, G. & Henikoff, S. (2024), Chromatin as an old and new anticancer target, TRENDS IN CANCER 10(8): 696-707.
- Landman, S.L.; Ressing, M.E.; Gram, A.M.; Tjokrodirijo, R.T.N.; Veelen, P.A.V.; Neefjes, J.; Hoeben, R.C.; Veen, A.G. van der & Berlin, I. (2024), Epstein-Barr virus nuclear antigen EBNA3A modulates IRF3-dependent IFNβ expression, Journal of Biological Chemistry 300(9).
- Stévenin, V.; Coipan, C.E.; Duijster, J.W.; Elsland, D.M.V.; Voogd, L.; Bigey, L.; Hoek, A.H.A.M.V.; Wijnands, L.M.; Janssen, L.; Akkermans, J.J.L.L.; Neefjes-Borst, A.; Franz, E.; Mughini-Gras, L. & Neefjes, J. (2024), Multi-omics analyses of cancer-linked clinical salmonellae reveal bacterial-induced host metabolic shift and mTOR-dependent cell transformation, CELL REPORTS 43(11).
- Gelder, M.A. van; Li, Y.F.; Wander, D.P.A.; Berlin, I.; Overkleeft, H.S.; Zanden, S.Y. van der & Neefjes, J.J.C. (2024), Novel N,N-dimethyl-idarubicin analogues are effective cytotoxic agents for ABCB1-overexpressing, doxorubicin-resistant cells, Journal of Medicinal Chemistry 67(16): 13802-13812.
- Wijdeven, R.H.; Luk, S.J.; Schoufour, T.A.W.; Zanden, S.Y.V.; Cabezuelo, M.; Heemskerk, M.H.M. & Neefjes, J. (2024), Balanced epigenetic regulation of MHC class I expression in tumor cells by the histone ubiquitin modifiers BAP1 and PCGF1, The Journal of Immunology 212(3).
- Ciurli, A.; Mohammed, Y.; Ammon, C.; Derks, R.J.E.; Olivier-Jimenez, D.; Ducarmon, Q.R.; Slingerland, M.; Neefjes, J.J.C. & Giera, M. (2024), Spatially and temporally resolved metabolome of the human oral cavity, iScience 27(2).
- Bie, F.J. de; Dettingmeijer, M.D.; Zanden, S.Y. van der; Neefjes, J. & Vermeer, M.H. (2024), The effect of Anthracycline treatment on primary cutaneous T-cell lymphoma cells, European Journal of Cancer 211: S56-S56.
- Cabukusta, B.; Pauwels, S.B.; Akkermans, J.J.; Blomberg, N.; Mulder, A.A.; Koning, R.; Giera, M. & Neefjes, J. (2024), The ORP9-ORP11 dimer promotes sphingomyelin synthesis, eLife 12.
- Linden, E. ter; Abels, E.R.; Solinge, T.S. van; Neefjes, J. & Broekman, M.L.D. (2024), Overcoming Barriers in Glioblastoma-Advances in Drug Delivery Strategies, Cells 13(12).
- Cabukusta, B.; Berlin, I.; Elsland, D.M. van; Forkink, I.; Spits, M.; Jong, A.W.M. de; Akkermans, J.J.L.L.; Wijdeven, R.H.M.; Janssen, G.M.C.; Veelen, P.A. van & Neefjes, J. (2023), Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs (vol 33, 108475, 2020), Cell Reports 42(7).
- Gan, J.; Vries, J. de; Akkermans, J.J.L.L.; Mohammed, Y.; Tjokrodirijo, R.T.N.; Ru, A.H. de; Kim, R.Q.; Vargas, D.A.; Pol, V.; Fasan, R.; Veelen, P.A. van; Neefjes, J.; Dam, H. van; Ovaa, H.; Sapmaz, A. & Geurink, P.P. (2023), Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2, ACS Chemical Biology 18(9): 2003-2013.
- Middelburg, J.; Ghaffari, S.; Schoufour, T.A.W.; Sluijter, M.; Schaap, G.; Göynük, B.; Sala, B.M.; Al-Tamimi, L.; Scheeren, F.; Franken, K.L.M.C.; Akkermans, J.J.L.L.; Cabukusta, B.; Joosten, S.A.; Derksen, I.; Neefjes, J.; Burg, S.H. van der; Achour, A.; Wijdeven, R.H.M.; Weidanz, J. & Hall, T. van (2023), The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent, Cell Reports 42(12).
- Stévenin, V. & Neefjes, J. (2023), Soft agar colony formation assay to quantify mouse embryonic fibroblast transformation after Salmonella infection, STAR Protocols 4(3).
- Zanden, S.Y. van der; Jongsma, M.L.M.; Neefjes, A.C.M.; Berlin, I. & Neefjes, J. (2023), Maintaining soluble protein homeostasis between nuclear and cytoplasmic compartments across mitosis, Trends in Cell Biology 33(1): 18-29.
- Kapteijn, M.Y.; Zwaan, S.; Linden, E. ter; Laghmani, E.; Akker, R.F.P. van den; Rondon, A.M.R.; Zanden, S.Y. van der; Neefjes, J.; Versteeg, H.H. & Buijs, J.T. (2023), Temozolomide and lomustine induce tissue factor expression and procoagulant activity in glioblastoma cells in vitro, Cancers 15(8).
- Cremer, T.; Voortman, L.M.; Bos, E.; Jongsma, M.L.M.; Haar, L.R. ter; Akkermans, J.J.L.L.; Ormeno, C.M.T.; Wijdeven, R.H.; Vries, J. de; Kim, R.Q.; Janssen, G.M.C.; Veelen, P.A. van; Koning, R.I.; Neefjes, J. & Berlin, I. (2023), RNF26 binds perinuclear vimentin filaments to integrate ER and endolysosomal responses to proteotoxic stress, The EMBO Journal 42(18).
- Gelder, M.A. van; Zanden, S.Y. van der; Vriends, M.B.L.; Wagensveld, R.A.; Marel, G.A. van der; Codee, J.D.C.; Overkleeft, H.S.; Wander, D.P.A. & Neefjes, J.J.C. (2023), Re-exploring the anthracycline chemical space for better anti-cancer compounds, Journal of Medicinal Chemistry 66(16).
- Olajide, O.M.; Osman, M.K.; Robert, J.; Kessler, S.; Toews, L.K.; Thamamongood, T.; Neefjes, J.; Wrobel, A.G.; Schwemmle, M.; Ciminski, K. & Reuther, P. (2023), Evolutionarily conserved amino acids in MHC-II mediate bat influenza, PLoS Biology 21(7).
- Buck, T.M.; Quinn, P.M.J.; Pellissier, L.P.; Mulder, A.A.; Jongejan, A.; Lu, X.F.; Boon, N.; Koot, D.; Almushattat, H.; Arendzen, C.H.; Vos, R.M.; Bradley, E.J.; Freund, C.; Mikkers, H.M.M.; Boon, C.J.F.; Moerland, P.D.; Baas, F.; Koster, A.J.; Neefjes, J.; Berlin, I.; Jost, C.R. & Wijnholds, J. (2023), CRB1 is required for recycling by RAB11A+vesicles in human retinal organoids, Stem Cell Reports 18(9): 1793-1810.
- Jongsma, M.L.M.; Bakker, N. & Neefjes, J. (2023), Choreographing the motor-driven endosomal dance, Journal of Cell Science 136(5).
- Berlin, I.; Sapmaz, A.; Stevenin, V. & Neefjes, J. (2023), Ubiquitin and its relatives as wizards of the endolysosomal system, Journal of Cell Science 136(4).
- Elsland, D.M. van; Duijster, J.W.; Zhang, J.L.; Stevenin, V.; Zhang, Y.G.; Zha, L.; Xia, Y.L.; Franz, E.; Sun, J.; Mughini-Gras, L. & Neefjes, J. (2022), Repetitive non-typhoidal Salmonella exposure is an environmental risk factor for colon cancer and tumor growth, Cell Reports Medicine 3(12).
- Elsland, D.M.; Duijster J.W. van; Zhang, J.; Stévenin, V.; Zhang, Y.; Zha, L.; Xia, Y.; Franz, E.; Sun, J.; Mughini-Gras, L. & Neefjes, J. (2022), Repetitive exposure to non-typhoidal Salmonellae is an environmental risk factor for colon cancer, Cell Host & Microbe.
- Fletcher, E.; Kerzeli, I.; Cordfunke, R.; Nasi, A.; Törnqvist, G.; Valentijn, R.; Lindqvist, F.; Dillmann, I.; Lord, M.; Bouwman, N.; Neefjes, J.; Dolezal, N.; Franken, K.; McArdle, S.; Ahmad, M.; Johansson, S.; Ossendorp, F.; Haggman, M.; Lilleby, W.; Ullenhag, G.; Ladjevardi, S.; Jarblad, J.; Drijfhout, J.W. & Mangsbo, S. (2022), Promoting immunogenicity of synthetic long peptide vaccines based on in vivo IgG complex formation: Preclinical evaluation and clinical entry of the TET platform, Cancer Research 82(12).
- Berner, F.; Bomze, D.; Lichtensteiger, C.; Walter, V.; Niederer, R.; Ali, O.H.; Wyss, N.; Bauer, J.; Freudenmann, L.K.; Marcu, A.; Wolfschmitt, E.M.; Haen, S.; Gross, T.; Abdou, M.T.; Diem, S.; Knopfli, S.; Sinnberg, T.; Hofmeister, K.; Cheng, H.W.; Toma, M.; Klumper, N.; Purde, M.T.; Pop, O.T.; Jochum, A.K.; Pascolo, S.; Joerger, M.; Fruh, M.; Jochum, W.; Rammensee, H.G.; Laubli, H.; Holzel, M.; Neefjes, J.; Walz, J. & Flatz, L. (2022), Autoreactive napsin A-specific T cells are enriched in lung tumors and inflammatory lung lesions during immune checkpoint blockade, Science Immunology 7(75).
- Brouwer, T.P.; Zanden, S.Y. van der; Ploeg, M. van der; Eendenburg, J.D.H. van; Bonsing, B.A.; Miranda, N.F.C.C. de; Neefjes, J.J. & Vahrmeijer, A.L. (2022), The identification of the anthracycline aclarubicin as an effective cytotoxic agent for pancreatic cancer, Anti-Cancer Drugs 33(7): 614-621.
- Chora, A.F.; Pedroso, D.; Kyriakou, E.; Pejanovic, N.; Colaco, H.; Gozzelino, R.; Barros, A.; Willmann, K.; Velho, T.; Moita, C.F.; Santos, I.; Pereira, P.; Carvalho, S.; Martins, F.B.; Ferreira, J.A.; Almeida, S.F. de; Benes, V.; Anrather, J.; Weis, S.; Soares, M.P.; Geerlof, A.; Neefjes, J.; Sattler, M.; Messias, A.C.; Neves-Costa, A.; Moita, L.F. & Abu-Amer, Y. (2022), DNA damage independent inhibition of NF-kappa B transcription by anthracyclines, eLife 11.
- Wang, Y.M.; Zanden, S.Y. van der; Leerdam, S. van; Tersteeg, M.M.H.; Kastelein, A.; Michel, S.; Neefjes, J.; Meijer, J.H. & Deboer, T. (2022), Induction of fatigue by specific anthracycline cancer drugs through disruption of the circadian pacemaker, Cancers 14(10).
- Reits, E. & Neefjes, J. (2022), HLA molecules in transplantation, autoimmunity and infection control: A comic book adventure, HLA: Immune Response Genetics 100(4): 301-311.
- Harryvan, T.J.; Visser, M.; Bruin, L. de; Plug, L.; Griffioen, L.; Mulder, A.; Veelen, P.A. van; Noort, G.J.V. van; Jongsma, M.L.; Meeuwsen, M.H.; Wiertz, E.J.; Santegoets, S.J.; Hardwick, J.C.; Hall, T. van; Neefjes, J.; Burg, S.H. van der; Hawinkels, L.J.A.C. & Verdegaal, E.M.E. (2022), Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S, Journal for ImmunoTherapy of Cancer 10(3).
- Wijdeven, R.H.; Cabukusta, B.; Behr, F.M.; Qiu, X.; Amiri, D.; Borras, D.M.; Arens, R.; Liang, Y. & Neefjes, J. (2022), CRISPR activation screening identifies VGLL3-TEAD1-RUNX1/3 as a transcriptional complex for PD-L1 expression, The Journal of Immunology 209(5): 907-915.
- Stevenin, V. & Neefjes, J. (2022), Control of host PTMs by intracellular bacteria: An opportunity toward novel anti-infective agents, Cell chemical biology 29(5): 741-756.
- Jongsma M.L.M., Waard A.A. de, Raaben M., Zhang T., Cabukusta B., Platzer R., Blomen V.A., Xagara A., Verkerk T., Bliss S., Kong X., Gerke C., Janssen L., Stickel E., Holst S., Plomp R., Mulder A., Ferrone S., Claas F.H.J., Heemskerk M.H.M., Griffioen M., Halenius A., Overkleeft H.S., Huppa J.B., Wuhrer M., Brummelkamp T.R., Neefjes J. & Spaapen R.M. (2021), The SPPL3-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses, Immunity 54(1): 132-150.
- Wander D.P.A., Zanden S.Y. van der, Vriends M.B.L. Veen B.C. van, Vlaming J.G.C., Bruyning T., Hansen T., Marel G.A. van der, Overkleeft H.S., Neefjes J.J.C. & Codée J.D.C. (2021), Synthetic (N,N-dimethyl)doxorubicin glycosyl diastereomers to dissect modes of action of anthracycline anticancer drugs, Journal of Organic Chemistry (JOC) 86(8): 5757-5770.
- Jongsma, M.L.M.; Waard, A.A. de; Raaben, M.; Zhang, T.; Cabukusta, B.; Platzer, R.; Blomen, V.A.; Xagara, A.; Verkerk, T.; Bliss, S.; Kong, X.R.; Gerke, C.; Janssen, L.; Stickel, E.; Holst, S.; Plomp, R.; Mulder, A.; Ferrone, S.; Claas, F.H.J.; Heemskerk, M.H.M.; Griffioen, M.; Halenius, A.; Overkleeft, H.; Huppa, J.B.; Wuhrer, M.; Brummelkamp, T.R.; Neefjes, J. & Spaapen, R.M. (2021), The SPPL3-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses, Immunity 54(1): 132-+.
- Cremer, T.; Jongsma, M.L.M.; Trulsson, F.; Vertegaal, A.C.O.; Neefjes, J. & Berlin, I. (2021), The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway, Cell Reports 34(3).
- Neefjes J & Cabukusta B (2021), What the VAP: the expanded VAP family of proteins interacting with FFAT and FFAT-related motifs for interorganellar contact , Contact 4(2515-2564).
- Aman, J.; Duijvelaar, E.; Botros, L.; Kianzad, A.; Schippers, J.R.; Smeele, P.J.; Azhang, S.; Bartelink, I.H.; Bayoumy, A.A.; Bet, P.M.; Boersma, W.; Bonta, P.I.; Boomars, K.A.T.; Bos, L.D.J.; Bragt, J.J.M.H. van; Braunstahl, G.J.; Celant, L.R.; Eger, K.A.B.; Geelhoed, J.J.M.; Glabbeek, Y.L.E. van; Grotjohan, H.P.; Hagens, L.A.; Happe, C.M.; Hazes, B.D.; Heunks, L.M.A.; Heuvel, M. van den; Hoefsloot, W.; Hoek, R.J.A.; Hoekstra, R.; Hofstee, H.M.A.; Juffermans, N.P.; Kemper, E.M.; Kos, R.; Kunst, P.W.A.; Lammers, A.; Lee, I. van der; Lee, E.L. van der; Maitland-van der Zee, A.H.; Asam, P.F.M.M.; Mieras, A.; Muller, M.; Neefjes, E.C.W.; Nossent, E.J.; Oswald, L.M.A.; Overbeek, M.J.; Pamplona, C.C.; Paternotte, N.; Pronk, N.; Raaf, M.A. de; Raaij, B.F.M. van; Reijrink, M.; Schultz, M.J.; Neto, A.S.; Slob, E.M.A.; Smeenk, F.W.J.M.; Smit, M.R.; Smits, A.J.; Stalenhoef, J.E.; Tuinman, P.R.; Vanhove, A.L.E.M.; Wessels, J.N.; Wezenbeek, J.C.C. van; Noordegraaf, A.V.; Man, F.S. de & Bogaard, H.J. (2021), Imatinib in patients with severe COVID-19, The Lancet Respiratory Medicine 9(9): 957-968.
- Jongsma, M.L.M.; Waard, A.A. de; Raaben, M.; Zhang, T.; Cabukusta, B.; Platzer, R.; Blomen, V.A.; Xagara, A.; Verkerk, T.; Bliss, S.; Kong, X.R.; Gerke, C.; Janssen, L.; Stickel, E.; Holst, S.; Plomp, R.; Mulder, A.; Ferrone, S.; Claas, F.H.J.; Heemskerk, M.H.M.; Griffioen, M.; Halenius, A.; Overkleeft, H.; Huppa, J.B.; Wuhrer, M.; Brummelkamp, T.R.; Neefjes, J. & Spaapen, R.M. (2021), The SPPL3-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses (vol 54, 132.e1, 2021), Immunity 54(2): 387-387.
- Spits, M.; Heesterbeek, I.T.; Voortman, L.M.; Akkermans, J.J.; Wijdeven, R.H.; Cabukusta, B. & Neefjes, J. (2021), Mobile late endosomes modulate peripheral endoplasmic reticulum network architecture, EMBO Reports 22(3).
- Duijster, J.; Mughini-Gras, L.; Neefjes, J. & Franz, E. (2021), Occupational exposure and risk of colon cancer, BMJ Open 11(8).
- Perrin, P.; Janssen, L.; Janssen, H.; Broek, B. van den; Voortman, L.M.; Elsland, D. van; Berlin, I. & Neefjes, J. (2021), Retrofusion of intralumenal MVB membranes parallels viral infection and coexists with exosome release, Current Biology 31(17): 3884-+.
- Duijster, J.W.; Franz, E.; Neefjes, J. & Mughini-Gras, L. (2021), Bacterial and parasitic pathogens as risk factors for cancers in the gastrointestinal tract: a review of current epidemiological knowledge, Frontiers in Microbiology 12.
- Berner, F.; Niederer, R.; Luimstra, J.J.; Pop, O.T.; Jochum, A.K.; Purde, M.T.; Ali, O.H.; Bomze, D.; Bauer, J.; Freudenmann, L.K.; Marcu, A.; Wolfschmitt, E.M.; Haen, S.; Gross, T.; Dubbelaar, M.L.; Abdou, M.T.; Baumgaertner, P.; Appenzeller, C.; Cicin-Sain, C.; Lenz, T.; Speiser, D.E.; Ludewig, B.; Driessen, C.; Jorger, M.; Fruh, M.; Jochum, W.; Cozzio, A.; Rammensee, H.G.; Walz, J.; Neefjes, J. & Flatz, L. (2021), Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survival, OncoImmunology 10(1).
- Mishto, M.; Rodriguez-Hernandez, G.; Neefjes, J.; Urlaub, H. & Liepe, J. (2021), Response: commentary: an in silico- in vitro pipeline identifying an HLA-A*02:01+KRAS G12V+spliced epitope candidate for a broad tumor-immune response in cancer patients, Frontiers in Immunology 12.
- Bakke, O.; Margiotta, A.; Frei, D.; Skjeldal, F.; Sendstad, I.; Janssen, L. & Neefjes, J. (2021), Invariant chain regulates the endosomal pathway through interactions with the SNARE machinery, Scandinavian Journal of Immunology 94(6).
- Ciurli, A.; Derks, R.J.E.; Liebl, M.; Ammon, C.; Neefjes, J. & Giera, M. (2021), Spatially resolved sampling of the human oral cavity for metabolic profiling, STAR Protocols 2(4).
- Duijster, J.W.; Hansen, J.V.; Franz, E.; Neefjes, J.J.C.; Frisch, M.; Mughini-Gras, L. & Ethelberg, S. (2021), Association between Salmonella infection and colon cancer, Epidemiology and Infection 149.
- Jongsma, M.L.M.; Neefjes, J. & Spaapen, R.M. (2021), Playing hide and seek: tumor cells in control of MHC class I antigen presentation, Molecular Immunology 136: 36-44.
- Wander, D.P.A.; Zanden, S.Y. van der; Vriends, M.B.L.; Veen, B.C. van; Vlaming, J.G.C.; Bruyning, T.; Hansen, T.; Marel, G.A. van der; Overkleeft, H.S.; Neefjes, J.J.C. & Codee, J.D.C. (2021), Synthetic (N,N-dimethyl)doxorubicin glycosyl diastereomers to dissect modes of action of anthracycline anticancer drugs, Journal of Organic Chemistry 86(8): 5757-5770.
- Hulst, M.B.; Grocholski, T.; Neefjes, J.J.C.; Wezel, G.P. van & Metsa-Ketela, M. (2021), Anthracyclines: biosynthesis, engineering and clinical applications, Natural Product Reports.
- Maurits E., Graaff M.J. van de, Maiorana S., Wander D.P.A., Dekker P.M., Zanden S.Y. van der, Florea B.I., Neefjes J.J.C., Overkleeft H.S. & Kasteren S.I. van (2020), Immunoproteasome inhibitor-doxorubicin conjugates target multiple myeloma cells and release doxorubicin upon low-dose photon irradiation, Journal of the American Chemical Society 142(16): 7250-7253.
- Qiao X., Zanden S.Y. van der, Wander D.P.A., Borràs D.M., Song J.Y., Li X., Duikeren S. van, Gils N. van, Rutten A., Herwaarden T. van, Tellingen O. van, Giacomelli E., Bellin M., Orlova V., Tertoolen L.G.J., Gerhardt S., Akkermans J.J., Bakker J.M., Zuur C.L., Pang B., Smits A.M., Mummery C.L., Smit L., Arens R., Li J., Overkleeft H.S. & Neefjes J.J.C. (2020), Uncoupling DNA damage from chromatin damage to detoxify doxorubicin, Proceedings of the National Academy of Sciences 117(26): 15182-15192.
- Neefjes J.J.C., Overkleeft H.S., Ploegh H.L. & Schulman B. (2020), Obituary Huib Ovaa (1973-2020), Cell chemical biology 27(6): 645-646.
- Wander D.P.A., Zanden S.Y. van der, Marel G.A. van der, Overkleeft H.S., Neefjes J.J.C. & Codee J.D.C. (2020), Doxorubicin and aclarubicin: shuffling anthracycline glycans for improved anticancer agents, Journal of Medicinal Chemistry 63(21): 12814-12829.
- Jongsma, M.L.M.; Bakker, J.; Cabukusta, B.; Liv, N.; Elsland, D. van; Fermie, J.; Akkermans, J.L.L.; Kuijl, C.; Zanden, S.Y. van der; Janssen, L.; Hoogzaad, D.; Kant, R. van der; Wijdeven, R.H.; Klumperman, J.; Berlin, I. & Neefjes, J. (2020), SKIP-HOPS recruits TBC1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport, EMBO Journal 39(6).
- Boomen, D.J.H. van den; Sienkiewicz, A.; Berlin, I.; Jongsma, M.L.M.; Elsland, D.M. van; Luzio, J.P.; Neefjes, J.J.C. & Lehner, P.J. (2020), A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export, Nature Communications 11(1).
- Wang, Y.; Leerdam, S. van; Derzanden, S. van; Domenie, E.; Michel, S.; Walschots, Q.; Neefjes, J.; Meijer, J. & Deboer, T. (2020), Chemotherapy reduces running wheel activity and alters the strength of the output of the circadian clock, Journal of Sleep Research 29: 136-137.
- Wander, D.P.A.; Zanden, S.Y. van der; Marel, G.A. van der; Overkleeft, H.S.; Neefjes, J. & Codee, J.D.C. (2020), Doxorubicin and aclarubicin, Journal of Medicinal Chemistry 63(21): 12814-12829.
- Margiotta, A.; Frei, D.M.; Sendstad, I.H.; Janssen, L.; Neefjes, J. & Bakke, O. (2020), Invariant chain regulates endosomal fusion and maturation through an interaction with the SNARE Vti1b, Journal of Cell Science 133(19).
- Zanden, S.Y. van der; Qiao, X.H. & Neefjes, J. (2020), New insights into the activities and toxicities of the old anticancer drug doxorubicin, FEBS Journal 288(21).
- Neefjes, J.; Overkleeft, H.; Ploegh, H. & Schulman, B. (2020), Obituary Huib Ovaa (1973-2020), Cell chemical biology 27(6): 645-646.
- Qiao, X.H.; Zanden, S.Y. van der; Wander, D.P.A.; Borras, D.M.; Song, J.Y.; Li, X.Y.; Duikeren, S. van; Gils, N. van; Rutten, A.; Herwaarden, T. van; Tellingen, O. van; Giacomelli, E.; Bellin, M.; Orlova, V.; Tertoolen, L.G.J.; Gerhardt, S.; Akkermans, J.J.; Bakker, J.M.; Zuur, C.L.; Pang, B.X.; Smits, A.M.; Mummery, C.L.; Smit, L.; Arens, R.; Li, J.M.; Overkleeft, H.S. & Neefjes, J. (2020), Uncoupling DNA damage from chromatin damage to detoxify doxorubicin, Proceedings of the National Academy of Sciences 117(26): 15182-15192.
- Jongsma, M.L.M.; Bakker, J.; Cabukusta, B.; Liv, N.; Elsland, D. van; Fermie, J.; Akkermans, J.L.L.; Kuijl, C.; Zanden, S.Y. van der; Janssen, L.; Hoogzaad, D.; Kant, R. van der; Wijdeven, R.H.; Klumperman, J.; Berlin, I. & Neefjes, J. (2020), SKIP-HOPS recruits TBC1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport, EMBO Journal 39.
- Maurits, E.; Graaff, M.J. van de; Maiorana, S.; Wander, D.P.A.; Dekker, P.M.; Zanden, S.Y. van der; Florea, B.I.; Neefjes, J.J.C.; Overkleeft, H.S. & Kasteren, S.I. van (2020), Immunoproteasome inhibitor-doxorubicin conjugates target multiple myeloma cells and release doxorubicin upon low-dose photon irradiation, Journal of the American Chemical Society 142(16): 7250-7253.
- Zanden, S.Y. van der; Luimstra, J.J.; Neefjes, J.; Borst, J. & Ovaa, H. (2020), Opportunities for Small Molecules in Cancer Immunotherapy, Trends in Immunology 41(6): 493-511.
- Mankor, J.M.; Zwierenga, A.F.; Dumoulin, D.W.; Neefjes, J.J.C. & Aerts, J.G.J.V. (2020), A brief report on combination chemotherapy and anti-programmed death (ligand) 1 treatment in small-cell lung cancer, European Journal of Cancer 137: 40-44.
- Cremer, T.; Neefjes, J. & Berlin, I. (2020), The journey of Ca2+ through the cell - pulsing through the network of ER membrane contact sites, Journal of Cell Science 133(24).
- Cabukusta, B.; Berlin, I.; Elsland, D.M. van; Forkink, I.; Spits, M.; Jong, A.W.M. de; Akkermans, J.J.L.L.; Wijdeven, R.H.M.; Janssen, G.M.C.; Veelen, P.A. van & Neefjes, J. (2020), Human VAPome analysis reveals MOSPD1 and MOSPD3 as membrane contact site proteins interacting with FFAT-related FFNT motifs, Cell Reports 33(10).
- Lohman, E.D.; Duijster, J.; Koerkamp, B.G.; Post, R. van der; Franz, E.; Gras, L.M. & Reuver, P. de (2020), Severe salmonella spp. or campylobacter spp. infection and the risk of biliary tract cancer, Cancers 12(11).
- Schurink, B.; Roos, E.; Radonic, T.; Barbe, E.; Bouman, C.S.C.; Boer, H.H. de; Bree, G.J. de; Bulle, E.B.; Aronica, E.M.; Florquin, S.; Fronczek, J.; Heunks, L.M.A.; Jong, M.D. de; Guo, L.H.; Long, R. du; Lutter, R.; Molenaar, P.C.G.; Neefjes-Borst, E.A.; Niessen, H.W.M.; Noesel, C.J.M. van; Roelofs, J.J.T.H.; Snijder, P.E.J.; Soer, E.C.; Verheij, J.; Vlaar, A.P.J.; Vos, W.; Wel, N.N. van der; Wal, A.C. van der; Valk, P. van der & Bugiani, M. (2020), Viral presence and immunopathology in patients with lethal COVID-19, The Lancet Microbe 1(7): E290-E299.
- Janssen A.P.A., Grimm S.H., Wijdeven R.H.M., Lenselink E.B., Neefjes J.J.C., Boeckel C.A.A. van, Westen G.J.P. van & Stelt M. van der (2019), Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome-Inhibitor Interaction Landscapes, Journal of Chemical Information and Modeling 59(3): 1221-1229.
- Sapmaz, A.; Berlin, I.; Bos, E.; Wijdeven, R.H.; Janssen, H.; Konietzny, R.; Akkermans, J.J.; Erson-Bensan, A.E.; Koning, R.I.; Kessler, B.M.; Neefjes, J. & Ovaa, H. (2019), USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7, Nature Communications 10.
- Perrin, P.; Jongsma, M.L.M.; Neefjes, J. & Berlin, I. (2019), The labyrinth unfolds: architectural rearrangements of the endolysosomal system in antigen-presenting cells, Current Opinion in Immunology 58: 1-8.
- Duijster, J.W.; Franz, E.; Neefjes, J.J.C. & Mughini-Gras, L. (2019), Occupational risk of salmonellosis and campylobacteriosis: a nationwide population-based registry study, Occupational and Environmental Medicine 76(9): 617-624.
- Spits, M.; Janssen, L.J.; Voortman, L.M.; Kooij, R.; Neefjes, A.C.M.; Ovaa, H. & Neefjes, J. (2019), Homeostasis of soluble proteins and the proteasome post nuclear envelope reformation in mitosis, Journal of Cell Science 132(10).
- Logtenberg, M.E.W.; Jansen, J.H.M.; Raaben, M.; Toebes, M.; Franke, K.; Brandsma, A.M.; Matlung, H.L.; Fauster, A.; Gomez-Eerland, R.; Bakker, N.A.M.; Schot, S. van der; Marijt, K.A.; Verdoes, M.; Haanen, J.B.A.G.; Berg, J.H. van den; Neefjes, J.; Berg, T.K. van den; Brummelkamp, T.R.; Leusen, J.H.W.; Scheeren, F.A. & Schumacher, T.N. (2019), Glutaminyl cyclase is an enzymatic modifier of the CD47-SIRP alpha axis and a target for cancer immunotherapy, Nature Medicine 25(4): 612-+.
- Janssen, A.P.A.; Grimm, S.H.; Wijdeven, R.H.M.; Lenselink, E.B.; Neefjes, J.; Boeckel, C.A.A. van; Westen, G.J.P. van & Stelt, M. van der (2019), Drug Discovery Maps, a Machine Learning Model That Visualizes and Predicts Kinome-Ilnhibitor Interaction Landscapes, Journal of Chemical Information and Modeling 59(3): 1221-1229.
- Grimm, S.H.; Gagestein, B.; Keijzer, J.F.; Liu, N.; Wijdeven, R.H.; Lenselink, E.B.; Tuin, A.W.; Nieuwendijk, A.M.C.H. van den; Westen, G.J.P. van; Boeckel, C.A.A. van; Overkleeft, H.S.; Neefjes, J. & Stelt, M. van der (2019), Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors, Bioorganic and Medicinal Chemistry 27(5): 692-699.
- Berner, F.; Bomze, D.; Diem, S.; Ali, O.H.; Fassler, M.; Ring, S.; Niederer, R.; Ackermann, C.J.; Baumgaertner, P.; Pikor, N.; Cruz, C.G.; Veen, W. van de; Akdis, M.; Nikolaev, S.; Laubli, H.; Zippelius, A.; Hartmann, F.; Cheng, H.W.; Honger, G.; Recher, M.; Goldman, J.; Cozzi, A.; Fruk, M.; Neefjes, J.; Driessen, C.; Ludewig, B.; Hegazy, A.N.; Jochum, W.; Speiser, D.E. & Flatz, L. (2019), Association of Checkpoint Inhibitor-Induced Toxic Effects With Shared Cancer and Tissue Antigens in Non-Small Cell Lung Cancer, JAMA Oncology 5(7): 1043-1047.
- Mishto, M.; Mansurkhodzhaev, A.; Ying, G.; Bitra, A.; Cordfunke, R.A.; Henze, S.; Paul, D.; Sidney, J.; Urlaub, H.; Neefjes, J.; Sette, A.; Zajonc, D.M. & Liepe, J. (2019), An in silico-in vitro Pipeline Identifying an HLA-A*02:01(+) KRAS G12V(+) Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients, Frontiers in Immunology 10.
- Aslam, M.A.; Alemdehy, M.F.; Pritchard, C.E.J.; Song, J.Y.; Muhaimin, F.I.; Wijdeven, R.H.; Huijbers, I.J.; Neefjes, J. & Jacobs, H. (2019), Towards an understanding of C9orf82 protein/CAAP1 function, PLoS ONE 14(1).
- Loeff, F.C.; Rijs, K.; Egmond, E.H.M. van; Zoutman, W.H.; Qiao, X.H.; Kroes, W.G.M.; Veld, S.A.J.; Griffioen, M.; Vermeer, M.H.; Neefjes, J.; Falkenburg, J.H.F.; Halkes, C.J.M. & Jedema, I. (2019), Loss of the GPI-anchor in B-lymphoblastic leukemia by epigenetic downregulation of PIGH expression, American Journal of Hematology 94(1): 93-102.
- Perrin, P.; Jongsma, M.L.M.; Neefjes, J. & Berlin, I. (2019), The labyrinth unfolds: architectural rearrangements of the endolysosomal system in antigen-presenting cells, Current Opinion in Immunology 58(June 2019).
- Aslam, M.A.; Alemdehy, M.F.; Pritchard, C.E.J.; Song, J.Y.; Muhaimin, F.I.; Wijdeven, R.H.; Huijbers, I.J.; Neefjes, J. & Jacobs, H. (2019), Towards an understanding of C9orf82 protein/CAAP1 function, PLoS ONE 14(1).
- Mishto, M.; Mansurkhodzhaev, A.; Ying, G.; Bitra, A.; Cordfunke, R.A.; Henze, S.; Paul, D.; Sidney, J.; Urlaub, H.; Neefjes, J.; Sette, A.; Zajonc, D.M. & Liepe, J. (2019), An in silico-in vitro Pipeline Identifying an HLA-A*02:01(+) KRAS G12V(+) Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients, Frontiers in Immunology 10.
- Elsland D.M. van, Pujals S., Bakkum T., Bos E., Oikonomeas-Koppasis N., Berlin I., Neefjes J., Meijer A.H., Koster A.J., Albertazzi L. & Kasteren S.I. van (2018), Ultrastructural Imaging of Salmonella-Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens, ChemBioChem 19(16): 1766-1770.
- Kasteren S.I. van, Neefjes J.J.C. & Ovaa H. (2018), Creating molecules that modulate immune responses, Nature Reviews Chemistry 2: 184-193.
- Mughini-Gras, L.; Schaapveld, M.; Kramers, J.; Mooij, S.; Neefjes-Borst, E.A.; Pelt, W. van & Neefjes, J. (2018), Increased colon cancer risk after severe Salmonella infection, PLoS ONE 13(1).
- Lamers, M.; Berlin, I. & Neefjes, J. (2018), Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck, Current Biology 28(2): R83-R86.
- Elsland, D.M. van; Pujals, S.; Bakkum, T.; Bos, E.; Oikonomeas-Koppasis, N.; Berlin, I.; Neefjes, J.; Meijer, A.H.; Koster, A.J.; Albertazzi, L. & Kasteren, S.I. van (2018), Ultrastructural Imaging of Salmonella-Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens, ChemBioChem 19(16): 1766-1770.
- Schunselaar, L.M.; Monkhorst, K.; Noort, V. van der; Wijdeven, R.; Peters, D.; Zwart, W.; Neefjes, J. & Baas, P. (2018), Trophoblast Glycoprotein is Associated With a Favorable Outcome for Mesothelioma and a Target for Antibody Drug Conjugates, Journal of Thoracic Oncology 13(10): 1577-1587.
- Distefano, M.B.; Haugen, L.H.; Wang, Y.; Perdreau-Dahl, H.; Kjos, I.; Jia, D.; Morth, J.P.; Neefjes, J.; Bakke, O. & Progida, C. (2018), TBC1D5 controls the GTPase cycle of Rab7b, Journal of Cell Science 131(17).
- Verweij, F.J.; Bebelman, M.P.; Jimenez, C.R.; Garcia-Vallejo, J.J.; Janssen, H.; Neefjes, J.; Knol, J.C.; Goeij-de Haas, R. de; Piersma, S.R.; Baglio, S.R.; Verhage, M.; Middeldorp, J.M.; Zomer, A.; Rheenen, J. van; Coppolino, M.G.; Hurbain, I.; Raposo, G.; Smit, M.J.; Toonen, R.F.G.; Niel, G. van & Pegtel, D.M. (2018), Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling, Journal of Cell Biology 217(3): 1129-1142.
- Cabukusta, B. & Neefjes, J. (2018), Mechanisms of lysosomal positioning and movement, Traffic 19(10): 761-769.
- Schunselaar, L.M.; Quispel-Janssen, J.M.M.F.; Kim, Y.; Alifrangis, C.; Zwart, W.; Baas, P. & Neefjes, J. (2018), Chemical Profiling of Primary Mesothelioma Cultures Defines Subtypes with Different Expression Profiles and Clinical Responses, Clinical Cancer Research 24(7): 1761-1770.
- Wijdeven, R.H.; Luijn, M.M. van; Wierenga-Wolf, A.F.; Akkermans, J.J.; Elsen, P.J. van den; Hintzen, R.Q. & Neefjes, J. (2018), Chemical and genetic control of IFN gamma-induced MHCII expression, EMBO Reports 19(9).
- Elsland, D. van & Neefjes, J. (2018), Bacterial infections and cancer, EMBO Reports 19(11).
- Luimstra, J.J.; Garstka, M.A.; Roex, M.C.J.; Redeker, A.; Janssen, G.M.C.; Veelen, P.A. van; Arens, R.; Falkenburg, J.H.F.; Neefjes, J. & Ovaa, H. (2018), A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells, Journal of Experimental Medicine 215(5): 1493-1504.
- Kasteren, S.I. van; Neefjes, J. & Ovaa, H. (2018), Creating molecules that modulate immune responses, Nature Reviews Chemistry 2(8): 184-193.
- Mulder, M.P.C.; Merkx, R.; Witting, K.F.; Hameed, D.S.; Atmioui, D. el; Lelieveld, L.; Liebelt, F.; Neefjes, J.; Berlin, I.; Vertegaal, A.C.O. & Ovaa, H. (2018), Total Chemical Synthesis of SUMO and SUMO-Based Probes for Profiling the Activity of SUMO-Specific Proteases, Angewandte Chemie International Edition 57(29): 8958-8962.
- Bonifacino, J.S. & Neefjes, J. (2017), Moving and positioning the endolysosomal system, Current Opinion in Cell Biology 47: 1-8.
- Dohmen, A.J.C.; Qiao, X.H.; Duursma, A.; Wijdeven, R.H.; Lieftink, C.; Hageman, F.; Morris, B.; Halonen, P.; Vens, C.; Brekel, M.W.M. van den; Ovaa, H.; Neefjes, J. & Zuur, C.L. (2017), Identification of a novel ATM inhibitor with cancer cell specific radiosensitization activity, Oncotarget 8(43): 73925-73937.
- Bakker, J.; Spits, M.; Neefjes, J. & Berlin, I. (2017), The EGFR odyssey - from activation to destruction in space and time, Journal of Cell Science 130(24): 4087-4096.
- Gagnaire, A.; Nadel, B.; Raoult, D.; Neefjes, J. & Gorvel, J.P. (2017), Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer, Nature Reviews Microbiology 15(2): 109-128.
- Neefjes, J.; Jongsma, M.M.L. & Berlin, I. (2017), Stop or Go? Endosome Positioning in the Establishment of Compartment Architecture, Dynamics, and Function, Trends in Cell Biology 27(8): 580-594.
- Jongsma, M.L.M.; Berlin, I.; Wijdeven, R.H.M.; Janssen, L.; Janssen, G.M.C.; Garstka, M.A.; Janssen, H.; Mensink, M.; Veelen, P.A. van; Spaapen, R.M. & Neefjes, J. (2016), An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport, Cell 166(1): 152-166.
- Mulder, M.P.C.; Witting, K.; Berlin, I.; Pruneda, J.N.; Wu, K.P.; Chang, J.G.; Merkx, R.; Bialas, J.; Groettrup, M.; Vertegaal, A.C.O.; Schulman, B.A.; Komander, D.; Neefjes, J.; Oualid, F. el & Ovaa, H. (2016), A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes, Nature Chemical Biology 12(7): 523-+.
- Wijdeven, R.H.; Janssen, H.; Nahidiazar, L.; Janssen, L.; Jalink, K.; Berlin, I. & Neefjes, J. (2016), Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway, Nature Communications 7.
- Spits, M. & Neefjes, J. (2016), Immunoproteasomes and immunotherapy-a smoking gun for lung cancer?, Journal of thoracic disease 8(7): E558-E563.
- Wijdeven, R.H.; Pang, B.X.; Assaraf, Y.G. & Neefjes, J. (2016), Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics, Drug Resistance Updates 28: 65-81.
- Stolze, S.C.; Liu, N.; Wijdeven, R.H.; Tuin, A.W.; Nieuwendijk, A.M.C.H. van den; Florea, B.I.; Stelt, M. van der; Marel, G.A. van der; Neefjes, J.J. & Overkleeft, H.S. (2016), Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes, Molecular BioSystems 12(6): 1809-1817.
- Rock, K.L.; Reits, E. & Neefjes, J. (2016), Present Yourself! By MHC Class I and MHC Class II Molecules, Trends in Immunology 37(11): 724-737.
- Unanue, E.R.; Turk, V.; Neefjes, J.; Littman, D.R. & Yokoyama, W.M. (2016), Variations in MHC Class II Antigen Processing and Presentation in Health and Disease, Annual Review of Immunology 34: 265-297.
- Garstka, M.A.; Fish, A.; Celie, P.H.N.; Joosten, R.P.; Janssen, G.M.C.; Berlin, I.; Hoppes, R.; Stadnik, M.; Janssen, L.; Ovaa, H.; Veelen, P.A. van; Perrakis, A. & Neefjes, J. (2015), The first step of peptide selection in antigen presentation by MHC class I molecules, Proceedings of the National Academy of Sciences 112(5): 1505-1510.
- Spaapen, R.M.; Blomen, V.; Veelen, P.A. van; Jongsma, M.L.; Schrikkema, B.; Heijden, T. van der; Janssen, L.; Janssen, G.M.C.; Raaben, M.; Schumacher, T.; Brummelkamp, T.R. & Neefjes, J. (2015), Identification of novel essential regulators in the MHC class I network, Molecular Immunology 68(2): 143-143.
- Kasteren S.I. van, Overkleeft H.S., Ovaa H. & Neefjes J.J.C. (2014), Chemical biology of antigen presentation by MHC molecules, Current Opinion in Immunology 26: 21-31.
- Ekkebus R., Kasteren S.I. van, Kulathu Y., Scholten A., Berlin I., Geurink P.P., Jong A. de, Goerdayal S., Neefjes J.J.C., Heck A.J.R., Komander D. & Ovaa H. (2013), On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases, Journal of the American Chemical Society 135(8): 2867-2870.
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- Kuijl C., Tuin A.W., Overkleeft H.S. & Neefjes J.J.C. (2008), Reciprocal chemical genetics for swift lead and target identification, Molecular Biosystems 4(10): 1001-1008.
- Koppers-Lalic D, Verweij MC, Lipinska AD, Wang Y, Quinten E, Reits EA, Koch J, Loch S, Rezende MM, Daus F, Bienkowska-Szewczyk K, Osterrieder N, Mettenleiter TC, Heemskerk MHM, Tampe R, Neefjes JJ, Chowdhury SI, Ressing ME, Rijsewijk FAM & Wiertz EJHJ (2008), Varicellovirus UL49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP, PLoS Pathogens 4(5).
- Kuijl C., Savage N.D.L., Marsman M., Tuin A.W., Janssen L., Egan D.A., Ketema M., Nieuwendijk A.M.C.H. van den, Eeden S.J.F. van den, Geluk A., Poot A., Marel G.A. van der, Beijersbergen R.L., Overkleeft H.S., Ottenhoff T.H.M. & Neefjes J.J. (2007), Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1, Nature 450: 725-730.
- Berkers C.R., Leeuwen F.W. van, Groothuis T.A., Peperzak V., Tilburg E.W. van, Borst J., Neefjes J.J.C. & Ovaa H. (2007), Profiling proteasome activity in tissue with fluorescent probes, Molecular Pharmaceutics 4(5): 739-748.
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