Roxanne Kieltyka
Associate professor
- Name
- Dr. R.E. Kieltyka
- Telephone
- +31 71 527 4441
- r.e.kieltyka@chem.leidenuniv.nl
- ORCID iD
- 0000-0001-9152-1810
Roxanne Kieltyka focuses her research on the design, synthesis and use of supramolecular biomaterials. Her goal is to synthetically replicate cell-specific microenvironments within them to instruct cellular behaviour in development and disease.
More information about Roxanne Kieltyka
PhD candidates
News
-
ERC Starting Grant for Roxanne Kieltyka: stem cells in gels -
Five ERC Starting Grants for young researchers from Leiden -
EU awards COFUND grant for 18 Post-docs working on the Origin and Evolution of Life -
Roxanne Kieltyka in NRC: 'My dream is a gel for every cell' -
Roxanne Kieltyka interviewed by Leidsch Dagblad -
Roxanne Kieltyka interviewed by Nemo Kennislink -
Roxanne Kieltyka elected as one of Talented 12 in chemistry -
DNA as a supramolecular building block
Curriculum Vitae
Personal information
Nationality: Canadian
Education
2009 PhD, Faculty of Chemistry, McGill University, Canada
Thesis title: ‘Platinum-based DNA binding agents as telomerase inhibitors and cancer therapeutics’
Advisor: Prof. Dr. Hanadi Sleiman
2003 BSc in Materials Chemistry, Faculty of Chemistry, University of Toronto, Canada
Current and previous research positions
2021 – now Associate Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2013 – 2021 Tenure track Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
2009 – 2012 Postdoctoral Researcher, Eindhoven University of Technology, The Netherlands (Prof. E.W. Meijer)
Grants, awards, recognitions since 2010
2014 NWO-CW ECHO-STIP grant (k€ 260)
2012 NWO-CW Veni grant (k€ 250)
Contribution to teaching and supervision
Two courses developed for MSc Chemistry and MSc Life Science and Technology: Biomaterials and Supramolecular Chemistry.
Participated in educational outreach activities: University Pre-Class and Junior Science Lab.
Supervision of 5 PhD students since 2013. Current employment of recent PhD students; Willem Noteborn, Postdoctoral researcher at Leiden University Medical Center; Victorio Saez Talens, Investigator at ITENE, ES.
Other responsibilities since 2010
- Symposium organizer 255th ACS National Meeting-POLY Division “International Symposium on Biorelated Polymers: Innovation in Biomedical Polymers”, New Orleans, LA, USA (2018)
- Symposium organizer 253rd ACS National Meeting-POLY Division “Structure to function in Supramolecular Polymer Materials” San Francisco, CA, USA (2017)
- Committee member VVViO, Vereniging voor Vernieuwingsimpuls Onderzoekers (organization for personal grant holders) (2017-present)
- Committee member LST Education, Leiden Institute of Chemistry (2017-present)
- Guest editor of Macromolecular Rapid Communications (special issue on Supramolecular polymers) (2017)
- Scientific Panel Member FWO-Vlaanderen - SBW&T40: Organic chemistry for the evaluation of the new applications for Doctoral (PhD) grant strategic basic research (SB) (2016-Present)
- Proposal reviewer NWO, VENI-CW (2016)
- Meeting organizer NextGenChem@NL, Leiden University (2015)
- Reviewer for Angewandte Chemie, Advanced Functional Materials, ACS Biomacromolecules, Advanced Healthcare Materials, Small, Scientific Reports, Langmuir, ACS Applied Materials and Interfaces, among others (2012-Present)
Publication record including five recent representative publications
21 papers with >670 citations, H-index 10
Full publication record: ResearcherID, Google Scholar or Leiden University
- Noteborn W.E.M., Zwagerman D.N.H., Saez Talens V., Maity C., van der Mee L, Poolman J.M., Mytnyk S., van Esch J.H., Kros A., Eelkema R., Kieltyka R.E., Crosslinker-induced effects on the gelation pathway of a low molecular weight hydrogel. Adv. Mater. 2017, 29, 1603769.
- Noteborn W.E.M., Saez Talens V., Kieltyka R.E., Reversible loading of nanoscale components on a supramolecular polymer fiber by DNA-strand displacement. ChemBioChem 2017, 18, 1995.
- Lopez Mora N.F., Gao Y., Gertrude Gutierrez M., Peruzzi J., Bakker I., Peters R., Siewert B., Bonnet S., Kieltyka R.E.*, van Hest J.C.M., Malmstadt N., Kros A., Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their encapsulation of polymersomes. Soft Matter 2017, 13, 5580.
- Saez Talens V., Englebienne P., Trinh T.T., Noteborn W.E.M., Voets I.K., Kieltyka R.E., Aromatic gain in a supramolecular polymer. Angew. Chem. Int. Ed. 2015, 54, 10502-10506.
- Kieltyka R.E., Pape A.C.H., Albertazzi L., Nakano Y., Bastings M.M.C., Voets I.K., Dankers P.Y.W., Meijer E.W, Mesocale modulation of supramolecular ureidopyrimidinone-based poly(ethylene glycol) transient networks in water. JACS. 2013, 30, 11159-11164.
Presentations including five presentations at international conferences since 2010
- Probing hydrogen-bond aromaticity coupling in squaramide-based supramolecular polymers. 253rd ACS national meeting, Supramolecular polymers: from advanced structure to functionality, April 2017, San Diego, CA, USA.
- Balancing structure and function in low molecular weight gelator materials synthesized under catalytic control. 252nd ACS national meeting, Symposium on Advanced Functional Biopolymers & Biomaterials, August 2016, Philadelphia, Pennsylvania, PA, USA.
- Hydrogen-bond aromaticity coupling in supramolecular polymers. 251st ACS national meeting, Supramolecular polymers: from advanced structure to functionality, March 2016, San Diego, CA, USA.
- Aromatic gain as a driving force for supramolecular polymerization. 2015 International chemical congress of pacific basin societies (Pacifichem), December 2015, Honolulu, HI, USA.
- Aromatic gain in a supramolecular polymer. IUPAC 11th International conference on advanced polymers via macromolecular engineering (APME), October 2015, Tokyo, Japan.
Associate professor
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- Janssen M.L., Liu T., Özel M., Bril M., Thelu H.V.P. & Kieltyka R.E. (2024), Dynamic exchange in 3D cell culture hydrogels based on crosslinking of cyclic thiosulfinates, Angewandte Chemie (International Edition) 63(6): e202314738.
- Noteborn W.E.M., Vittala S.K., Torredemer M.B., Maity C., Versluis F., Eelkema R. & Kieltyka R.E. (2023), Switching the mode of drug release from a reaction-coupled low-molecular-weight gelator system by altering its reaction pathway, Biomacromolecules 24(1): 377-386.
- Zhang X., Liu T., Boyle A.L., Bahreman A., Bao L., Jing Q., Xue H., Kieltyka R.E., Kros A., Schneider G.F. & Fu W. (2022), Dielectric-modulated biosensing with ultrahigh-frequency-operated graphene field-effect transistors, Advanced Materials 34(7): 2106666.
- Tong. C., Wondergem A.J., Brink M. van den, Kwakernaak M.C., Chen Y., Hendrix M.M.R.M., Voets I.K., Danen E.H.J., Le Dévédec S., Heinrich D.M. & Kieltyka R.E. (2022), Spatial and temporal modulation of cell instructive cues in a filamentous supramolecular biomaterial, ACS Applied Materials and Interfaces 14(15): 17042-17054.
- Zhang X., Liu T., Boyle A.L., Bahreman A., Jing Q., Xue H., Kieltyka R.E., Kros A., Schneider G.F. & Fu W. (2022), Dielectric‐modulated biosensing with ultrahigh‐frequency‐operated graphene field‐effect transistors, Advanced Materials 34(7): 2106666.
- Baker M.B., Bosman A.W., Cox M. A.J., Dankers P.Y.W., Dias A., Jonkheijm P. & Kieltyka R.E. (2022), Supramolecular biomaterials in the Netherlands, Tissue Engineering Part B: Reviews 28(11-12): 511-524.
- Liu T., Berk L. van den, Wondergem J.A.J., Tong C., Kwakernaak M.C., Braak B. ter, Heinrich D., Water B. van de & Kieltyka R.E. (2021), Squaramide‐based supramolecular materials Drive hepG2 spheroid differentiation, Advanced Healthcare Materials 10(11): 2001903.
- Saez Talens V., Arias-Alpizar G., Makurat D.M.M., Davis J., Bussmann J., Kros A. & Kieltyka R.E. (2020), Stab2-mediated clearance of supramolecular polymer nanoparticles in zebrafish embryos, Biomacromolecules 21(3): 1060-1068.
- Tong C., Wondergem J.A.J., Heinrich D. & Kieltyka R.E. (2020), Photopatternable, Branched Polymer Hydrogels Based on Linear Macromonomers for 3D Cell Culture Applications, ACS Macro Letters 9(6): 882-888.
- Saez Talens V., Davis J., Wu C.H., Wen Z., Lauria F., Gupta K., Babu Sai S., Rudge R., Boraghi M., Hagemeijer A., Trinh T., Englebienne P., Voets I.K., Wu J.L. & Kieltyka R.E. (2020), Thiosquaramide-Based Supramolecular Polymers: Aromaticity Gain in a Switched Mode of Self-Assembly, Journal of the American Chemical Society 142(47): 19907-19916.
- Meijer M.S., Saez Talens V., Hilbers M.F., Kieltyka R.E., Brouwer A.M., Natile M.M. & Bonnet S.A. (2019), NIR-Light-Driven Generation of Reactive Oxygen Species Using Ru(II)-Decorated Lipid-Encapsulated Upconverting Nanoparticles, Langmuir 35(37): 12079−12090.
- Talens V.S., Makurat D.M.M., Liu T.X., Dai W., Guibert C., Noteborn W.E.M., Voets I.K. & Kieltyka R.E. (2019), Shape modulation of squaramide-based supramolecular polymer nanoparticles, Polymer Chemistry 10(23): 3146-3153.
- Kieltyka R.E., Matson J.P. & Besenius P. (2018), Structure to Function in Supramolecular Polymers and Materials, Macromolecular Rapid Communications 39(17): 1800574.
- Askes S.H.C., Bossert N., Bussmann J., Talens V.S., Meijer M.S., Kieltyka R.E., Kros A., Bonnet S.A. & Heinrich D.M. (2018), Dynamics of dual-fluorescent polymersomes with durable integrity in living cancer cells and zebrafish embryos, Biomaterials 168: 54-63.
- Noteborn W.E.M., Wondergem A.J., Lurchenko A., Chariyez-Prinz F., Donato D.M., Voets I.K., Heinrich D.M. & Kieltyka R.E. (2018), Grafting from a hybrid DNA-covalent polymer by hybridization chain reaction, Macromolecules 51(14): 5157–5164.
- Noteborn W.E.M., Zwagerman D.N.H., Talens Saez V., Maity C., Van der Mee L., Poolman J.M., Mytnyk S., Van Esch J.H., Kros A., Eelkema R. & Kieltyka R.E. (2017), Crosslinker-Induced Effects on the Gelation Pathway of a Low Molecular Weight Hydrogel, Advanced Materials 29(12): 1603769.
- Noteborn W.E.M., Gao Y., Jesse W.J., Kros A. & Kieltyka R.E. (2017), Dual-Crosslinked Human Serum Albumin Polymer Hydrogels for Affinity-Based Drug Delivery, Macromolecular Materials and Engineering 302(10): 1700243.
- Lopez Mora N.L., Gao Y., Gutierrez M.G., Peruzzi J., Bakker I., Peters R.J.R.W., Siewert B., Bonnet S.A., Kieltyka R.E., Hest J.C.M. van, Malmstadt N. & Kros A. (2017), Evaluation of dextran(ethylene glycol) hydrogel films for giant unilamellar lipid vesicle production and their application for the encapsulation of polymersomes, SOFT MATTER 13(33): 5580-5588.
- Noteborn W.E.M., Saez Talens V. & Kieltyka R.E. (2017), Reversible Loading of Nanoscale Elements on a Multicomponent Supramolecular Polymer System by Using DNA Strand Displacement, ChemBioChem 18(20): 1995-1999.
- Siewert B., Langerman M., Hontani Y., Kennis J.T.M., Rixel V.H.S. van, Limburg B., Siegler M.A., Saez Talens V., Kieltyka R.E. & Bonnet S.A. (2017), Turning on the red phosphorescence of a [Ru(tpy)(bpy)(Cl)]Cl complex by amide substitution: self- aggregation, toxicity, and cellular localization of an emissive ruthenium-based amphiphile, Chemical Communications 53: 11126-11129.
- Bakker M.H., Kieltyka R.E., Albertazzi L. & Dankers P.Y.W. (2016), Modular supramolecular ureidopyrimidinone polymer carriers for intracellular delivery, RSC Advances 2016(6): 110600-110603.
- Saez Talens V., Englebienne P., Trinh T.T., Noteborn W.E.M., Voets I.K. & Kieltyka R.E. (2015), Aromatic Gain in a Supramolecular Polymer, Angewandte Chemie (International Edition) 54(36): 10502-10506.
- López Mora N., Hansen J.S., Gao Y., Ronald A.A., Kieltyka R.E., Malmstadt N. & Kros A. (2014), Preparation of size tunable giant vesicles from cross-linked dextran(ethylene glycol) hydrogels, Chemical Communications 50(16): 1953-1955.
- Pape A.C.H., Bastings M.M.C., Kieltyka R.E., Wyss H.M., Voets I.K., Meijer E.W. & Dankers P.Y.W. (2014), Mesoscale characterization of supramolecular transient networks using SAXS and rheology, International Journal of Molecular Science 15: 1096-1111.
- Bastings M.M.C., Koudstaal S., Kieltyka R.E., Nakano Y., Pape A.C.H., Feyen D.A.M., Van Slochteren F.J., Doevendans P.A., Sluijter J.P.G., Meijer E.W., Chamuleau S.A.J. & Dankers P.Y.W. (2014), A Fast pH-Switchable and Self-Healing Supramolecular Hydrogel Carrier for Guided, Local Catheter Injection in the Infarcted Myocardium, Advanced Healthcare Materials 3(1): 70-78.
- Gao Y., Kieltyka R.E., Jesse W., Norder B., Korobko A.V. & Kros A. (2014), Thiolated human serum albumin cross-linked dextran hydrogels as a macroscale delivery system, 10(27): 4869-4874.
- Kieltyka R., Pape A.C.H., Albertazzi L., Nakano Y., Bastings M.M.C., Voets I.K., Dankers P.Y.W. & Meijer E.W. (2013), Mesoscale Modulation of Supramolecular Ureidopyrimidinone-Based Poly(ethylene glycol) Transient Networks in Water, Journal of the American Chemical Society 135(30): 11159-11164.
- Castor K.J., Mancini J., Fakhoury J., Weill N., Kieltyka R., Englebienne P., Avakyan N., Mittermaier A., Autexier C., Moitessier N. & Sleiman H.F. (2012), Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes, ChemMedChem 7(1): 85-94.
- Kieltyka R.E., Bastings M.M., Almen G.C. van, Besenius P., Kemps E.W. & Dankers P.Y. (2012), Modular synthesis of supramolecular ureidopyrimidinone-peptide conjugates using an oxime ligation strategy, Chemical Communications 48(10): 1452-4.
- Dankers P.Y.W., Hermans T.M., Baughman T.W., Kamikawa Y., Kieltyka R.E., Bastings M.M., Janssen H.M., Sommerdijk N.A., Larsen A., Luyn M.J. van, Bosman A.W., Popa E.R., Fytas G. & Meijer E.W. (2012), Hierarchical formation of supramolecular transient networks in water: a modular injectable delivery system, Advanced Materials 24(20): 2703-9.
- Kieltyka R., Englebienne P., Moitessier N. & Sleiman H. (2010), Quantifying interactions between G-quadruplex DNA and transition-metal complexes, Methods in Molecular Biology 608: 223-55.
- Pierce S.E., Kieltyka R., Sleiman H.F. & Brodbelt J.S. (2009), Evaluation of binding selectivities and affinities of platinum-based quadruplex interactive complexes by electrospray ionization mass spectrometry, Biopolymers 91(4): 233-43.
- Kieltyka R., Fakhoury J., Moitessier N. & Sleiman H.F. (2008), Platinum phenanthroimidazole complexes as G-quadruplex DNA selective binders, Chemistry: a European Journal 14(4): 1145-1154.
- Kieltyka R., Englebienne P., Fakhoury J., Autexier C., Moitessier N. & Sleiman H.F. (2008), A platinum supramolecular square as an effective G-quadruplex binder and telomerase inhibitor, Journal of the American Chemical Society 130(31): 10040-10041.
- Kieltyka R., Moitessier N. & Sleiman H.F. (2007), Platinum metallointercalators to target G-quadruplex structures, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS 24(6): 706-706.