Robin Hartman
Head of emergency services
- Name
- Ing. R.J. Hartman
- Telephone
- +31 623262 122
- r.hartman@science.leidenuniv.nl
- ORCID iD
- 0000-0002-3078-3814
Robin Hartman is technician at the Division of Pharmacology. Since January 2008 Robin has been working at the division of Pharmacology, with a specialization in microsurgery he is assigned to several projects executing preclinical studies.
Since graduating from the Hogeschool Rotterdam & Omstreken in 1997 in Medical Biology, Robin Hartman has started his career as research engineer in Amsterdam. First, he worked at the Laboratory for Experimental Surgery in the Academic Medical Center. Since 2002, he acquired a position at the Netherlands Institute for Neuroscience. The institute is part of the Royal Netherlands Academy for Arts and Sciences. He worked in the group of Prof. Dr. Christiaan Levelt where research molecular mechanisms regulating developmental plasticity of the visual cortex were studied, from cellular- to systems level (website).
Head of emergency services
- Science
- Bedrijfsvoering
- Arbo- en milieudienst
- Puris E., Auriola S., Petralla S., Hartman R., Gynther M., Lange E.C.M. de & Fricker G. (2022), Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model, Neurobiology of Disease 169: 105741.
- Brink W.J. van den, Hartman R.J., Berg D.J. van den, Flik G., Gonzalez-Amoros B., Koopman N., Elassais-Schaap J., Graaf P.H. van der, Hankemeier T. & Lange E.C.M. de (2019), Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain, CPT: Pharmacometrics and Systems Pharmacology 8(2): 107-117.
- Wong Y.C., Ilkova T.I., Wijk R.C. van, Hartman R.J. & Lange E.C.M. de (2018), Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in nonanesthetized rat, European Journal of Pharmaceutical Sciences 111: 514–525.
- Brink W.J. van den, Berg D.J. van den, Bonsel F.E.M., Hartman R.J., Wong Y.C., Graaf P.H. van der & Lange E.C.M. de (2018), Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D2 receptor activation using multi-biomarker pharmacokinetic/pharmacodynamic modelling, British Journal of Pharmacology 175(19): 3832-3843.
- Yamamoto Y., Välitalo P.A., Berg D.J. van den, Hartman R.J., Brink W. van den, Wong Y.C., Huntjens D.R., Proost J.H., Vermeulen A., Krauwinkel W., Bakshi S.D., Aranzana-Climent V., Marchand S., Dahyot-Fizelier C., Couet W., Danhof M., Hasselt J.G.C. van & Lange E.C.M. de (2017), A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations, Pharmaceutical Research 34(2): 333–351.
- Shimizu S., Hoedt S.M. den, Mangas-Sanjuan V., Cristea S., Geuer J.K., Berg D.-J. van den, Hartman R., Bellanti F. & Lange E.C.M. de (2017), Target-Site Investigation for the Plasma Prolactin Response: Mechanism-Based Pharmacokinetic-Pharmacodynamic Analysis of Risperidone and Paliperidone in the Rat, Drug Metabolism and Disposition 45(2): 152-159.
- Kervezee L., Berg D.J. van den, Hartman R.J., Meijer J.H. & Lange E.C.M. de (2017), Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite, European Journal of Pharmaceutical Sciences 109: S122-S130.
- Yamamoto Y., Valitalo P.A.J., Huntjens D.R., Proost J.H., Vermeulen A., Krauwinkel W., Beukers M.W., Berg D.J. van den, Hartman R.J., Wong Y.C., Danhof M., Hasselt J.G.C. van & Lange E.C.M. de (2017), Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model, CPT: Pharmacometrics and Systems Pharmacology 6(11): 765–777.
- Westerhout J., Van den Berg D.J., Hartman R., Danhof M. & De Lange E.C. (2014), Prediction of methotrexate CNS distribution in different species - influence of disease conditions, European Journal of Pharmaceutical Sciences 2014(Jan 22): 0928-0987.
- Rip J., Chen L., Hartman R., Heuvel A. van den, Reijerkerk A., Kregten J. van, Boom B. van der, Appeldoorn C., Boer M. de, Maussang D., Lange E.C. de & Gaillard P.J. (2014), Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood-brain barrier in rats, Journal of Drug Targeting 22(3): .
- Kervezee L., Hartman R.J., Berg D.J. van den, Shimizu S., Yamamoto Y., Meijer J.H. & Lange E.C.M. de (2014), Diurnal variation in P-glycoprotein-mediated transport and cerebrospinal fluid turnover in the brain, AAPS Journal 16(5): 1029-1037.
- Chakravarthy S., Keck T., Roelandse M., Hartman R.J., Jeromin A., Perry S., Hofer S.B., Mrsic-Flogel T. & Levelt C.N. (2008), Cre-dependent expression of multiple transgenes in isolated neurons of the adult forebrain, PLoS ONE 3(8): 3059.
- Heimel J.A., Hartman R.J., Hermans J.M. & Levelt C.N. (2007), Screening mouse vision with intrinsic signal optical imaging, European Journal of Neuroscience 25(3): 795-804.
- Chakravarthy S., Saiepour M.H., Bence M., Perry S., Hartman R.J., Couey J.J., Mansvelder H.D. & Levelt C.N. (2006), Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus, Proceedings of the National Academy of Sciences 103(4): 1071-1076.
- Abrahamse S.L., Runnard Heimel P. van, Hartman R.J., Chamuleau R.A. & Gulik T.M. van (2003), Induction of necrosis and DNA fragmentation during hypothermic preservation of hepatocytes in UW, HTK, and Celsior solutions, Cell Transplantation 12(1): 59-68.
- Straatsburg I.H., Abrahamse S.L., Song S.W., Hartman R.J. & Gulik T.M. van (2002), Evaluation of rat liver apoptotic and necrotic cell death after cold storage using UW, HTK, and Celsior, Transplantation 74(4): 458-464.
- Abrahamse S.L., Kerkhove M.P. van de, Sosef M.N., Hartman R., Chamuleau R.A. & Gulik T.M. van (2002), Treatment of acute liver failure in pigs reduces hepatocyte function in a bioartificial liver support system, International Journal of Artificial Organs 25(10): 966-974.
- Sosef M.N., Abrahamse L.S., Kerkhove M.P. van de, Hartman R.J., Chamuleau R.A. & Gulik T.M. van (2002), Assessment of the AMC-bioartificial liver in the anhepatic pig, Transplantation 73(2): 204-209.