Rianne de Kleine
Assistant professor
- Name
- Dr. R.A. de Kleine
- Telephone
- +31 71 527 5435
- r.a.de.kleine@fsw.leidenuniv.nl
- ORCID iD
- 0000-0002-1040-5517
Rianne de Kleine (PhD thesis “Enhancing exposure therapy for PTSD” (2016)) is Assistant Professor at the Department of Clinical Psychology. Her research focuses on the efficacy of exposure therapy for anxiety-related disorder. She is part of the research team investigating the (cost)effectiveness of three exposure-based treatment strategies for childhood abuse related PTSD (IMPACT study). Furthermore, she investigates enhancement strategies for exposure therapy aimed at reducing speech anxiety, such as testosterone augmentation (together with the Radboud University and NijCare) and neurostimulation (Leiden University/LUBEC). In 2019 she was awarded a NWO-VENI scholarship for the project: Optimizing Exposure Therapy for PTSD. In this project different enhancement strategies will be tested to optimize inhibitory learning during exposure. This study will be completed in collaboration with PsyQ Psychotrauma unit The Hague and LUBEC.
Rianne de Kleine has been involved in the teaching of several bachelor’s and master’s level courses. Currently, she supervises students for their Master theses.
Besides her work at Leiden University, Rianne de Kleine works as a counseling psychologist at Parnassia Group/PsyQ and is in training to become a licensed health-care psychologist.
PhD Supervision
- Chris Hoeboer: Moderators and Mediators of Trauma Focused Treatment (Leiden University; 2017-2021)
- Moniek Hutschemaekers: Testosterone as an enhancer of exposure efficacy (Radboud University; 2017-2023)
- Marike Kooistra: Optimizing Exposure Therapy for Posttraumatic Stress Disorder (Leiden University, 2020-2024)
Assistant professor
- Faculteit der Sociale Wetenschappen
- Instituut Psychologie
- Klinische Psychologie
Researcher
- Faculteit der Sociale Wetenschappen
- Instituut Psychologie
- Klinische Psychologie
- Hoeber C.M. Kullberg M.-L.J. Oprel D.A.C. Schoorl M. Van Minnen A. Antypa N. Mouthaan J. De Kleine R.A. Van der Does A.J.W. (2024), Impact of three variants of prolonged exposure therapy on comorbid diagnoses in patients with childhood abuse-related PTSD, Cognitive Behaviour Therapy : .
- Oprel D.A.C., Hoeboer C.M., Schoorl S.M.D., Kleine R.A. de, Does A.J.W. van der & Minnen A. van (2024), Working alliance in exposure-based treatments of posttraumatic stress disorder related to childhood abuse, Journal of Consulting and Clinical Psychology 92(7): 399-409.
- Hutschemaekers M. H., de Kleine R. A., Kampman M., Smits J. A. & Roelofs K. (2023), Social avoidance and testosterone enhanced exposure efficacy in women with social anxiety disorder: a pilot investigation, Psychoneuroendocrinology 158: 1-7 (106372).
- De Kleine R., Hutschemaekers M., Hendriks G., Kampman M., Papalini S., Van Minnen A. & Vervliet B. (2023), Impaired action-safety learning and excessive relief during avoidance in patients with anxiety disorders, Journal of Anxiety Disorders 96: 1-9 (102698).
- Kullberg M.L.J., Schoorl S.M.D., Oprel D.A.C., Hoeboer C.M., Smit F., Does A.J.W. van der, Kleine R.A. de, Minnen A. van & Hout W. van den (2023), Exposure-based treatments for childhood abuserelated post-traumatic stress disorder in adults: a health-economic evaluation, European Journal of Psychotraumatology 14(1): 1-11 (2171752).
- Kooistra M.J., Hoeboer C.M., Oprel D.A.C., Schoorl S.M.D., Does A.J.W. van der, Heide J.J. ter, Minnen A. van & Kleine R.A. de (2023), Changes in trauma-related cognitions predict subsequent symptom improvement during prolonged exposure in patients with childhood abuse-related PTSD, Behaviour Research and Therapy 163: 104284.
- Hoeboer C.M., Kleine R.A. de, Molendijk M.L., Schoorl S.M.D., Oprel D.A.C., Mouthaan J., Does A.J.W. van der & Minnen A. van (2022), De invloed van dissociatieve symptomen op de effectiviteit van psychotherapie voor posttraumatische-stressklachten: Een meta-analyse, Gedragstherapie 55: 86-106.
- Oprel D.A.C., Hoeboer C.M., Schoorl S.M.D., Kleine R.A. de Cloitre M. Wigarde I.G., Minnen A. van & Does A.J.W. van der (2021), Effect of prolonged exposure, intensified prolonged exposure and STAIR+prolonged exposure in patients with PTSD related to childhood abuse : a randomized controlled trial, European Journal of Psychotraumatology 12(1): 1-13 (185151).
- Hutschemaekers M.H.M., De Kleine R.A., Hendriks G.J., Kampman M. & Roelofs K. (2021), The enhancing effects of testosterone in exposure treatment for social anxiety disorder: a randomized proof-of-concept trial, Translational Psychiatry 11(1): 432.
- Hoeboer C.M., Kleine R.A. de, Oprel D.A.C., Schoorl S.M.D., Does A.J.W. van der & Minnen A. van (2021), Does complex PTSD predict or moderate treatment outcomes of three variants of exposure therapy?, Journal of Anxiety Disorders 80: 1-8 (102388).
- Hoeboer C.M., Oprel D.A.C., Kleine R.A.D., Schwartz B., Deisenhofer A.-K., Schoorl M., Van Der Does W.A.J., Minnen A. van & Lutz W. (2021), Personalization of treatment for patients with childhood-abuse-related Posttraumatic Stress Disorder, Journal of Clinical Medicine 10(19): 1-15 (4522).
- Hoeboer C.M., Oprel D.A.C., Schoorl M., Does A.J.W. van der, Minnen A. van, Kleine R.A. de & Kooistra M.J. (2021), Temporal relationship between change in subjective distress and PTSD symptom decrease during prolonged exposure therapy for Posttraumatic Stress Disorder, Behavior Therapy : 1-12.
- Hoeboer C.M., Kleine R.A. de, Molendijk M.L., Schoorl S.M.D., Oprel D.A.C., Mouthaan J., Does A.J.W. van der & Minnen A. van (2020), Impact of dissociation on the effectiveness of psychotherapy for post-traumatic stress disorder: meta-analysis, BJ Psych Open 6(3): e53.
- Hutschemaekers M.H.M., Kleine R.A. de, Davis M.L., Kampman M., Smits J.A.J. & Roelofs K. (2020), Endogenous testosterone levels are predictive of symptom reduction with exposure therapy in social anxiety disorder, Psychoneuroendocrinology 115: 104612.
- Kivelä L., Krause-Utz A., Mouthaan J., Schoorl M., Kleine R. de, Elzinga B., Eikelenboom M., Penninx B.W.J.H., Does W. van der & Antypa N. (2019), Longitudinal course of suicidal ideation and predictors of its persistence – A NESDA study, Journal of Affective Disorders 257: 365-375.
- Rosenfield D, Smits J.A.J., Hofmann S.G., Mataix-Cols D., Fernández de la Cruz L., Andersson E., Rück C., Monzani B., Pérez-Vigil A., Frumento P., Davis M., De Kleine R.A., Difede J., Dunlop B.W., Farrell L.J., Geller D., Gerardi M., Guastella A.J., Hendriks G.J., Kushner M.G., Lee F.S., Lenze E.J., Levinson C.A., McConnell H., Jens Plag, Pollack M.H., Resslern J.K., RodebaughT.L., Rothbaum R.O., Storch Eric A., Andreas Ströhle, Tart Candyce D., Tolinz D.F., Minnen Agnes van, Waters Allison M., Weems Carl F., Sabine Wilhelmm, Katarzyna Wykaj, Margaret Altemus, Page Anderson, Judith Cukor, Claudia Finck, Geffken Gary R., Fabian Golfels, Goodman Wayne K., Gutner Cassidy A., Isobel Heyman, Tanja Jovanovic, Adam B. lewin, McNamara Joseph P., Murphy Tanya K., Seth Norrholm, Paul Thuras, Cynthia Turner & Otto M.W. (2019), Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis, Journal of Anxiety Disorders 68: 102149.
- De Kleine R.A., Woud M.L., Ferentzi H., Hendriks G.J., Broekman T., Becker E.S. & Van Minnen A. (2019), Appraisal-based cognitive bias modification in patients with posttraumatic stress disorder: a randomised clinical trial, European Journal of Psychotraumatology 10(1): 1-13.
- Woud M.L., Cwik J., De Kleine R.A., Blackwell S.E. & Margraf J. (2019), Assessing trauma-related, dysfunctional appraisals indirectly by means of a scenario-based approach, Cognitive Therapy and Research 43(1): 185-198.
- De Kleine R.A., Hagenaars M.A. & Van Minnen A. (2018), Tonic Immobility during re-experiencing in Posttraumatic Stress Disorder, Psychiatry Research 270: 1105-1109.
- Oprel D.A.C., Hoeboer C.M., Schoorl S.M.D., De Kleine R.A., Wigard I.G., Cloitre M., Van Minnen A. & Van der Does A.J.W. (2018), Improving treatment for patients with childhood abuse related posttraumatic stress disorder (IMPACT study): protocol for a multicenter randomized trial comparing prolonged exposure with intensified prolonged exposure and phase-based treatment, BMC Psychiatry 18: e385.
- Van Minnen A., Hendriks L., De Kleine R.A., Hendriks G.J., Verhagen M. & De Jongh A. (2018), Therapist rotation: a novel approach for implementation of trauma-focused treatment in PTSD, European Journal of Psychotraumatology 9(1): e1492836.
- Hendriks L., De Kleine R.A., Hendriks G.J., Broekman T.B. & Van Minnen A. (2018), Intensive prolonged exposure therapy for chronic PTSD patients following multiple trauma and multiple treatment attempts, European Journal of Psychotraumatology 9(1): 1-15.
- Van Minnen A., De Kleine R.A. & Hendriks G.J. (2018), PTSS en co-morbiditeit. In: Spinhoven P., Bockting C., Ruhe E. & Spijker J. (Eds.), Comorbiditeit van psychische stoornissen. Utrecht: De Tijdstroom. 115-130.
- Powers M.B., De Kleine R.A. & Smits J.A.J. (2017), Core Mechanisms of Cognitive Behavioral Therapy for Anxiety and Drepression: A Review, The Psychiatric Clinics of North America 40(4): 611-623.
- Hendriks L., De Kleine R.A., Heyvaert M., Becker E.S. & Hendriks G.J. (2017), Intensive Prolonged Exposure Treatment for Adolescent Complex Posttraumatic Stress Disorder: A Single-Trial Design, Journal of Child Psychology and Psychiatry 58(11): 1229-1238.
- De Kleine R.A., Hendriks L., Becker E.S., Broekman T.G. & Van Minnen A. (2017), Harm Expectancy Violation during Exposure therapy for Posttraumatic Stress Disorder, Journal of Anxiety Disorders 49: 48-52.
- Mataix-Cols D., Fernandez de la Cruz L., Monzani B., Rosenfield D., Andersson E., Perez-Vigil A., Frumento P., De Kleine R.A., Difede J., Dunlop B.W., Farrell L.J., Geller D., Gerardi M., Guastella A.J., Hofmann S.G., Hendriks G.J., Kushner M.G., Lee F.S., Lenze E.J., Levinson C.A., McConnell H., Otto M.W., Plag J., Pollack M.H., Ressler K.J., Rodebaugh T.L., Rothbaum B.O., Scheeringa M.S., Siewert-Siegmund A., Smits J.A.J., Storch E.A., Strohle A., Tart C.D., Tolin D.F., Van Minnen A., Waters A.M., Weems C.F., Wilhelm S., Wyka K. Davis, M., Ruck & C. (2017), D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders: A Systematic Review and Meta-analysis, JAMA Psychiatry 74(5): 501-510.
- Van Minnen A., De Kleine R.A.B. & Hendriks L. (2017), Richtlijnen bij moeizaam verlopende exposurebehandelingen van patiënten met een PTSS. In: Keijsers G., Minnen A. van, Verbraak M., Hoogduin K. & Emmelkamp P. (Eds.), Protocollaire Behandelingen van Volwassenen met Psychische Klachten no. 1: Boom uitgevers.. 370-389.
- Hoogduin K., Keijsers G. & De Kleine R.A. (2017), Protocollaire behandeling van patienten met een conversieve fluisterspraak (afonie). In: Keijsers G., Minnen A. van, Verbraak M., Hoogduin K. & Emmelkamp P. (Eds.), Protocollaire Behandelingen van Volwassenen met Psychische Klachten no. 3. Amsterdam: Boom uitgevers. 265-274.
- Hoogduin K., De Kleine R.A., Van Minnen A., Tibben M., Stormink C., Andeweg E. & Roggeveen P. (2017), Protocollaire behandeling van patiënten met een conversiestoornis (functioneel-neurologisch-symptoomstoornis). In: Keijsers G., Minnen A. van, Verbraak M., Hoogduin K. & Emmelkamp P. (Eds.), Protocollaire Behandelingen van Volwassenen met Psychische Klachten. no. 3. Amsterdam: Boom Uitgevers. 283-349.
- Berg D.P.G. van den, Vleugel B.M. van der, Bont P.A.J.M. de, Thijssen G., Roos C. de, Kleine R.A. de, Kraan T., Ising H., Jongh A. de, Minnen A. van & Gaag M. van der (2016), Exposing therapists to trauma-focused treatment in psychosis: Effects on credibility, expected burden, and harm expectancies, European Journal of Psychotraumatology 7(1): e31712.
- Otto M.W., Kredlow M.A., Smits J.A., Hofmann S.G., Tolin D.F., De Kleine R.A., Van Minnen A., Evins A.E. & Pollack M.H. (2016), Enhancement of Psychosocial Treatment With D-Cycloserine: Models, Moderators, and Future Directions, Biological Psychiatry 80(4): 274-283.
- De Kleine R.A., Smits J.A., Hendriks G.J., Becker E.S. & Van Minnen A. (2015), Extinction learning as a moderator of d-cycloserine efficacy for enhancing exposure therapy in posttraumatic stress disorder, Journal of Anxiety Disorders 34: 63-67.
- De Kleine R.., Hendriks G.J., Smits J.A., Broekman T.G. & Van Minnen A. (2014), Prescriptive variables for d-cycloserine augmentation of exposure therapy for posttraumatic stress disorder, Journal of Psychiatric Research 48(1): 40-46.
- De Kleine R.A., Rothbaum B.O. & Van Minnen A. (2013), Pharmacological enhancement of exposure-based treatment in PTSD: A qualitative review, European Journal of Psychotraumatology 4(1): 1-15.
- De Kleine R.A., Hendriks G.J., Kusters W.J., Broekman T.G. & Van Minnen A. (2012), A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder, Biological Psychiatry 71(11): 962-968.
- Hendriks L., De Kleine R.A., Van Rees M., Bult C. & Van Minnen A. (2010), Feasibility of brief intensive exposure therapy for PTSD patients with childhood sexual abuse: a brief clinical report, European Journal of Psychotraumatology 1(1): e5626.