Rian van den Nieuwendijk
Analyst
- Name
- A.M.C.H. van den Nieuwendijk
- Telephone
- +31 71 527 4483
- nieuwend@chem.leidenuniv.nl
More information about Rian van den Nieuwendijk
Rian van den Nieuwendijk (born March 14th, 1963) studied chemistry at the HS Leiden. During an internship (1984 -1985) at the Natural Products group of the Free University in Amsterdam he worked on the synthesis of C19-diterpene alkaloids under the guidance of dr. J.L. van der Baan. After graduation, his first job was found in the Organic Synthesis Research group of Naarden International (nowadays Quest International) working in the pre-development section. (1985 – 1989). In 1989 he made a move to the Biomaterials Research Group of prof. dr. K. de Groot at the Leiden University Medical Center. From 1991 – 2000 he worked in the Bio-organic Reactivity department of dr. J. Brussee and prof. dr. A. van der Gen. In this period research was focussed on the development of new Horner-Wittig reagents and the synthesis and applications of chiral cyanohydrins, with high enantiomeric purity. After a year of outplacement to the Pharmacochemistry group of prof. dr. A.P. IJzerman he joined the Bio-organic Synthesis group of prof. dr. H.S. Overkleeft in July 2001.
Present research is focused on the development of new routes towards deoxy aza-sugars and new PKB inhibitors via the use of nitriles in a Dibal-H reduction – transimination – NaBH4 reduction reaction sequence.
Research interests: Enzymatic- and enantio-selective synthesis of natural products, (unnatural)amino acids, Horner-Wittig reactions, chiral cyanohydrins, ring closing metathesis, proteomics, enzyme inhibitors, protein targeting devices and molecular probes.
Analyst
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Bio-organic Synthesis
- Thaler M., Ofman T.P., Kok K., Heming J.J.A., Moran E., Pickles I., Leijs A.A., Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruijgrok G., Armstrong Z., Salgado-Benvindo C., Ninaber D.K., Snijder E.J., Boeckel C.A.A. van, Artola M., Davies G.J., Overkleeft H.S. & Hemert M.J. van (2024), Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses, ACS Central Science 10(8): 1594-1608.
- Kuo C.L., Su Q., Nieuwendijk A.M.C.H. van den, Beenakker T.J.M., Offen W.A., Willems L.I., Boot R.G., Sarris A.J.C., Rosa Alcalde Marques A.R.A., Codée J.D.C., Marel G.A. van der, Florea B.I., Davies G.J., Overkleeft H.S. & Aerts J.M.F.G. (2023), The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe, Organic and Biomolecular Chemistry 21(38): 7813-7820.
- Chen Y., Nieuwendijk A.M.C.H. van den, Wu L., Moran E., Skoulikopoulou F., Riet V. van, Overkleeft H.S., Davies G.J. & Armstrong Z.W.B. (2023), Molecular basis for inhibition of heparanases and β-glucuronidases by siastatin B, Journal of the American Chemical Society 146(1): 125-133.
- Rowland R.J., Chen Y., Breen I., Wu L., Offen W.A., Beenakker T.J.M., Su Q., Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Artola Perez de Azanza M.E., Overkleeft H.S. & Davies G.J. (2021), Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents, Chemistry: a European Journal 27: 1-13.
- Liu B., Mechelen J. van, Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2019), Synthesis of glycosylated 1-deoxynojirimycins starting from natural and synthetic disaccharides, European Journal of Organic Chemistry 2019(1): 118-129.
- Artola Perez de Azanza M.E., Wouters S., Schröder S.P., Boer C. de, Chen Y., Petracca R., Nieuwendijk A.M.C.H. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2019), Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors, European Journal of Organic Chemistry 2019(6): 1397-1404.
- Rooden E.J. van, Kohsiek M.J.J., Kreekel R., Esbroeck A.C.M. van, Nieuwendijk A.M.C.H. van den, Janssen A.P.A., Berg R.J.B.H.N. van den, Overkleeft H.S. & Stelt M. van der (2018), Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and alpha,beta-Hydrolase Domain Containing Protein 6, Chemistry - An Asian Journal 13(22): 3491-3500.
- Deng H., Kooijman S., Nieuwendijk A.M.C.H. van den, Ogasawara D., Wel T. van der, Dalen F. van, Baggelaar M.P., Janssen F.J., Berg R.J.B.H.N. van der, Dulk J. den, Cravatt B.F., Overkleeft H.S., Rensen P.C. & Stelt M. van der (2017), Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding, Journal of Medicinal Chemistry 60(1): 428-440.
- Deng H., Wel T. van der, Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Janssen F.J., Baggelaar M.P., Overkleeft H.S. & Stelt M. van der (2017), Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-alpha and ABHD6 inhibitors, MEDCHEMCOMM 8(5): 982-988.
- Lahav D., Liu B., Berg R.J.B.H.N. van den, Nieuwendijk A.M.C.H. van den, Wennekes T., Ghisaidoobe A.T., Breen I., Ferraz M.J., Kuo C.L., Wu L., Geurink P.P., Ovaa H., Marel G.A. van der, Stelt M. van der, Boot R.G., Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2017), A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase, Journal of the American Chemical Society 138(40): 14192-14197.
- Stolze S.C., Liu N., Wijdeven R.H., Tuin A.W., Nieuwendijk A.M. van den, Florea B.I., Stelt M. van der, Marel G.A. van der, Neefjes J.J. & Overkleeft H.S. (2016), Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes, Molecular Biosystems 12(6): 1809-1817.
- Ogasawara D., Deng H., Viader A., Baggelaar M.P., Breman A., Dulk H. den, Nieuwendijk A.M.C.H. van den, Soethoudt M., Wel T. van der, Zhou J., Overkleeft H.S., Sanchez-Alavez M., Mori S., Nguyen W., Conti B., Liu X., Chen Y., Liu Q., Cravatt B.F. & Stelt M. van der (2016), Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition, Proceedings of the National Academy of Sciences 113(1): 26-33.
- Nabuurs R.J.A., Kapoerchan V.V., Metaxas A., Hafith S., Backer M. de, Welling M.M., Jiskoot W., Nieuwendijk A.M.C.H. van den, Windhorst A.D., Overkleeft H.S., Buchem M.A. van, Overhand M. & Weerd L. van der (2016), Bis-pyridylethenyl benzene as novel backbone for amyloid-beta binding compounds, Bioorganic & Medicinal Chemistry 24(23): 6139-6148.
- Bruin G. de, Mock E.D., Hoogendoorn S., Nieuwendijk A.M.C.H. van den, Mazurek J., Marel G.A. van der, Florea B.I. & Overkleeft H.S. (2016), Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib, Chemical Communications 52(21): 4064-4067.
- Wisse P., Geus M.A.R. de, Cross G., Nieuwendijk A.M.C.H. van den, Rooden E.J. van, Berg R.J.B.H.N. van den, Aerts J.M.F.G., Marel G.A. van der, Codée J.D.C. & Overkleeft H.S. (2015), Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy, Journal of Organic Chemistry (JOC) 80(14): 7258-65.
- Jiang J., Kallemeijn W.W., Wright D.W., Nieuwendijk A.M.C.H. van den, Coco Rohde V., Folch E.C., Elst H. van den, Florea B.I., Scheij S., Donker-Koopman W.E., Verhoek M., Li N., Schürmann M., Mink D., Boot R.G., Codée J.D.C., Marel G.A. van der, Davies G.J., Aerts J.M.F.G. & Overkleeft H.S. (2015), In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 alpha-L-fucosidases, Chemical Science 6(5): 2782-2789.
- Ghisaidoobe Amar T., Van den Berg Richard J.B.H.N., Butt Saleem S., Strijland Anneke, Donker-Koopman Wilma E., Scheij Saskia, Van den Nieuwendijk Adrianus M.C.H., Koomen Gerrit-Jan, Van Loevezijn Arnold, Leemhuis Mark, Wennekes Tom, Van der Stelt Mario, Van der Marel Gijsbert A., Van Boeckel Constant A.A., Aerts Johannes M.F.G. & Overkleeft Herman S. (2014), Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors, Journal of Medicinal Chemistry 57(21): 9096-9104.
- Ongay Sara, Hermans Jos, Bruins Andries P., Nieuwendijk Adrianus M.C.H., Overkleeft Hermen & Bischoff Rainer (2013), Electron Transfer and Collision Induced Dissociation of Non-Derivatized and Derivatized Desmosine and Isodesmosine, Journal of The American Society for Mass Spectrometry 24(1): 83-91.
- Gillis J., Schipper-Krom S., Juenemann K., Gruber A., Coolen S., Nieuwendijk A.M.C.H. van den, Veen H. van, Overkleeft H.S., Goedhart J., Kampinga H.H. & Reits E.A. (2013), The DNAJB6 and DNAJB8 Protein Chaperones Prevent Intracellular Aggregation of Polyglutamine Peptides, Journal of Biological Chemistry 288(24): 17225-17237.
- Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruben M., Witte M.D., Brussee J., Boot R.G., Marel G.A. van der, Aerts J.M.F.G. & Overkleeft H.S. (2012), Synthesis of Eight 1-Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin, European Journal of Organic Chemistry 2012(18): 3437-3446.
- Witte M.D., Kallemeijn W.W., Aten J., Li K.Y., Strijland A., Donker-Koopman W.E., Nieuwendijk A.M.C.H. van den, Bleijlevens B., Kramer G., Florea B.I., Hooibrink B., Hollak C.E.M., Ottenhoff R., Boot R.G., Marel G.A. van der, Overkleeft H.S. & Aerts J.M.F.G. (2010), Ultrasensitive in situ visualization of active glucocerebrosidase molecules, Nature Chemical Biology 6(12): 907-913.
- Geurink P.P., Liu N., Spaans M.P., Downey S.L., Nieuwendijk A.M.C.H. van der, Marel G.A. van der, Kisselev A.F., Florea B.I. & Overkleeft H.S. (2010), Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome's Chymotrypsin-like Sites, Journal of Medicinal Chemistry 53(5): 2319-2323.
- Nieuwendijk A.M.C.H. van, Ruben M., Engelsma S.E., Risseeuw M.D.P., Berg R.J.B.H.N. van den, Boot R.G., Aerts J.M.F.G., Brussee J., Marel G.A. van der & Overkleeft H.S. (2010), Synthesis of L-altro-1-Deoxynoprimycin, D-allo-1-Deoxynoprimycin, and D-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin, 12(17): 3957-3959.
- Kuijl C., Savage N.D.L., Marsman M., Tuin A.W., Janssen L., Egan D.A., Ketema M., Nieuwendijk A.M.C.H. van den, Eeden S.J.F. van den, Geluk A., Poot A., Marel G.A. van der, Beijersbergen R.L., Overkleeft H.S., Ottenhoff T.H.M. & Neefjes J.J. (2007), Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1, Nature 450: 725-730.
- Vlasie M.D., Comuzzi C., Nieuwendijk A.M.C.H. van den, Prudencio M., Overhand M. & Ubbink M. (2007), Long-range-distance NMR effects in a protein labeled with a lanthanide-DOTA chelate, Chemistry: a European Journal 13(6): 1715-1723.
- Verdoes M., Florea B.I., Linden W.A. van der, Renou D., Nieuwendijk A.M.C.H. van den, Marel G.A. van der & Overkleeft H.S. (2007), Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors, Organic and Biomolecular Chemistry 5(9): 1416-1426.
- Swieten P.F. van, Samuel E., Hernandez R.O., Nieuwendijk A.M.C.H. van den, Leeuwenburgh M.A., Marel G.A. van der, Kessler B.M., Overkleeft H.S. & Kisselev A.F. (2007), A cell-permeable inhilbitor and activity-based probe for the caspase-like activity of the proteasome, Bioorganic and Medicinal Chemistry Letters 17(12): 3402-3405.
- Vlasie M.D., Comuzzi C., Nieuwendijk A.M.C.H. van den, Prudêncio M., Overhand M. & Ubbink M. (2006), Long-range distance NMR effects in a protein labeled with a lanthanide-DOTA chelate, Chemistry: a European Journal : .
- Verdoes M., Florea B.I., Menendez-Benito V., Maynard C.J., Witte M.D., Van der Linden W.A., Van den Nieuwendijk A.M., Hofmann T., Berkers C.R., Van Leeuwen F.W., Groothuis T.A., Leeuwenburgh M.A., Ovaa H., Neefjes J.J., Filippov D.V., Van der Marel G.A., Dantuma N.P. & Overkleeft H.S. (2006), A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo, Chemistry & Biology 13(11): 1217-1226.
- Swieten P.F. van, Maehr R., Nieuwendijk A.M.C.H. van den, Kessler B.M., Reich M., Wong C.S., Kalbacher H., Leeuwenburgh M.A., Driessen C., Marel G.A. van der, Ploegh H.L. & Overkleeft H.S. (2004), Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases, Bioorganic and Medicinal Chemistry Letters 14(12): 3131-3134.
- Nieuwendijk A.M.C.H. van den, Ghisaidoobe A.B.T., Overkleeft H.S., Brussee J. & Gen A. van der (2004), Conversion of chiral unsaturated cyanohydrins into chiral carba- and heterocycles via ring-closing metathesis, Tetrahedron 60(46): 10385-10396.
- Steenis J.H. van, Nieuwendijk A.M.C.H. van den & Gen A. van der (2004), alpha-fluoroacrylonitriles: Horner-Wittig synthesis and conversion into 2-fluoroallylamines and C-(1-fluorovinyl)nitrones, Journal of Fluorine Chemistry 125(1): 107-117.
- Nieuwendijk A.M.C.H. van den, Pietra D., Heitman L.H., Göblyös A. & IJzerman A.P. (2004), Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors, Journal of Medicinal Chemistry 47(3): 663-672.
- Deghati P.Y.F., Borghini A., Nieuwendijk A.M.C.H. van den & Dissen-de Groote M. (2003), Inhibition of nucleoside transport by new analogues of nitrobenzylthioinosine,, Bioorganic & Medicinal Chemistry 11(6): 899-908.
- Deghati P.Y.F., Borghini A., Nieuwendijk A.M.C.H. van den, Dissen-de Groote M. & IJzerman A.P. (2003), Inhibition of nucleoside transport by new analogues of nitrobenzylthioinosine, Bioorganic & Medicinal Chemistry 11(6): 899-908.
- Herk T. van, Brussee J.M., Nieuwendijk A.M.C.H. van den, Klein P.A.M. van der, IJzerman A.P., Stannek C., Burmeister A. & Lorenzen A. (2003), Pyrazole derivatives as partial Agonists for the nicotinic acid receptor, Journal of Medicinal Chemistry 46(18): 3945-3951.
- Ovaa H., Swieten P.F. van, Kessler B.M., Leeuwenburgh M.A., Fiebiger E., Nieuwendijk A.M.C.H. van den, Galardy P.J., Marel G.A. van der, Ploegh H.L. & Overkleeft H.S. (2003), Chemistry in living cells: Detection of active proteasomes by a two-step labeling strategy, Angewandte Chemie (International Edition) 42(31): 3626-3629.
- Herk T. van, Brussee J., Nieuwendijk A.M.C.H. van den, Klein P.A.M. van der, IJzerman A.P., Stannek C., Burmeister A. & Lorenzen A. (2003), Pyrazole derivatives as partial agonists for the nicotinic receptor, Journal of Medicinal Chemistry 46: 3945-3951.
- Herk T. van, Brussee J., Nieuwendijk A.M.C.H. van den, Klein P.A. van der, IJzerman A.P., Stannek C., Burmeister A. & Lorenzen A. (2003), Pyrazole derivatives as partial agonists for the nicotinic acid receptor, Journal of Medicinal Chemistry 46: 3945-3951.
- Ovaa H., Swieten P.F. van, Kessler B.M., Leeuwenburgh M.A., Fiebiger E., Nieuwendijk A.M.C.H. van den, Galardy P.J., Marel G.A. van der, Ploegh H.L. & Overkleeft H.S. (2003), Chemistry in living cells: Detection of active proteasomes by a two-step labeling strategy, Angewandte Chemie - International Edition in English 42: 3626-3629.
- Deghati P.Y.F., Borghini A., Nieuwendijk A.M.C.H. van den, Dissen-de Groote M. & IJzerman A.P. (2002), Inhibition of nucleoside transport by new analogs of nitrobenzylthioinosine, Bioorganic & Medicinal Chemistry 11: 899-908.
- Marcus J., Meurs P.J. van, Nieuwendijk A.M.C.H. van den, Porchet M., Brussee J. & Gen A. van der (2000), Synthesis of γ-hydroxy-α,β-unsaturated esters and nitriles from chiral cyanohydrins, Tetrahedron 56(16): 2491-2495.
- Marcus J., Meurs P.J. van, Nieuwendijk A.M.C.H. van den, Porchet M., Brussee J. & Gen A. van der (2000), Synthesis of gamma-hydroxy-alfa, beta-unsaturated esters and nitriles from chiral cyanohydrins, Tetrahedron 56: 2491-2495.
- Nieuwendijk A.M.C.H. van den, Kriek N.M.A.J., Brussee J., Boom J.H. van & Gen A. van der (2000), Stereoselective synthesis of (2R,5R)- and (2S,5R)-5-hydroxylysine, European Journal of Organic Chemistry 2000(22): 3683-3691.
- Nieuwendijk A.M.C.H. van den, Benningshof J.C.J., Wegman V., Koppele J.M. te, Brussee J. & Gen A. van der (1999), Synthesis of Reduced Collagen Crosslinks, Bioorganic and Medicinal Chemistry Letters 9(12): 1673-1676.