Merei Huigsloot
Head of Education Office
- Name
- Dr. M. Huigsloot
- Telephone
- +31 71 527 6319
- m.huigsloot@lacdr.leidenuniv.nl
Head of Education Office
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Onderwijs
- Bowe R.A., Cox O.T., Ayllón V., Tresse E., Healy N.C., Edmunds S.J., Huigsloot M. & O'Connor R. (2014), PDLIM2 regulates transcription factor activity in epithelial-to-mesenchymal transition via the COP9 signalosome, Molecular Biology of the Cell 25(1): 184-195.
- Voets A.M., Huigsloot M., Lindsey P.J., Leenders A.M., Koopman W.J., Willems P.H., Rodenburg R.J., Smeitink J.A. & Smeets H.J. (2012), Transcriptional changes in OXPHOS complex I deficiency are related to anti-oxidant pathways and could explain the disturbed calcium homeostasis, Biochimica et Biophysica Acta: Molecular Basis of Disease 1822(7): 1161-1168.
- Huigsloot M., Nijtmans L.G., Szklarczyk R., Baars M.J., Van den Brand M.A., Hendriksfranssen M.G., Van den Heuvel L.P., Smeitink J.A., Huynen M.A. & Rodenburg R.J. (2011), A mutation in C2orf64 causes impaired cytochrome c oxidase assembly and mitochondrial cardiomyopathy, American Journal of Human Genetics 88(4): 488-493.
- Jonckheere A.I., Huigsloot M., Lammens M., Jansen J., Van den Heuvel L.P., Spiekerkoetter U., Von Kleist-Retzow J.C., Forkink M., Koopman W.J., Szklarczyk R., Huynen M.A., Fransen J.A., Smeitink J.A. & Rodenburg R.J. (2011), Restoration of complex V deficiency caused by a novel deletion in the human TMEM70 gene normalizes mitochondrial morphology, Mitochondrion 11(6): 954-963.
- Jonckheere A.I., Huigsloot M., Janssen A.J., Kappen A.J., Smeitink J.A. & Rodenburg R.J. (2010), High-throughput assay to measure oxygen consumption in digitonin-permeabilized cells of patients with mitochondrial disorders, Clinical Chemistry 56(3): 424-31.
- Willis J.H., Capaldi R.A., Huigsloot M., Rodenburg R.J., Smeitink J. & Marusich M.F. (2009), Isolated deficiencies of OXPHOS complexes I and IV are identified accurately and quickly by simple enzyme activity immunocapture assays, Biochimica et Biophysica Acta. Bioenergetics 1787(5): 533-538.
- Kruse J.J., Svensson J.P., Huigsloot M., Giphart-Gassler M., Schoonen W.G., Polman J.E., Jean Horbach G., Water B. van de & Vrieling H. (2007), A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 617(1-2): 58-70.
- Nimwegen M.J. van, Huigsloot M., Camier A., Tijdens R.B. & Water B. van de (2006), Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells, Molecular Pharmacology 70(4): 1330-1339.
- Loughran G., Healy N.C., Kiely P.A., Huigsloot M., Kedersha N.L. & O'Connor R. (2005), Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth, Molecular Biology of the Cell 16(4): 1811-1822.
- Loughran G., Huigsloot M., Kiely P.A., Smith L.M., Floyd S., Ayllon V. & O'Connor R. (2005), Gene expression profiles in cells transformed by overexpression of the IGF-I receptor, Oncogene 24(40): 6185-6193.
- Huigsloot M., Tijdens R.B. & Water B. van de (2003), Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2, Molecular Pharmacology 64(4): 965-973.
- Huigsloot M., Tijdens R.B., Mulder G.J. & Water B. van de (2002), Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary (MTLn3) cells, Journal of Biological Chemistry 277(39): 35869-35879.
- Huigsloot M., Tijdens R.B., Mulder G.J. & Water B. van de (2001), Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells, Biochemical Pharmacology 62(8): 1087-1097.
- Water B. van de, Houtepen F., Huigsloot M. & Tijdens R.B. (2001), Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury, Journal of Biological Chemistry 276(39): 36183-36193.
- Water B. van de, Tijdens R.B., Verbrugge A., Huigsloot M., Dihal A.A., Stevens J.L., Jaken S. & Mulder G.J. (2000), Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells, Journal of Biological Chemistry 275(33): 25805-25813.
- Hackeng C.M., Huigsloot M., Pladet M.W., Nieuwenhuis H.K., Rijn H.J. van & Akkerman J.W. (1999), Low-density lipoprotein enhances platelet secretion via Integrin-αIIbβ3–Mediated Signaling, Arteriosclerosis, Thrombosis, and Vascular Biology 19(2): 239-247.