Meindert Danhof
Professor emeritus of Pharmacology
- Name
- Prof.dr. M. Danhof
- Telephone
- +31 71 527 6351
- m.danhof@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-2319-6830
Meindert Danhof (Prof. Dr.) is professor at the Division of Pharmacology.
More information about Meindert Danhof
News
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Prestigious award for pharmacologist Meindert Danhof -
‘Take medicine target saturation into account’ -
Founding father of pharmacological models -
Pharmaceutical World Congress. An interview with its chair: Prof. dr. Meindert Danhof -
Winning the 2016 Pharmaceutical Research Meritorious Manuscript Award -
25 Years Bio-Pharmaceutical Sciences: Combined fascination
Professor Danhof studied Pharmacy at Groningen University and received his Pharm D in 1976. His PhD was obtained from Leiden University in 1980 under the direction of Professor D.D. Breimer. From 1980-1983, he was a post-doctoral research fellow with Professor G. Levy, in the Department of Pharmaceutics, State University of New York at Buffalo, USA. He received further specialist training in clinical pharmacology as a visiting scientist at Stanford University Medical center between 1983-1986. Professor Danhof’s research interest is in the development of new theoretical concepts in pharmacokinetic-pharmacodynamic [PKPD] modeling.
In recent years, important contributions in his research have been on the incorporation of i] receptor theory and ii] dynamical systems analysis. This has resulted in a new class of ‘mechanism-based’ PKPD models with considerably improved properties for extrapolation and prediction. His most recent research focuses on the development of novel concepts of ‘disease system analysis’. Meindert Danhof has an active interest in the dissemination of PKPD modeling concepts through the organization of international conferences, workshops and courses.
He is the Founder and Chairman of the series of international conferences ‘Measurement and Kinetics of In Vivo Drug Effects’ in Noordwijkerhout, the Netherlands in 1990, 1994, 1998, 2002, 2006, 2010 and 2014. In 1998, he has established LAP&P Consultants BV, which provides a professional infrastructure for consultancy services in the area of advanced PKPD modeling to the pharmaceutical industry, including actual data-analysis and clinical trial simulation. In 2007, he was the founder of the ‘TIPharma mechanism-based PKPD modeling platform’, which aims at the development of a mechanism-based PKPD model library and database for application in drug discovery and development.
Meindert Danhof is professor of pharmacology in both the Faculty of Science and the Faculty of Medicine and was Scientific Director of the Leiden Academic Centre for Drug Research between 2005 and 2013. He is the Immediate Past President of the European Federation of Pharmaceutical Sciences (EUFEPS) and President of the 6th FIP Pharmaceutical Sciences World Congress (PSWC) on May 21-24 in Stockholm, Sweden.
Meindert Danhof has been a Fellow of the American Association of Pharmaceutical Sciences (AAPS) since 1998. In 1993, he received the Organon Research Prize for his contributions to research on PKPD relationships and in 1997 the ‘FIP Pharmaceutical Scientist of the Year Award’ at the 57th World Congress of Pharmacy and Pharmaceutical Sciences in Vancouver, Canada. In 2004, he received the Rawls Palmer Award at the 105th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics in Miami, USA, and in 2006 he received the ‘New Safe Medicines Faster Award’ of the European Federation of Pharmaceutical Sciences.
In 2009 he was the recipient of the Distinguished Scientist Award of the American College of Clinical Pharmacology (ACCP) and in 2010 he received the Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolism of the American Association of Pharmaceutical Sciences (AAPS)
Meindert Danhof currently supervises the following PhD candidates:
- Wilbert de Witte
- Vincent Dubois
- Yumi Yamamoto
- Sven van Dijkman
- Eline van Maanen
Professor emeritus of Pharmacology
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Pharmacology
- Faculteit Geneeskunde
- Divisie 4
- Klinische Farmacie en Toxicologie
- Danhof M., Graaf P.H. van der, Post T.M., Visser S.A.G., Zuideveld K.P. & Schmidt S. (2024), In memoriam Lambertus (“Bert”) A. Peletier 29 March 1937–16 December 2023: furthering quantitative pharmacology through applied mathematics, CPT: Pharmacometrics & Systems Pharmacology 13(10): 1611-1614.
- Brussee J.M., Krekels E.H.J., Calvier E.A.M., Palic S., Rostami-Hodjegan A., Danhof M., Barrett J.S., Wildt S.N. de & Knibbe C.A.J. (2019), A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children, AAPS Journal 21(5): 81.
- Blussé van Oud-Alblas H.J., Brill M.J.E., Peeters M.Y.M., Tibboel D., Danhof M. & Knibbe C.A.J. (2019), Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints, BMC Anesthesiology 19: 15.
- Witte W.E.A. de, Danhof M., Graaf P.H. van der & Lange E.C.M. de (2019), The implications of target saturation for the use of drug-target residence time, Nature Reviews Drug Discovery 18(1): 82-84.
- Calvier E.A.M., Krekels E.H.J., Yu H., Välitalo P.A.J., Johnson T.N., Rostami-Hodjegan A., Tibboel D., Graaf P.H. van der, Danhof M. & Knibbe C.A.J. (2018), Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments, CPT: Pharmacometrics and Systems Pharmacology 7(3): 175-185.
- Witte W.E.A. de, Rottschäfer V., Danhof M., Graaf P.H. van der, Peletier L.A. & Lange E.C.M. de (2018), Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models, Journal of Pharmacokinetics and Pharmacodynamics 45(4): 621-635.
- Witte W.E.A. de, Rottschäfer V., Danhof M., Graaf P.H. van der, Peletier L.A. & Lange E.C.M. de (2018), Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models, Journal of Pharmacokinetics and Pharmacodynamics 45(5): 763.
- Wite W.E.A. de, Versfelt J.W., Kuzikov M., Rolland S., Georgi V., Gribbon P., Gul S., Huntjens D., Graaf P.H. van der, Danhof M., Fernández-Montalván A., Witt G. & Lange E.C.M. de (2018), In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations, British Journal of Pharmacology 175(21): 4121-4136.
- Yamamoto Y., Välitalo P.A., Wong Y.C., Huntjens D.R., Proost J.H., Vermeulen A., Krauwinkel W., Beukers M.W., Kokki H., Kokki M., Danhof M., Hasselt J.G.C. van & Lange E.C.M. de (2018), Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach, European Journal of Pharmaceutical Sciences 112: 168-179.
- Calvier E.A.M., Krekels E.H.J., Välitalo P.A.J., Rostami-Hodjegan A., Tibboel D., Danhof M. & Knibbe C.A.J. (2017), Allometric Scaling of Clearance in Paediatric Patients: When Does the Magic of 0.75 Fade?, Clinical Pharmacokinetics 56(3): 273-285.
- Yamamoto Y., Välitalo P.A., Berg D.J. van den, Hartman R.J., Brink W. van den, Wong Y.C., Huntjens D.R., Proost J.H., Vermeulen A., Krauwinkel W., Bakshi S.D., Aranzana-Climent V., Marchand S., Dahyot-Fizelier C., Couet W., Danhof M., Hasselt J.G.C. van & Lange E.C.M. de (2017), A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations, Pharmaceutical Research 34(2): 333–351.
- Yamamoto Y., Danhof M. & Lange E.C.M. de (2017), Microdialysis: the key to physiologically based model prediction of human CNS target site concentrations, AAPS Journal 19(4): 891-909.
- Yamamoto Y., Valitalo P.A.J., Huntjens D.R., Proost J.H., Vermeulen A., Krauwinkel W., Beukers M.W., Berg D.J. van den, Hartman R.J., Wong Y.C., Danhof M., Hasselt J.G.C. van & Lange E.C.M. de (2017), Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model, CPT: Pharmacometrics and Systems Pharmacology 6(11): 765–777.
- Yamamoto Y., Danhof M. & Lange E.C.M. de (2017), Erratum to: Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations, AAPS Journal 19(4): 1249-1252.
- Taneja A., Vermeulen A., Huntjens D.R.H., Danhof M., Lange E.C.M. de & Proost J.H. (2017), Modeling of prolactin response following dopamine D-2 receptor antagonists in rats: can it be translated to clinical dosing?, Pharmacology Research and Perspectives 5(6): e00364.
- Vlot A.H.C., Witte W.E.A. de, Danhof M., Graaf P.H. van der, Westen G.J.P. van & Lange E.C.M. de (2017), Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling, AAPS Journal 20(1): 11.
- Hasselt J.G. van, Rizk M.L., Lala M., Chavez-Eng C., Visser S.A., Kerbusch T., Danhof M., Rao G. & Graaf P.H. van der (2016), Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid, British Journal of Clinical Pharmacology 81: 1113–1123.
- Taneja A., Vermeulen A., Huntjens D.R.H., Danhof M., Lange E.C.M. de & Proost J.H. (2016), A comparison of two semi-mechanistic models for prolactin release and prediction of receptor occupancy following administration of dopamine D-2 receptor antagonists in rats, European Journal of Pharmacology 789: 202-214.
- Witte W.E., Wong Y.C., Nederpelt I., Heitman L.H., Danhof M., Graaf P.H. van der, Gilissen R.A. & De Lange E.C. (2016), Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients, Expert Opinion on Drug Discovery 11(1): 45-63.
- Valitalo P.A.J., Griffioen K., Rizk M., Visser S., Danhof M., Rao M., Graaf P. & Hasselt J.G.C. van (2016), Structure-based prediction of anti-infective drug concentrations in the human lung epithelial lining fluid, Pharmaceutical Research 33(4): 856-867.
- Bakshi S.D., Lange E.C.M. de, Graaf P.H. van der, Danhof M. & Peletier L.A. (2016), Understanding the Behavior of Systems Pharmacology Models Using Mathematical Analysis of Differential Equations: Prolactin Modeling as a Case Study, CPT: Pharmacometrics and Systems Pharmacology 5(7): 339-351.
- Brill M.J.E., Välitalo P.A.J., Darwich A.S., Ramshorst B. van, Dongen H.P. van, Rostami-Hodjegan A., Danhof M. & Knibbe C.A. (2016), Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1-OH-midazolam in morbidly obese and weight loss surgery patients, CPT: Pharmacometrics and Systems Pharmacology 5(1): 20-30.
- Dubois V.F.S., Witte W.E.A. de, Visser S.A., Danhof M. & Della Pasqua O. (2016), Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans, 33(1): 40-51.
- Witte W.E.A. de, Danhof M., Graaf P.H. van der & Lange E.C.M. de (2016), In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant, Trends in Pharmacological Sciences 37(10): 831-842.
- Krekels E.H.J., Ham S. van, Allegaert K., Hoon J. de, Tibboel D., Danhof M. & Knibbe C.A.J. (2015), Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants, European Journal of Clinical Pharmacology 71(9): 1075-82.
- Musuamba F.T., Teutonico D., Maas H.J., Facius A., Yang S., Danhof M. & Della Pasqua O. (2015), Prediction of Disease Progression, Treatment Response and Dropout in Chronic Obstructive Pulmonary Disease (COPD), 32(2): 617-27.
- Dubois Vincent F.S., Yu Huixin, Danhof Meindert & Della Pasqua Oscar (2015), Model-based evaluation of drug-induced QTc prolongation for compounds in early development, British Journal of Clinical Pharmacology 79(1): 148-161.
- Bellanti F., Wijk R.C. van, Danhof M. & Della Pasqua O.E. (2015), Integration of PKPD relationships into benefit-risk analysis, British Journal of Clinical Pharmacology 80(5): 979-991.
- Bellanti F., Vecchio G.C. del, Putti M.C., Cosmi C., Fotzi I., Bakshi S.D., Danhof M. & Della Pasqua O.E. (2015), Model-Based Optimisation of Deferoxamine Chelation Therapy, 33(2): 498-509.
- Knibbe C.A., Brill M.J., Van Rongen A., Diepstraten J., Van der Graaf P.H. & Danhof M. (2015), Drug disposition in obesity: toward evidence-based dosing, Annual Review of Pharmacology and Toxicology 55: 149-67.
- Johnson Martin, Kozielska Magdalena, Reddy Venkatesh Pilla, Vermeulen An, Barton Hugh A., Grimwood Sarah, De Greef Rik, Groothuis Geny M.M., Danhof Meindert & Proost Johannes H. (2014), Dopamine D2 Receptor Occupancy as a Predictor of Catalepsy in Rats: A Pharmacokinetic-Pharmacodynamic Modeling Approach, 31(10): 2605-2617.
- Piana Chiara, Zhao Wei, Adkison Kimberly, Burger David, Jacqz-Aigrain Evelyne, Danhof Meindert & Della Pasqua Oscar (2014), A model- based approach for the evaluation of once daily dosing of lamivudine in HIV- infected children, British Journal of Clinical Pharmacology 77(5): 852-860.
- Piana Chiara, Zhao Wei, Adkison Kimberly, Burger David, Jacqz-Aigrain Evelyne, Danhof Meindert & Della Pasqua Oscar (2014), Covariate effects and population pharmacokinetics of lamivudine in HIVinfected children, British Journal of Clinical Pharmacology 77(5): 861-872.
- Snelder N., Ploeger B.A., Luttringer O., Rigel D.F., Fu F., Beil M., Stanski D.R. & Danhof M. (2014), Drug effects on the CVS in conscious rats: separating cardiac output into heart rate and stroke volume using PKPD modelling, 171(22): 5076-5092.
- Dubois Vincent F.S., Van der Graaf Piet, Leishman Derek, Gallacher David, McMahon Nick, Visser Sandra, Danhof Meindert & Della Pasqua Oscar (2014), Translating the gap in the evaluation of drug-induced QTc-interval prolongation from in vivo to the clinic, Journal of Pharmacological and Toxicological Methods 70(3): 324-324.
- De Cock Roosmarijn F.W., Allegaert Karel, Vanhaesebrouck Sophie, De Hoon Jan, Verbesselt Rene, Danhof Meindert & Knibbe Catherijne A.J. (2014), Low but Inducible Contribution of Renal Elimination to Clearance of Propylene Glycol in Preterm and Term Neonates, Therapeutic Drug Monitoring 36(3): 278-287.
- Sahota Tarjinder, Sanderson Ian, Danhof Meindert & Della Pasqua Oscar (2014), Model-based analysis of thromboxane B-2 and prostaglandin E-2 as biomarkers in the safety evaluation of naproxen, Toxicology and Applied Pharmacology 278(3): 209-219.
- Romero Klaus, Sinha Vikram, Allerheiligen Sandra, Danhof Meindert, Pinheiro Jose, Kruhlak Naomi, Wang Yaning, Wang Sue-Jane, Sauer John-Michael, Marier J.F., Corrigan Brian, Rogers James, Heerspink H.J., Lambers Gumbo Tawanda, Vis Peter, Watkins Paul, Morrison Tina, Gillespie William, Gordon Mark Forrest, Stephenson Diane, Hanna Debra, Pfister Marc, Lalonde Richard & Colatsky Thomas (2014), Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop, Journal of Pharmacokinetics and Pharmacodynamics 41(6): 545-552.
- Wang Chenguang, Allegaert Karel, Tibboel Dick, Danhof Meindert, Van der Marel Caroline D., Mathot Ron A.A. & Knibbe Catherijne A.J. (2014), Population Pharmacokinetics of Paracetamol Across the Human Age-Range From (Pre) term Neonates, Infants, Children to Adults, 54(6): 619-629.
- Bellanti Francesco, Danhof Meindert & Della Pasqua Oscar (2014), Population pharmacokinetics of deferiprone in healthy subjects, British Journal of Clinical Pharmacology 78(6): 1397-1406.
- Strougo Ashley, Yassen Ashraf, Monnereau Claire, Danhof Meindert & Freijer Jan (2014), Predicting the "First dose in children" of CYP3A-metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7-CYP3A4 switch at young ages, 54(9): 1006-1015.
- Snelder Nelleke, Ploeger Bart A., Luttringer Olivier, Stanski Donald R. & Danhof Meindert (2014), Translational Pharmacokinetic Modeling of Fingolimod (FTY720) as a Paradigm Compound Subject to Sphingosine Kinase-Mediated Phosphorylation, Drug Metabolism and Disposition 42(9): 1367-1378.
- Mochel J.P., Fink M., Peyrou M., Soubret A., Giraudel J.M. & Danhof M. (2014), Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs, Pharmaceutical Research : .
- Stringer F., DeJongh J., Enya K., Koumura E., Danhof M. & Kaku K. (2014), Evaluation of the Long-Term Durability and Glycemic Control of Fasting Plasma Glucose and Glycosylated Hemoglobin for Pioglitazone in Japanese Patients with Type 2 Diabetes, diabetes-technology-and-therapeutics : .
- Stringer F., DeJongh J., Scott G. & Danhof M. (2014), A model-based approach to analyze the influence of UGT2B15 polymorphism driven pharmacokinetic differences on the pharmacodynamic response of the PPAR agonist sipoglitazar, British Journal of Clinical Pharmacology 54(4): 453-61.
- De Cock R.F., Allegaert K., Sherwin C.M., Nielsen E.I., De Hoog M., Van den Anker J.N., Danhof M. & Knibbe C.A. (2014), A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates, Pharmacological Research 31(3): 754-67.
- Wang C., Allegaert K., Peeters M.Y., Tibboel D., Danhof M. & Knibbe C.A. (2014), The allometric exponent for scaling clearance varies with age: a study on seven propofol datasets ranging from preterm neonates to adults, British Journal of Clinical Pharmacology 77(1): 149-59.
- Gotta V., Cools F., Van Ammel K., Gallacher D.J., Visser S.A., Sannajust F., Morissette P., Danhof M. & Van der Graaf P.H. (2014), Sensitivity of pharmacokinetic-pharmacodynamic analysis for detecting small magnitudes of QTc prolongation in preclinical safety testing, Journal of Pharmacological and Toxicological Methods 72C: 1-10.
- Westerhout J., Van den Berg D.J., Hartman R., Danhof M. & De Lange E.C. (2014), Prediction of methotrexate CNS distribution in different species - influence of disease conditions, European Journal of Pharmaceutical Sciences 2014(Jan 22): 0928-0987.
- Krekels E.H.J., Tibboel D., Wildt S.N. de, Ceelie I., Dahan A., Dijk M. van, Danhof M. & Knibbe C.A.J. (2014), Evidence-based morphine dosing for postoperative neonates and infants, Clinical Pharmacokinetics 53(6): 553-563.
- Cock R.F.W. de, Allegaert K., Brussee J.M., Sherwin C.M., Mulla H., Hoog M. de, Anker J.N. van den, Danhof M. & Knibbe C.A.J. (2014), Simultaneous pharmacokinetic modeling of gentamicin, tobramycin and vancomycin clearance from neonates to adults: towards a semi-physiological function for maturation in glomerular filtration, Pharmaceutical Research 31(10): 2643-2654.
- De Cock R.F.W., Smits A., Allegaert K., De Hoon J., Saegeman V., Danhof M. & Knibbe C.A.J. (2014), Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates, Journal of Antimicrobial Chemotherapy 69(5): 1330-1338.
- Taneja A., Troconiz I.F., Danhof M. & Della Pasqua O. (2014), Semi-mechanistic Modelling of the Analgesic Effect of Gabapentin in the Formalin-Induced Rat Model of Experimental Pain, 31(3): 593-606.
- Mochel Jonathan P., Fink Martin, Bon Charlotte, Peyrou Mathieu, Bieth Bruno, Desevaux Cyril, Deurinck Mark, Giraudel Jerome M. & Danhof Meindert (2014), Influence of feeding schedules on the chronobiology of renin activity, urinary electrolytes and blood pressure in dogs, 31(5): 715-730.
- Piana Chiara, Danhof Meindert & Della Pasqua Oscar (2014), Influence of covariate distribution on the predictive performance of pharmacokinetic models in paediatric research, British Journal of Clinical Pharmacology 78(1): 145-157.
- Chain Anne S.Y., Dieleman Jeanne P., Van Noord Charlotte, Hofman Albert, Stricker Bruno H.C., Danhof Meindert, Sturkenboom Miriam C.J.M. & Della Pasqua Oscar (2013), Not-in-trial simulation I: Bridging cardiovascular risk from clinical trials to real-life conditions, British Journal of Clinical Pharmacology 76(6): 964-972.
- Ince Ibrahim, Knibbe Catherijne A.J., Danhof Meindert & De Wildt Saskia N. (2013), Developmental Changes in the Expression and Function of Cytochrome P450 3A Isoforms: Evidence from In Vitro and In Vivo Investigations, Clinical Pharmacokinetics 52(5): 333-345.
- Ince Ibrahim, De Wildt Saskia N., Wang Chengueng, Peeters Mariska Y.M., Burggraaf Jacobus, Jacqz-Aigrain Evelyne, Van den Anker John N., Tibboel Dick, Danhof Meindert & Knibbe Catherijne A.J. (2013), A Novel Maturation Function for Clearance of the Cytochrome P450 3A Substrate Midazolam from Preterm Neonates to Adults, Clinical Pharmacokinetics 52(7): 555-565.
- Zhao Wei, Piana Chiara, Danhof Meindert, Burger David, Della Pasqua Oscar & Jacqz-Aigrain Evelyne (2013), Population pharmacokinetics of abacavir in infants, toddlers and children, British Journal of Clinical Pharmacology 75(6): 1525-1535.
- De Cock Roosmarijn F.W., Knibbe Catherijne A.J., Kulo Aida, De Hoon Jan, Verbesselt Rene, Danhof Meindert & Allegaert Karel (2013), Developmental pharmacokinetics of propylene glycol in preterm and term neonates, British Journal of Clinical Pharmacology 75(1): 162-171.
- Westerhout Joost, Smeets Jean, Danhof Meindert & De Lange Elizabeth C.M. (2013), The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid, Journal of Pharmacokinetics and Pharmacodynamics 40(3): 327-342.
- Taneja A., Troconiz I.F., Danhof M. & Della Pasqua O. (2013), Semi-mechanistic Modelling of the Analgesic Effect of Gabapentin in the Formalin-Induced Rat Model of Experimental Pain, Pharmaceutical Research 31(3): 593-606.
- Visser S.A., Manolis E., Danhof M. & Kerbusch T. (2013), Modeling and simulation at the interface of nonclinical and early clinical drug development, CPT: Pharmacometrics and Systems Pharmacology 2(2): .
- Stringer F., Ploeger B.A., DeJongh J., Scott G., Urquhart R., Karim A. & Danhof M. (2013), Evaluation of the impact of UGT polymorphism on the pharmacokinetics and pharmacodynamics of the novel PPAR agonist sipoglitazar , International Journal of Clinical Pharmacology and Therapeutics 53(3): 256-63.
- Wang C., Allegaert K., Tibboel D., Danhof M., Marel C.D. van der, Mathot R.A. & Knibbe C.A. (2013), Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults, The Journal of Clinical Pharmacology : .
- Wang C., Sadhavisvam S., Krekels E.H., Dahan A., Tibboel D., Danhof M., Vinks A.A. & Knibbe C.A. (2013), Developmental changes in morphine clearance across the entire paediatric age range are best described by a bodyweight-dependent exponent model , Clinical Drug Investigation 33(7): 523-34.
- Pilla Reddy V., Kozielska M., Johnson M., Mafirakureva N., Vermeulen A., Liu J., Greef R. de, Rujescu D., Groothuis G.M., Danhof M. & Proost J.H. (2013), Population pharmacokinetic-pharmacodynamic modeling of haloperidol in patients with schizophrenia using positive and negative syndrome rating scale , 33(6): 731-9.
- De Cock R.F., Allegaert K., Sherwin C.M., Nielsen E.I., Hoog M. de, Anker J.N. van den, Danhof M. & Knibbe C.A. (2013), A neonatal amikacin covariate model can be used to predict ontogeny of other drugs eliminated through glomerular filtration in neonates, Pharmaceutical Research 31(3): 754-67.
- Piana C., Zhao W., Adkison K., Burger D., Jacqz-Aigrain E., Danhof M. & Della Pasqua O. (2013), A model-based approach for the evaluation of once daily dosing of lamivudine in HIV-infected children, British Journal of Clinical Pharmacology : .
- Stringer F., Dejongh J., Scott G. & Danhof M. (2013), A model-based approach to analyze the influence of UGT2B15 polymorphism driven pharmacokinetic differences on the pharmacodynamic response of the PPAR agonist sipoglitazar, British Journal of Clinical Pharmacology 54(4): 453-61.
- Piana C., Zhao W., Adkison K., Burger D., Jacqz-Aigrain E., Danhof M. & Della Pasqua O. (2013), Covariate effects and population pharmacokinetics of lamivudine in HIV-infected children, British Journal of Clinical Pharmacology : .
- Wang C., Allegaert K., Peeters M.Y., Tibboel D., Danhof M. & Knibbe C.A. (2013), The allometric exponent for scaling clearance varies with age: a study on seven propofol datasets ranging from preterm neonates to adults, British Journal of Clinical Pharmacology 77(1): 149-59.
- Cock R.F. de, Allegaert K., Vanhaesebrouck S., Hoon J. de, Verbesselt R., Danhof M. & Knibbe C.A. (2013), Low but Inducible Contribution of Renal Elimination to Clearance of Propylene Glycol in Preterm and Term Neonates, Therapeutic Drug Monitoring : .
- Knibbe C.A., Tibboel D., Wildt S.N. de, Hoog M. de, Tjoeng M.M. & Danhof M. (2013), [Individualized dosing guidelines for children], Nederlands Tijdschrift voor Geneeskunde 157(16): A4214.
- Chain A.S., Sturkenboom M.C., Danhof M. & Della Pasqua O.E. (2013), Establishing in vitro to clinical correlations in the evaluation of cardiovascular safety pharmacology, Drug Discovery Today 10(3): 373-83.
- Kozielska Magdalena, Reddy Venkatesh Pilla, Johnson Martin, De Ridder Filip, Vermeulen An, Liu Jing, Groothuis Geny M.M., Danhof Meindert & Proost Johannes H. (2013), Sensitivity of individual items of the Positive and Negative Syndrome Scale (PANSS) and items subgroups to differentiate between placebo and drug treatment in schizophrenia, Schizophrenia Research 146(1-3): 53-58.
- Mochel Jonathan P., Fink Martin, Peyrou Mathieu, Desevaux Cyril, Deurinck Mark, Giraudel Jerome M. & Danhof Meindert (2013), Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to blood pressure and renal physiology, Chronobiology International 30(9): 1144-1159.
- Reddy Venkatesh Pilla, Kozielska Magdalena, Johnson Martin, Mafirakureva Nyashadzaishe, Vermeulen An, Liu Jing, De Greef Rik, Rujescu Dan, Groothuis Geny M.M., Danhof Meindert & Proost Johannes H. (2013), Population Pharmacokinetic-Pharmacodynamic Modeling of Haloperidol in Patients With Schizophrenia Using Positive and Negative Syndrome Rating Scale, 33(6): 731-739.
- Chain Anne S.Y., Dubois Vincent F.S., Danhof Meindert, Sturkenboom Miriam C.J.M. & Della Pasqua Oscar (2013), Identifying the translational gap in the evaluation of drug-induced QT(c) interval prolongation, British Journal of Clinical Pharmacology 76(5): 708-724.
- Bartelink Imke Heleen, Belitser Svetlana V., Knibbe Catherijne A.J., Danhof Meindert, De Pagter Anne J., Egberts Toine C.G. & Boelens Jaap Jan (2013), Immune Reconstitution Kinetics as an Early Predictor for Mortality using Various Hematopoietic Stem Cell Sources in Children, Biology of blood and marrow transplantation 19(2): 305-313.
- Stringer Frances, Ploeger Bart A., DeJongh Joost, Scott Graham, Urquhart Richard, Karim Aziz & Danhof Meindert (2013), Evaluation of the Impact of UGT Polymorphism on the Pharmacokinetics and Pharmacodynamics of the Novel PPAR Agonist Sipoglitazar, The Journal of Clinical Pharmacology 53(3): 256-263.
- Mochel J.P., Peyrou M., Fink M., Strehlau G., Mohamed R., Giraudel J.M., Ploeger B. & Danhof M. (2013), Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) peptides heightens the understanding of the effect of benazepril in dogs, 36(2): 174-180.
- Post T.M., Schmidt S., Peletier L.A., Greef R. de, Kerbusch T. & Danhof M. (2013), Application of a mechanism-based disease systems model for osteoporosis to clinical data, Journal of Pharmacokinetics and Pharmacodynamics 40(2): 143–156.
- Snelder N., Ploeger B.A., Luttringer O., Rigel D.F., Webb R.L., Feldman D., Fu F., Beil M., Jin L., Stanski D.R. & Danhof M. (2013), PKPD modelling of the interrelationship between mean arterial BP, cardiac output and total peripheral resistance in conscious rats, British Journal of Pharmacology 169(7): 1510-1524.
- Reddy Venkatesh Pilla, Kozielska Magdalena, Suleiman Ahmed Abbas, Johnson Martin, Vermeulen An, Liu Jing, De Greef Rik, Groothuis Geny M.M., Danhof Meindert & Proost Johannes H. (2013), Pharmacokinetic-pharmacodynamic modeling of antipsychotic drugs in patients with schizophrenia Part I: The use of PANSS total score and clinical utility, Schizophrenia Research 146(1-3): 144-152.
- Reddy Venkatesh Pilla, Kozielska Magdalena, Suleiman Ahmed Abbas, Johnson Martin, Vermeulen An, Liu Jing, De Greef Rik, Groothuis Geny M.M., Danhof Meindert & Proost Johannes H. (2013), Pharmacokinetic-pharmacodynamic modelling of antipsychotic drugs in patients with schizophrenia: Part II: The use of subscales of the PANSS score, Schizophrenia Research 146(1-3): 153-161.
- Krekels E.H.J., Johnson T.N., Hoedt S.M. den, Rostami-Hodjegan A., Danhof M., Tibboel D. & Knibbe C.A.J. (2012), From Pediatric Covariate Model to Semiphysiological Function for Maturation: Part II-Sensitivity to Physiological and Physicochemical Properties, CPT: Pharmacometrics and Systems Pharmacology 2012(1): e10.
- Krekels E.H.J., Neely M., Panoilia E., Tibboel D., Capparelli E., Danhof M., Mirochnick M. & Knibbe C.A.J. (2012), From pediatric covariate model to semiphysiological function for maturation: part I-extrapolation of a covariate model from morphine to Zidovudine, CPT: Pharmacometrics and Systems Pharmacology 2012(1): e9.
- Wang C., Peeters M.Y., Allegaert K., Blussé van Oud-Alblas H.J., Krekels E.H.J., Tibboel D., Danhof M. & Knibbe C.A.J. (2012), A bodyweight-dependent allometric exponent for scaling clearance across the human life-span, 29(6): 1570-1581.
- Stevens J., Ploeger B.A., Hammarlund-Udenaes M., Osswald G., Graaf P.H. van der, Danhof M. & Lange E.C.M. de (2012), Mechanism-based PK-PD model for the prolactin biological system response following an acute dopamine inhibition challenge: quantitative extrapolation to humans, Journal of Pharmacokinetics and Pharmacodynamics 39(5): 463-477.
- Taneja A., Nyberg J., Lange E.C. de, Danhof M. & Della Pasqua O.E. (2012), Application of ED-optimality to screening experiments for analgesic compounds in an experimental model of neuropathic pain, Journal of Pharmacokinetics and Pharmacodynamics 39(6): 673-681.
- Krekels E.H.J., Danhof M., Tibboel D. & Knibbe C.A.J. (2012), Ontogeny of hepatic glucuronidation; methods and results, Current Drug Metabolism 13(6): 728-743.
- Westerhout J., Ploeger B., Smeets J., Danhof M. & Lange E.C.M. de (2012), Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats, AAPS Journal 14(3): 543-553.
- Knibbe C.A., Krekels E.H. & Danhof M. (2011), Advances in paediatric pharmacokinetics, Expert Opinion on Drug Metabolism & Toxicology 7(1): 1-8.
- Pilla Reddy V., Kozielska M., Johnson M., Vermeulen A., De Greef R., Liu J., Groothuis G.M., Danhof M. & Proost J.H. (2011), Structural models describing placebo treatment effects in schizophrenia and other neuropsychiatric disorders, Clinical Pharmacokinetics 50(7): .
- Ince I., De Wildt S.N., Peeters M.Y.M., Murry D.J., Tibboel D., Danhof M. & Knibbe C.A. (2011), Criticall Illness Is a Major Determinant for Midazolam and Metabolite Clearance in Children, British Journal of Clinical Pharmacology 72(5): .
- Knibbe C.A. & Danhof M. (2011), Individualized dosing regimens in children based on population PKPD modelling: are we ready for it?, 415(1-2): .
- Chain A.S., Krudys K.M., Danhof M. & Della Pasqua O. (2011), Assessing the Probability of Drug-Induced QTc-Interval Prolongation During Clinical Drug Development, Clinical Pharmacology & Therapeutics 90(6): .
- Westerhout J., Danhof M. & De Lange E.C. (2011), Preclinical prediction of human brain target site concentrations: considerations in extrapolating to the clinical setting, JOURNAL OF PHARMACEUTICAL SCIENCES 100(9): .
- Bartelink I.H., Belitser S.V., Knibbe C.A.J., Danhof M., De Pagter A.J., Egberts A.C.G. & Boelens J.J. (2011), Cd3+Cd4+and Cd3+Cd8+-Lymphocytes as Biomarkers Predicting the Long Term Outcome of Pediatric Haematopoietic Stem Cell Transplantation Recipients, Biology of Blood and Marrow Transplantation 17(2): .
- Schmidt S., Post T.M., Peletier L.A., Boroujerdi M.A. & Danhof M. (2011), Coping with time scales in disease systems analysis: application to bone remodeling, Journal of Pharmacokinetics and Pharmacodynamics 38(6): 873-900.
- Snelder N., Ploeger B., Danhof M., Stanski D., Rigel D., Webb R., Feldman D. & Luttringer O. (2011), Drug Effects on the Cardiovascular System - Development of a Mechanism-Based Pharmacodynamic Model to Improve Translation Drug Research, Clinical Pharmacology & Therapeutics 89: .
- Bartelink I.H., Boelens J.J., Bredius R.G.M., Egberts A.C.G., Biering M., Shaw P., Nath C.E., Hempel G., Zwaveling J., Danhof M. & Knibbe C.A.J. (2011), Optimizing the Busulfan Dosing Regimen to Get a More Predictable Exposure: A Data Driven Analysis, Biology of Blood and Marrow Transplantation 17(2): .
- Schmidt S., Post T.M., Peletier L.A., Boroujerdi M.A. & Danhof M. (2011), Mathematical Model Reduction: An Innovative Tool for Analyzing Complex Dynamic Disease Systems, The Journal of Clinical Pharmacology 51(9): .
- Cock R.F.W. de, Piana C., Krekels E.H.J., Danhof M., Allegaert K. & Knibbe C.A.J. (2011), The role of population PK-PD modelling in paediatric clinical research, European Journal of Clinical Pharmacology 67(Suppl 1): 5-16.
- Johnson M., Kozielska M., Reddy V.P., Vermeulen A., Li C., Grimwood S., De Greef R., Groothuis G.M.M., Danhof M. & Proost J.H. (2011), Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling of the Dopamine D(2) Receptor Occupancy of Olanzapine in Rats, PHARMACEUTICAL RESEARCH 28(10): .
- Krekels E.H.J., Hasselt J.G.C. van, Tibboel D., Danhof M. & Knibbe C.A.J. (2011), Systematic evaluation of the descriptive and predictive performance of paediatric morphine population models, Pharmaceutical Research 28(4): 797-811.
- Piana C., Danhof M. & Della Pasqua O.E. (2011), Impact of Non-Adherence to Antiretroviral Therapy in Hiv-Infected Children, Basic & Clinical Pharmacology & Toxicology 109: .
- Santen G.W., Van Zwet E., Bettica P., Gomeni R.A., Danhof M. & Della Pasqua O. (2011), From trial and error to trial simulation III: a framework for interim analysis in efficacy trials with antidepressant drugs, Clinical Pharmacology & Therapeutics 89(4): .
- Cella M., Zhao W., Jacqz-Aigrain E.M., Burger D., Danhof M. & Della Pasqua O. (2011), Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?, British Journal of Clinical Pharmacology 72(3): .
- Ackaert O.W., De Graan J., Shi S., Vreeken R., Della Pasqua O.E., Dijkstra D., Westerink B.H., Danhof M. & Bouwstra J.A. (2011), The Pharmacokinetics and Pharmacological Effect of (S)-5-OH-DPAT Following Controlled Delivery with Transdermal Iontophoresis, JOURNAL OF PHARMACEUTICAL SCIENCES 100(7): .
- Teutonico D., Musuamba F., Maas H.J., Facius A., Yang S., Danhof M. & Della Pasqua O.E. (2011), Multivariate Patient Simulation for Clinical Trial Optimization in Copd, Basic & Clinical Pharmacology & Toxicology 109: .
- Bartelink I.H., Boelens J.J., Bredius R.G.M., Egberts A.C.G., Bierings M., Shaw P., Hempel G., Zwaveling J., Danhof M. & Knibbe C.A.J. (2011), Modeling of the Age-Related Pharmacokinetics in Children. A Data-Driven Analysis of Busulfan Prior to Haemopoietic Stem Cell Transplantation, British Journal of Clinical Pharmacology 72(5): .
- Van Kralingen S., Diepstraten J., Peeters M.Y., Deneer V.H., Van Ramshorst B., Wiezer R.J., Van Dongen E.P., Danhof M. & Knibbe C.A. (2011), Population pharmacokinetics and pharmacodynamics of propofol in morbidly obese patients, Clinical Pharmacokinetics 50(11): .
- Bartelink I.H., Belitser S.V., Knibbe C.A.J., Danhof M., De Pagter P.J., Egberts A.C.G. & Boelens J.J. (2011), Cd3+Cd4+-Lymphocytes as Biomarker Predicting the Outcome of Pediatric Haematopoietic Stem Cell Transplantation Recipients, British Journal of Clinical Pharmacology 72(5): .
- Krekels E.H., DeJongh J., Van Lingen R.A., Van der Marel C.D., Choonara I., Lynn A.M., Danhof M., Tibboel D. & Knibbe C.A. (2011), Predictive performance of a recently developed population pharmacokinetic model for morphine and its metabolites in new datasets of (preterm) neonates, infants and children, Clinical Pharmacokinetics 50(1): 51-63.
- Krekels E.H.J., Van Ham S., Allegaert K., De Hoon J., Tibboel D., Danhof M. & Knibbe C.A.J. (2011), Paracetamol Pharmacokinetics in Term and Preterm Neonates, British Journal of Clinical Pharmacology 72(5): .
- Strougo A., Yassen A., Krauwinkel W., Danhof M. & Freijer J. (2011), A semiphysiological population model for prediction of the pharmacokinetics of drugs under liver and renal disease conditions, Drug Metabolism and Disposition 39(7): .
- Chain A.S.Y., Dieleman J.P., Danhof M., Stricker B.H.Ch., Della Pasqua O.E. & Sturkenboom M.C.J.M. (2011), Validation of a Not-in-Trial Simulation Tool for Cardiovascular Risk Mitigation, Pharmacoepidemiology and Drug Safety 20: .
- Bartelink I.H., Jol-Van der Zijde E.M., Boelens J.J., Bredius R.G.M., Egberts A.C.G., Danhof M., Van Tol MJD & Knibbe C.A.J. (2011), Optimization of Anti-Thymocyte Globulin Exposure in Paedi-Atric Bone Marrow Transplantation in Order to Design an Individualized Dosing Regimen, Biology of Blood and Marrow Transplantation 17(2): .
- De Cock R.F.W., Allegaert K., De Hoog M., Sherwin C.M.T., Danhof M. & Knibbe C.A.J. (2011), Predicting Glomerular Filtration Rate Using Clearance of Amikacin in Neonates - Model Evaluation, British Journal of Clinical Pharmacology 72(5): .
- Wang C., Peeters M.Y.M., Allegaert K., Tibboel D., Danhof M. & Knibbe C.A.J. (2011), Scaling Clearance of Propofol from Preterm Neonates to Adults, British Journal of Clinical Pharmacology 72(5): .
- Stevens J., Ploeger B.A., Van der Graaf P.H., Danhof M. & De Lange E.C. (2011), Systemic and Direct Nose-to-Brain Transport Pharmacokinetic Model for Remoxipride after Intravenous and Intranasal Administration, Drug Metabolism and Disposition 39(12): .
- Danhof M. (2011), Mechanism-Based Pkpd Modeling: Principle and Applications, Basic & Clinical Pharmacology & Toxicology 109: .
- Muller A.E., Mouton J.W., Oostvogel P.M., Dorr P.J., Voskuyl R.A., DeJongh J., Steegers E.A. & Danhof M. (2010), Pharmacokinetics of clindamycin in pregnant women in the peripartum period, Antimicrobial Agents and Chemotherapy 54(5): .
- Press R.R., Ploeger B.A., Den Hartigh J., Van der Straaten T., Van Pelt H., Danhof M., De Fijter H. & Guchelaar H.J. (2010), Explaining variability in ciclosporin exposure in adult kidney transplant recipients, European Journal of Clinical Pharmacology 66(6): .
- Steeg T.J. van, Krekels E.H.J., Freijer J., Danhof M. & Lange E.C.M. de (2010), Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)), JOURNAL OF PHARMACEUTICAL SCIENCES 99(5): 2511-2520.
- Della Pasqua O., Santen G.W. & Danhof M. (2010), The missing link between clinical endpoints and drug targets in depression, Trends in Pharmacological Sciences 31(4): .
- Stevens J., Van den Berg D.J., De Ridder S., Niederlander H.A., Van der Graaf P.H., Danhof M. & De Lange E.C. (2010), Online solid phase extraction with liquid chromatography-tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 878(13-14): .
- Bender G., Florian J.A., Bramwell S., Field M.J., Tan K.K., Marshall S., DeJongh J., Bies R.R. & Danhof M. (2010), Pharmacokinetic-pharmacodynamic analysis of the static allodynia response to pregabalin and sildenafil in a rat model of neuropathic pain, Journal of Pharmacology and Experimental Therapeutics 334(2): .
- Cella M., Gorter de Vries F., Burger D., Danhof M. & Della Pasqua O. (2010), A model-based approach to dose selection in early pediatric development, Clinical Pharmacology & Therapeutics 87(3): .
- Post T.M., Cremers S.C., Kerbusch T. & Danhof M. (2010), Bone physiology, disease and treatment: towards disease system analysis in osteoporosis, Clinical Pharmacokinetics 49(2): .
- Cella M., Knibbe C.A., Danhof M. & Pasqua O.D. (2010), What is the right dose for children?, British Journal of Clinical Pharmacology 70(4): .
- De Cock R.F., Piana C., Krekels E.H., Danhof M., Allegaert K. & Knibbe C.A. (2010), The role of population PK-PD modelling in paediatric clinical research, European Journal of Clinical Pharmacology : .
- Peeters M.Y., Allegaert K., Blusse van Oud-Alblas H.J., Cella M., Tibboel D., Danhof M. & Knibbe C.A. (2010), Prediction of propofol clearance in children from an allometric model developed in rats, children and adults versus a 0.75 fixed-exponent allometric model, Clinical Pharmacokinetics 49(4): .
- Romero K., Corrigan B., Tornoe C.W., Gobburu J.V., Danhof M., Gillespie W.R., Gastonguay M.R., Meibohm B. & Derendorf H. (2010), Pharmacometrics as a discipline is entering the "industrialization" phase: standards, automation, knowledge sharing, and training are critical for future success, The Journal of Clinical Pharmacology 50(9 Suppl): .
- Stevens J., Berg D.J. van den, Ridder S. de, Niederländer H.A., Graaf P.H. van der, Danhof M. & Lange E.C.M. de (2010), Online solid phase extraction with liquid chromatography-tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 878(13-14): 969-975.
- Steeg T.J. van, Boralli V.B., Krekels E.H.J., Slijkerman P., Freijer J., Danhof M. & Lange E.C.M. de (2009), Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach, JOURNAL OF PHARMACEUTICAL SCIENCES 98(10): 3816-28.
- Knibbe C.A.J., Krekels E.H.J., Anker J.N. van den, DeJongh J., Santen G.W., Dijk M. van, Simons S.H., Lingen R.A. van, Jacqz-Aigrain E.M., Danhof M. & Tibboel D. (2009), Morphine glucuronidation in preterm neonates, infants and children younger than 3 years, Clinical Pharmacokinetics 48(6): 371-385.
- Danhof M., Lange E.C.M. de, Della Pasqua O.E., Ploeger B.A. & Voskuyl R.A. (2008), Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research, Trends in Pharmacological Sciences 29(4): 186-191.
- Peeters M.Y., Bras L.J., DeJongh J., Wesselink R.M., Aarts L.P., Danhof M. & Knibbe C.A.J. (2008), Disease Severity Is a Major Determinant for the Pharmacodynamics of Propofol in Critically Ill Patients, Clinical Pharmacology & Therapeutics 83(3): 443-451.
- Post T.M., Freijer J.L., Ploeger B.A. & Danhof M. (2008), Extensions to the Visual Predictive Check to facilitate model performance evaluation, Journal of Pharmacokinetics and Pharmacodynamics 35(2): 185-202.
- Ravenstijn P.G.M., Merlini M., Hameetman M., Murray T.K., Ward M.A., Lewis H., Ball G., Mottart C., Ville de Goyet C. de, Lemarchand T., Belle K. van, O'Neill M.J., Danhof M. & Lange E.C.M. de (2008), The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments, Journal of Pharmacological and Toxicological Methods 57(2): 114-130.
- Geldof M., Freijer J.L., Beijsterveldt L. van, Langlois X. & Danhof M. (2008), Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex, British Journal of Pharmacology 154(6): 1369-1378.
- Peeters M.Y., Aarts L.P., Boom F.A., Bras L.J., Tibboel D., Danhof M. & Knibbe C.A.J. (2008), Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients, European Journal of Clinical Pharmacology 64(3): 329-334.
- Groenendaal D., Frijer J., Rosier A., Mik D. de, Nichols G., Hersey A., Ayrton A.D., Danhof M. & Lange E.C. de (2008), Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics, European Journal of Pharmaceutical Sciences 34(2-3): 149-163.
- Muller A.E., Dörr P.J., Mouton J.W., Jongh J. de, Oostvogel P.M., Steegers E.A., Voskuyl R.A. & Danhof M. (2008), The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women, British Journal of Clinical Pharmacology 66(6): 866-874.
- Liefaard L.C., Ploeger B.A., Molthoff C.F., Jong H.W. de, Dijkstra J., Weerd L van der, Lammertsma A.A., Danhof M. & Voskuyl R.A. (2008), Changes in GABA(A) receptor properties in amygdala kindled animals: In vivo studies using [(11)C]flumazenil and positron emission tomography, Epilepsia : .
- Clinckers R., Smolders I., Michotte Y., Ebinger G., Danhof M., Voskuyl R.A. & Della Pasqua O.E. (2008), Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain, British Journal of Pharmacology 155(7): 1127-1138.
- Huntjens D.R.H., Spalding D.J., Danhof M. & Della Pasqua O.E. (2008), Differences in the sensitivity of behavioural measures of pain to the selectivity of cyclo-oxygenase inhibitors, European Journal of Pain : .
- Maas H.J., Snelder N., Danhof M. & Della Pasqua O.E. (2008), Prediction of attack frequency in migraine treatment, Cephalalgia 28(8): 847-855.
- Maas H.J., Spruit M.A., Danhof M. & Della Pasqua O.E. (2008), Relevance of absorption rate and lag time to the onset of action in migraine, Clinical Pharmacokinetics 47(2): 139-146.
- Yassen A., Olofsen E., Kan J., Dahan A. & Danhof M. (2008), Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats, PHARMACEUTICAL RESEARCH 25(1): 183-193.
- Huntjes D.R., Danhof M. & Della Pasqua O.E. (2008), Pharmacokinetic-pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors, Rheumatology 44(7): 846-859.
- Santen G.W.E., Danhof M. & Della Pasqua O.E. (2008), Evaluation of treatment response in depression studies using a Bayesian parametric cure rate model, J. Psychiatr. Res. 42(14): 1189-1197.
- Steeg T.J. van, Freijer J.L., Danhof M. & Lange E.C.M. de (2008), Mechanism-based pharmacodynamic modeling of S(-)-Atenolol: Estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model, Journal of Pharmacology and Experimental Therapeutics 324(3): 1234-1342.
- Muller A.E., Jongh J. de, Oostvogel P.M., Voskuyl R.A., Dörr P.J., Danhof M. & Mouton J.W. (2008), Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes, American Journal of Obstetrics and Gynecology 198(1): 1-6.
- Santen G.W.E., Gomeni R., Danhof M. & Pasqua O.D. (2008), Sensitivity of the individual items of the Hamilton depression rating scale to response and its consequences for the assessment of efficacy, J. Psychiatr. Res. 42(12): 1000-1009.
- Geldof M., Freijer J.L., Peletier L.A., Beijsterveldt L. van & Danhof M. (2008), Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex, European Journal of Pharmaceutical Sciences 33(3): 217-229.
- Verpoorte R., Crommelin D.J.A., Danhof M., Gilissen L.J., Schuitmaker H., Greef J. van der & Witkamp R.F. (2008), Commentary: "A systems view on the future of medicine: Inspiration from Chinese medicine?", : .
- Ince I., Wildt S.N. de, Tibboel D., Danhof M. & Kribbe C.A. (2008), Tailor-made drug treatment for children Creation of an infrastructure for data-sharing and population PK-PD modeling, Drug Discovery Today : .
- Huntjens D.R.H., Strougo A., Chain A., Metcalf A., Summerfield S., Spalding D.J., Danhof M. & Pasqua O.D. (2008), Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats, British Journal of Pharmacology 153(5): 1072-1084.
- Geldof M., Freijer J.L., Beijsterveldt L. van & Danhof M. (2008), Pharmacokinetic Modeling of Non-Linear Brain Distribution of Fluvoxamine in the Rat, PHARMACEUTICAL RESEARCH 25(4): 792-804.
- Yassen A, Olofsen E, Kan J, Dahan A & Danhof M (2008), Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats, Pharmaceutical Research 25(1).
- Peeters MMM, Bras LJ, DeJongh J, Wesselink RMJ, Aarts LPHJ, Danhof M & Knibbe CAJ (2008), Disease severity is a major determinant for the pharmacodynamics of propofol in critically ill patients, Clinical Pharmacology and Therapeutics 83(3).
- Yassen A., Olofsen E., Kan J., Dahan A. & Danhof M. (2007), Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine, Clinical Pharmacokinetics 46(5): 433-447.
- Geldof M., Freijer J.L., Beijsterveldt L. van, Vermote P.C., Megens A.A. & Danhof M. (2007), Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior, European Journal of Pharmaceutical Sciences 32(3): 200-208.
- Steeg T.J. van, Krekels E.H., Danhof M. & Lange E.C.M. de (2007), Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats, Journal of Pharmacological and Toxicological Methods 56(1): 72-78.
- Rolan P., Danhof M., Stanski D. & Peck C. (2007), Current issues relating to drug safety especially with regard to the use of biomarkers: a meeting report and progress update, European Journal of Pharmaceutical Sciences 30(2): 107-112.
- Yassen A., Olofsen E., Romberg R., Sarton E.Y., Teppema L.J.S.M., Danhof M. & Dahan A. (2007), Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers, Clinical Pharmacology & Therapeutics 81(1): 50-58.
- Muller A.E., Jongh J. de, Bult Y., Goessens W.H., Mouton J.W., Danhof M. & Anker J.N. van den (2007), Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks, Antimicrobial Agents and Chemotherapy 10: 3720-3725.
- Groenendaal D., Freijer J.L., Mik D. de, Bouw M.R., Danhof M. & Lange E.C.M. de (2007), Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG, British Journal of Pharmacology 151(5): 713-720.
- Groenendaal D., Freijer J.L., Mik D. de, Bouw M.R., Danhof M. & Lange E.C.M. de (2007), Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux, British Journal of Pharmacology 151(5): 701-712.
- Press R.R., Ploeger B.A., Hartigh J. den, Straaten R.J.H.M. van der, Pelt J. van, Danhof M., Fijter J.W. de & Guchelaar H.J. (2007), Improved Dose Prediction of Tacrolimus in De Novo Kidney Transplant Patients with Population Pharmacokineetic Modelling Including Genetic Polymorphisms, American Journal of Transplantation 7(suppl.2): 440-440.
- Press R.R., Ploeger B.A., Hartigh J. den, Bemelman F.J., Homan van der Heide J.J., Danhof M., Guchelaar H.J. & Fijter J.W. de (2007), TDM of Everolimus in Stable Renal Transplant Patients after CNI Withdrawal, Therapeutic Drug Monitoring 29(4): 488-488.
- Press R.R., Ploeger B.A., Hartigh J. den, Straaten R.J.H.M. van der, Pelt J. van, Danhof M., Fijter J.W. de & Guchelaar H.J. (2007), Dose Prediction of Tacrolimus in de novo Kidney Transplant Patients with Population Pharmacokinetic Modelling Including Genetic Polymorphisms, Therapeutic Drug Monitoring 29(4): 530-530.
- Steeg T.J. van, Krekels E.H.J., Danhof M. & Lange E.C.M. de (2007), Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats, Journal of Pharmacological and Toxicological Methods 56(1): 72-78.
- Press R.R., Ploeger B.A., Hartigh J. den, Straaten R.J.H.M. van der, Pelt J. van, Danhof M., De Fijter J.W. & Guchelaar H.J. (2007), Improved dose prediction of tacrolimus in de novo kidney transplant patients with population pharmacokinetic modelling including genetic polymorphisms, Bootcongres 2007. Wetenschappelijke voorjaarsvergadering van de Ned. Transplantatie Vereniging : 63.
- Liefaard L.C., Gunput R.A., Danhof M. & Voskuyl R.A. (2007), Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy, Epilepsia 48(7): 1378-1387.
- Zuideveld K.P., Graaf P.H. van der, Peletier L.A. & Danhof M. (2007), Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man, PHARMACEUTICAL RESEARCH 24(11): 2031-2039.
- Steeg T.J. van, Freijer J.L., Danhof M. & Lange E.C.M. de (2007), Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint, British Journal of Pharmacology 151(3): 356-366.
- Anisimov V.V., Maas H.J., Danhof M. & Della Pasqua O.E. (2007), Analysis of responses in migraine modelling using hidden Markov models, Statistics in Medicine 26(22): 4163-4178.
- Danhof M., Jongh J. de, Lange J., Della Pasqua O.E., Ploeger B.A. & Voskuyl R.A. (2007), Mechanism-Based Pharmacokinetic-Pharmacodynamic Modeling: Biophase Distribution, Receptor Theory, and Dynamical Systems Analysis, Annual Review of Pharmacology and Toxicology 47: 357-400.
- Yassen A., Kan J., Olofsen E., Suidgeest E., Dahan A. & Danhof M. (2007), Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats, Journal of Pharmacology and Experimental Therapeutics 321(2): 598-607.
- Jonker D.M., Voskuyl R.A. & Danhof M. (2007), Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?, Epilepsia 48(3): 412-434.
- Yassen A., Olofsen E., Dorp E.L. van, Sarton E.Y., Teppema L.J.S.M., Danhof M. & Dahan A. (2007), Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone: a study in healthy volunteers, Clinical Pharmacokinetics 46(11): 965-980.
- Yassen A, Kan JM, Olofsen E, Suidgeest E, Dahan A & Danhof M (2007), Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats, Journal of Pharmacology and Experimental Therapeutics 321(2).
- Yassen A, Olofsen E, van Dorp E, Sarton E, Teppema L, Danhof M & Dahan A (2007), Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone - A study in healthy volunteers, Clinical Pharmacokinetics 46(11).
- Yassen A, Ofsen E, Kan JM, Dahan A & Danhof M (2007), Animal-to-human extrapolation of the pharmacokinetic and pharmacodynamic properties of buprenorphine, Clinical Pharmacokinetics 46(5).
- Press RR, Ploeger BA, den Hartigh J, van der Straaten RJHM, van Pelt J, Danhof M, de Fijter JW & Guchelaar HJ (2007), Improved dose prediction of tacrolimusin de novo kidney transplant patients with population pharmacokinetic modelling including genetic polymorphismis., American Journal of Transplantation 7.
- Yassen A, Ofsen E, Romberg R, Sarton E, Teppema L, Danhof M & Dahan A (2007), Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers, Clinical Pharmacology and Therapeutics 81(1).
- Press RR, Ploeger BA, den Hartigh J, Bemelman FJ, van der Heides JJH, Danhof M, Guchelaar HJ & de Fijter JW (2007), TDM of everolimus in stable renal transplant patients after CNI withdrawal, Therapeutic Drug Monitoring 29(4).
- Press RR, Ploeger BA, den Hartigh J, van der Straaten RJHM, van Pelt J, Danhof M, de Fijter JW & Guchelaar HJ (2007), Dose prediction of tacrolimus in de novo kidney transplant patients with population pharmacokinetic modelling including genetic polymorphisms, Therapeutic Drug Monitoring 29(4).
- Freijer J.L., Post T.M., Ploeger B.A., DeJongh J. & Danhof M. (2006), Application of the Convection-Dispersion Equation to Modelling Oral Drug Absorption, Bulletin of Mathematical Biology : .
- Franciosi L.G., Page C.P., Celli B.R., Cazzola M., Walker M.J., Danhof M., Rabe K.F. & Della Pasqua O.E. (2006), Markers of exacerbation severity in chronic obstructive pulmonary disease, Respiratory Research 7: 74-87.
- Huntjens D.R.H., Spalding D.J., Danhof M. & Della Pasqua O.E. (2006), Correlation between in vitro and in vivo concentration-effect relationships of naproxen in rats and healthy volunteers, British Journal of Pharmacology 148(4): 396-404.
- Peeters M.Y., Prins S.A., Knibbe C.A.J., DeJongh J., Schaik R.H. van, Dijk M. van, Heiden I. van der, Tibboel D. & Danhof M. (2006), Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery, Anesthesiology 104(3): 466-474.
- Nugroho A.K., Romeijn S.G., Zwier R., Vries J.B. de, Dijkstra D., Wikström H., Pasqua O.D., Danhof M. & Bouwstra J.A. (2006), Pharmacokinetics and pharmacodynamics analysis of transdermal iontophoresis of 5-OH-DPAT in rats: in vitro - in vivo correlation, JOURNAL OF PHARMACEUTICAL SCIENCES 95: 1570-1585.
- Winter W. de, DeJongh J., Post T.M., Ploeger B.A., Urquhart R., Moules I., Eckland D. & Danhof M. (2006), A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus, Journal of Pharmacokinetics and Pharmacodynamics 33(3): 313-343.
- Press R.R., Hartigh J. den, Cremers S.C.L.M., Danhof M., Fijter J.W. de & Guchelaar H.-J. (2006), Dose dependent drug disposition of tacrolimus, Bootcongres 2006 : 51-51.
- Press R.R., Ploeger B., Hartigh J. den, Cremers S.C.L.M., Danhof M., Fijter J.W. de & Guchelaar H.-J. (2006), Population pharmacokinetics of ciclosporine in kidney transplant patients, Bootcongres 2006 : 27-27.
- Yassen A., Kan J., Olofsen E., Suidgeest E., Dahan A. & Danhof M. (2006), Mechanism based pharmacokinetic/pharmacodynamic modelling of the respiratory depressant effects of buprenorphine in rats, Journal of Pharmacology and Experimental Therapeutics 319: 682-692.
- Bijl H., Yassen A., Olofsen E., Teppema L.J.S.M., Danhof M. & Dahan A. (2006), Full reversal of buprenorphine-induced respiratory depression by the opioid receptor antagonist naloxone, Nederlands Tijdschrift voor Anesthesiologie 19: 58-64.
- Yassen A., Olofsen E., Bijl H., Romberg R., Sarton E.Y., Danhof M. & Dahan A. (2006), Mechanism-based pharmacokinetic/pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers, Anesthesiology 104: 1232-1242.
- Dahan A., Yassen A., Romberg R., Sarton E.Y., Teppema L.J.S.M., Olofsen E. & Danhof M. (2006), Buprenorphine induces ceiling in respiratory depression but not in analgesia, British Journal of Anaesthesia 96(5): 627-632.
- Dorp E.L. van, Yassen A., Sarton E.Y., Romberg R., Olofsen E., Teppema L.J.S.M., Danhof M. & Dahan A. (2006), Naloxone reversal of buprenorphine-induced respiratory depression, Anesthesiology 105(1): 51-57.
- Maas H.J., Danhof M. & Della Pasqua O.E. (2006), Prediction of headache response in migraine treatment, Cephalalgia 26: 416-422.
- Yassen A., Kan J., Olofsen E., Suidgeest E., Dahan A. & Danhof M. (2006), Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats, Journal of Pharmacology and Experimental Therapeutics 319(2): 682-692.
- Maas H.J., Danhof M. & Della Pasqua O.E. (2006), A model-based approach to treatment comparison in acute migraine, British Journal of Clinical Pharmacology 62(5): 591-600.
- Peeters M.Y., Prins S.A., Knibbe C.A.J., DeJongh J., Mathot R.A.A., Warris C., Schaik R.H. van, Tibboel D. & Danhof M. (2006), Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery, Anesthesiology 105(6): 1135-1146.
- Swart E.L., Zuideveld K.P., Jongh J. de, Danhof M., Thijs L.G. & Strack van Schijndel R.M. (2006), Population pharmacodynamic modelling of lorazepam- and midazolam-induced sedation upon long-term continuous infusion in critically ill patients, European Journal of Clinical Pharmacology 62(3): 185-194.
- Geldof M., Freijer J.L., Beijsterveldt L. van, Timmerman P., Ahnaou A., Drinkenburg W.H. & Danhof M. (2006), Population pharmacokinetic model of fluvoxamine in rats: Utility for application in animal behavioral studies, European Journal of Pharmaceutical Sciences 30(1): 45-55.
- Franciosi L.G., Page C.P., Celli B.R., Cazzola M., Walker M.J., Danhof M., Rabe K.F. & Della Pasqua O.E. (2006), Markers of disease severity in chronic obstructive pulmonary disease, Pulmonary Pharmacology and Therapeutics 19: 189-199.
- van Dorp E, Yassen A, Sarton E, Romberg R, Olofsen E, Teppema L, Danhof M & Dahan A (2006), Naloxone reversal of buprenorphine-induced respiratory depression, Anesthesiology 105(1).
- Franciosi LG, Page CP, Celli BR, Cazzola M, Walker MJ, Danhof M, Rabe KF & Della Pasqua OE (2006), Markers of exacerbation severity in chronic obstructive pulmonary disease, Respiratory Research 7.
- Yassen A, Kan JM, Olofsen E, Suidgeest E, Dahan A & Danhof M (2006), Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats, Journal of Pharmacology and Experimental Therapeutics 319(2).
- Yassen A, Olofsen E, Romberg R, Sarton E, Danhof M & Dahan A (2006), Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers, Anesthesiology 104(6).
- Dahan A, Yassen A, Romberg R, Sarton E, Teppema L, Olofsen E & Danhof M (2006), Buprenorphine induces ceiling in respiratory depression but not in analgesia, British Journal of Anaesthesia 96(5).
- Yassen A., Olofsen E., Dahan A. & Danhof M. (2005), Pharmacokinetic-Pharmacodynamic modelling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics, Journal of Pharmacology and Experimental Therapeutics 313: 1136-1149.
- Schaddelee M.P., Read K.D., Cleypool C.G., IJzerman A.P., Danhof M. & Boer A.G. de (2005), Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents, European Journal of Pharmaceutical Sciences 24(1): 59-66.
- Jonker D.M., Visser S.A.G., Graaf P.H. van der, Voskuyl R.A. & Danhof M. (2005), Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo, Pharmacology and Therapeutics 106(1): 1-18.
- Jonker D.M., Visser S.A.G., Graaf P.H. van der, Voskuyl R.A. & Danhof M. (2005), Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo, Pharmacology and Therapeutics 106(1): 1-18.
- Nugroho A.K., Li L., Dijkstra D., Wikstrom H., Danhof M. & Bouwstra J.A. (2005), Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro. J Control Release, JOURNAL OF CONTROLLED RELEASE 21(2): 393-403.
- Swart E.L., Jongh J. de, Zuideveld K.P., Danhof M., Thijs L.G. & Strack-Van Schijndel R.J.M. (2005), Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration, American Journal of Kidney Diseases 45(2): 360-371.
- Post T.M., Freijer J.L., DeJongh J. & Danhof M. (2005), Disease system analysis: basic disease progression models in degenerative disease, PHARMACEUTICAL RESEARCH 22(7): 1038-1049.
- Dahan A., Yassen A., Bijl H., Romberg R., Sarton E.Y., Teppema L.J.S.M., Olofsen E. & Danhof M. (2005), Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats, British Journal of Anaesthesia 94(6): 825-834.
- Franciosi L.G., Page C.P., Celli B.R., Cazzola M., Walker M.J., Danhof M., Rabe K.F. & Della Pasqua O.E. (2005), Markers of disease severity in chronic obstructive pulmonary disease, Pulmonary Pharmacology and Therapeutics Eprint: .
- Visser C.C., Stevanovic S., Voorwinden L.H., Bloois L. van, Gaillard P.J., Danhof M., Crommelin D.J.A. & Boer A.G. de (2005), Targeting liposomes with protein drugs to the blood-brain barrier in vitro, European Journal of Pharmaceutical Sciences 25(2-3): 299-305.
- Schaddelee M.P., Collins S.D., DeJongh J., Boer A.G. de, IJzerman A.P. & Danhof M. (2005), Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain, European Journal of Pharmaceutical Sciences 514(2-3): 131-140.
- Groenendaal D., Blom-Roosemalen M.C.M., Danhof M. & Lange E.C.M. de (2005), High-performance liquid chromatography of nalbuphine, butorphanol and morphine in blood and brain microdialysate samples: application to pharmacokinetic/pharmacodynamic studies in rats, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 822(1-2): 230-237.
- Knibbe C.A.J., Zuideveld K.P., Aarts L.P., Kuks P.F.M. & Danhof M. (2005), Allometric relationships between the pharmacokinetics of propofol in rats, children and adults, British Journal of Clinical Pharmacology 59(6): 705-711.
- Danhof M., Alvan G., Dahl S.G., Kuhlmann J. & Paintaud G. (2005), Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers, PHARMACEUTICAL RESEARCH 22(9): 1432-1437.
- Yassen A., Olofsen E., Dahan A. & Danhof M. (2005), Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics, Journal of Pharmacology and Experimental Therapeutics 313(3): 1136-1149.
- Li G.L., Vries J.J. de, Steeg T.J. van, Bussche H. van den, Maas H.J., Reeuwijk H.J.E.M., Danhof M., Bouwstra J.A. & Laar T. van (2005), Transdermal iontophoretic delivery of apomorphine in patient¿s improved by surfactant formulation pretreatment, JOURNAL OF CONTROLLED RELEASE 101: 199-208.
- Liefaard L.C., Ploeger B.A., Molthoff C.F., Boellaard R., Lammertsma A.A., Danhof M. & Voskuyl R.A. (2005), Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography, Molecular Imaging and Biology 7(6): 411-421.
- Nugroho A.K., Li L., Dijkstra D., Wikstrom H., Danhof M. & Bouwstra J.A. (2005), Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro, JOURNAL OF CONTROLLED RELEASE 103(2): 393-403.
- Nugroho A.K., Danhof M., Bouwstra J.A. & Della Pasqua O.E. (2005), Compartmental modeling of transdermal iontophoretic transport II: in vivo model derivation and application, PHARMACEUTICAL RESEARCH 22(3): 335-346.
- Prins S.A., Peeters M.Y., Houmes R.J., Dijk M. van, Knibbe C.A.J., Danhof M. & Tibboel D. (2005), Propofol 6% as sedative in children under 2 years of age following major craniofacial surgery, British Journal of Anaesthesia 94(5): 630-635.
- Li G.L., Steeg T.J. van, Putter H., Spek J. van der, Pavel S., Danhof M. & Bouwstra J.A. (2005), Cutaneous side-effects of transdermal iontophotresis with and without surfactant pretreatment: a single-blinded, randomized controlled trial, British Journal of Dermatology 153: 404-412.
- Dahan A., Yassen A., Bijl H., Romberg R., Sarton E.Y., Teppema L.J.S.M., Olofsen E. & Danhof M. (2005), A comparison of the respiratory effects of intravenous buprenorphine and fentanyl in hu, British Journal of Anaesthesia 96: 825-834.
- Li G.L., Steeg T.J. van, Putter H., Spek J. van der, Pavel S., Danhof M. & Bouwstra J.A. (2005), Cutaneous side-effects of transdermal iontophoresis with and without surfactant pretreatment: a single-blinded, randomized controlled trial, British Journal of Dermatology 153(2): 404-412.
- Dahan A, Yassen A, Bijl H, Romberg R, Sarton E, Teppema L, Olofsen E & Danhof M (2005), Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats, British Journal of Anaesthesia 94(6).
- Yassen A, Olofsen E, Dahan A & Danhof M (2005), Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: Role of receptor equilibration kinetics, Journal of Pharmacology and Experimental Therapeutics 313(3).
- Li GL, Van Steeg TJ, Putter H, Van Der Spek J, Pavel S, Danhof M & Bouwstra JA (2005), Cutaneous side-effects of transdermal iontophoresis with and without surfactant pretreatment: a single-blinded, randomized controlled trial, British Journal of Dermatology 153(2).
- Knibbe C.A.J., Naber H., Aarts L.P.H.J., Kuks P.F.M. & Danhof M. (2004), Long-term sedation with propofol 60 mg/ml versus Propofil 10 mg/ml in critically ill, mechanically ventilated patients, Acta Anaesthesiologica Scandinavica 48: 302-307.
- Jonker D.M., Voskuyl R.A. & Danhof M. (2004), Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat, Epilepsia 45: 424-435.
- Zuideveld K.P., Graaf P.H. van der, Newgreen D., Thurlow R., Petty N., Jordan P., Peletier L.A. & Danhof M. (2004), Mechanism-based pharmacokinetic/pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body termperature in rats, Journal of Pharmacology and Experimental Therapeutics 308: 1012-1020.
- Nugroho A.K., Pasqua O.D., Danhof M. & Bouwstra J.A. (2004), Compartmental modeling of transdermal iotophoretic transport: I. In vitro Model derivation and application, Pharmacological Research 21: 1974-1984.
- Visser C.C., Stevanovic S., Voorwinden L.H., Gaillard P.J., Crommelin D.J.A., Danhof M. & Boer A.G. de (2004), Validation of the transferrin receptor for drug targeting to brain capillary endothelial cells in vitro, Journal of Drug Targeting 12: 145-150.
- Schaddelee M.P., DeJongh J., Collins S.D., Boer A.G. de, IJzerman A.P. & Danhof M. (2004), Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5'deoxy-N6-cylopentyladenosine in the mononeuropathic rat, European Journal of Pharmacology 504: 7-15.
- Danhof M., Graaf P.H. van der, Visser S.A.G. & Zuideveld K.P. (2004), Mechanism-based pharmacodynamic modelling for prediction of exposure response. In: D'Argenio D.Z. (Ed.), Advanced Methods of Pharmacokinetic & Pharmacodynamic Systems Analysis. Boston: Kluwer Academic Publishers. 49-65.
- Schaddelee M.P., Groenendaal D., DeJongh J., Cleypool C.G., IJzerman A.P., Boer A.G. de & Danhof M. (2004), Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists, Journal of Pharmacology and Experimental Therapeutics 311: 1138-1146.
- Li G.L., Vries J.J. de, Steeg T.J. van, Bussche H. van den, Maas H.J., Reeuwijk H.J.E.M., Danhof M., Bouwstra J.A. & Laar T. van (2004), Transdermal iontophoretic delivery of apomorphine in patients inproved by sufactant formulation pretreatment, JOURNAL OF CONTROLLED RELEASE 101: 199-208.
- Nugroho A.K., Li G.L., Danhof M. & Bouwstra J.A. (2004), Transdermal iontophoresis of rotigotine across human stratum corneum in vitro: influence of pH and NaCI concentration, PHARMACEUTICAL RESEARCH 21: 844-850.
- Visser C.C., Voorwinden L.H., Crommelin D.J.A., Danhof M. & Boer A.G. de (2004), Characterization and Modulation of the Transferrin Receptor on Brain Capillary Endothelial Cells, PHARMACEUTICAL RESEARCH 21: 761-769.
- Swart E.L., Zuideveld K.P., DeJongh J., Danhof M., Thijs L.G. & Strack van Schijndel R.M. (2004), Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients, British Journal of Clinical Pharmacology 57: 135-145.
- Swart E.L., Zuideveld K.P., Jongh J. de, Danhof M. & Thijs L.G. (2004), Population pharmacokinetics of lorazepam and midazolam in ICU patients after long-term continuous infusion, British Journal of Clinical Pharmacology 57(2): 135-145.
- Li G.L., Danhof M., Frederik P.M. & Bouwstra J.A. (2003), Pretreatment of water-based surfactant affects transdermal iontophoretic delivery of R-apomorphine in vitro, PHARMACEUTICAL RESEARCH 20: 653-659.
- Visser S.A.G., Wolters F.L.C., Gubbens-Stibbe J.M., Tukker E., Graaf P.H. van der, Peletier L.A. & Danhof M. (2003), Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations, Journal of Pharmacology and Experimental Therapeutics 304(1): 88-101.
- Li G., Danhof M., Frederik P.M. & Bouwstra J.A. (2003), Pretreatment with a water-based surfactant formulation affects transdermal iontophoretic delivery of R-apomorphine in vitro, PHARMACEUTICAL RESEARCH 20(4): 653-659.
- Jonker D.M., Mheen C. van de, Eilers P.H.C., Kruk A.R., Voskuyl R.A. & Danhof M. (2003), Anticonvulsant drugs differentially suppress individual ictal signs: A pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat, Behavioral Neuroscience 117(5): 1076-1085.
- Bueters T.J.H., Helden H.P. van, IJzerman A.P. & Danhof M. (2003), Low efficacy adenosine A1 agonists inhibit striatal acetylcholine release in rats improving central selectivity of action, Neuroscience Letters 343: 57-61.
- Bueters T.J.H., Joosen M.J.A., Helden H.P.M., IJzerman A.P. & Danhof M. (2003), Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin, Journal of Pharmacology and Experimental Therapeutics 304: 1307-1313.
- Bueters T.J.H., IJzerman A.P., Helden H.P.M. & Danhof M. (2003), Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A1 receptor partial agonist 2'-deoxy-N6-cyclopentyladenosine in sarin-poisoned rats, Toxicology and Applied Pharmacology 192: 86-94.
- Bueters T.J.H., Duivenvoorde L.M. van, Danhof M., IJzerman A.P. & Helden H.P. van (2003), Cyclopentyladenosine and some of its low-efficacy derivatives inhibit striatal synaptosomal release of acetylcholine to a similar degree, European Journal of Pharmacology 481: 141-146.
- Schaddelee M.P., Voorwinden H.L., Tilburg E.W. van, Pateman T.J., IJzerman A.P., Danhof M., Soudijn W. & Wijngaarden I. van (2003), Medicinal chemistry of adenosine A1 receptor ligands, Current Topics in Medicinal Chemistry 3: 355-367.
- Schaddelee M.P., Voorwinden H.L., Groenendaal D., Hersey A., IJzerman A.P., Danhof M. & Boer A.G. de (2003), Blood-Brain Barrier transport of Synthetic adenosine A1 receptor agonists in vitro: structure transport relationships, European Journal of Pharmaceutical Sciences 20: 347-356.
- Visser S.A.G., Gubbens-Stibbe J.M., Graaf P.H. van der, Danhof M. & Peletier L.A. (2003), Mechanism-based Pharmacokinetic/Pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in viro-in vivi modulators, Journal of Pharmacology and Experimental Therapeutics 304: 88-101.
- Visser S.A.G., Wolters F.L.C., Graaf P.H. van der, Peletier L.A. & Danhof M. (2003), Dose-Dependent EEG Effects of Zolpidem Provide Evidence for GABAA Receptor Subtype Selectivity in Vivo, Journal of Pharmacology and Experimental Therapeutics 304: 1251-1257.
- Li G.L., Grossklaus A., Danhof M. & Bouwstra J.A. (2003), Iontophoric R-apomorphine delivery in combination with surfactant pretreatment: in vitro validation studies, 266: 61-68.
- Visser S.A.G., Graaf P.H. van der, Danhof M. & Peletier L.A. (2003), Mechanism-Based Modeling of the Pharmacodynamic Interaction of Alphaxalone and Midazolam in Rats, Journal of Pharmacology and Experimental Therapeutics 307: 765-775.
- Jonker D.M., Vermeij D.A.C., Edelbroek P.M., Voskuyl R.A., Piotrovsky V.K. & Danhof M. (2003), Pharmacodynamic Analysis of the Interaction between Tiagabine and Midazolam with an Allosteric Model that Incorporates Signal Transduction, Epilepsia 44: 329-338.
- Jonker DM, van de Mheen C, Eilers PHC, Kruk AR, Voskuyl RA & Danhof M (2003), Anticonvulsant drugs differentially suppress individual ictal signs: A pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat, Behavioral Neuroscience 117(5).
- Li G.L., Geest R. van der, Chanet L., Zanten E. van, Danhof M. & Bouwstra J.A. (2002), In itro iontophoresis of R-apomorphine across human stratum corneum. Structure-transport relationship of penetration enhancement, JOURNAL OF CONTROLLED RELEASE 84: 49-57.
- Lange E.C.M. de & Danhof M. (2002), Considerations in the Use of Cerebrospinal Fluid Pharmacokinetics to Predict Brain Target Concentrations in the Clinical Setting; Implications of the Barriers between Blood and Brain, Clinical Pharmacokinetics 41: 691-703.
- Zuideveld K.P., Rusic-Pavletic J., Maas J., Peletier L.A., Graaf P.H. van der & Danhof M. (2002), Pharmacokinetic-Pharmacodynamic modeling of buspirone and its metabolite 1-(2-Pyrimidinyl)-Piperazine in rats, Journal of Pharmacology and Experimental Therapeutics 303: 1130-1137.
- Knibbe C.A.J., Zuideveld K.P., Jongh J. de, Kuks P.F.M., Aarts L.L.P. & Danhof M. (2002), Population pharmacokinetic and pharmacodynamic modeling of propofol for long-term sedation in critically ill patients: A comparison between propofol 6% and propofol 1%, Clinical Pharmacology & Therapeutics 72: 670-684.
- Swart E.L., Hoven B. van der, Groeneveld A.B.J., Touw D.J. & Danhof M. (2002), Correlation between midazolam and lidocaine pharmacokinetics and EMGX formulation in healthy volunteers, Br. J. Clin. Pharmacol. 53: 133-139.
- Zuideveld K.P., Gestel A. van, Peletier L.A., Graaf P.H. van der & Danhof M. (2002), Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A-receptor agonist flesinoxan, European Journal of Pharmacology 445: 43-54.
- Bueters T.J.H., Groen B., Danhof M., IJzerman A.P. & Helden H.P.M. (2002), Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication, Archives of Toxicology 76: 650-656.
- Bueters T.J.H., Helden H.P.M., Danhof M. & IJzerman A.P. (2002), Effects of the adenosine A1 receptor allosteric modulators PD81,723 and LUF5484 on the striatal acetylcholine release, European Journal of Pharmacology 454: 177-182.
- Danhof M. & Visser S.A.G. (2002), Pharmaco-encephalography and pharmacokinetic-pharmacodynamic modelling: focus on pre-clinical steps, Methods and Findings in Experimental and Clinical Pharmacology 24: 127-128.
- Visser S.A.G., Gladdines W.W.F.T., Graaf P.H. van der, Peletier L.A. & Danhof M. (2002), Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABAA receptor in vivo, Journal of Pharmacology and Experimental Therapeutics 303: 616-626.
- Zuideveld K.P., Treijtel N., Maas H.J., Gubbens-Stibbe J.M., Peletier L.A., Graaf P.H. van der & Danhof M. (2002), A competitive interaction model predicts the effect of WAY-100,635 on the Time Course of R-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin-Induced Hypothermia, Journal of Pharmacology and Experimental Therapeutics 300: 330-338.
- Knibbe C.A.J., Melenhorst-de Jong G., Mestrom M., Rademaker C.M.A., Reijnvaan A.F.A., Zuideveld K.P., Kuks P.F.M., Vught H. van & Danhof M. (2002), Pharmacokinetic and effects of propofol 6% for short-term sedation in paediatric patients following cardiac Surgery, Br. J. Clin. Pharmacol. 54: 415-422.
- Visser S.A.G., Smulders J.G.M., Reijers B.P.R., Graaf P.H. van der, Peletier L.A. & Danhof M. (2002), Mechanism-based pharmacokinetic-pharmacodynamic modelling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats, Journal of Pharmacology and Experimental Therapeutics 302: 1158-1167.
- Li G.L., Geest R. van der, Chanet L., Zanten E. van, Danhof M. & Bouwstra J.A. (2002), In vitro iontophoresis of R-apomorphine across human stratum corneum. Structure-transport relationship of penetration enhancement, JOURNAL OF CONTROLLED RELEASE 7: 49-57.
- Danhof M. (2002), Electroencephalography parameters as biomarkers: extrapolation from laboratory animals to humans, Methods and Findings in Experimental and Clinical Pharmacology 24: 63-64.
- Tuk B., Gool T. & Danhof M. (2002), Mechanism-based pharmacodynamic modelling of the interaction of midazolam, bretazenil and zolpidem with ethano, Journal of Pharmacokinetics and Pharmacodynamics 29: 235-250.
- Li GL, van der Geest R, Chanet L, van Zanten E, Danhof M & Bouwstra JA (2002), In vitro iontophoresis of R-apomorphine across human stratum corneum - Structure-transport relationship of penetration enhancement, Journal of Controlled Release 84(1-2).
- Cleton A., Graaf P.H. van der, Ghijsen W., Voskuyl R.A. & Danhof M. (1999), Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy, PHARMACEUTICAL RESEARCH 16: 1702-1709.
- Cleton A., Mazee D., Voskuyl R.A. & Danhof M. (1999), Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats, British Journal of Pharmacology 127: 227-235.
- Graaf P.H. van der, Nilsson J., Schaick E.A. van & Danhof M. (1999), Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat, JOURNAL OF PHARMACEUTICAL SCIENCES 88: 306-312.
- Cox E.H., Langemeijer M.W.E., Gubbens-Stibbe J.M., Muir K.T. & Danhof M. (1999), The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model, Anesthesiology : .
- Tuk B., Oostenbruggen M.F. van, Herben V.M.M., Mandema J.W. & Danhof M. (1999), Characterization of the pharmacodynamic interaction between parent drug and metabolite: midazolam and a-OH-midazolam, Journal of Pharmacology and Experimental Therapeutics : .
- Cleton A., Greef H.J.J.M., Edelbroek P.M., Voskuyl R.A. & Danhof M. (1999), Stereoselective central nervous system effects of the R- and S- isomers of the GABA uptake blocker N-(4,4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat, British Journal of Pharmacology 128: 1651-1658.
- Della Paschoa O.E., Kruk M.R., Voskuyl R.A. & Danhof M. (1998), Effects of repeated siezure induction on seizure activity, post-ictal and nterictal behavior, Brain Research Bulletin 814: 199-208.
- Della Paschoa O.E., Kruk M.R. & Danhof M. (1998), Pharmacokinetic-pharmacodynamic modelling of behavioural responses, Neuroscience & Biobehavioral Reviews 23: 229-236.
- Graaf P.H. van der, Schaick E.A. van, Visser S.A.G., Greef H.J.M.M. de, IJzerman A.P. & Danhof M. (1998), Mechanism-based pharmacokinetic-pharmacodynamic modeling of anti-lipolytic effects of adenosine A1 receptor agonists in rats: prediction of tissue-dependent efficay in vivo, Journal of Pharmacology and Experimental Therapeutics : .
- Schaick E.A. van, Zuideveld K.P., Tukker H.J., Langemeijer M.W.E., IJzerman A.P. & Danhof M. (1998), Metabolic and cardiovascular effects of the adenosine A(1) receptor agonist N-6-(p-sulfophenyl)adenosine in diabetic Zucker rats: Influence of the disease on the selectivity of action, Journal of Pharmacology and Experimental Therapeutics 287(1): 21-30.
- Schaick E.A. van, Greef H.J.M.M. de, IJzerman A.P. & Danhof M. (1998), Physiological indirect effect modeling of the antilipolytic effects of adenosine A1-receptor agonists, Journal of Pharmacokinetics and Biopharmaceutics 25(6): 673-694.
- Schaick E.A. van, Tukker H.J., Roelen H.C.P.F., IJzerman A.P. & Danhof M. (1998), Selectivity of action of 8-alkylamino analogues of N-6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats, British Journal of Pharmacology 124(3): 607-618.
- Cleton A., Graaf P.H. van der, Voskuyl R.A. & Danhof M. (1998), Mechanism-based modelling of the adaptive changes in the pharmacodynamics of midazolan in rats with experimentally induced epilepsy. In: Danhof M. & Steimer J.L. (Eds.), Measurements and kinetics of in vivo drug effects. Advances in simultaneous pharmacokinetic pharmacodynamic modelling. Leiden: LACDR.
- Cleton A., Greef H.J.M.M. de, Edelbroek P.M., Voskuyl R.A. & Danhof M. (1998), Pharmacokinetic-pharmacodynamic modeling of the EEG-effect of the GABA uptake inhibitors R- and S-tiagabine. In: Danhof M. & Steimer J.L. (Eds.), Measurement and kinetics of in vivo drug effects. Advances in simultaneous pharmacokinetic/pharmacodynamic modelling. Leiden: LACDR. 143-145.
- Della Paschoa O.E., Kruk M.R., Hamstra R., Voskuyl R.A. & Danhof M. (1998), Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern, British Journal of Pharmacology 125: 997-1004.
- Geest R. van der, Laar T. van, Kruger P.P., Gubbens-Stibbe J.M., Bodde H.E., Roos R.A.C. & Danhof M. (1998), Pharmacokinetics, enantiomer interconversion and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease, Clinical Neuropharmacology 21: 159-168.
- Cox E.H., Langemeijer M.W.E. & Danhof M. (1998), Pharmacokinetic-pharmacodynamic modelling of the analgesic effect of alfentanil in the rat using tooth pulp evoked potentials, Journal of Pharmacological and Toxicological Methods 39: 19-27.
- Cox E.H., Kerbusch T., Graaf P.H. van der & Danhof M. (1998), Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the m-opioid receptor, Journal of Pharmacology and Experimental Therapeutics 284(3): 1095-1103.
- Cleton A., Greef H.J.M.M. de, Edelbroek P.M., Voskuyl R.A. & Danhof M. (1998), Application of a combined "effect compartment/indirect response model" to the nervous system effects of tiagabine in the rat, Journal of Pharmacokinetics and Biopharmaceutics : .
- Della Paschoa O.E., Kruk M.R., Hamstra R., Voskuyl R.A. & Danhof M. (1998), Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure threshold and pattern, British Journal of Pharmacology 125: 997-1004.
- Della Paschoa O.E., Voskuyl R.A. & Danhof M. (1998), Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate, British Journal of Pharmacology 125: 1610-1616.
- Della Paschoa O.E., Mandema J.W., Voskuyl R.A. & Danhof M. (1998), Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effect of phenytoin in rats, Journal of Pharmacology and Experimental Therapeutics 284(2): 460-466.
- Laar T. van, Geest R. van der, Danhof M., Boddé H.E., Goossens P.H. & Roos R.A.C. (1998), Stepwise intravenous infusion of apomorphine to determine the therapeutic window in patients with Parkinson's disease, Clinical Neuropharmacology 21(3): 152-158.
- Geest R. van der, Danhof M. & Boddé H.E. (1998), Validation and testing of a new iontophoretic continuous flow through transport cell, JOURNAL OF CONTROLLED RELEASE 51: 85-91.
- Knibbe C.A.J., Voortman H.-J., Aarts L.P.H.J., Kuks P.F.M., Lange R., Langemeijer H.J.M. & Danhof M. (1998), Pharmacokinetics, induction of anaesthesia and safety characteristics of propofol 6% SAZN versus propofol 1% SAZN and diprivan®-10 after bolus injection, British Journal of Clinical Pharmacology : .
- Snoeck H.J.M., Donck K. ver, Jacqmin P., Belle H. van, Dupont A.G., Peer A. van & Danhof M. (1998), Physiological red blood cell kinetic model to explain the apparent discrepancy between adenosine breakdown inhibition and nucleoside transporter occupancy of draflazine, Journal of Pharmacology and Experimental Therapeutics 286: 142-149.
- Danhof M., Geest R. van der, Laar T. van & Boddé H.E. (1998), An integrated pharmacokinetic-pharmacodynamic approach to optimization of R-apomorphine delivery in Parkinson's disease, Advanced Drug Delivery Reviews 33: 253-263.
- Cox E.H., Knibbe C.A.J., Koster V.S., Langemeijer M.W.E., Tukker H.J., Lange R., Kuks P.F.M., Langemeijer H.J.M., Lie-A-Huen L. & Danhof M. (1998), Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol, Pharmacological Research 15(3): 442-448.
- Tuk B., Herben V.M.M., Mandema J.W. & Danhof M. (1998), Relevance of arteriovenous concentration differences in pharmacokinetic-pharmacodynamic modelling of midazolam, Journal of Pharmacology and Experimental Therapeutics 284(1): 202-207.
- Cleton A., Voskuyl R.A. & Danhof M. (1998), Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy, British Journal of Pharmacology 125: 615-620.
- Sandt I.C.J. van der, Boer A.G. de, Danhof M. & Breimer D.D. (1998), Selectivity of P-glycoprotein substrates rhodamine-123 and doxorubicin in wild-type and MDR1 cDNA transfected LLC-PK1 cells, British Journal of Pharmacology : 130P.
- Cox E.H., Kuipers J.A. & Danhof M. (1998), Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats: assessment of rapid functional adaptation, British Journal of Pharmacology 124: 1534-1540.
- Boer A.G. de, Gaillard P.J., Lange E.C.M. de, Danhof M., Vries H.E. de, Kuiper J. & Breimer D.D. (1997), Drug transport across blood-brain barriers: in vitro vs. in vivo models, Developments in animal and veterinary sciences 27: 873-879.
- Lange E.C.M. de, Danhof M., Boer A.G. de & Breimer D.D. (1997), Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier, Brain research reviews 25(1): 27-49.
- Geest R. van der, Laar T. van, Gubbens-Stibbe J.M., Bodde H.E. & Danhof M. (1997), Iontophoretic delivery of R-apomorphine: an in vivo study in patients with Parkinson's disease, PHARMACEUTICAL RESEARCH 14: 1803-1809.
- Della Paschoa O.E., Kruk M.R., Voskuyl R.A., Danhof M. & Hamstra R. (1997), Seizure patterns in kindling and cortical stimulation models of experimental epilepsy, Brain Research 770(1-2): 221-227.
- Geest R. van der, Kruger P.P., Gubbens-Stibbe J.M., Laar T. van, Bodde H.E. & Danhof M. (1997), Assay of R-apomorphine, S-apomorphine, apocodeine, isoapocodeine and their glucuronade and sulphate conjugates in plasma and urine of patients with Parkinson's disease, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 702: 131-141.
- Lange E.C.M. de (1997), Effect of perfusate tonicity and temperature on microdialysate AUC values of acetaminophen and atenolol obtained from rat cortical brain. In: Boer A.G. de & Sutanto W. (Eds.), Drug transport across the blood-brain-barrier. In vitro and in vivo techniques. Amsterdam: Harwood Academic Publishers. 157-163.
- Lange E.C.M. de, Vries J.D. de, Zurcher C., Danhof M., Boer A.G. de & Breimer D.D. (1995), The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain, 12(12): 1924-1931.
- Lange E.C.M. de, Hesselink M.B., Danhof M., Boer A.G. de & Breimer D.D. (1995), The use of intracerebral microdialysis to determine changes in blood-brain-barrier transport, 12(1): 129-133.
- Lange E.C.M. de, Danhof M., Zurcher C., Boer A.G. de & Breimer D.D. (1995), Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability, Brain Research 702(1-2): 261-265.
- Lange E.C.M. de, Bouw M.R., Mandema J.W., Danhof M., Boer A.G. de & Breimer D.D. (1995), Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat-brain, British Journal of Pharmacology 116(5): 2538-2544.
- Boer A.G. de, Vries H.E. de, Lange E.C.M. de, Danhof M., Kuiper J. & Breimer D.D. (1994), Drug transport to the brain: in-vitro versus in-vivo approaches, 28(1-3): 259-263.
- Lange E.C.M. de, Danhof M., Boer A.G. de & Breimer D.D. (1994), Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brain, Brain Research 666(1): 1-8.
- Lange E.C.M. de, Danhof M., Boer A.G. de & Breimer D.D. (1993), The use of intracerebral microdialysis to study blood-brain-barrier transport in health, after modification and in disease. In: Drewes L.R. & Betz A.L. (Eds.), Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology no. 331. New York: Springer. 257-262.
- Lange E.C.M. de, Danhof M., Boer A.G. de & Breimer D.D. (1991), The use of intracerebral microdialysis for the characterization of drug transport into the brain. Rollema H., Westerink B.H.C. & Drijfhout W.J. (Eds.), 5th International Conference on In Vivo Methods. Monitoring molecules in neuroscience 21 September 1991 - 24 September 1991: International Society for Monitoring Molecules in Neuroscience. 74-75.
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