Meindert Danhof (Prof. Dr.) is professor at the Division of Pharmacology.

More information about Meindert Danhof

Professor Danhof  studied Pharmacy at Groningen University and received his Pharm D in 1976. His PhD was obtained from Leiden University in 1980 under the direction of Professor D.D. Breimer. From 1980-1983, he was a post-doctoral research fellow with Professor G. Levy, in the Department of Pharmaceutics, State University of New York at Buffalo, USA. He received further specialist training in clinical pharmacology as a visiting scientist at Stanford University Medical center between 1983-1986. Professor Danhof’s research interest is in the development of new theoretical concepts in pharmacokinetic-pharmacodynamic [PKPD] modeling.

In recent years, important contributions in his research have been on the incorporation of i] receptor theory and ii] dynamical systems analysis. This has resulted in a new class of ‘mechanism-based’ PKPD models with considerably improved properties for extrapolation and prediction. His most recent research focuses on the development of novel concepts of ‘disease system analysis’. Meindert Danhof has an active interest in the dissemination of PKPD modeling concepts through the organization of international conferences, workshops and courses.

He is the Founder and Chairman of the series of international conferences ‘Measurement and Kinetics of In Vivo Drug Effects’ in Noordwijkerhout, the Netherlands in 1990, 1994, 1998, 2002,  2006, 2010 and 2014. In 1998, he has established LAP&P Consultants BV, which provides a professional infrastructure for consultancy services in the area of advanced PKPD modeling to the pharmaceutical industry, including actual data-analysis and clinical trial simulation. In 2007, he was the founder of the ‘TIPharma mechanism-based PKPD modeling platform’, which aims at the development of a mechanism-based PKPD model library and database for application in drug discovery and development.

Meindert Danhof is professor of pharmacology in both the Faculty of Science and the Faculty of Medicine and was Scientific Director of the Leiden Academic Centre for Drug Research  between 2005 and 2013. He is the Immediate Past President of the European Federation of Pharmaceutical Sciences (EUFEPS) and President of the 6^th FIP Pharmaceutical Sciences World Congress (PSWC) on May 21-24 in Stockholm, Sweden.

Meindert Danhof has been a Fellow of the American Association of Pharmaceutical Sciences (AAPS) since 1998. In 1993, he received the Organon Research Prize for his contributions to research on PKPD relationships and in 1997 the ‘FIP Pharmaceutical Scientist of the Year Award’ at the 57th World Congress of Pharmacy and Pharmaceutical Sciences in Vancouver, Canada. In 2004, he received the Rawls Palmer Award at the 105th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics in Miami, USA, and in 2006 he received the ‘New Safe Medicines Faster Award’ of the European Federation of Pharmaceutical Sciences.

In 2009 he was the recipient of the Distinguished Scientist Award of the American College of Clinical Pharmacology (ACCP) and in 2010 he received the Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolism of the American Association of Pharmaceutical Sciences (AAPS)

Meindert Danhof currently supervises the following PhD candidates:

• Wilbert de Witte
• Vincent Dubois
• Yumi Yamamoto
• Sven van Dijkman
• Eline van Maanen

Publications

Activities