Matthias Barz
Professor Biotherapeutics delivery
- Name
- Prof.dr. M. Barz
- Telephone
- +31 71 527 4479
- m.barz@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-1749-9034
Matthias Barz is the head of the division of BioTherapeutics and Professor of Biotherapeutic Delivery
More information about Matthias Barz
News
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Four NWO Open Competition grants for Leiden researchers -
Publication from the Barz Lab in Advanced Materials -
How drugs work better when encapsulated in nanoparticles -
Drugs with fewer side effects through a collaboration between LACDR and PTS -
Leiden researchers join forces against tuberculosis -
Dies Natalis all about innovating and connecting -
Publication on the design of multifunctionalized nanoparticles -
New professor of Biotherapeutics Delivery at LACDR
PhD candidates
Former PhD Candidates
Biography
Matthias Barz studied chemistry at the Johannes Gutenberg-University Mainz (Germany) and Seoul National University (South Korea). After graduation in 2006 he received his PhD in polymer chemistry from the Johannes Gutenberg-University Mainz (Germany) working under the supervision of Prof. R. Zentel. Afterwards he worked in the laboratories of Dr. Maria J. Vicent at the CIPF (2010-2011) and Prof. T. Kirchhausen at Boston Children’s Hospital, Harvard Medical School (2011-2013) as a postdoctoral research fellow.
In 2013 he became independent junior research group leader and started his habilitation at the Institute of Organic Chemistry at the Johannes Gutenberg-University Mainz (Germany). After having received the venia legendi for organic chemistry in 2016 he joined the Leiden Academic Center for Drug Research (LACDR) as Full Professor for Biotherapeutic Delivery in 2020. His research focusses on the development of functional nanoparticles base on polypept(o)ides form diagnosis and therapy. Up to now, Matthias Barz has published more than 100 research papers, commentaries, reviews, book chapters and patents. For his independent research he received numerous awards, including the highly prestigious Chemiedozentenpreis (Young Faculty Award of the German Industry Fonds), the Young Faculty Scholarship of the Dr. Hermann-Schnell-Foundation, (German Chemical Society, Devision of Macromolecular Chemistry) and was named ACS PMSE Young Investigator in 2018.
Professor Biotherapeutics delivery
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Drug Delivery Technology
- Bi D., Hal A. van, Aschmann D., Shen M., Zhang H., Su L., Arias Alpizar G., Kros A., Barz M. & Bussmann J. (2024), Deconvolving passive and active targeting of liposomes bearing LDL receptor binding peptides using the zebrafish embryo model, Small 20(32): 2310781.
- Shalgunov V., Broek S.L. van den, Andersen I.V., Raval N.R., Schäfer G., Barz M., Herth M.M. & Battisti U.M. (2024), Evaluation of F-537-Tetrazine in a model for brain pretargeting imaging: comparison to N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine, Nuclear Medicine and Biology 128-129: 108877.
- Horvat N.K., Chocarro S., Marques O., Bauer T.A., Qiu R., Diaz-Jimenez A., Helm B., Chen Y., Sawall S., Sparla R., Su L., Klingmüller U., Barz M., Hentze M.W., Sotillo R. & Muckenthaler M.U. (2024), Superparamagnetic iron oxide Nanoparticles reprogram the tumor microenvironment and reduce lung cancer regrowth after crizotinib treatment, ACS Nano 18(17): 11025-11041.
- Simic L., Miravet Martí R., Duro-Castaño A., Nebot V.J. & Barz M. (2024), Utility of triethyloxonium tetrafluoroborate for chloride removal during sarcosine N-carboxyanhydride synthesis: improving NCA purity, Chemistry: a European Journal 30(31): e202304375.
- Schwiertz D.T., Heck A., Muhl C., Su L. & Barz M. (2024), Design of cross-linkable polypept(o)ide-based AB3 miktoarm star polymers through advances in PeptoMiktoStar synthesis, European Polymer Journal 210: 112989.
- Barz M., Parak W.J. & Zentel R. (2024), Concepts and approaches to reduce or avoid protein corona formation on nanoparticles: challenges and opportunities, Advanced Science 11(34): 2402935.
- Schneider P., Zhang H., Simic L., Dai Z., Schroers B., Akilli-Oeztuerk O., Lin J., Durak F., Schunke J., Bolduan V., Bogaert B., Schwiertz D.T., Schäfer G., Bros M., Grabbe S., Schattenberg J.M., Raemdonck K., Koynov K., Diken M., Kaps L. & Barz M. (2024), Multicompartment polyion complex micelles based on triblock polypept(o)ides mediate efficient siRNA delivery to cancer-associated fibroblasts for antistromal therapy of hepatocellular carcinoma, Advanced Materials 36(41): 2404784.
- Bi D., Wilhelmy C., Unthan D., Keil I.S., Zhao B., Kolb B., Koning R.I., Graewert M.A., Wouters B., Zwier R., Bussmann J., Hankemeier T., Diken M., Haas H., Langguth P., Barz M. & Zhang H. (2024), On the influence of fabrication methods and materials for mRNA-LNP production: from size and morphology to internal structure and mRNA delivery performance in vitro and on vivo, Advanced Healthcare Materials : 2401252.
- Schwiertz D.T., Angelina J., Zhang H. & Barz M. (2024), Miktoarm star-polypept(o)ide-based polyion complex micelles for the delivery of large nucleic acids, Biomacromolecules 25(10): 6539-6554.
- Bauer T.A., Simić L., Guyse J.F.R. van, Duro-Castaño A., Nebot V.J. & Barz M. (2024), Polypept(o)ides: origins, synthesis, applications and future directions, Progress in Polymer Science 158: 101889.
- Chen X.B., Yang H., Song X., Liang H., Wei Y., Lu J., Barz M., Jin R.R. & Nie Y. (2023), Integrated and dual-responsive lipopeptide nanovector with parallel effect to tumor and micro-environment regulation by efficient gene and drug co-delivery, Chinese Chemical Letters 34(5): 107753.
- Bauer T.A., Alberg I., Zengerling L.A., Besenius P., Koynov K., Slütter B.A., Zentel R., Que I., Zhang H. & Barz M. (2023), Tuning the cross-linking density and cross-linker in core cross-linked polymeric micelles and its effects on the particle stability in human blood plasma and mice, Biomacromolecules 24(8): 3545-3556.
- Wilhelmy C., Keil I.S., Uebbing L., Schroer M.A., Franke D., Nawroth T., Barz M., Sahin U., Haas H., Diken M. & Langguth P. (2023), Polysarcosine-functionalized mRNA lipid nanoparticles tailored for immunotherapy, Pharmaceutics 15(8): 2068.
- Breder-Bonk C., Docter D., Barz M., Strieth S., Knauer S.K., Gül D. & Stauber R.H. (2023), The apoptosis inhibitor protein survivin is a critical cytoprotective resistor against silica-based nanotoxicity, Nanomaterials 13(18): 2546.
- Bi D., Unthan D.M., Hu L., Bussmann J., Remaut K., Barz M. & Zhang H. (2023), Polysarcosine-based lipid formulations for intracranial delivery of mRNA, Journal of Controlled Release 356: 1-13.
- Dal N.K., Schäfer G., Thompson A.M., Schmitt S., Redinger N., Alonso-Rodriguez N., Johann K., Ojong J., Wohlmann J., Best A., Koynov K., Zentel R., Schaible U.E., Griffiths G., Barz M. & Fenaroli F. (2023), Π-Π interactions stabilize PeptoMicelle-based formulations of Pretomanid derivatives leading to promising therapy against tuberculosis in zebrafish and mouse models, Journal of Controlled Release 354: 851-868.
- Bauer T.A. Schramm J., Fenaroli F., Siemer S., Seidl C.I., Rosenauer C., Bleul R., Stauber R., Koynov K., Maskos M. & Barz M. (2023), Complex structures made simple: continuous flow production of core cross-linked polymeric micelles for paclitaxel pro-drug-delivery, Advanced Materials 35(21): 2210704.
- Capelôa L., Schwiertz D. & Barz M. (2023), Facile synthesis of AA'B- and ABC-type polypept(o)ide miktoarm star polymers utilizing polysarcosine end group functionalization for core introduction, European Polymer Journal 187: 111896.
- Shalgunov V., Lopes van den Broek S., Vang Andersen I., García Vázquez R., Raval N.R., Palner M., Mori Y., Schäfer G., Herrmann B., Mikula H., Beschorner N., Nedergaard M., Syvänen S., Barz M., Moos Knudsen G., Battisti U.M. & Herth M.M. (2023), Pretargeted imaging beyond the blood-brain barrier, RSC Medicinal Chemistry 14(3): 444-453.
- García-Vázquez R., Battisti U.M., Shalgunov V., Schäfer G., Barz M. & Herth M.M. (2022), [11C]Carboxylated tetrazines for facile labeling of trans-cyclooctene-functionalized PeptoBrushes, Macromolecular Rapid Communications 43(12): 2100655.
- Capelôa L., Yazdi M., Zhang H., Chen X., Nie Y., Wagner E., Lächelt U. & Barz M. (2022), Cross-linkable polyion complex micelles from polypept(o)ide-based ABC-triblock copolymers for siRNA delivery, Macromolecular Rapid Communications 43(12): 2100698.
- Shalgunov V., Engudar G., Bohrmann L., Wharton L., Maskell K., Johann K., Barz M., Schaffer P., Herth M.M. & Radchenko V. (2022), Radiolabeling of a polypeptide polymer for intratumoral delivery of alpha-particle emitter, 225Ac, and beta-particle emitter, 177Lu, Nuclear Medicine and Biology 104-105: 11-21.
- Dal N.K., Speth M., Johann K., Barz M., Beauvineau C., Wohlmann J., Fenaroli F., Gicquel B., Griffiths G. & Alonso-Rodriguez N. (2022), The zebrafish embryo as an in vivo model for screening nanoparticle-formulated lipophilic anti-tuberculosis compounds, Disease Models & Mechanisms 15(1): dmm049147.
- Schmitt S., Nuhn L., Barz M., Butt H.J. & Koynov K. (2022), Shining light on polymeric drug nanocarriers with fluorescence correlation spectroscopy, Macromolecular Rapid Communications 43(12): 2100892.
- Shahneh F., Johann K., Bohn T., Klein M., Bopp T., Barz M. & Becker C. (2022), Suppression of cAMP formation by inhibitor-loaded polypept(o) ide micelles inhibits melanoma growth by preserving an inflammatory myeloid cell phenotype, Experimental Dermatology 31(2): E48-E48.
- Barz M., Nuhn L. & Theato P. (2022), A tribute to Rudolf Zentel and his lifetime research achievements, Macromolecular Rapid Communications 43(12): 2200311.
- Barz M., Nuhn L., Hörpel G. & Zentel R. (2022), From self-organization to tumor-immune therapy: how things started and how they evolved, Macromolecular Rapid Communications 43(12): 2100829.
- Bauer T.A., Muhl C., Schollmeyer D. & Barz M. (2021), Racemic S-(ethylsulfonyl)-dl-cysteine N-Carboxyanhydrides improve chain lengths and monomer conversion for beta-sheet-controlled ring-opening polymerization, Macromolecular Rapid Communications 42(8): 2000470.
- Bauer T. A., Imschweiler J., Muhl C., Weber B. & Barz M. (2021), Secondary structure-driven self-assembly of thiol-reactive polypept(o)ides, Biomacromolecules 22(5): 2171-2180.
- Bauer T.A., Horvat N.K., Marques O., Chocarro S., Mertens C., Colucci S., Schmitt S., Carrella L.M., Morsbach S., Koynov K., Fenaroli F., Blümler P., Jung M., Sotillo R., Hentze M.W., Muckenthaler M.U. & Barz M. (2021), Core cross‐linked polymeric micelles for specific iron delivery: inducing sterile inflammation in macrophages, Advanced Healthcare Materials 10(19): 2100385.
- Chen X., Jin R., Jiang Q., Bi Q., He T., Song X., Barz M., Ai H., Shuai X. & Nie Y. (2021), Delivery of siHIF-1α to reconstruct tumor normoxic microenvironment for effective chemotherapeutic and photodynamic anticancer treatments, Small 17(25): 2100609.
- Kappel C., Seidl C., Medina-Montano C., Schinnerer M., Alberg I., Leps C., Sohl J., Hartmann A.K., Fichter M., Kuske M., Schunke J., Kuhn G., Tubbe I., Paßlick D., Hobernik D., Bent R., Haas K., Montermann E., Walzer K., Diken M., Schmidt M., Zentel R., Nuhn L., Schild H., Tenzer S., Mailänder V., Barz M., Bros M. & Grabbe S. (2021), Density of conjugated antibody determines the extent of Fc receptor dependent capture of nanoparticles by liver sinusoidal endothelial cells, ACS Nano 15(9): 15191-15209.
- Bauer T.A., Eckrich J., Wiesmann N., Kuczelinis F., Sun W., Zeng X., Weber B., Wu S., Bings N.H., Strieth S. & Barz M. (2021), Photocleavable core cross-linked polymeric micelles of polypept(o)ides and ruthenium(II) complexes, Journal of Materials Chemistry B 9(39): 8211-8223.
- Sun Z., Qiao D., Shi Y., Barz M., Liu L. & Chen Y. (2021), Precision wormlike nanoadjuvant governs potency of vaccination, Nano Letters 21(17): 7236-7243.
- Johann K., Bohn T., Shahneh F., Luther N., Birke A., Jaurich H., Helm M., Klein M., Raker V.K., Bopp T., Barz M. & Becker C. (2021), Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression, Nature Communications 12(1): 5981.
- Siemer S., Bauer T.A., Scholz P., Breder C., Fenaroli F., Harms G., Dietrich D., Dietrich J., Rosenauer C., Barz M., Becker S., Strieth S., Reinhardt C., Fauth T., Hagemann J. & Stauber R.H. (2021), Targeting cancer chemotherapy resistance by precision medicine-driven nanoparticle-formulated cisplatin, ACS Nano 15(11): 18541–18556.
- Schwiertz D., Holm R. & Barz M. (2020), Facile synthesis of amphiphilic AB3 and A3B miktoarm PeptoMiktoStars, Polymer Journal 52: 119-132.
- Liang H., Bi Q.J., Hu A., Chen X.B., Jin R.R., Song X., Ke B.W., Barz M. & Nie Y. (2020), A nitroreductase and glutathione responsive nanoplatform for integration of gene delivery and near-infrared fluorescence imaging, Chemical Communications 56(51): 6949-6952.
- Liang H., Chen X.B., Jin R.R., Ke B.W., Barz M., Ai H. & Nie Y. (2020), Integration of indocyanine green analogs as near-infrared fluorescent carrier for precise imaging-guided gene delivery, Small 16(10): 1906538.
- Alberg I., Kramer S., Schinnerer M., Hu Q.Z., Seidl C., Leps C., Drude N., Mockel D., Rijcken C., Lammers T., Diken M., Maskos M., Morsbach S., Landfester K., Tenzer S., Barz M. & Zentel R. (2020), Polymeric nanoparticles with neglectable protein corona, Small 16(18): e1907574.
- Chen C.J., Wunderlich K., Mukherji D., Koynov K., Heck A.J., Raabe M., Barz M., Fytas G., Kremer K., Ng D.Y.W. & Weil T. (2020), Precision anisotropic brush polymers by sequence controlled chemistry, Journal of the American Chemical Society 142(3): 1332-1340.
- Johann K., Svatunek D., Seidl C.I., Rizzelli S., Bauer T.A., Braun L., Koynov K., Mikula H. & Barz M. (2020), Tetrazine- and trans-cyclooctene-functionatised potypept(o)ides for fast bioorthogonal tetrazine ligation, Polymer Chemistry 11(27): 4396-4407.
- Steen E.J.L., Jorgensen J.T., Johann K., Norregaard K., Sohr B., Svatunek D., Birke A., Shalgunov V., Edem P.E., Rossin R., Seidl C., Schmid F., Robillard M.S., Kristensen J.L., Mikula H., Barz M., Kjaer A. & Herth M.M. (2020), Trans-cyclooctene-functionalized peptobrushes with improved reaction kinetics of the tetrazine ligation for pretargeted nuclear imaging, ACS Nano 14(1): 568-584.
- Dal N.J.K., Kocere A., Wohlmann J., Herck S. van, Bauer T.A., Resseguier J., Bagherifam S., Hyldmo H., Barz M., Geest B.G. de & Fenaroli F. (2020), Zebrafish embryos allow prediction of nanoparticle circulation times in mice and facilitate quantification of nanoparticle-cell interactions, Small 16(5): 1906719.
- Nogueira S.S., Schlegel A., Maxeiner K., Weber B., Barz M., Schroer M.A., Blanchet C.E., Svergun D.I., Ramishetti S., Peer D., Langguth P., Sahin U. & Haas H. (2020), Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA delivery, ACS Applied Nano Material 3(11): 10634-10645.
- Darguzyte M., Holm R., Baier J., Drude N., Schultze J., Koynov K., Schwiertz D.T., Dadfar S.M., Lammers T., Barz M. & Kiessling F. (2020), Influence of riboflavin targeting on tumor accumulation and internalization of peptostar based drug delivery systems, Bioconjugate Chemistry 31(12): 2691-2696.
- Holm R., Schwiertz D.T., Weber B., Schultze J., Kuhn J., Koynov K., Lächelt. U. & Barz M. (2020), Multifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential, Macromolecular Bioscience 20(1): 1900152.
- Steinborn B., Hirschle P., Hohn M., Bauer T., Barz M., Wuttke S., Wagner E. & Lachelt U. (2019), Core-shell functionalized zirconium-pemetrexed coordination nanoparticles as carriers with a high drug content, Advanced Therapeutics 2(11): 1900120.
- Mantha S., Qi S.H., Barz M. & Schmid F. (2019), How ill-defined constituents produce well-defined nanoparticles: effect of polymer dispersity on the uniformity of copolymeric micelles, Physical Review Materials 3(2): 026002 .
- Holm R., Douverne M., Weber B., Bauer T., Best A., Ahlers P., Koynov K., Besenius P. & Barz M. (2019), Impact of Branching on the Solution Behavior and Serum Stability of Starlike Block Copolymers, Biomacromolecules 20(1): 375-388.
- Alkilany A.M., Zhu L., Weller H., Mews A., Parak W.J., Barz M. & Feliu N. (2019), Ligand density on nanoparticles: A parameter with critical impact on nanomedicine, Advanced Drug Delivery Reviews 143: 22-36.
- Sun Q.X., Barz M., Geest B.G. de, Diken M., Hennink W.E., Kiessling F., Lammers T. & Shi Y. (2019), Nanomedicine and macroscale materials in immuno-oncology, Chemical Society Reviews 48(1): 351-381.
- Bleher S., Buck J., Muhl C., Sieber S., Barnert S., Witzigmann D., Huwyler J., Barz M. & Suss R. (2019), Poly(sarcosine) surface modification imparts stealth-like properties to liposomes, Small 15(50): 1904716.
- Muhl C., Conrad M., Unthan D. & Barz M. (2019), Synthesis and characterization of bisalkylated polysarcosine-based lipopolymers, European Polymer Journal 120: 109223.
- Zimpel A., Danaf N. Al, Steinborn B., Kuhn J., Hohn M., Bauer T., Hirschle P., Schrimpf W., Engelke H., Wagner E., Barz M., Lamb D.C., Lachelt U. & Wuttke S. (2019), Coordinative Binding of Polymers to Metal-Organic Framework Nanoparticles for Control of Interactions at the Biointerface, ACS Nano 13(4): 3884-3895.
- Fenaroli F., Repnik U., Xu Y.T., Johann K., Herck S. van, Dey P., Skjeldal F.M., Frei D.M., Bagherifam S., Kocere A., Haag R., Geest B.G. de, Barz M., Russell D.G. & Griffiths G. (2018), Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models, ACS Nano 12(8): 8646-8661.
- Otter R., Klinker K., Spitzer D., Schinnerer M., Barz M. & Besenius P. (2018), Folding induced supramolecular assembly into pH-responsive nanorods with a protein repellent shell, Chemical Communications 54(4): 401-404.
- Theek B., Baues M., Gremse F., Pola R., Pechar M., Negwer I., Koynov K., Weber B., Barz M., Jahnen-Dechent W., Storm G., Kiessling F. & Lammers T. (2018), Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors, Journal of Controlled Release 282: 25-34.
- Negwer I., Best A., Schinnerer M., Schafer O., Capeloa L., Wagner M., Schmidt M., Mailander V., Helm M., Barz M., Butt H.J. & Koynov K. (2018), Monitoring drug nanocarriers in human blood by near-infrared fluorescence correlation spectroscopy, Nature Communications 9: 5306.
- Settanni G., Schafer T., Muhl C., Barz M. & Schmid F. (2018), Poly-sarcosine and poly(ethylene-glycol) interactions with proteins investigated using molecular dynamics simulations, Computational and Structural Biotechnology Journal 16: 543-550.
- Birke A., Ling J. & Barz M. (2018), Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications, Progress in Polymer Science 81: 163-208.
- Beck S., Schultze J., Rader H.J., Holm R., Schinnerer M., Barz M., Koynov K. & Zentel R. (2018), Site-specific DBCO modification of DEC205 antibody for polymer conjugation, Polymers 10(2): 141.
- Weber B., Birke A., Fischer K., Schmidt M. & Barz M. (2018), Solution Properties of Polysarcosine: From Absolute and Relative Molar Mass Determinations to Complement Activation, Macromolecules 51(7): 2653-2661.
- Muhl C., Schäfer O., Bauer T., Räder H.J. & Barz M. (2018), Poly(S-ethylsulfonyl-l-homocysteine): An α-Helical Polypeptide for Chemoselective Disulfide Formation, Macromolecules 51(20): 8188-8196.
- Klein P.M., Klinker K., Zhang W., Kern S., Kessel E., Wagner E. & Barz M. (2018), Efficient shielding of polyplexes using heterotelechelic polysarcosines, Polymers 10(6): 689.
- Otter R., Henke N.A., Berac C., Bauer T., Barz M., Seiffert S. & Besenius P. (2018), Secondary structure-driven hydrogelation using foldable telechelic polymer-peptide conjugates, Macromolecular Rapid Communications 39(17): 1800459.
- Schäfer O. & Barz M. (2018), Of thiols and disulfides: methods for chemoselective formation of asymmetric disulfides in synthetic peptides and polymers, Chemistry: a European Journal 24(47): 12131-12142.
- Tsvetkova Y., Beztsinna N., Baues M., Klein D., Rix A., Golombek S.K., Rawashdeh W. Al, Gremse F., Barz M., Koynov K., Banala S., Lederle W., Lammers T. & Kiessling F. (2017), Balancing Passive and Active Targeting to Different Tumor Compartments Using Riboflavin-Functionalized Polymeric Nanocarriers, Nano Letters 17(8): 4665-4674.
- Heller P., Hobernik D., Lächelt U., Schinnerer M., Weber B., Schmidt M., Wagner E., Bros M. & Barz M. (2017), Combining reactive triblock copolymers with functional cross-linkers: A versatile pathway to disulfide stabilized-polyplex libraries and their application as pDNA vaccines, Journal of Controlled Release 258: 146-160.
- Weil T. & Barz M. (2017), From Polymers to Functional Biomaterials, Macromolecular Bioscience 17(10): 1700307.
- Bartneck M., Schlößer C.T., Barz M., Zentel R., Trautwein C., Lammers T. & Tacke F. (2017), Immunomodulatory Therapy of Inflammatory Liver Disease Using Selectin-Binding Glycopolymers, ACS Nano 11(10): 9689-9700.
- Weber B., Kappel C., Scherer M., Helm M., Bros M., Grabbe S. & Barz M. (2017), PeptoSomes for Vaccination: Combining Antigen and Adjuvant in Polypept(o)ide-Based Polymersomes, Macromolecular Bioscience 17(10): 1700061.
- Sato K., Ji W., Palmer L.C., Weber B., Barz M. & Stupp S.I. (2017), Programmable assembly of peptide amphiphile via noncovalent-to-covalent bond conversion, Journal of the American Chemical Society 139(26): 8995-9000.
- Klinker K., Schäfer O., Huesmann D., Bauer T., Capelôa L., Braun L., Stergiou N., Schinnerer M., Dirisala A., Miyata K., Osada K., Cabral H., Kataoka K. & Barz M. (2017), Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size, Shape, and Function of Core Cross-Linked Nanostructures, Angewandte Chemie (International Edition) 56(32): 9608-9613.
- Heller P., Zhou J., Weber B., Hobernik D., Bros M., Schmid F. & Barz M. (2017), The Influence of Block Ionomer Microstructure on Polyplex Properties: Can Simulations Help to Understand Differences in Transfection Efficiency?, Small 13(17): 1603694.
- Ahlers P., Frisch H., Holm R., Spitzer D., Barz M. & Besenius P. (2017), Tuning the pH-Switch of Supramolecular Polymer Carriers for siRNA to Physiologically Relevant pH, Macromolecular Bioscience 17(10): 1700111.
- Schafer O., Klinker K., Braun L., Huesmann D., Schultze J., Koynov K. & Barz M. (2017), Combining Orthogonal Reactive Groups in Block Copolymers for Functional Nanoparticle Synthesis in a Single Step, ACS Macro Letters 6(10): 1140-1145.
- Fokina A., Klinker K., Braun L., Jeong B.G., Bae W.K., Barz M. & Zentel R. (2016), Multidentate polysarcosine-based ligands for water-soluble quantum dots, Macromolecules 49(10): 3663-3671.
- Weber B., Seidl C., Schwiertz D., Scherer M., Bleher S., Suss R. & Barz M. (2016), Polysarcosine-based lipids: from lipopolypeptoid micelles to stealth-like lipids in Langmuir Blodgett monolayers, Polymers 8(12): 427.
- Tappertzhofen K., Beck S., Montermann E., Huesmann D., Barz M., Koynov K., Bros M. & Zentel R. (2016), Bioreducible poly-L-lysine-poly[HPMA] block copolymers obtained by RAFT-polymerization as efficient polyplex-transfection reagents, Macromolecular Bioscience 16(1): 106-120.
- Zhou J.J., Barz M. & Schmid F. (2016), Complex formation between polyelectrolytes and oppositely charged oligoelectrolytes, The Journal of Chemical Physics 144(16): 164902.
- Huesmann D., Schafer O., Braun L., Klinker K., Reuter T. & Barz M. (2016), Exploring new activating groups for reactive cysteine NCAs, Tetrahedron Letters 57(10): 1138-1142.
- Schafer O., Huesmann D. & Barz M. (2016), Poly(S-ethylsulfonyl-L-cysteines) for chemoselective disulfide formation, Macromolecules 49(21): 8146-8153.
- Schafer O., Huesmann D., Muhl C. & Barz M. (2016), Rethinking cysteine protective groups: S-alkylsulfonyl-L-cysteines for chemoselective disulfide formation, Chemistry: a European Journal 22(50): 18085-18091.
- Hu Q., Rijcken C.J.F., Gaal E. van, Brundel P., Kostkova H., Etrych T., Weber B., Barz M., Kiessling F., Prakash J., Storm G., Hennink W.E. & Lammers T. (2016), Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications, Journal of Controlled Release 244(Part B): 314-325.
- Huesmann D., Sevenich A., Weber B. & Barz M. (2015), A head-to-head comparison of poly(sarcosine) and poly(ethylene glycol) in peptidic, amphiphilic block copolymers, Polymer 67: 240-248.
- Hortz C., Birke A., Kaps L., Decker S., Wachtersbach E., Fischer K., Schuppan D., Barz M. & Schinidt M. (2015), Cylindrical brush polymers with polysarcosine side chains: a novel biocompatible carrier for biomedical applications, Macromolecules 48(7): 2074-2086.
- Holm R., Klinker K., Weber B. & Barz M. (2015), Synthesis of amphiphilic block copolypept(o)ides by bifunctional initiators: making PeptoMicelles redox sensitive, Macromolecular Rapid Communications 36(23): 2083-2091.
- Barz M., Gotze S., Loges N., Schuler T., Theato P., Tremel W. & Zentel R. (2015), Well-defined carbohydrate-based polymers in calcium carbonate crystallization: influence of stereochemistry in the polymer side chain on polymorphism and morphology, European Polymer Journal 69: 628-635.
- Talelli M., Barz M., Rijcken C.J.F., Kiessling F., Hennink W.E. & Lammers T. (2015), Core-crosslinked polymeric micelles: principles, preparation, biomedical applications and clinical translation, Nano Today 10(1): 93-117.
- Heller P., Mohr N., Birke A., Weber B., Reske-Kunz A., Bros M. & Barz M. (2015), Directed interactions of block copolypept(o) ides with mannose-binding receptors: PeptoMicelles targeted to cells of the innate immune system, Macromolecular Rapid Communications 15(1): 63-73.
- Klinker K. & Barz M. (2015), Polypept(o) ides: hybrid systems based on polypeptides and polypeptoids, Macromolecular Rapid Communications 36(22): 1943-1957.
- Heller P., Weber B., Birke A. & Barz M. (2015), Synthesis and sequential deprotection of triblock copolypept(o)ides using orthogonal protective group chemistry, Macromolecular Rapid Communications 36(1): 38-44.
- Holm R., Klinker K., Weber B. & Barz M. (2015), Synthesis of amphiphilic block copolypept(o)ides by bifunctional initiators: making PeptoMicelles redox sensitive, Macromolecular Rapid Communications 36(23): 2083-2091.
- Barz M., Gotze S., Loges N., Schuler T., Theato P., Tremel W. & Zentel R. (2015), Well-defined carbohydrate-based polymers in calcium carbonate crystallization: influence of stereochemistry in the polymer side chain on polymorphism and morphology, European Polymer Journal 69: 628-635.
- Mohr N., Barz M., Forst R. & Zentel R. (2014), A deeper insight into the postpolymerization modification of polypenta fluorophenyl methacrylates to poly(N-(2-hydroxypropyl) methacrylamide), Macromolecular Rapid Communications 35(17): 1522-1527.
- Schieferstein H., Kelsch A., Reibel A., Koynov K., Barz M., Buchholz H.G., Bausbacher N., Thews O., Zentel R. & Ross T.L. (2014), F-18-radiolabeling, preliminary evaluation of folate-pHPMA conjugates via PET, Macromolecular Bioscience 14(10): 1396-1405.
- Heller P., Birke A., Huesmann D., Weber B., Fischer K., Reske-Kunz A., Bros M. & Barz M. (2014), Introducing PeptoPlexes: polylysine-block-polysarcosine based polyplexes for transfection of HEK 293T cells, Macromolecular Bioscience 14(10): 1380-1395.
- Nuhn L., Barz M. & Zentel R. (2014), New perspectives of HPMA-based copolymers derived by post-polymerization modification, Macromolecular Bioscience 14(5): 607-618.
- Birke A., Huesmann D., Kelsch A., Weilbacher M., Xie J., Bros M., Bopp T., Becker C., Landfester K. & Barz M. (2014), Polypeptoid-block-polypeptide copolymers: synthesis, characterization, and application of amphiphilic block copolypept(o)ides in drug formulations and miniemulsion techniques, Biomacromolecules 15(2): 548-557.
- Luxenhofer R., Barz M. & Schillmeier M. (2014), Quo Vadis Nanomedicine?, Nanomedicine 9(14): 2083-2086.
- Huesmann D., Birke A., Klinker K., Turk S., Rader H.J. & Barz M. (2014), Revisiting secondary structures in NCA polymerization: influences on the analysis of protected polylysines, Macromolecules 47(3): 928-936.
- Conejos-Sanchez I., Duro-Castano A., Birke A., Barz M. & Vicent M.J. (2013), A controlled and versatile NCA polymerization method for the synthesis of polypeptides, Polymer Chemistry 4(11): 3182-3186.
- Barz M., Duro-Castano A. & Vicent M.J. (2013), A versatile post-polymerization modification method for polyglutamic acid: synthesis of orthogonal reactive polyglutamates and their use in "click chemistry", Polymer Chemistry 4(10): 2989-2994.
- Dietzsch M., Barz M., Schueler T., Klassen S., Schreiber M., Susewind M., Loges N., Lang M., Hellmann N., Fritz M., Fischer K., Theato P., Kuhnle A., Schmidt M., Zentel R. & Tremel W. (2013), PAA-PAMPS copolymers as an efficient tool to control CaCO3 scale formation, Langmuir 29(9): 3080-3088.
- Tappertzhofen K., Metz V.V., Hubo M., Barz M., Postina R., Jonuleit H. & Zentel R. (2013), Synthesis of maleimide-functionalyzed HPMA-copolymers and in vitro characterization of the aRAGE- and human immunoglobulin (huIgG)polymer conjugates, Macromolecular Bioscience 13(2): 203-214.
- Shukoor M.I., Natalio F., Tahir M.N., Barz M., Weber S., Brochhausen C., Zentel R., Schreiber L.M., Brieger J. & Tremel W. (2012), CpG-DNA loaded multifunctional MnO nanoshuttles for TLR9-specific cellular cargo delivery, selective immune-activation and MRI, Journal of Materials Chemistry B 22(18): 8826-8834.
- Kelsch A., Tomcin S., Rausch K., Barz M., Mailander V., Schmidt M., Landfester K. & Zentel R. (2012), HPMA Copolymers as surfactants in the preparation of biocompatible nanoparticles for biomedical application, Biomacromolecules 13(12): 4179-4187.
- Barz M., Arminan A., Canal F., Wolf F., Koynov K., Frey H., Zentel R. & Vicent M.J. (2012), P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency, Journal of Controlled Release 163(1): 63-74.
- Hemmelmann M., Knoth C., Schmitt U., Allmeroth M., Moderegger D., Barz M., Koynov K., Hiemke C., Rosch F. & Zentel R. (2011), HPMA based amphiphilic copolymers mediate central nervous effects of domperidone, Macromolecular Rapid Communications 32(9-10): 712-717.
- Barz M., Luxenhofer R., Zentel R. & Vicent M.J. (2011), Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure-property relationships to better defined therapeutics, Polymer Chemistry 2(9): 1900-1918.
- Herth M.M., Barz M., Jahn M., Zentel R. & Rosch F. (2010), As-72/74-labeling of HPMA based polymers for long-term in vivo PET imaging, Bioorganic and Medicinal Chemistry Letters 20(18): 5454-5458.
- Scheibe P., Barz M., Hemmelmann M. & Zentel R. (2010), Langmuir-Blodgett films of biocompatible poly(HPMA)-block-poly(lauryl methacrylate) and poly(HPMA)-random-poly(lauryl methacrylate): influence of polymer structure on membrane formation and stability, Langmuir 26(8): 5661-5669.
- Barz M., Wolf F.K., Canal F., Koynov K., Vicent M.J., Frey H. & Zentel R. (2010), Synthesis, characterization and preliminary biological evaluation of P(HPMA)-b-P(LLA) copolymers: a new type of functional biocompatible block copolymer, Macromolecular Rapid Communications 31(17): 1492-1500.
- Barz M., Canal F., Koynov K., Zentel R. & Vicent M.J. (2010), Synthesis and in vitro evaluation of defined HPMA folate conjugates: influence of aggregation on folate receptor (FR) mediated cellular uptake, Biomacromolecules 11(9): 2274-2282.
- Tahir M.N., Natalio F., Berger R., Barz M., Theato P., Schroder H.C., Muller W.E.G. & Tremel W. (2009), Growth of fibrous aggregates of silica nanoparticles: fibre growth by mimicking the biogenic silica patterning processes, Soft Matter 5(19): 3657-3662.
- Shukoor M.I., Natalio F., Tahir M.N., Wiens M., Tarantola M., Therese H.A., Barz M., Weber S., Terekhov M., Schroder H.C., Muller W.E.G., Janshoff A., Theato P., Zentel R., Schreiber L.M. & Tremel W. (2009), Pathogen-mimicking MnO nanoparticles for selective activation of the TLR9 pathway and imaging of cancer cells, Advanced Functional Materials 19(23): 3717-3725.
- Herth M.M., Barz M., Moderegger D., Allmeroth M., Jahn M., Thews O., Zentel R. & Rosch F. (2009), Radioactive labeling of defined HPMA-based polymeric structures using [F-18]FETos for in vivo imaging by positron emission tomography, Biomacromolecules 10(7): 1697-1703.
- Barz M., Luxenhofer R., Zentel R. & Kabanov A.V. (2009), The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells, Biomaterials 30(29): 5682-5690.
- Wang J.J., Tahir M.N., Kappl M., Tremel W., Metz N., Barz M., Theato P. & Butt H.J. (2008), Influence of binding-site density in wet bioadhesion, Advanced Materials 20(20): 3872-3876.
- Scientific Advisory Board Member