Martijn Manson
Assistant professor
- Name
- Dr. M.L. Manson
- Telephone
- +31 71 527 6805
- m.l.manson@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-5508-8615
Martijn Manson is assistant professor at the Division of BioTherapeutics
More information about Martijn Manson
PhD Candidates
Biography
Martijn Manson graduated as a pharmacist at the University of Utrecht in 2010. Between 2011-2015 he conducted his PhD studies in respiratory pharmacology at the Karolinska Institute (Stockholm, Sweden) under the supervision of Prof. Sven-Erik Dahlén and Ass. Prof. Mikael Adner. During this period he worked on unraveling the mechanism(s) of action of a potential novel class of bronchodilators and examined the interplay between airway smooth muscle function and inflammation. Subsequently he conducted an industrial postdoc in the Respiratory division of AstraZeneca (Gothenburg, Sweden), where he under the guidance of prof. Robert Newton (University of Calgary, Canada) investigated the molecular interactions between glucocorticoids and β2-adrenoceptor agonists underlying their synergistic regulation of gene transcription.
Following his research period abroad Martijn returned in 2017 to the Netherlands, where he was appointed as lecturer at the Leiden Academic Centre of Drug Research (LACDR). Together with fellow pharmacists at the LUMC and LACDR he developed the educational program of the 3-year Master of Pharmacy that started in 2016. In this role, Martijn evolved the content and teaching materials for the course central nervous system and the scientific research projects of the Master Pharmacy. In parallel, he applied his expertise in pharmacology for the teaching of a wide variety of subjects within this educational program.
Martijn is currently employed as assistant professor within the LACDR and coordinator of the research proposal (10 EC), TOO2 (2 EC) and the Research projects (30 EC) within the Master of Pharmacy. Furthermore, he is teaching in both the Bachelor Biopharmaceutical Sciences and the Master of Pharmacy on the pathophysiology and pharmacotherapy of respiratory diseases. Simultaneously, since 2020 he has initiated, in collaboration with the hospital pharmacy of the LUMC, a new research line focused on improving our understanding of phenoconversion.
Assistant professor
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Pharmacology
- Sun M.,Manson M.L., Guo T. & Lange E.C.M. de (2024), CNS viral infections—what to consider for improving drug treatment: a plea for using mathematical modeling approaches, CNS Drugs 38(5): 349-373.
- Jong L.M. de, Harpal C, Berg D. van den., Hoekstra M., Peter N.J., Rissmann R., Swen J.J. & Manson M.L. (2024), CYP and non-CYP drug metabolizing enzyme families exhibit differential sensitivities towards pro-inflammatory cytokine modulation, Drug Metabolism and Disposition 52(12): 1429-1437.
- Jong L.M. de, Boussallami S., Sánchez-López E., Giera M., Tushuizen M.E., Hoekstra M., Hawinkels L.J.A.C., Rissmann R., Swen J.J. & Manson M.L. (2023), The impact of CYP2C19 genotype on phenoconversion by concomitant medication, Frontiers in Pharmacology 14: 1201906.
- Liu F., Aulin L.B.S. & Manson M.L. Krekels E.H.J. Hasselt J.G.C. van (2023), Unraveling the effects of acute inflammation on pharmacokinetics: a model-based analysis focusing on renal glomerular filtration rate and cytochrome P450 3A4-mediated metabolism, European Journal of Drug Metabolism and Pharmacokinetics 48: 623–631.
- Jong L.M. de, Zhang Z., Hartog Y. de, Sijsenaar T.J.P., Martins Cardoso R., Manson M.L., Hankemeier T., Lindenburg P.W., Salvatori D.C.F., Eck M. van & Hoekstra M. (2022), PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice, Scientific Reports 12(1): 483.
- Jong L.M. de, Klomp S.D., Treijtel N., Rissmann R., Swen J.J. & Manson M.L. (2022), A systematic review on disease-drug-drug interactions with immunomodulating drugs: a critical appraisal of risk assessment and drug labelling, British Journal of Clinical Pharmacology 88(10): 4387-4402.
- Klomp S.D. Manson M.L. Guchelaar H. Swen J.J. (2020), Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review, Journal of Clinical Medicine 9(9): 2890.
- Jong L.M. de, Jiskoot W., Swen J.J. & Manson M.L. (2020), Distinct effects of inflammation on Cytochrome p450 regulation and drug metabolism: lessons from experimental models and a potential role for pharmacogenetics, Genes 11(12): 1509.
- Manson M.L. Säfholm J. James A. Johnsson A.K. Bergman P. Al-Ameri M. Orre A.C. Kärrman-Mårdh C. Dahlén S.E. Adner M. (2019), IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways, Journal of Allergy and Clinical Immunology 145(3): 808-817.
- Säfholm J. Manson M.L. Bood J. Al-Ameri M. Orre A.C. Raud J. Dahlén S.E. Adner M. (2019), Mannitol triggers mast cell-dependent contractions of human small bronchi and prostacyclin bronchoprotection, Journal of Allergy and Clinical Immunology 144(4): 984-992.
- Rider C.F., Altonsy M.O., Mostafa M.M., Shah S.V., Sasse S., Manson M.L., Yan D., Kärrman-Mårdh C., Miller-Larsson A.M., Gerber A.N., Giembycz M.A. & Newton R. (2018), Long-acting β2-adrenoceptor agonists enhance glucocorticoid receptor (GR)-mediated transcription by gene-specific mechanisms rather than generic effects via GR, Molecular Pharmacology 94(3): 1031-1046.
- Manson M.L., Rojnik Z., Thorn K., Mardh C.K. & Newton R. (2018), The CREB-Regulated Transcription Coactivators, CRTC2/3, Facilitate the Synergistic Induction of RGS2 by LABAs and Glucocorticoids in Human Bronchial Epithelial Cells. American Journal of Respiratory and Critical Care Medicine. American Thoracic Society , San Diego. 18 May 2018 - 23 May 2018. [conference poster].
- Marquardt N., Kekalainen E., Chen P., Kvedaraite E., Wilson J.N., Ivarsson M.A., Mjosberg J., Berglin L. & Safholm J. (2017), Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69-CD56dim cells, Journal of Allergy and Clinical Immunology 139(4): 1321-1330.e4.
- Larsson O.J. Manson M.L. Starkhammar M. Fuchs B. Adner M. Georén S.K. Cardell L.O. (2016), The bronchodilatory capacity of imiquimod: the existence of two mechanisms, American Journal of Physiology - Lung Cellular and Molecular Physiology 311(1): L178-L179.
- Larsson O.J. Manson M.L.Starkhammar M. Fuchs B. Adner M. Georén S.K. Cardell L.O. (2016), The TLR7 agonist imiquimod induces bronchodilation via a nonneuronal TLR7-independent mechanism: a possible role for quinoline in airway dilation, American Journal of Physiology 310(11): L1121-L1129.
- Säfholm J., Manson M.L., Bood J., Delin I., Orre A.C., Bergman P., Al-Ameri M., Dahlén S.E. & Adner M. (2015), Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor, Journal of Allergy and Clinical Immunology 136(5): 1232-1239.
- Protudjer J.L.P., Binnmyr J., Grundstrom J., Manson M.L., Marquardt N., Safholm J. & Ullemar V. (2015), Allergy trainees' perspectives on career opportunities: results from a trainee-organized retreat, Allergy 70(11): 1353-1355.
- Manson M.L., Säfholm J., Al-Emeri M., Bergman P., Orre A.C., Sward K., James A., Dahlén S.E. & Adner M. (2014), Bitter taste receptor agonists mediate relaxation of human and rodent vascular smooth muscle, European Journal of Pharmacology 740: 302-311.
- Pulkkinen V., Manson M.L., Säfholm J., Adner M. & Dahlén S.E. (2012), The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea, American Journal of Physiology - Lung Cellular and Molecular Physiology 303(11): L956-L966.
- Manson M.L. Derissen E. Wijermans P. Schellens J. Beijnen J. (2011), Demethylating medication in myelodysplastic syndrome: Epigenetics as a target for therapy | Demethylerende medicatie bij myelodysplastisch syndroom, Nederlands Tijdschrift voor Geneeskunde 155(4): A3167.
- Nascholing reviewen astma
- Special Interest Group (SIG) Long