More information about Mark Overhand

Biography

Mark Overhand was born on September 14th 1964 in Rotterdam. From 1982-1986 Mark started his studies in chemistry at the van ‘t Hoff Instituut in Rotterdam. During this period he was an intern at the Technical University of Delft were he was initiated in the art of organic chemistry in the group of Leen Maat (supervisors: Jan Linders en Joop Lie). His thesis describing the multi-step synthesis of a morphine analog was rewarded with the golden spatula by the KNCV. Mark then decided to study chemistry at Leiden University (1986-1989). In this city he performed higher sugar chemistry in the group of Prof. Van Boom under the direct supervision of Geert-Jan Boons and Gijs van der Marel. Subsequently, he went to Charlottesville, Virginia where he received his Ph.D. under the directions of Prof. Hecht (1990-1994). Thereafter, Mark moved back to the old world where he was a post-doctoral fellow in the group of Prof. Seebach at the ETH in Zürich (1995-1996). Currently, he is back in the old nest in Leiden as an associate professor.

Curriculum Vitae

Personal information

Nationality:   Dutch
Date of birth:   14 September 1964

Education

1995   PhD, University of Virginia, United States of America, Januari 1995. Thesis title: “The synthesis of DNA damaging and imaging agents”
Advisor: Dr. S.M. Hecht
1990   MSc in Chemistry, Leiden Institute of Chemistry, Leiden University, The Netherlands

Current and previous research positions

2003 – now    Associate Professor (tenured), Leiden Institute of Chemistry, Leiden University, The Netherlands
1998 – 2003   Research Assistant Professor, Leiden Institute of Chemistry, Leiden University, The Netherlands
1996 – 1998   Postdoctoral researcher (STW), Leiden Institute of Chemistry, Leiden University (Prof. HJ van Boom, Prof. GA van der Marel)
1995 – 1996   Recipient of Eidgenössische Stipendien für ausländische Studierende, ETH, Zurich, Switserland (Prof. D. Seebach)

Awards

Best teacher of the faculty (2007-2008)

Contribution to teaching and supervision

• Courses for BSc Chemistry (MST), Life Science and Technology (LST) and Biopharmaceutical Sciences (BFW): Org Chem 1 & 2, Lab. Course org chem.
• Courses for MSc students: Org Chem 4, Total Synthesis, Biopolymers

Co-supervision of 6 PhD students and 2 postdoctoral fellows since 2010.

Publication record including five recent representative publications

116 papers with >2500 citations, H-index 34 (Web of Science, sept 2023)

• Miao, Q; Dekkers, R; Gupta, KBSS; Overhand, M; Dasgupta, R; Ubbink, M: Rigidified and Hydrophilic DOTA-like Lanthanoid Ligands: Design, Synthesis, and Dynamic Properties Inorg. Chem. 2023, 8, 429. DOI: 10.1021/acs.inorgchem.2c03768
• Miao, Q; Nitsche, C; Orton, H; Overhand, M; Otting, G; Ubbink, M: Paramagnetic Chemical Probes for Studying Biological Macromolecules Chem. Rev. 2022, 122, 9571.
• Miao, Q; Zurlo, E; de Bruin, D; Wondergem, JAJ; Skinner, SP; Timmer, M; Blok, A; Heinrich, D; Overhand, M; Huber, M; Ubbink, M: A Two-Armed Probe for In-Cell DEER Measurements on Proteins. Chem. A Eur. J. 2021, 27, 6994. DOI: 10.1021/acs.chemrev.1c00708
• Miao, Q; Liu, WM; Kock, T; Blok, A; Timmer, M; Overhand, M; Ubbink, M: A Double-Armed, Hydrophilic Transition Metal Complex as a Paramagnetic NMR Probe Angew. Chem. Int. Ed. 2019, 58, 13093. DOI: 10.1002/anie.201906049
• Nabuurs, RJA; Kapoerchan, VV; Metaxas, A; Hafith, S; de Backer, M; Welling, MM; Jiskoot, W; van den Nieuwendijk, AMCH; Windhorst, AD; Overkleeft, HS ; van Buchem, MA; Overhand, M; van der Weerd, L: Bis-pyridylethenyl benzene as novel backbone for amyloid-beta binding compounds Bioorg. Med. Chem. 2016, 24, 6139. DOI: 10.1016/j.bmc.2016.05.022

Publications