Marina Gorostiola González
PhD candidate / guest
- Name
- M. Gorostiola González MSc
- Telephone
- +31 71 527 2727
- m.gorostiola.gonzalez@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0003-1568-0881
Marina is a PhD student at the division of Drug Discovery and Safety under the supervision of of Prof. Dr. Adriaan IJzerman, Prof.Dr. Gerard van Westen, and Dr. Laura Heitman. She works on artificial intelligence and structure-based approaches to characterize the role of selected membrane proteins in breast cancer.
Before I started a PhD a Leiden University, I studied Pharmacy at University of Salamanca (Spain), with an exchange program at the University of Malta. I finished my five-year Bachelor & Master program with honors in 2017 with a thesis on the use of computational tools to improve drug dosing in celiac patients in the department of Bio-Pharmaceutical Sciences. This was my first contact with computational drug research, but definitely not my last. After that, I decided to move to the Netherlands to do a research master in Bio-Pharmaceutical Sciences at Leiden University. Here, I focused on computational drug discovery, which led me to do a research project in the group of Prof.Dr. Gerard van Westen on screening of cancer mutations directed towards rational design of kinase inhibitors. Seeking industrial experience, I conducted a second research project at Galapagos NV in Mechelen (Belgium) in the Molecular Modeling & Design group, under the supervision of Dr. Bart Lenselink. My work there focused on the development of a 3D machine learning-based scoring function for kinase-ligand interactions. In 2019 I graduated Cum Laude from my master, having completed a full track for a computational drug discovery specialization, including several courses from Uppsala University (Sweden).
From December 2019, I am engaged in a PhD track at the Leiden Academic Centre for Drug Research (LACDR) in the division of Drug Discovery and Safety. My project is under the umbrella of the ONCODE institute for cancer research and is performed under the supervision of Prof. Dr. Adriaan IJzerman, Prof. Dr. Gerard van Westen, and Dr. Laura Heitman. Within my project, I will focus on artificial intelligence and structure-based approaches to characterize the role of selected membrane proteins in breast cancer. In this project, I will use data analysis tools in combination with structure-based methods (i.e. docking, molecular dynamics), as well as machine learning approaches, to rationalize the possibility of targeting such proteins in the context of cancer, which potentially could lead to novel oncology therapies.
PhD candidate / guest
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
- Gorostiola González M. (24 January 2025), Getting personal: advancing personalized oncology through computational analysis of membrane proteins (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University). Supervisor(s): Westen G.J.P. van, Heitman L.H. & IJzerman A.P.
- Gorostiola González M.: Rakers P.R.J., Jespers W., IJzerman A.P. & Heitman L.H. Westen G.J.P. van (2024), Computational characterization of membrane proteins as anticancer targets: current challenges and opportunities, International Journal of Molecular Sciences 25(7): 3698.
- Veggel L. van, Mocking T.A.M., Sijben H.J., Liu R., Gorostiola González M., Dilweg M.A., Royakkers J., Li A., Kumar V., Dong Y.Y., Bullock A., Sauer D.B., Diliën H., Westen G.J.P. van, Schreiber R., Heitman L.H. & Vanmierlo T. (2024), Still in search for an EAAT activator: GT949 does not activate EAAT2, nor EAAT3 in impedance and radioligand uptake assays, ACS Chemical Neuroscience 15(7): 1424-1431.
- Gorostiola González M., Broek R.L. van den, Braun T.G.M., Chatzopoulou Chatzi A., Jespers W., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2023), 3DDPDs: describing protein dynamics for proteochemometric bioactivity prediction. A case for (mutant) G protein-coupled receptors, Journal of Cheminformatics 15(1): 74.
- Mullowney M.W., Duncan K.R., Elsayed S.S., Garg N., Hooft J.J.J. van der, Martin N.I., Meijer D., Terlouw B.R., Biermann F., Blin K., Durairaj J., Gorostiola González M., Helfrich E.J.N., Huber F., Leopold-Messer S., Rajan K., Rond T. de, Santen J.A. van, Sorokina M., Balunas M.J., Beniddir M.A., Bergeijk D.A. van, Carroll L.M., Clark C.M., Clevert D.A., Dejong C.A., Du C., Ferrinho S., Grisoni F., Hofstetter A., Jespers W., Kalinina O.V., Kautsar S.A., Kim H., Leao T.F., Masschelein J., Rees E.R., Reher R., Reker D., Schwaller P., Segler M., Skinnider M.A., Walker A.S., Willighagen E.L., Zdrazil B., Ziemert N., Goss R.J.M., Guyomard P., Volkamer A., Gerwick W.H., Kim H.U., Müller R., Wezel G.P. van, Westen G.J.P. van, Hirsch A.K.H., Linington R.G., Robinson S.L. & Medema M.H. (2023), Artificial intelligence for natural product drug discovery, Nature Reviews Drug Discovery 22: 895-916.
- Gorostiola Gonzalez M., Sijben H.J., Dall' Acqua L., Liu R., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2023), Molecular insights into disease-associated glutamate transporter (EAAT1 / SLC1A3) variants using in silico and in vitro approaches, Frontiers in Molecular Biosciences 10: 1286673.
- Hollander L.S. den, Béquignon O.J.M., Wang X., Wezel K. van, Broekhuis J.D., Gorostiola Gonzalez M., Visser K.E. de, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2023), Corrigendum to "Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism" [Biochem. Pharmacol. 208 (2023) 115399], Biochemical Pharmacology 209: 115540 (115450).
- Gorostiola Gonzalez M., Janssen A.P.A., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2022), Oncological drug discovery: AI meets structure-based computational research, Drug Discovery Today 27(6): 1661-1670.
- Feng C.L., Wang X., Jespers W., Liu R., Zamarbide Losada S.D., Gorostiola Gonzalez M., Westen G.J.P. van, Danen E.H.J. & Heitman L.H. (2022), Cancer-associated mutations of the adenosine A2A receptor have diverse influences on ligand binding and receptor functions, Molecules 27(15): 4676.
- Bongers B.J., Gorostiola González M., Wang X., Vlijmen H. van, Jespers W., Gutiérrez-de-Terán H., Ye K., IJzerman A.P., Heitman L.H. & Westen G.J.P. van (2022), Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors, Scientific Reports 12(1): 21534.
- Hollander L.S. den, Béquignon O.J.M., Wang X., Wezel K. van, Broekhuis J., Gorostiola González M., Visser K.E. de, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2022), Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism, Biochemical Pharmacology 208: 115399.
- Kovacikova K., Gorostiola González M., Jones R., Requera J., Gigante A., Pérez-Pérez M.J., Pürstinger G., Moesslacher J., Langer T., Jeong L.S., Delang L., Neyts J., Snijder E.J., Westen G.J.P. van & Hemert M.J. van (2021), Structural insights into the mechanisms of action of functionally distinct classes of chikungunya virus nonstructural protein 1 inhibitors, Antimicrobial Agents and Chemotherapy 65(7): e02566-20.
- Burggraaff L. Lenselink E.B. Jespers W. Engelen J. van Bongers B.J. Gorostiola Gonzalez M. Liu R. Hoos H.H. Vlijmen H. van IJzerman A.P. Westen G.J.P. van (2020), Successive statistical and structure-based modeling to identify chemically novel kinase inhibitors, Journal of Chemical Information and Modeling 60(9): 4283-4295.