Manfred Wuhrer
Professor Proteomics and Glycomics
- Name
- Prof.dr. M. Wuhrer
- Telephone
- +31 71 526 9111
- m.wuhrer@lumc.nl
- ORCID iD
- 0000-0002-0814-4995
Manfred Wuhrer is professor of Proteomics and Glycomics and head of the Center for Proteomics and Metabolomics of the Leiden University Medical Center (LUMC)). He is also chairman of the Dutch Society for Mass Spectrometry (NVMS).
More information about Manfred Wuhrer
Manfred Wuhrer is professor of Proteomics and Glycomics and head of the Center for Proteomics and Metabolomics of the Leiden University Medical Center (LUMC)). He is also chairman of the Dutch Society for Mass Spectrometry (NVMS).
Academic career
Manfred Wuhrer studied Biochemistry at Regensburg University, Germany. He obtained a PhD from Giessen University in 1999 on the Characterization of Stage-Specifically expressed Glycolipids of the Human Parasite Schistosoma mansoni. In 2003 he came to the LUMC establishing a research line on mass spectrometric glycosylation analysis.
In 2013 Manfred Wuhrer became Professor Analytics of Biomolecular Interactions at VU University Amsterdam. In 2015 he was appointed Professor in Proteomics and Glycomics at the LUMC heading the Center of Proteomics and Metabolomics.
Professor Proteomics and Glycomics
- Faculteit Geneeskunde
- Divisie 4
- Klinische Farmacie en Toxicologie
- Claushuis, B.; Cordfunke, R.A.; Ru, A.H. de; Angeren, J. van; Baumann, U.; Veelen, P.A. van; Wuhrer, M.; Corver, J.; Drijfhout, J.W. & Hensbergen, P.J. (2024), Non-prime- and prime-side profiling of Pro-Pro endopeptidase specificity using synthetic combinatorial peptide libraries and mass spectrometry, The FEBS Journal.
- Madunic, K.; Luijkx, Y.M.C.A.; Mayboroda, O.A.; Janssen, G.M.C.; Veelen, P.A.V.; Strijbis, K.; Wennekes, T.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2023), O-glycomic and proteomic signatures of spontaneous and butyrate-stimulated colorectal cancer cell line differentiation, Molecular & Cellular Proteomics 22(3).
- Moran, A.B.; Elgood-Hunt, G.; Burgt, Y.E.M. van der; Wuhrer, M.; Mesker, W.E.; Tollenaar, R.A.E.M.; Spencer, D.I.R. & Lageveen-Kammeijer, G.S.M. (2023), Serum N-glycosylation RPLC-FD-MS assay to assess colorectal cancer surgical interventions, Biomolecules 13(6).
- Wang, D.; Madunic, K.; Zhang, T.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2023), Profound diversity of the N-glycome from microdissected regions of colorectal cancer, stroma, and normal colon mucosa, Engineering 26: 32-43.
- Moran, A.B.; Domínguez-Vega, E.; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2023), Software-assisted data processing workflow for intact glycoprotein mass spectrometry, Journal of Proteome Research 22(4): 1367-1376.
- Wojcik, I.; Wuhrer, M.; Heeringa, P.; Stegeman, C.A.; Rutgers, A. & Falck, D. (2023), Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise, Frontiers in Immunology 14.
- Porcino, G.N.; Bladergroen, M.R.; Dotz, V.; Nicolardi, S.; Memarian, E.; Gardinassi, L.G.; Costa, C.H.N.; Almeida, R.P.D.; Santos, I.K.F.D. & Wuhrer, M. (2023), Total serum N-glycans mark visceral leishmaniasis in human infections with Leishmania infantum, iScience 26(7).
- Boelaars, K.; Goossens-Kruijssen, L.; Wang, D.; Winde, C.M. de; Rodriguez, E.; Lindijer, D.; Springer, B.; Avila, I.V.; Haas, A. de; Wehry, L.; Boon, L.; Mebius, R.E.; Montfoort, N. van; Wuhrer, M.; Haan, J.M.M. den; Vliet, S.J. van & Kooyk, Y. van (2023), Unraveling the impact of sialic acids on the immune landscape and immunotherapy efficacy in pancreatic cancer, Journal for ImmunoTherapy of Cancer 11(11).
- Tol, B.D.M. van; Doodewaerd, B.R. van; Lageveen-Kammeijer, G.S.M.; Jansen, B.C.; Talavera Ormeño, C.M.P.; Hekking, P.J.M.; Sapmaz, A.; Kim, R.Q.; Moutsiopoulou, A.; Komander, D.; Wuhrer, M.; Heden van Noort, G.J. van der; Ovaa, H. & Geurink, P.P. (2023), Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes, Nature Communications 14(1).
- Frkatovic-Hodzic, A.; Mijakovac, A.; Miskec, K.; Nostaeva, A.; Sharapov, S.Z.; Landini, A.; Haller, T.; Akker, E.V.; Sharma, S.; Cuadrat, R.R.C.; Mangino, M.; Li, Y.; Keser, T.; Rudman, N.; Stambuk, T.; Pucic-Bakovic, M.; Trbojevic-Akmacic, I.; Gudelj, I.; Stambuk, J.; Pribic, T.; Radovani, B.; Tominac, P.; Fischer, K.; Beekman, M.; Wuhrer, M.; Gieger, C.; Schulze, M.B.; Wittenbecher, C.; Polasek, O.; Hayward, C.; Wilson, J.F.; Spector, T.D.; Koettgen, A.; Vuckovic, F.; Aulchenko, Y.S.; Vojta, A.; Kristic, J.; Klaric, L.; Zoldos, V. & Lauc, G. (2023), Mapping of the gene network that regulates glycan clock of ageing, Aging 15(24): 14509-14552.
- Wang, W.; Nier, C.R. de; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2023), In-depth glycoproteomic assay of urinary prostatic acid phosphatase, ACS Measurement Science Au 4(1): 117-126.
- Svecla, M.; Nour, J.; Bladergroen, M.R.; Nicolardi, S.; Zhang, T.; Beretta, G.; Wuhrer, M.; Norata, G.D. & Falck, D. (2023), Impact of asialoglycoprotein receptor and mannose receptor deficiency on murine plasma N-glycome profiles, Molecular & Cellular Proteomics 22(9).
- Marco, F. di; Blöchl, C.; Esser-Skala, W.; Schäpertöns, V.; Zhang, T.; Wuhrer, M.; Sandra, K.; Wohlschlager, T. & Huber, C.G. (2023), Glycoproteomics of a single protein: revealing tens of thousands of Myozyme glycoforms by hybrid HPLC-MS approaches, Molecular & Cellular Proteomics 22(9).
- Naber, A.; Demus, D.; Slieker, R.; Nicolardi, S.; Beulens, J.W.J.; Elders, P.J.M.; Lieverse, A.G.; Sijbrands, E.J.G.; Hart, L.M.; Wuhrer, M. & Hoek, M. van (2023), Apolipoprotein-CIII O-glycosylation, a link between GALNT2 and plasma lipids, International Journal of Molecular Sciences 24(19).
- Holborough-Kerkvliet, M.D.; Mucignato, G.; Moons, S.J.; Psomiadou, V.; Konada, R.S.R.; Pedowitz, N.J.; Pratt, M.R.; Kissel, T.; Koeleman, C.A.M.; Tjokrodirijo, R.T.N.; Veelen, P.A. van; Huizinga, T.; Schie, K.A.J. van; Wuhrer, M.; Kohler, J.J.; Bonger, K.M.; Boltje, T.J. & Toes, R.E.M. (2023), A photoaffinity glycan-labeling approach to investigate immunoglobulin glycan-binding partners, Glycobiology 33(9): 732-744.
- Blochl, C.; Wang, D.; Mayboroda, O.A.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2023), Transcriptionally imprinted glycomic signatures of acute myeloid leukemia, Cell & Bioscience 13(1).
- Coillie, J. van; Pongracz, T.; Rahmoller, J.; Chen, H.J.; Geyer, C.E.; Vught, L.A. van; Buhre, J.S.; Sustic, T.; Osch, T.L. van; Steenhuis, M.; Hoepel, W.; Wang, W.J.; Lixenfeld, A.S.; Nouta, J.; Keijzer, S.; Linty, F.; Visser, R.; Larsen, M.D.; Martin, E.L.; Kunsting, I.; Lehrian, S.; Kopylow, V. von; Kern, C.; Lunding, H.B.; Winther, M. de; Mourik, N. van; Rispens, T.; Graf, T.; Slim, M.A.; Minnaar, R.P.; Bomers, M.K.; Sikkens, J.J.; Vlaar, A.P.J.; Schoot, C.E. van der; Dunnen, J. den; Wuhrer, M.; Ehlers, M.; Vidarsson, G.; Fatebenefratelli-Sacco Infect Dis & UMC COVID-19 S HCW Study Grp (2023), The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees, EBioMedicine 87.
- Spanov, B.; Baartmans, B.; Olaleye, O.; Nicolardi, S.; Govorukhina, N.; Wuhrer, M.; Merbel, N.C. van de & Bischoff, R. (2023), Revealing charge heterogeneity of stressed trastuzumab at the subunit level, Analytical and Bioanalytical Chemistry 415(8): 1505-1513.
- Schaick, G. van; Dominguez-Vega, E.; Castel, J.; Wuhrer, M.; Hernandez-Alba, O. & Cianferani, S. (2023), Online collision-induced unfolding of therapeutic monoclonal antibody glyco-variants through direct hyphenation of cation exchange chromatography with native ion mobility-mass spectrometry, Analytical Chemistry 95(8).
- Buhre, J.S.; Pongracz, T.; Kunsting, I.; Lixenfeld, A.S.; Wang, W.J.; Nouta, J.; Lehrian, S.; Schmelter, F.; Lunding, H.B.; Duhring, L.; Kern, C.; Petry, J.; Martin, E.L.; Foh, B.; Steinhaus, M.; Kopylow, V. von; Sina, C.; Graf, T.; Rahmoller, J.; Wuhrer, M. & Ehlers, M. (2023), mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine, Frontiers in Immunology 13.
- Wang, D.; Kuzyk, V.; Madunic, K.; Zhang, T.; Mayboroda, O.A.; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2023), In-depth analysis of the N-glycome of colorectal cancer cell lines, International Journal of Molecular Sciences 24(5).
- Volkov, M.; Brinkhaus, M.; Schie, K.A. van; Bondt, A.; Kissel, T.; Kooi, E.J. van der; Bentlage, A.E.H.; Koeleman, C.A.M.; Taeye, S.W. de; Derksen, N.I.; Dolhain, R.J.E.M.; Braig-Scherer, U.; Huizinga, T.W.J.; Wuhrer, M.; Toes, R.E.M.; Vidarsson, G. & Woude, D. van der (2023), IgG Fab glycans hinder FcRn-mediated placental transport, The Journal of Immunology 210(2): 158-167.
- Oskam, N.; Damelang, T.; Streutker, M.; Heer, P.; Nouta, J.; Koeleman, C.; Coillie, J. van; Wuhrer, M.; Vidarsson, G. & Rispens, T. (2023), Factors affecting IgG4-mediated complement activation, Frontiers in Immunology 14.
- Guo, R.R.; Lageveen-Kammeijer, G.S.M.; Wang, W.J.; Dalebout, H.; Zhang, W.A.; Wuhrer, M.; Liu, L.; Heijs, B. & Voglmeir, J. (2023), Analysis of Immunogenic Galactose-alpha-1,3-galactose-Containing N-Glycans in beef, mutton, and pork tenderloin by Combining Matrix-Assisted Laser Desorption/Ionization-mass spectroscopy and capillary electrophoresis hyphenated with mass spectrometry via electrospray ionization, Journal of Agricultural and Food Chemistry 71(9).
- Xu, R.Y.; Wang, X.X.; Safi, S.; Braunegger, N.; Ederveen, A.H.; Rottmann, M.; Wittbrodt, J.; Wuhrer, M.; Wesslowski, J. & Davidson, G. (2023), N-glycosylation of LRP6 by B3GnT2 promotes Wnt/βcatenin signalling, Cells 12(6).
- Mayboroda, O.A.; Lageveen-Kammeijer, G.S.M.; Wuhrer, M. & Dolhain, R.J.E.M. (2023), An integrated glycosylation signature of rheumatoid arthritis, Biomolecules 13(7).
- Blöchl, C.; Gstöttner, C.; Sénard, T.; Stork, E.M.; Scherer, H.U.; Toes, R.E.M.; Wuhrer, M. & Domínguez-Vega, E. (2023), A robust nanoscale RP HPLC-MS approach for sensitive Fc proteoform profiling of IgG allotypes, Analytica Chimica Acta 1279.
- Marco, F. di; Blümel, G.; Blöchl, C.; Wuhrer, M. & Huber, C.G. (2023), A semi-automated hybrid HPLC-MS approach for in-depth characterization of intact non-covalent heterodimer glycoforms of gonadotropin biopharmaceuticals, Analytica Chimica Acta 1274.
- Graaf, E.L. de; Larsen, M.D.; Bolt, N. van der; Visser, R.; Verhagen, O.J.H.M.; Ederveen, A.L.H.; Koeleman, C.A.M.; Schoot, C.E. van der; Wuhrer, M. & Vidarsson, G. (2023), Assessment of IgG-Fc glycosylation from individual RhD-specific B cell clones reveals regulation at clonal rather than clonotypic level, Immunology.
- Szittner, Z.; Bentlage, A.E.H.; Temming, A.R.; Schmidt, D.E.; Visser, R.; Lissenberg-Thunnissen, S.; Mok, J.Y.; Esch, W.J.E. van; Sonneveld, M.E.; Graaf, E.L. de; Wuhrer, M.; Porcelijn, L.; Haas, M. de; Schoot, C.E. van der & Vidarsson, G. (2023), Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia, Frontiers in Immunology 14.
- Kaplonek, P.; Cizmeci, D.; Kwatra, G.; Izu, A.; Lee, J.S.L.; Bertera, H.L.; Fischinger, S.; Mann, C.; Amanat, F.; Wang, W.J.; Koen, A.L.; Fairlie, L.; Cutland, C.L.; Ahmed, K.; Dheda, K.; Barnabas, S.L.; Bhorat, Q.E.; Briner, C.; Krammer, F.; Saphire, E.O.; Gilbert, S.C.; Lambe, T.; Pollard, A.J.; Nunes, M.; Wuhrer, M.; Lauffenburger, D.A.; Madhi, S.A. & Alter, G. (2023), ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19, Nature Immunology 24(7): 1161-+.
- Svecla, M.; Nour, J.; Bladergroen, M.; Nicolardi, S.; Wuhrer, M.; Falck, D. & Norata, G. (2023), CIRCULATING GLYCOME AND PROTEOME SIGNATURE ON ASGR1 AND MRC1 DEFICIENT MICE, Atherosclerosis 379.
- Coillie, J. van; Pongracz, T.; Sustic, T.; Wang, W.J.; Nouta, J.; Gars, M. le; Keijzer, S.; Linty, F.; Cristianawati, O.; Keijser, J.B.D.; Visser, R.; Vught, L.A. van; Slim, M.A.; Mourik, N. van; Smit, M.J.; Sander, A.; Schmidt, D.E.; Steenhuis, M.; Rispens, T.; Nielsen, M.A.; Mordmüller, B.G.; Vlaar, A.P.J.; Schoot, C.E. van der; Roozendaal, R.; Wuhrer, M.; Vidarsson, G.; UMC COVID-19 S3 HCW Study Grp; Fatebenefratelli-Sacco Infect; Radboud Univ Med Ctr RUMC & COUGH1 Study Grp (2023), Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines, iScience 26(9).
- Romer, T.B.; Khoder-Agha, F.; Aasted, M.K.M.; Haan, N. de; Horn, S.; Dylander, A.; Zhang, T.; Pallesen, E.M.H.; Dabelsteen, S.; Wuhrer, M.; Hogsbro, C.F.; Thomsen, E.A.; Mikkelsen, J.G. & Wandall, H.H. (2023), CRISPR-screen identifies ZIP9 and dysregulated Zn2+ homeostasis as a cause of cancer-associated changes in glycosylation, Glycobiology 33(9).
- Schaick, G. van; Wuhrer, M. & Domínguez-Vega, E. (2023), Dopant-enriched nitrogen gas to boost ionization of glycoproteins analyzed with native liquid chromatography coupled to nano-electrospray ionization, Analytica Chimica Acta 1265.
- Schaick, G. van; Pot, S.; Schouten, O.; Hartog, J. den; Akeroyd, M.; Hoeven, R.V.; Bijleveld, W.; Abello, N.; Wuhrer, M.; Olsthoorn, M. & Dominguez-Vega, E. (2023), Evaluating the effect of glycation on lipase activity using boronate affinity chromatography and mass spectrometry, Food Chemistry 421.
- Wang, W.; Zhang, T.; Nouta, J.; Veelen, P.A. van; Haan, N. de; Reijke, T.M. de; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2023), Human prostate-specific antigen carries N-glycans with ketodeoxynononic acid, Engineering 26: 119-131.
- Memarian, E.; Heijmans, R.; Slieker, R.C.; Sierra, A.; Gornik, O.; Beulens, J.W.J.; Hanic, M.; Elders, P.; Pascual, J.; Sijbrands, E.; Lauc, G.; Dotz, V.; Barrios, C.; Hart, L.M. 't; Wuhrer, M. & Hoek, M. van (2023), IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes, Diabetes/Metabolism Research and Reviews 39(7).
- Clerc, F.; Reiding, K.R.; Haan, N. de; Koeleman, C.A.M.; Ederveen, A.L.H.; Manetti, N.; Dotz, V.; Annese, V.; Wuhrer, M. & IBD-BIOM Consortium (2023), Immunoglobulin A glycosylation differs between Crohn's disease and ulcerative colitis, Journal of Proteome Research 22(10): 3213-3224.
- Chinello, C.; Haan, N. de; Capitoli, G.; Trezzi, B.; Radice, A.; Pagani, L.; Criscuolo, L.; Signorini, S.; Galimberti, S.; Sinico, R.A.; Wuhrer, M. & Magni, F. (2022), Definition of IgG subclass-specific glycopatterns in idiopathic membranous nephropathy: Aberrant IgG glycoforms in blood, International Journal of Molecular Sciences 23(9).
- Grunert, I.; Heinrich, K.; Ernst, J.; Hingar, M.; Briguet, A.; Leiss, M.; Wuhrer, M.; Reusch, D. & Bulau, P. (2022), Detailed analytical characterization of a bispecific IgG1 CrossMab antibody of the knob-into-hole format applying various stress conditions revealed pronounced stability, ACS Omega 7(4): 3671-3679.
- Haan, N. de; Pucic-Bakovic, M.; Novokmet, M.; Falck, D.; Lageveen-Kammeijer, G.; Razdorov, G.; Vuckovic, F.; Trbojevic-Akmacic, I.; Gornik, O.; Hanic, M.; Wuhrer, M.; Lauc, G. & Human Glycome Project (2022), Developments and perspectives in high-throughput protein glycomics: enabling the analysis of thousands of samples, Glycobiology 32(8): 651-663.
- Kissel, T.; Hafkenscheid, L.; Wesemael, T.J.; Tamai, M.; Kawashiri, S.Y.; Kawakami, A.; El-Gabalawy, H.S.; Schaardenburg, D.; Rantapaa-Dahlqvist, S.; Wuhrer, M.; Mil, A.H.M.V.V.; Allaart, C.F.; Woude, D.; Scherer, H.U.; Toes, R.E.M. & Huizinga, T.W.J. (2022), IgG Anti-Citrullinated Protein Antibody Variable Domain Glycosylation Increases Before the Onset of Rheumatoid Arthritis and Stabilizes Thereafter: A Cross-Sectional Study Encompassing ∼1,500 Samples, Arthritis & Rheumatology 74(7): 1147-1158.
- Zhang, J.; Zhang, Z.J.; Holst, S.; Bloechl, C.; Madunic, K.; Wuhrer, M.; Dijke, P. ten & Zhang, T. (2022), Transforming growth factor-beta challenge alters the N-, O-, and glycosphingolipid glycomes in PaTu-S pancreatic adenocarcinoma cells, Journal of Biological Chemistry 298(3).
- Kissel, T.; Ge, C.R.; Hafkenscheid, L.; Kwekkeboom, J.C.; Slot, L.M.; Cavallari, M.; He, Y.B.; Schie, K.A. van; Vergroesen, R.D.; Kampstra, A.S.B.; Reijm, S.; Stoeken-Rijsbergen, G.; Koeleman, C.; Voortman, L.M.; Heitman, L.H.; Xu, B.Z.; Pruijn, G.J.M.; Wuhrer, M.; Rispens, T.; Huizinga, T.W.J.; Scherer, H.U.; Reth, M.; Holmdahl, R. & Toes, R.E.M. (2022), Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation, Science Advances 8(6).
- Schaick, G. van; Haselberg, R.; Somsen, G.W.; Wuhrer, M. & Dominguez-Vega, E. (2022), Studying protein structure and function by native separation-mass spectrometry, Nature Reviews Chemistry 6(3): 215-231.
- Kenno, S.; Gieseler-Tillmann, J.; Kordowski, A.; Borus, S.; Bieber, K.; Ludwig, R.; Lux, A.; Wuhrer, M.; Nimmerjahn, F. & Köhl, J. (2022), The C5a/C5aR1 axis drives autoimmune inflammation in pemphigoid disease through the control of early Tfh cell activation, IgG autoantibody formation and IgG Fc-glycan composition, Molecular Immunology 141: 223-224.
- Madunic, K.; Mayboroda, O.A.; Zhang, T.; Weber, J.; Boons, G.J.; Morreau, H.; Vlierberghe, R. van; Wezel, T. van; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2022), Specific (sialyl-)Lewis core 2 O-glycans differentiate colorectal cancer from healthy colon epithelium, Theranostics 12(10): 4498-4512.
- Bharadwaj, P.; Shrestha, S.; Pongracz, T.; Concetta, C.; Sharma, S.; Moine, A. le; Haan, N. de; Murakami, N.; Riella, L.V.; Holovska, V.; Wuhrer, M.; Marchant, A. & Ackerman, M.E. (2022), Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation, Cell Reports Medicine 3(11).
- Siekman, S.L.; Pongracz, T.; Wang, W.J.; Nouta, J.; Kremsner, P.G.; Silva-Neto, P.V. da; Esen, M.; Kreidenweiss, A.; Held, J.; Trape, A.A.; Fendel, R.; Santos, I.K.F.D. & Wuhrer, M. (2022), The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity, Frontiers in Immunology 13.
- Falck, D.; Lechmann, M.; Momcilovic, A.; Thomann, M.; Koeleman, C.A.M.; Jany, C.; Malik, S.; Wuhrer, M. & Reusch, D. (2022), Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model, mAbs 14(1).
- Grunert, I.; Heinrich, K.; Hingar, M.; Ernst, J.; Winter, M.; Bomans, K.; Wagner, K.; Fevre, A.; Reusch, D.; Wuhrer, M. & Bulau, P. (2022), Comprehensive multidimensional liquid chromatography-mass spectrometry for the characterization of charge variants of a bispecific antibody, Journal of The American Society for Mass Spectrometry 33(12): 2319-2327.
- Vergoossen, D.L.E.; Plomp, J.J.; Gstottner, C.J.; Fillie-Grijpma, Y.E.; Augustinus, R.; Verpalen, R.L.K.; Wuhrer, M.; Parren, P.W.H.I.; Dominguez-Vega, E.; Maarel, S.M. van der; Verschuuren, J.J.G.M. & Huijbers, M.G. (2022), FUNCTIONAL MONOVALENCY AMPLIFIES THE PATHOGENICITY OF ANTI-MUSK IGG4 IN MYASTHENIA GRAVIS, Muscle & Nerve 65: S10-S10.
- Kissel, T.; Toes, R.E.M.; Huizinga, T.W.J. & Wuhrer, M. (2022), Glycobiology of rheumatic diseases, Nature Reviews Rheumatology 19.
- Levink, I.J.M.; Klatte, D.C.F.; Hanna-Sawires, R.G.; Vreeker, G.C.M.; Ibrahim, I.S.; Burgt, Y.E.M. van der; Overbeek, K.A.; Koopmann, B.D.M.; Cahen, D.L.; Fuhler, G.M.; Wuhrer, M.; Bonsing, B.A.; Tollenaar, R.A.E.M.; Vleggaar, F.P.; Vasen, H.F.A.; Leerdam, M.E. van; Bruno, M.J. & Mesker, W.E. (2022), Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals, Pancreatology 22(4): 497-506.
- Zhang, J.; Zon, G. van der; Ma, J.; Mei, H.L.; Cabukusta, B.; Agaser, C.C.; Madunic, K.; Wuhrer, M.; Zhang, T. & Dijke, P. ten (2022), ST3GAL5-catalyzed gangliosides inhibit TGF-beta-induced epithelial-mesenchymal transition via T beta RI degradation, The EMBO Journal 42.
- Moran, A.B.; Gardner, R.A.; Wuhrer, M.; Lageveen-Kammeijer, G.S.M. & Spencer, D.I.R. (2022), Sialic acid derivatization of fluorescently labeled N-glycans allows linkage differentiation by reversed-phase liquid chromatography-fluorescence detection-mass spectrometry, Analytical Chemistry 94(18): 6639-6648.
- Rossi, M.; Altea-Manzano, P.; Demicco, M.; Doglioni, G.; Bornes, L.; Fukano, M.; Vandekeere, A.; Cuadros, A.M.; Fernandez-Garcia, J.; Riera-Domingo, C.; Jauset, C.; Planque, M.; Alkan, H.F.; Nittner, D.; Zuo, D.M.; Broadfield, L.A.; Parik, S.; Pane, A.A.; Rizzollo, F.; Rinaldi, G.; Zhang, T.; Teoh, S.T.; Aurora, A.B.; Karras, P.; Vermeire, I.; Broekaert, D.; Elsen, J. van; Knott, M.M.L.; Orth, M.F.; Demeyer, S.; Eelen, G.; Dobrolecki, L.E.; Bassez, A.; Brussel, T. van; Sotlar, K.; Lewis, M.T.; Bartsch, H.; Wuhrer, M.; Veelen, P. van; Carmeliet, P.; Cools, J.; Morrison, S.J.; Marine, J.C.; Lambrechts, D.; Mazzone, M.; Hannon, G.J.; Lunt, S.Y.; Grunewald, T.G.P.; Park, M.; Rheenen, J. van & Fendt, S.M. (2022), PHGDH heterogeneity potentiates cancer cell dissemination and metastasis, Nature 605(7911): 747-+.
- Trbojevic-Akmaciic, I.; Lageveen-Kammeijer, G.S.M.; Heijs, B.; Petrovic, T.; Deris, H.; Wuhrer, M. & Lauc, G. (2022), High-throughput glycomic methods, Chemical Reviews 122(20).
- Boyaval, F.; Dalebout, H.; Zeijl, R. van; Wang, W.J.; Farina-Sarasqueta, A.; Lageveen-Kammeijer, G.S.M.; Boonstra, J.J.; McDonnell, L.A.; Wuhrer, M.; Morreau, H. & Heijs, B. (2022), High-Mannose N-glycans as malignant progression markers in early-stage colorectal cancer, Cancers 14(6).
- Wang, D.; Maduni, K.; Zhang, T.; Mayboroda, O.A.; Lageveen-Kammeijer, G.S.M. & Wuhrer, M. (2022), High diversity of glycosphingolipid glycans of colorectal cancer cell lines reflects the cellular differentiation phenotype, Molecular & Cellular Proteomics 21(6).
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- Wojcik, I.; Schmidt, D.E.; Neef, L.A. de; Rab, M.A.E.; Meek, B.; Weerdt, O. de; Wuhrer, M.; Schoot, C.E. van der; Zwaginga, J.J.; Haas, M. de; Falck, D. & Vidarsson, G. (2021), A functional spleen contributes to afucosylated IgG in humans, Scientific Reports 11(1).
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- Jongsma, M.L.M.; Waard, A.A. de; Raaben, M.; Zhang, T.; Cabukusta, B.; Platzer, R.; Blomen, V.A.; Xagara, A.; Verkerk, T.; Bliss, S.; Kong, X.R.; Gerke, C.; Janssen, L.; Stickel, E.; Holst, S.; Plomp, R.; Mulder, A.; Ferrone, S.; Claas, F.H.J.; Heemskerk, M.H.M.; Griffioen, M.; Halenius, A.; Overkleeft, H.; Huppa, J.B.; Wuhrer, M.; Brummelkamp, T.R.; Neefjes, J. & Spaapen, R.M. (2021), The SPPL3-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses, Immunity 54(1): 132-+.
- Pfeifle, R.; Kittler, J.; Wuhrer, M.; Schett, G. & Kronke, G. (2021), The impacht of IL-17A on IGG sialylation in humans, Annals of the Rheumatic Diseases 80(Suppl 1): 1042-1043.
- Rodrigues, J.G.; Duarte, H.O.; Gomes, C.; Balmana, M.; Martins, A.M.; Hensbergen, P.J.; Ru, A.H. de; Lima, J.; Albergaria, A.; Veelen, P.A. van; Wuhrer, M.; Gomes, J. & Reis, C.A. (2021), Terminal alpha 2,6-sialylation of epidermal growth factor receptor modulates antibody therapy response of colorectal cancer cells, Cellular Oncology 44(4): 835-850.
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- Zeerleder, S.; Engel, R.; Zhang, T.; Roem, D.; Mierlo, G. van; Wagenaar-Bos, I.; Ham, S.M. van; Wuhrer, M.; Wouters, D. & Jongerius, I. (2021), Sugar Matters: Improving In Vivo Clearance Rate of Highly Glycosylated Recombinant Plasma Proteins for Therapeutic Use, Pharmaceuticals 14(1).
- Gstottner, C.; Zhang, T.; Resemann, A.; Ruben, S.; Pengelley, S.; Suckau, D.; Welsink, T.; Wuhrer, M. & Dominguez-Vega, E. (2021), Structural and functional characterization of SARS-CoV-2 RBD domains produced in mammalian cells, Analytical Chemistry 93(17): 6839-6847.
- Duarte, H.O.; Rodrigues, J.G.; Gomes, C.; Hensbergen, P.J.; Ederveen, A.L.H.; Ru, A.H. de; Mereiter, S.; Polonia, A.; Fernandes, E.; Ferreira, J.A.; Veelen, P.A. van; Santos, L.L.; Wuhrer, M.; Gomes, J. & Reis, C.A. (2021), ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab, Oncogene 40(21): 3719-3733.
- Pont, L.; Kuzyk, V.; Benavente, F.; Sanz-Nebot, V.; Mayboroda, O.A.; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2021), Site-specific N-linked glycosylation analysis of human carcinoembryonic antigen by sheathless capillary electrophoresis-tandem mass spectrometry, Journal of Proteome Research 20(3): 1666-1675.
- Martin, M.A.; Wuhrer, M. & Falck, D. (2021), Serum and plasma immunoglobulin G Fc N-glycosylation is stable during storage, Journal of Proteome Research 20(5): 2935-2941.
- Alves, I.; Santos-Pereira, B.; Dalebout, H.; Santos, S.; Vicente, M.M.; Campar, A.; Thepaut, M.; Fieschi, F.; Strahl, S.; Boyaval, F.; Vizcaino, R.; Silva, R.; Holst-Bernal, S.; Vasconcelos, C.; Santos, L.; Wuhrer, M.; Marinho, A.; Heijs, B. & Pinho, S.S. (2021), Protein Mannosylation as a Diagnostic and Prognostic Biomarker of Lupus Nephritis: An Unusual Glycan Neoepitope in Systemic Lupus Erythematosus, Arthritis and Rheumatology.
- Moran, A.B.; Dominguez-Vega, E.; Nouta, J.; Pongracz, T.; Reijke, T.M. de; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2021), Profiling the proteoforms of urinary prostate-specific antigen by capillary electrophoresis-mass spectrometry, Journal of Proteomics 238.
- Memarian, E.; Hart, L.M. 't; Slieker, R.C.; Lemmers, R.F.L.; Heijden, A.A. van der; Rutters, F.; Nijpels, G.; Schoep, E.; Lieverse, A.G.; Sijbrands, E.J.G.; Wuhrer, M.; Hoek, M. van & Dotz, V. (2021), Plasma protein N-glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes, BMJ Open Diabetes Research and Care 9(1).
- Pirro, M.; Mohammed, Y.; Ru, A.H. de; Janssen, G.M.C.; Tjokrodirijo, R.T.N.; Madunic, K.; Wuhrer, M.; Veelen, P.A. van & Hensbergen, P.J. (2021), Oxonium ion guided analysis of quantitative proteomics data reveals site-specific O-glycosylation of anterior gradient protein 2 (AGR2), International Journal of Molecular Sciences 22(10).
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- Schaick, G. van; Dominguez-Vega, E.; Gstottner, C.; Berg-Verleg, J.H. van den; Schouten, O.; Akeroyd, M.; Olsthoorn, M.M.A.; Wuhrer, M.; Heck, A.J.R.; Abello, N. & Franc, V. (2021), Native structural and functional proteoform characterization of the prolyl-alanyl-specific endoprotease EndoPro from Aspergillus niger, Journal of Proteome Research 20(10).
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- Lageveen-Kammeijer, G.S.M.; Kuster, B.; Reusch, D. & Wuhrer, M. (2021), High sensitivity glycomics in biomedicine, Mass Spectrometry Reviews.
- Falck, D.; Thomann, M.; Lechmann, M.; Koeleman, C.A.M.; Malik, S.; Jany, C.; Wuhrer, M. & Reusch, D. (2021), Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody, mAbs 13(1).
- Vergoossen, D.L.E.; Plomp, J.J.; Gstottner, C.; Fillie-Grijpma, Y.E.; Augustinus, R.; Verpalen, R.; Wuhrer, M.; Parren, P.W.H.I.; Dominguez-Vega, E.; Maarel, S.M. van der; Verschuuren, J.J. & Huijbers, M.G. (2021), Functional monovalency amplifies the pathogenicity of anti-MuSK IgG4 in myasthenia gravis, Proceedings of the National Academy of Sciences 118(13).
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- Madunic, K.; Wagt, S.; Zhang, T.; Wuhrer, M. & Lageveen-Kammeijer, G.S.M. (2021), Dopant-enriched nitrogen gas for enhanced electrospray ionization of released glycans in negative ion mode, Analytical Chemistry 93(18): 6919-6923.
- Nicolardi, S.; Joseph, A.A.; Zhu, Q.; Shen, Z.N.; Pardo-Vargas, A.; Chiodo, F.; Molinaro, A.; Silipo, A.; Burgt, Y.E.M. van der; Yu, B.; Seeberger, P.H. & Wuhrer, M. (2021), Analysis of synthetic monodisperse polysaccharides by wide mass range ultrahigh-resolution MALDI mass spectrometry, Analytical Chemistry 93(10): 4666-4675.
- Verkerk, T.; Waard, A.A. de; Bliss, S.; Koomen, S.J.I.; Buitenwerf, F.; Zhang, T.; Gerke, C.; Halenius, A.; Stockinger, H.; Wuhrer, M.; Schoot, E. van der & Spaapen, R.M. (2021), Expression of neolacto-series glycosphingolipids by tumors impairs the function of low-affinity immune receptor-ligand pairs, European Journal of Immunology 51: 61-61.
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- Braster, R.; Bogels, M.; Benonisson, H.; Wuhrer, M.; Plomp, R.; Bentlage, A.E.H.; Korthouwer, R.; Visser, R.; Verbeek, J.S.; Egmond, M. van & Vidarsson, G. (2021), Afucosylated IgG targets Fc gamma RIV for enhanced tumor therapy in mice, Cancers 13(10).
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- Volkov, M.; Schie, K. van; Bondt, A.; Kissel, T.; Brinkhaus, M.; Bentlage, A.; Koeleman, C.; Taeye, S. de; Dolhain, R.; Wuhrer, M.; Toes, R.; Vidarsson, G. & Woude, D. van der (2021), ACPA illustrating the impact of ICG fabglycosylation on transplacental transfer of antibodies and their binding to the neonatal FC-Receptor (FCRN), Annals of the Rheumatic Diseases 80(1): 1044-1044.
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- Kissel, T.; Wesemael, T.J. van; Lundquist, A.; Kokkonen, H.; Kawakami, A.; Tamai, M.; Schaardenburg, D. van; Wuhrer, M.; Huizinga, T.W.J.; Scherer, H.U.; Woude, D. van der; Rantapaa-Dahlqvist, S. & Toes, R.E.M. (2021), Genetic predisposition (HLA-SE) is associated with ACPA-IgG variable domain glycosylation in the predisease phase of RA, Annals of the Rheumatic Diseases.
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- Lippold, S.; Nicolardi, S.; Wuhrer, M. & Falck, D. (2019), Proteoform-Resolved Fc & x264;RIIIa Binding Assay for Fab Glycosylated Monoclonal Antibodies Achieved by Affinity Chromatography Mass Spectrometry of Fc Moieties, Frontiers in Chemistry 7.
- Vreeker, G.C.M.; Bladergroen, M.R.; Nicolardi, S.; Mesker, W.E.; Tollenaar, R.A.E.M.; Burgt, Y.E.M. van der & Wuhrer, M. (2019), Dried blood spot N-glycome analysis by MALDI mass spectrometry, Talanta 205.
- Culver, E.L.; Bovenkamp, F.S. van de; Derksen, N.I.L.; Koers, J.; Cargill, T.; Barnes, E.; Neef, L.A. de; Koeleman, C.A.M.; Aalberse, R.C.; Wuhrer, M. & Rispens, T. (2019), Unique patterns of glycosylation in immunoglobulin subclass G4-related disease and primary sclerosing cholangitis, Journal of Gastroenterology and Hepatology 34(10): 1878-1886.
- Tyshchuk, O.; Gstottner, C.; Funk, D.; Nicolardi, S.; Frost, S.; Klostermann, S.; Becke, T.; Jolkver, E.; Schumacher, F.; Koller, C.F.; Volger, H.R.; Wuhrer, M.; Bulau, P. & Molhoj, I. (2019), Characterization and prediction of positional 4-hydroxyproline and sulfotyrosine, two post-translational modifications that can occur at substantial levels in CHO cells-expressed biotherapeutics, mAbs 11(7): 1219-1232.
- Westhrin, M.; Kovcic, V.; Bondt, A.; Holst, S.; Zhang, Z.J.; Sundan, A.; Slordahl, T.S.; Waage, A.; Wuhrer, M. & Standal, T. (2019), Glycosylationof Immunoglobulins Determine Bone Loss in Multiple Myeloma, Blood 134.
- Wuhrer, M. (2019), Paucity of Paucimannosylation Revoked, Proteomics 19(21-22).
- Tillmann J., Kovacs B., Kordowski A., Wuhrer M., Ludwig R., Karsten C. M. & Koehl J. (2019), The C5a/C5aR1 axis drives the development of autoimmune skin blistering disease through regulation of IgG auto-antibody production, IgG1 Fc glycosylation and cytokine production, European Journal of Immunology 49: 206-206.
- Biwi, J.; Clarisse, C.; Biot, C.; Kozak, R.P.; Madunic, K.; Mortuaire, M.; Wuhrer, M.; Spencer, D.I.R.; Schulz, C.; Guerardel, Y.; Lefebvre, T. & Vercoutter-Edouart, A.S. (2019), OGT Controls the Expression and the Glycosylation of E-cadherin, and Affects Glycosphingolipid Structures in Human Colon Cell Lines, Proteomics 19(21-22).
- Fernandez, I.M.; Macrini, C.; Krumbholz, M.; Hensbergen, P.J.; Ederveen, A.L.H.; Winklmeier, S.; Vural, A.; Kurne, A.; Jenne, D.; Kamp, F.; Gerdes, L.A.; Hohlfeld, R.; Wuhrer, M.; Kumpfel, T. & Meinl, E. (2019), The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients, Frontiers in Immunology 10.
- Rojas-Macias, M.A.; Mariethoz, J.; Andersson, P.; Jin, C.S.; Venkatakrishnan, V.; Aoki, N.P.; Shinmachi, D.; Ashwood, C.; Madunic, K.; Zhang, T.; Miller, R.L.; Horlacher, O.; Struwe, W.B.; Watanabe, Y.; Okuda, S.; Levander, F.; Kolarich, D.; Rudd, P.M.; Wuhrer, M.; Kettner, C.; Packer, N.H.; Aoki-Kinoshita, K.F.; Lisacek, F. & Karlsson, N.G. (2019), Towards a standardized bioinformatics infrastructure for N- and O-glycomics, Nature Communications 10.
- Hafkenscheid, L.; Moel, E. de; Smolik, I.; Tanner, S.; Meng, X.B.; Jansen, B.C.; Bondt, A.; Wuhrer, M.; Huizinga, T.W.J.; Toes, R.E.M.; El-Gabalawy, H. & Scherer, H.U. (2019), N-Linked Glycans in the Variable Domain of IgG Anti-Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis, Arthritis and Rheumatology.
- Burgt, Y.E.M. van der; Kilgour, D.P.A.; Tsybin, Y.O.; Srzentic, K.; Fornelli, L.; Beck, A.; Wuhrer, M. & Nicolardi, S. (2019), Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry, Analytical Chemistry 91(3): 2079-2085.
- Zhang, T.; Waard, A.A. de; Wuhrer, M. & Spaapen, R.M. (2019), The Role of Glycosphingolipids in Immune Cell Functions, Frontiers in Immunology 10.
- Pirro, M.; Schoof, E.; Vliet, S.J. van; Rombouts, Y.; Stella, A.; Ru, A. de; Mohammed, Y.; Wuhrer, M.; Veelen, P.A. van & Hensbergen, P.J. (2019), Glycoproteomic Analysis of MGL-Binding Proteins on Acute T-Cell Leukemia Cells, Journal of Proteome Research 18(3).
- Hafkenscheid Lise, de Moel Emma C., Smolik Irene, Meng Xiaobo, Tanner Stacy, Jansen Bas C., Bondt Albert, Wuhrer Manfred, Huizinga Thomas, Toes Rene, El-Gabalawy Hani & Scherer Hans Ulrich (2019), N-LINKED GLYCANS IN THE VARIABLE DOMAIN OF ACPA-IGG IN THE DEVELOPMENT OF RHEUMATOID ARTHRITIS, Annals of the Rheumatic Diseases 78: 228-229.
- Kissel, T.; Schie, K.A. van; Hafkenscheid, L.; Lundquist, A.; Kokkonen, H.; Wuhrer, M.; Huizinga, T.W.J.; Scherer, H.U.; Toes, R. & Rantapaa-Dahlqvist, S. (2019), On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis, Annals of the Rheumatic Diseases 78(12): 1616-1620.
- Kissel, T.; Schie, K.A. van; Hafkenscheid, L.; Lundquist, A.; Kokkonen, H.; Wuhrer, M.; Huizinga, T.W.J.; Scherer, H.U.; Toes, R. & Rantapaa-Dahlqvist, S. (2019), On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis, Annals of the Rheumatic Diseases 78(12): 1616-1620.
- Temming, A.R.; Taeye, S.W. de; Graaf, E.L. de; Neef, L.A. de; Dekkers, G.; Bruggeman, C.W.; Koers, J.; Ligthart, P.; Nagelkerke, S.Q.; Zimring, J.C.; Kuijpers, T.W.; Wuhrer, M.; Rispens, T. & Vidarsson, G. (2019), Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity, Journal of Immunology 203(12): 3126-3135.
- Epp, A.; Hobusch, J.; Bartsch, Y.C.; Petry, J.; Lilienthal, G.M.; Koeleman, C.A.M.; Eschweiler, S.; Mobs, C.; Hall, A.; Morris, S.C.; Braumann, D.; Engellenner, C.; Bitterling, J.; Rahmoller, J.; Leliavski, A.; Thurmann, R.; Collin, M.; Moremen, K.W.; Strait, R.T.; Blanchard, V.; Petersen, A.; Gemoll, T.; Habermann, J.K.; Petersen, F.; Nandy, A.; Kahlert, H.; Hertl, M.; Wuhrer, M.; Pfutzner, W.; Jappe, U.; Finkelman, F.D. & Ehlers, M. (2018), Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions, Journal of Allergy and Clinical Immunology 141(1): 399-402.
- Sonneveld, M.E.; Koeleman, C.A.M.; Plomp, H.R.; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2018), Fc-Glycosylation in Human IgG1 and IgG3 Is Similar for Both Total and Anti-Red-Blood Cell Anti-K Antibodies, Frontiers in Immunology 9.
- Ferrantelli, E.; Farhat, K.; Ederveen, A.L.H.; Reiding, K.R.; Beelen, R.H.J.; Ittersum, F.J. van; Wuhrer, M. & Dotz, V. (2018), Effluent and serum protein N-glycosylation is associated with inflammation and peritoneal membrane transport characteristics in peritoneal dialysis patients, Scientific Reports 8.
- Reiding, K.R.; Vreeker, G.C.M.; Bondt, A.; Bladergroen, M.R.; Hazes, J.M.W.; Burgt, Y.E.M. van der; Wuhrer, M. & Dolhain, R.J.E.M. (2018), Serum Protein N-Glycosylation Changes with Rheumatoid Arthritis Disease Activity during and after Pregnancy, Frontiers in Medicine 4.
- Jansen, B.C.; Hafkenscheid, L.; Bondt, A.; Gardner, R.A.; Hendel, J.L.; Wuhrer, M. & Spencer, D.I.R. (2018), HappyTools: A software for high-throughput HPLC data processing and quantitation, PLoS ONE 13(7).
- Simurina, M.; Haan, N. de; Vuckovic, F.; Kennedy, N.A.; Stambuk, J.; Falck, D.; Trbojevic-Akmacic, I.; Clerc, F.; Razdorov, G.; Khon, A.; Latiano, A.; D'Inca, R.; Danese, S.; Targan, S.; Landers, C.; Dubinsky, M.; McGovern, D.P.B.; Annese, V.; Wuhrer, M.; Lauc, G. & Inflammatory Bowel Dis Biomarkers (2018), Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases, Gastroenterology 154(5): 1320-+.
- Wahl, A.; Akker, E. van den; Klaric, L.; Stambuk, J.; Benedetti, E.; Plomp, R.; Razdorov, G.; Trbojevic-Akmacic, I.; Deelen, J.; Heemst, D. van; Slagboom, P.E.; Vuckovic, F.; Grallert, H.; Krumsiek, J.; Strauch, K.; Peters, A.; Meitinger, T.; Hayward, C.; Wuhrer, M.; Beekman, M.; Lauc, G. & Gieger, C. (2018), Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns, Frontiers in Immunology 9.
- Bovenkamp, F.S. van de; Derksen, N.I.L.; Ooijevaar-de Heer, P.; Schie, K.A. van; Kruithof, S.; Berkowska, M.A.; Schoot, C.E. van der; IJspeert, H.; Burg, M. van der; Gils, A.; Hafkenscheid, L.; Toes, R.E.M.; Rombouts, Y.; Plomp, R.; Wuhrer, M.; Ham, S.M. van; Vidarsson, G. & Rispens, T. (2018), Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region, Proceedings of the National Academy of Sciences 115(8): 1901-1906.
- Culver Emma, van de Bovenkamp Fleur Sanne, Derksen Ninotska, Cargill Tamsin, Koeleman Carolien, Neef Lisa, Barnes Eleanor, Aalberse Rob, Wuhrer Manfred & Rispens Theo (2018), ALTERED FC AND FAB GLYCOSYLATION STATUS IN PATIENTS WITH IGG4-RELATED SCLEROSING CHOLANGITIS AND AUTOIMMUNE PANCREATITIS, Gut 67: A155-A155.
- Kammeijer, G.S.M.; Nouta, J.; Rosette, J.J.M.C.H. de la; Reijke, T.M. de & Wuhrer, M. (2018), An In-Depth Glycosylation Assay for Urinary Prostate-Specific Antigen, Analytical Chemistry 90(7): 4414-4421.
- Dekkers, G.; Bentlage, A.E.H.; Plomp, R.; Visser, R.; Koeleman, C.A.M.; Beentjes, A.; Mok, J.Y.; Esch, W.J.E. van; Wuhrer, M.; Rispens, T. & Vidarsson, G. (2018), Conserved Fc gamma R- glycan discriminates between fucosylated and afucosylated IgG in humans and mice, Molecular Immunology 94: 54-60.
- Dimitrov, B.; Himmelreich, N.; Ederveen, A.L.H.; Luchtenborg, C.; Okun, J.G.; Breuer, M.; Hutter, A.M.; Carl, M.; Guglielmi, L.; Hellwig, A.; Thiemann, K.C.; Jost, M.; Peters, V.; Staufner, C.; Hoffmann, G.F.; Hackenberg, A.; Paramasivam, N.; Wiemann, S.; Eils, R.; Schlesner, M.; Strahl, S.; Brugger, B.; Wuhrer, M.; Korenke, G.C. & Thiel, C. (2018), Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG, Molecular Genetics and Metabolism 123(3): 364-374.
- Engdahl, C.; Bondt, A.; Harre, U.; Raufer, J.; Pfeifle, R.; Camponeschi, A.; Wuhrer, M.; Seeling, M.; Martensson, I.L.; Nimmerjahn, F.; Kronke, G.; Scherer, H.U.; Forsblad-d'Elia, H. & Schett, G. (2018), Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women, Arthritis Research and Therapy 20.
- Kotsias Maximilianos, Kozak Radoslaw P., Gardner Richard A., Wuhrer Manfred & Spencer Daniel I. (2018), Improved and semi-automated reductive beta-elimination workflow for higher throughput protein O-glycosylation, Glycobiology 28(12): 1090-1090.
- Haan, N. de; Boeddha, N.P.; Ekinci, E.; Reiding, K.R.; Emonts, M.; Hazelzet, J.A.; Wuhrer, M. & Driessen, G.J. (2018), Differences in IgG Fc Glycosylation Are Associated with Outcome of Pediatric Meningococcal Sepsis, mBio 9(3).
- Haan, N. de; Tol, M. van; Driessen, G.; Wuhrer, M. & Lankester, A. (2018), IgG Fc Glycosylation After Hematopoietic Stem Cell Transplantation is Dissimilar to Donor Profiles, Bone Marrow Transplantation 53: 631-632.
- Schmidt, C.Q.; Ederveen, A.L.H.; Harder, M.J.; Wuhrer, M.; Stehle, T. & Blaum, B.S. (2018), Biophysical analysis of sialic acid recognition by the complement regulator Factor H, Glycobiology 28(10): 765-773.
- Lauc, G.; Vuckovic, F.; Bondt, A.; Pezer, M. & Wuhrer, M. (2018), Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG, Nature Communications 9.
- Link-Lenczowski, P.; Bubka, M.; Balog, C.I.A.; Koeleman, C.A.M.; Butters, T.D.; Wuhrer, M. & Litynska, A. (2018), The glycomic effect of N-acetylglucosaminyltransferase III overexpression in metastatic melanoma cells. GnT-III modifies highly branched N-glycans, Glycoconjugate Journal 35(2): 217-231.
- Engel, R.; Delvasto-Nunez, L.; Roem, D.; Mierlo, G. van; Holst, S.; Ederveen, A.L.H.; Buul, J.D. van; Wuhrer, M.; Wouters, D. & Zeerleder, S. (2018), alpha 1-Antichymotrypsin Present in Therapeutic Cl-Inhibitor Products Competes with Selectin-Sialyl Lewis(X) Interaction, Thrombosis and Haemostasis 118(12): 2134-2144.
- Zhang, Z.J.; Wuhrer, M. & Holst, S. (2018), Serum sialylation changes in cancer, Glycoconjugate Journal 35(2): 139-160.
- Jacobino, S.R.; Nederend, M.; Reijneveld, J.F.; Augustijn, D.; Jansen, J.H.M.; Meeldijk, J.; Reiding, K.R.; Wuhrer, M.; Coenjaerts, F.E.J.; Hack, C.E.; Bont, L.J. & Leusen, J.H.W. (2018), Reformatting palivizumab and motavizumab from IgG to human IgA impairs their efficacy against RSV infection in vitro and in vivo, mAbs 10(3): 453-462.
- Westhrin Marita, Kovcic Vlado, Bondt Albert, Holst Stephanie, Zhang Zeijan, Slordahl Tobias, Sundan Anders, Waage Anders, Wuhrer Manfred & Standal Therese (2018), A role for immunoglobulins in the osteolytic bone disease of multiple myeloma, Journal of Bone and Mineral Research 33: 341-341.
- Benedetti, E.; Pucic-Bakovic, M.; Keser, T.; Wahl, A.; Hassinen, A.; Yang, J.Y.; Liu, L.; Trbojevic-Akmacic, I.; Razdorov, G.; Stambuk, J.; Klaric, L.; Ugrina, I.; Selman, M.H.J.; Wuhrer, M.; Rudan, I.; Polasek, O.; Hayward, C.; Grallert, H.; Strauch, K.; Peters, A.; Meitinger, T.; Gieger, C.; Vilaj, M.; Boons, G.J.; Moremen, K.W.; Ovchinnikova, T.; Bovin, N.; Kellokumpu, S.; Theis, F.J.; Lauc, G. & Krumsiek, J. (2018), Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway (vol 8, 2017), Nature Communications 9.
- Stavenhagen, K.; Kayili, H.M.; Holst, S.; Koeleman, C.A.M.; Engel, R.; Wouters, D.; Zeerleder, S.; Salih, B. & Wuhrer, M. (2018), N- and O-glycosylation Analysis of Human C1-inhibitor Reveals Extensive Mucin-type O-Glycosylation, Molecular and Cellular Proteomics 17(6): 1225-1238.
- Knopf, J.; Magorivska, I.; Maier, J.M.; Spitzer, P.; Bilyy, R.; Biermann, M.H.C.; Hychka, K.; Bondt, A.; Wuhrer, M.; Toes, R.E.M.; Schett, G.; Herrmann, M. & Munoz, L.E. (2018), Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG, Journal of Neuroimmunology 320: 19-24.
- Haan, N. de; Tol, M.J.D. van; Driessen, G.J.; Wuhrer, M. & Lankester, A.C. (2018), Immunoglobulin G Fragment Crystallizable Glycosylation Hematopoietic Stem Cell Transplantation Is Dissimilar to Donor Profiles, Frontiers in Immunology 9.
- Schie, K.A. van; Kruithof, S.; Ooijevaar-de Heer, P.; Derksen, N.I.L.; Bovenkamp, F.S. van de; Saris, A.; Vidarsson, G.; Bentlage, A.E.H.; Jiskoot, W.; Romeijn, S.; Koning, R.I.; Bos, E.; Stork, E.M.; Koeleman, C.A.M.; Wuhrer, M.; Wolbink, G. & Rispens, T. (2018), Restricted immune activation and internalisation of anti-idiotype complexes between drug and antidrug antibodies, Annals of the Rheumatic Diseases 77(10): 1471-1479.
- Dotz, V.; Lemmers, R.F.H.; Reiding, K.R.; Ederveen, A.L.H.; Lieverse, A.G.; Mulder, M.T.; Sijbrands, E.J.G.; Wuhrer, M. & Hoek, M. van (2018), Plasma protein N-glycan signatures of type 2 diabetes, BBA - General Subjects 1862(12): 2613-2622.
- Clerc, F.; Novokmet, M.; Dotz, V.; Reiding, K.R.; Haan, N. de; Kammeijer, G.S.M.; Dalebout, H.; Bladergroen, M.R.; Vukovic, F.; Rapp, E.; Targan, S.R.; Barron, G.; Manetti, N.; Latiano, A.; McGovern, D.P.B.; Annese, V.; Lauc, G.; Wuhrer, M. & IBD-BIOM Consortium (2018), Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases, Gastroenterology 155(3): 829-843.
- de Haan Noortje, Holst Stephanie, Kammeijer Guinevere, Heijs Bram, Falck David, Reiding Karli & Wuhrer Manfred (2018), Linkage-specific sialic acid derivatization strategies for mass spectrometric profiling of glycans and glycopeptides in complex samples and tissues, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256.
- Plomp, R.; Haan, N. de; Bondt, A.; Murli, J.; Dotz, V. & Wuhrer, M. (2018), Comparative Glycomics of Immunoglobulin A and G From Saliva and Plasma Reveals Biomarker Potential, Frontiers in Immunology 9.
- Vreeker, G.C.M.; Nicolardi, S.; Bladergroen, M.R.; Plas, C.J. van der; Mesker, W.E.; Tollenaar, R.A.E.M.; Burgt, Y.E.M. van der & Wuhrer, M. (2018), Automated Plasma Glycomics with Linkage-Specific Sialic Acid Esterification and Ultrahigh Resolution MS, Analytical Chemistry 90(20): 11955-11961.
- Wahl, A.; Kasela, S.; Carnero-Montoro, E.; Iterson, M. van; Stambuk, J.; Sharma, S.; Akker, E. van den; Klaric, L.; Benedetti, E.; Razdorov, G.; Trbojevic-Akmacic, I.; Vuckovic, F.; Ugrina, I.; Beekman, M.; Deelen, J.; Heemst, D. van; Heijmans, B.T.; Wuhrer, M.; Plomp, R.; Keser, T.; Simurina, M.; Pavic, T.; Gudelj, I.; Kristic, J.; Grallert, H.; Kunze, S.; Peters, A.; Bell, J.T.; Spector, T.D.; Milani, L.; Slagboom, P.E.; Lauc, G.; Gieger, C. & B I O S Consortium (2018), IgG glycosylation and DNA methylation are interconnected with smoking, BBA - General Subjects 1862(3): 637-648.
- Bondt, A.; Hafkenscheid, L.; Falck, D.; Kuijper, T.M.; Rombouts, Y.; Hazes, J.M.W.; Wuhrer, M. & Dolhain, R.J.E.M. (2018), ACPA IgG galactosylation associates with disease activity in pregnant patients with rheumatoid arthritis, Annals of the Rheumatic Diseases 77(8): 1130-1136.
- Nicolardi S., Burgt Y.E.M. van der, Codée J.D.C., Wuhrer M., Hokke C.H. & Chiodo F. (2017), Structural Characterization of Biofunctionalized Gold Nanoparticles by Ultrahigh-Resolution Mass Spectrometry, ACS Nano 11(8): 8257-8264.
- Laan, L.C.; Williams, A.R.; Stavenhagen, K.; Giera, M.; Kooij, G.; Vlasakov, I.; Kalay, H.; Kringel, H.; Nejsum, P.; Thamsborg, S.M.; Wuhrer, M.; Dijkstra, C.D.; Cummings, R.D. & , I. van die (2017), The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells, FASEB Journal 31(2): 719-731.
- Haan, N. de; Reiding, K.R.; Kristic, J.; Ederveen, A.L.H.; Lauc, G. & Wuhrer, M. (2017), The N-glycosylation of Mouse immunoglobulin G (igg)-Fragment crystallizable Differs Between igg subclasses and strains, Frontiers in Immunology 8.
- Plomp, R.; Ruhaak, L.R.; Uh, H.W.; Reiding, K.R.; Selman, M.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Beekman, M. & Wuhrer, M. (2017), Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health, Scientific Reports 7.
- Nicolardi, S.; Burgt, Y.E.M. van der; Codee, J.D.C.; Wuhrer, M.; Hokke, C.H. & Chiodo, F. (2017), Structural Characterization of Biofunctionalized Gold Nanoparticles by Ultrahigh-Resolution Mass Spectrometry, ACS Nano 11(8): 8257-8264.
- Hafkenscheid, L.; Bondt, A.; Scherer, H.U.; Huizinga, T.W.J.; Wuhrer, M.; Toes, R.E.M. & Rombouts, Y. (2017), Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans, Molecular and Cellular Proteomics 16(2): 278-287.
- Kammeijer, G.S.M.; Jansen, B.C.; Kohler, I.; Heemskerk, A.A.M.; Mayboroda, O.A.; Hensbergen, P.J.; Schappler, J. & Wuhrer, M. (2017), Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis - electrospray ionization - mass spectrometry, Scientific Reports 7.
- Sonneveld, M.E.; Haas, M. de; Koeleman, C.; Haan, N. de; Zeerleder, S.S.; Ligthart, P.C.; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2017), Patients with IgG1-anti-red blood cell autoantibodies show aberrant Fc-glycosylation, Scientific Reports 7.
- Bondt, A.; Nicolardi, S.; Jansen, B.C.; Kuijper, T.M.; Hazes, J.M.W.; Burgt, Y.E.M. van der; Wuhrer, M. & Dolhain, R.J.E.M. (2017), IgA N- and O-gycosylation profiling reveals no association with the pregnancy-related improvement in rheumatoid arthritis, Arthritis Research and Therapy 19.
- Jonsson, S.; Sveinbjornsson, G.; Portilla, A.L.D.; Swaminathan, B.; Plomp, R.; Dekkers, G.; Ajore, R.; Ali, M.; Bentlage, A.E.H.; Elmer, E.; Eyjolfsson, G.I.; Gudjonsson, S.A.; Gullberg, U.; Gylfason, A.; Halldorsson, B.V.; Hansson, M.; Holm, H.; Johansson, A.; Johnsson, E.; Jonasdottir, A.; Ludviksson, B.R.; Oddsson, A.; Olafsson, I.; Olafsson, S.; Sigurdardottir, O.; Sigurdsson, A.; Stefansdottir, L.; Masson, G.; Sulem, P.; Wuhrer, M.; Wihlborg, A.K.; Thorleifsson, G.; Gudbjartsson, D.F.; Thorsteinsdottir, U.; Vidarsson, G.; Jonsdottir, I.; Nilsson, B. & Stefansson, K. (2017), Identification of sequence variants influencing immunoglobulin levels, Nature Genetics 49(8): 1182-+.
- Reiding, K.R.; Ruhaak, L.R.; Uh, H.W.; Bouhaddani, S. el; Akker, E.B. van den; Plomp, R.; McDonnell, L.A.; Houwing-Duistermaat, J.J.; Slagboom, P.E.; Beekman, M. & Wuhrer, M. (2017), Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health, Molecular and Cellular Proteomics 16(2): 228-242.
- Delannoy, C.P.; Rombouts, Y.; Groux-Degroote, S.; Holst, S.; Coddeville, B.; Harduin-Lepers, A.; Wuhrer, M.; Elass-Rochard, E. & Guerardel, Y. (2017), Glycosylation Changes Triggered by the Differentiation of Monocytic THP-1 Cell Line into Macrophages, Journal of Proteome Research 16(1): 156-169.
- Kemna, M.J.; Plomp, R.; Paassen, P. van; Jansen, B.C.; Koeleman, C.A.M.; Damoiseaux, J.G.M.C.; Wuhrer, M. & Tervaert, J.W.C. (2017), GLYCOSYLATION AND SIALYLATION LEVELS OF IGG PREDICT RELAPSES IN PATIENTS WITH PR3-ANCA ASSOCIATED VASCULITIS, Rheumatology 56: 119-120.
- Kemna, M.J.; Plomp, R.; Paassen, P. van; Koeleman, C.A.M.; Jansen, B.C.; Damoiseaux, J.G.M.C.; Tervaert, J.W.C. & Wuhrer, M. (2017), Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis, EBioMedicine 17: 108-118.
- Bruggeman, C.W.; Dekkers, G.; Bentlage, A.E.H.; Treffers, L.W.; Nagelkerke, S.Q.; Lissenberg-Thunnissen, S.; Koeleman, C.A.M.; Wuhrer, M.; Berg, T.K. van den; Rispens, T.; Vidarsson, G. & Kuijpers, T.W. (2017), Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fc gamma Receptor Profile, Journal of Immunology 199(1): 204-211.
- Gahoual, R.; Heidenreich, A.K.; Somsen, G.W.; Bulau, P.; Reusch, D.; Wuhrer, M. & Haberger, M. (2017), Detailed Characterization of Monoclonal Antibody Receptor Interaction Using Affinity Liquid Chromatography Hyphenated to Native Mass Spectrometry, Analytical Chemistry 89(10): 5404-5412.
- Dekkers, G.; Treffers, L.; Plomp, R.; Bentlage, A.E.H.; Boer, M. de; Koeleman, C.A.M.; Lissenberg-Thunnissen, S.N.; Visser, R.; Brouwer, M.; Mok, J.Y.; Matlung, H.; Berg, T.K. van den; Esch, W.J.E. van; Kuijpers, T.W.; Wouters, D.; Rispens, T.; Wuhrer, M. & Vidarsson, G. (2017), Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities, Frontiers in Immunology 8.
- Verhoeven, A.; Slagboom, E.; Wuhrer, M.; Giera, M. & Mayboroda, O.A. (2017), Automated quantification of metabolites in blood-derived samples by NMR, Analytica Chimica Acta 976: 52-62.
- Sonneveld, M.E.; Koelewijn, J.; Haas, M. de; Admiraal, J.; Plomp, R.; Koeleman, C.A.M.; Ederveen, A.L.H.; Ligthart, P.; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2017), Antigen specificity determines anti-red blood cell IgG-Fc alloantibody glycosylation and thereby severity of haemolytic disease of the fetus and newborn, British Journal of Haematology 176(4): 651-660.
- Falck, D.; Haberger, M.; Plomp, R.; Hook, M.; Bulau, P.; Wuhrer, M. & Reusch, D. (2017), Affinity purification of erythropoietin from cell culture supernatant combined with MALDI-TOF-MS analysis of erythropoietin N-glycosylation, Scientific Reports 7.
- Bondt, A.; Hafkenscheid, L.; Falck, D.; Kuijper, T.M.; Rombouts, Y.; Hazes, J.M.; Wuhrer, M. & Dolhain, R.J. (2017), REDUCED INCREASE OF ACPA IGG-FC GALACTOSYLATION DURING PREGNANCY IN COMPARISON TO TOTAL IGG: AN EXPLANATION WHY AUTOANTIBODY POSITIVE RA-PATIENTS IMPROVE LESS DURING PREGNANCY?, Annals of the Rheumatic Diseases 76: 509-509.
- Holst, S.; Belo, A.I.; Giovannetti, E.; , I. van die & Wuhrer, M. (2017), Profiling of different pancreatic cancer cells used as models for metastatic behaviour shows large variation in their N-glycosylation, Scientific Reports 7.
- Benedetti, E.; Pucic-Bakovic, M.; Keser, T.; Wahl, A.; Hassinen, A.; Yang, J.Y.; Liu, L.; Trbojevic-Akmacic, I.; Razdorov, G.; Stambuk, J.; Klaric, L.; Ugrina, I.; Selman, M.H.J.; Wuhrer, M.; Rudan, I.; Polasek, O.; Hayward, C.; Grallert, H.; Strauch, K.; Peters, A.; Meitinger, T.; Gieger, C.; Vilaj, M.; Boons, G.J.; Moremen, K.W.; Ovchinnikova, T.; Bovin, N.; Kellokumpu, S.; Theis, F.J.; Lauc, G. & Krumsiek, J. (2017), Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway, Nature Communications 8.
- Vreeker, G.C.M. & Wuhrer, M. (2017), Reversed-phase separation methods for glycan analysis, Analytical and Bioanalytical Chemistry 409(2): 359-378.
- Pfeifle, R.; Rothe, T.; Ipseiz, N.; Scherer, H.U.; Culemann, S.; Harre, U.; Ackermann, J.A.; Seefried, M.; Kleyer, A.; Uderhardt, S.; Haugg, B.; Huebert, A.J.; Daum, P.; Heidkamp, G.F.; Ge, C.R.; Bohm, S.; Lux, A.; Schuh, W.; Magorivskal, I.; Nandakumar, K.S.; Lonnblom, E.; Becker, C.; Dudziak, D.; Wuhrer, M.; Rombouts, Y.; Koeleman, C.A.; Toes, R.; Winkler, T.H.; Holmdahl, R.; Herrmann, M.; Bluml, S.; Nimmerjahn, F.; Schett, G. & Kronke, G. (2017), Regulation of autoantibody activity by the IL-23-T(H)17 axis determines the onset of autoimmune disease, Nature Immunology 18(1): 104-113.
- Falck D , Jansen BC , de Haan N & Wuhrer M (2017), High-Throughput Analysis of IgG Fc Glycopeptides by LC-MS., Methods in Molecular Biology.
- Kammeijer G.S., Kohler I., Jansen B.C., Hensbergen P.J., Mayboroda O.A., Falck D. & Wuhrer M. (2016), Dopant Enriched Nitrogen Gas Combined with Sheathless Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry for Improved Sensitivity and Repeatability in Glycopeptide Analysis, Analytical Chemistry 88(11): 5849-5856.
- Maier, M.; Reusch, D.; Bruggink, C.; Bulau, P.; Wuhrer, M. & Molhoj, M. (2016), Applying mini-bore HPAEC-MS/MS for the characterization and quantification of Fc N-glycans from heterogeneously glycosylated IgGs, Journal of Chromatography B 1033: 342-352.
- Jansen, B.C.; Falck, D.; Haan, N. de; Ederveen, A.L.H.; Razdorov, G.; Lauc, G. & Wuhrer, M. (2016), LaCyTools: A Targeted Liquid Chromatography-Mass Spectrometry Data Processing Package for Relative Quantitation of Glycopeptides, Journal of Proteome Research 15(7): 2198-2210.
- Pfeifle, R.; Rothe, T.; Scherer, H.U.; Wuhrer, M.; Rombouts, Y.; Koeleman, C.A.; Toes, R.; Holmdahl, R.; Herrmann, M.; Bluml, S.; Nimmerjahn, F.; Schett, G. & Kronke, G. (2016), IL-17/23 IN THE TRANSITION FROM AUTOIMMUNITY TO INFLAMMATION, Clinical and Experimental Rheumatology 34(4): 726-726.
- Breen, L.D.; Pucic-Bakovic, M.; Vuckovic, F.; Reiding, K.; Trbojevic-Akmacic, I.; Gajdosik, M.S.; Cook, M.I.; Lopez, M.J.; Wuhrer, M.; Camara, L.M.; Andjelkovic, U.; Dupuy, D.E. & Josic, D. (2016), IgG and IgM glycosylation patterns in patients undergoing image-guided tumor ablation, BBA - General Subjects 1860(8): 1786-1794.
- Clerc, F.; Reiding, K.R.; Jansen, B.C.; Kammeijer, G.S.M.; Bondt, A. & Wuhrer, M. (2016), Human plasma protein N-glycosylation, Glycoconjugate Journal 33(3): 309-343.
- Dotz, V. & Wuhrer, M. (2016), Histo-blood group glycans in the context of personalized medicine, BBA - General Subjects 1860(8): 1596-1607.
- Sonneveld, M.E.; Natunen, S.; Sainio, S.; Koeleman, C.A.M.; Holst, S.; Dekkers, G.; Koelewijn, J.; Partanen, J.; Schoot, C.E. van der; Wuhrer, M. & Vidarsson, G. (2016), Glycosylation pattern of anti-platelet IgG is stable during pregnancy and predicts clinical outcome in alloimmune thrombocytopenia, British Journal of Haematology 174(2): 310-320.
- Rombouts, Y.; Willemze, A.; Beers, J.J.B.C. van; Shi, J.; Kerkman, P.F.; Toorn, L. van; Janssen, G.M.C.; Zaldumbide, A.; Hoeben, R.C.; Pruijn, G.J.M.; Deelder, A.M.; Wolbink, G.; Rispens, T.; Veelen, P.A. van; Huizinga, T.W.J.; Wuhrer, M.; Trouw, L.A.; Scherer, H.U. & Toes, R.E.M. (2016), Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis, Annals of the Rheumatic Diseases 75(3): 578-585.
- Kammeijer, G.S.M.; Kohler, I.; Jansen, B.C.; Hensbergen, P.J.; Mayboroda, O.A.; Falck, D. & Wuhrer, M. (2016), Dopant Enriched Nitrogen Gas Combined with Sheathless Capillary Electrophoresis-Electrospray Ionization-Mass Spectrometry for Improved Sensitivity and Repeatability in Glycopeptide Analysis, Analytical Chemistry 88(11): 5849-5856.
- Klasic, M.; Kristic, J.; Korac, P.; Horvat, T.; Markulin, D.; Vojta, A.; Reiding, K.R.; Wuhrer, M.; Lauc, G. & Zoldos, V. (2016), DNA hypomethylation upregulates expression of the MGAT3 gene in HepG2 cells and leads to changes in N-glycosylation of secreted glycoproteins.
- Haan, N. de; Reiding, K.R.; Driessen, G.; Burg, M. van der & Wuhrer, M. (2016), Changes in Healthy Human IgG Fc-Glycosylation after Birth and during Early Childhood, Journal of Proteome Research 15(6): 1853-1861.
- Shubhakar, A.; Kozak, R.P.; Reiding, K.R.; Royle, L.; Spencer, D.I.R.; Fernandes, D.L. & Wuhrer, M. (2016), Automated High-Throughput Permethylation for Glycosylation Analysis of Biologics Using MALDI-TOF-MS, Analytical Chemistry 88(17): 8562-8569.
- Rombouts, Y.; Jonasdottir, H.S.; Ederveen, A.L.H.; Reiding, K.R.; Jansen, B.C.; Freysdottir, J.; Hardardottir, I.; Ioan-Facsinay, A.; Giera, M. & Wuhrer, M. (2016), Acute phase inflammation is characterized by rapid changes in plasma/peritoneal fluid N-glycosylation in mice, Glycoconjugate Journal 33(3): 457-470.
- Kolarich, D. & Wuhrer, M. (2016), Glycomics & Glycoproteomics in Glycoconjugate journal, Glycoconjugate Journal 33(3): 259-260.
- Hinneburg, H.; Stavenhagen, K.; Schweiger-Hufnagel, U.; Pengelley, S.; Jabs, W.; Seeberger, P.H.; Silva, D.V.; Wuhrer, M. & Kolarich, D. (2016), The Art of Destruction: Optimizing Collision Energies in Quadrupole-Time of Flight (Q-TOF) Instruments for Glycopeptide-Based Glycoproteomics, Journal of The American Society for Mass Spectrometry 27(3): 507-519.
- Hoffmann, M.; Marx, K.; Reichl, U.; Wuhrer, M. & Rapp, E. (2016), Site-specific O-Glycosylation Analysis of Human Blood Plasma Proteins, Molecular and Cellular Proteomics 15(2): 624-641.
- Plomp, R.; Bondt, A.; Haan, N. de; Rombouts, Y. & Wuhrer, M. (2016), Recent Advances in Clinical Glycoproteomics of Immunoglobulins (Igs), Molecular and Cellular Proteomics 15(7): 2217-2228.
- Jansen, B.C.; Bondt, A.; Reiding, K.R.; Lonardi, E.; Jong, C.J. de; Falck, D.; Kammeijer, G.S.M.; Dolhain, R.J.E.M.; Rombouts, Y. & Wuhrer, M. (2016), Pregnancy-associated serum N-glycome changes studied by high-throughput MALDI-TOF-MS.
- Stavenhagen, K.; Kayili, H.M.; Holst, S.; Koeleman, C.A.M.; Engel, R.; Wouters, D.; Zeerleder, S.; Salih, B. & Wuhrer, M. (2016), In-depth site-specific N- and O-Glycosylation analysis of human C1-Inhibitor reveals extensive mucin-type O-glycosylation, Glycobiology 26(12): 1474-1475.
- Hafkenscheid, L.; Scherer, H.U.; Huizinga, T.W.J.; Wuhrer, M.; Rombouts, Y. & Toes, R.E.M. (2016), Extensive glycosylation of Anti-Citrullinated Protein Antibodies variable domains in rheumatoid arthritis, Glycobiology 26(12): 1481-1482.
- Heijs, B.; Holst, S.; Briaire-de Bruijn, I.H.; Pelt, G.W. van; Ru, A.H. de; Veelen, P.A. van; Drake, R.R.; Mehta, A.S.; Mesker, W.E.; Tollenaar, R.A.; Bovee, J.V.M.G.; Wuhrer, M. & McDonnell, L.A. (2016), Multimodal Mass Spectrometry Imaging of N-Glycans and Proteins from the Same Tissue Section, Analytical Chemistry 88(15): 7745-7753.
- Beekman, M.; Uh, H.W.; Heemst, D. van; Wuhrer, M.; Ruhaak, L.R.; Gonzalez-Covarrubias, V.; Hankemeier, T.; Houwing-Duistermaat, J.J. & Slagboom, P.E. (2016), Classification for Longevity Potential: The Use of Novel Biomarkers, Frontiers in Public Health 4.
- Rombouts, Y.; Willemze, A.; Beers, J.J.B.C. van; Shi, J.; Kerkman, P.F.; Toorn, L. van; Janssen, G.M.C.; Zaldumbide, A.; Hoeben, R.C.; Pruijn, G.J.M.; Deelder, A.M.; Wolbink, G.; Rispens, T.; Veelen, P.A. van; Huizinga, T.W.J.; Wuhrer, M.; Trouw, L.A.; Scherer, H.U. & Toes, R.E.M. (2016), Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis, Annals of the Rheumatic Diseases 75(3): 578-585.
- Jansen, B.C.; Bondt, A.; Reiding, K.R.; Scherjon, S.A.; Vidarsson, G. & Wuhrer, M. (2016), MALDI-TOF-MS reveals differential N-linked plasma- and IgG-glycosylation profiles between mothers and their newborns.
- Bondt, A.; Nicolardi, S.; Jansen, B.C.; Stavenhagen, K.; Blank, D.; Kammeijer, G.S.M.; Kozak, R.P.; Fernandes, D.L.; Hensbergen, P.J.; Hazes, J.M.W.; Burgt, Y.E.M. van der; Dolhain, R.J.E.M. & Wuhrer, M. (2016), Longitudinal monitoring of immunoglobulin A glycosylation during pregnancy by simultaneous MALDI-FTICR-MS analysis of N- and O-glycopeptides.
- Holst, S.; Heijs, B.; Haan, N. de; Zeijl, R.J.M. van; Briaire-de Bruijn, I.H.; Pelt, G.W. van; Mehta, A.S.; Angel, P.M.; Mesker, W.E.; Tollenaar, R.A.; Drake, R.R.; Bovee, J.V.M.G.; McDonnell, L.A. & Wuhrer, M. (2016), Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues, Analytical Chemistry 88(11): 5904-5913.
- Rouwendal, G.J.A.; Lee, M.M. van der; Meyer, S.; Reiding, K.R.; Schouten, J.; Roo, G. de; Egging, D.F.; Leusen, J.H.W.; Boross, P.; Wuhrer, M.; Verheijden, G.F.; Dokter, W.H.; Timmers, M. & Ubink, R. (2016), A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA, mAbs 8(1): 74-86.
- Holst, S.; Deuss, A.J.M.; Pelt, G.W. van; Vliet, S.J. van; Garcia-Vallejo, J.J.; Koeleman, C.A.M.; Deelder, A.M.; Mesker, W.E.; Tollenaar, R.A.; Rombouts, Y. & Wuhrer, M. (2016), N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression, Molecular and Cellular Proteomics 15(1): 124-140.
- Meyer, S.; Nederend, M.; Jansen, J.H.M.; Reiding, K.R.; Jacobino, S.R.; Meeldijk, J.; Bovenschen, N.; Wuhrer, M.; Valerius, T.; Ubink, R.; Boross, P.; Rouwendal, G. & Leusen, J.H.W. (2016), Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting, mAbs 8(1): 87-98.
- Kozak, R.P.; Urbanowicz, P.A.; Punyadeera, C.; Reiding, K.R.; Jansen, B.C.; Royle, L.; Spencer, D.I.; Fernandes, D.L. & Wuhrer, M. (2016), Variation of Human Salivary O-Glycome.
- Hinneburg, H.; Stavenhagen, K.; Schweiger-Hufnagel, U.; Pengelley, S.; Jabs, W.; Seeberger, P.H.; Silva, D.V.; Wuhrer, M. & Kolarich, D. (2016), The Art of Destruction: Optimizing Collision Energies in Quadrupole-Time of Flight (Q-TOF) Instruments for Glycopeptide-Based Glycoproteomics, Journal of The American Society for Mass Spectrometry 27(3): 507-519.
- Reiding, K.R.; Ederveen, A.L.H.; Rombouts, Y. & Wuhrer, M. (2016), Murine Plasma N-Glycosylation Traits Associated with Sex and Strain, Journal of Proteome Research 15(10): 3489-3499.
- Dekkers, G.; Plomp, R.; Koeleman, C.A.M.; Visser, R.; Horsten, H.H. von; Sandig, V.; Rispens, T.; Wuhrer, M. & Vidarsson, G. (2016), Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans, Scientific Reports 6.
- Fettke, F.; Schumacher, A.; Canellada, A.; Toledo, N.; Bekeredjian-Ding, I.; Bondt, A.; Wuhrer, M.; Costa, S.D. & Zenclussen, A.C. (2016), Maternal and Fetal Mechanisms of B Cell Regulation during Pregnancy: Human Chorionic Gonadotropin Stimulates B Cells to Produce IL-10 While Alpha-Fetoprotein Drives Them into Apoptosis, Frontiers in Immunology 7.
- Jong, S.E. de; Selman, M.H.J.; Adegnika, A.A.; Amoah, A.S.; Riet, E. van; Kruize, Y.C.M.; Raynes, J.G.; Rodriguez, A.; Boakye, D.; Mutius, E. von; Knulst, A.C.; Genuneit, J.; Cooper, P.J.; Hokke, C.H.; Wuhrer, M. & Yazdanbakhsh, M. (2016), IgG1 Fc N-glycan galactosylation as a biomarker for immune activation, Scientific Reports 6.
- Bondt, A.; Wuhrer, M.; Kuijper, T.M.; Hazes, J.M.W. & Dolhain, R.J.E.M. (2016), Fab glycosylation of immunoglobulin G does not associate with improvement of rheumatoid arthritis during pregnancy, Arthritis Research and Therapy 18.
- Sonneveld, M.E.; Haas, M. de; Koeleman, C.; Ligthart, P.; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2016), Patients with Autoimmune Anti-Red Blood Cell IgG1 Have Different Total- and Autoantibody-IgG1 Glycosylation Compared to Healthy Controls, Blood 128(22).
- Reiding KR, Lonardi E, Hipgrave Ederveen AL & Wuhrer M (2016), Ethyl Esterification for MALDI-MS Analysis of Protein Glycosylation, Methods in Molecular Biology 1394: 151-162.
- Shubhakar, A.; Reiding, K.R.; Gardner, R.A.; Spencer, D.I.R.; Fernandes, D.L. & Wuhrer, M. (2015), High-Throughput Analysis and Automation for Glycomics Studies, Chromatographia 78(5-6): 321-333.
- Kapur, R.; Valle, L. della; Verhagen, O.J.H.M.; Ederveen, A.H.; Ligthart, P.; Haas, M. de; Kumpel, B.; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2015), Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D, Transfusion 55(3): 553-562.
- Giera, M. & Wuhrer, M. (2015), Recent Developments in Clinical Omics, Chromatographia 78(5-6): 305-306.
- Wuhrer, M.; Stavenhagen, K.; Koeleman, C.A.M.; Selman, M.H.J.; Harper, L.; Jacobs, B.C.; Savage, C.O.S.; Jefferis, R.; Deelder, A.M. & Morgan, M. (2015), Skewed Fc Glycosylation Profiles of Anti-proteinase 3 Immunoglobulin G1 Autoantibodies from Granulomatosis with Polyangiitis Patients Show Low Levels of Bisection, Galactosylation, and Sialylation, Journal of Proteome Research 14(4): 1657-1665.
- Reusch, D.; Haberger, M.; Maier, B.; Maier, M.; Kloseck, R.; Zimmermann, B.; Hook, M.; Szabo, Z.; Tep, S.; Wegstein, J.; Alt, N.; Bulau, P. & Wuhrer, M. (2015), Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles-Part 1: Separation-based methods, mAbs 7(1): 167-179.
- Stavenhagen, K.; Kolarich, D. & Wuhrer, M. (2015), Clinical Glycomics Employing Graphitized Carbon Liquid Chromatography-Mass Spectrometry, Chromatographia 78(5-6): 307-320.
- Sonneveld, M.E.; Plomp, R.; Admiraal, J.; Koeleman, C.; Hipgrave-Ederveen, A.; Koelewijn, J.; Ligthart, P.; Haas, M. de; Wuhrer, M.; Schoot, C.E. van der & Vidarsson, G. (2015), IgG Alloantibodies Against RBC Induced By Pregnancy or Transfusion Have Unique Glycosylation Patterns Which Correlate with Clinical Outcome of Hemolytic Disease of the Fetus or Newborn, Blood 126(23).
- Plomp, R.; Dekkers, G.; Rombouts, Y.; Visser, R.; Koeleman, C.A.M.; Kammeijer, G.S.M.; Jansen, B.C.; Rispens, T.; Hensbergen, P.J.; Vidarsson, G. & Wuhrer, M. (2015), Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3), Molecular and Cellular Proteomics 14(5): 1373-1384.
- Rombouts, Y.; Ewing, E.; Stadt, L.A. van de; Selman, M.H.J.; Trouw, L.A.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M.; Schaardenburg, D. van; Toes, R.E.M. & Scherer, H.U. (2015), Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis, Annals of the Rheumatic Diseases 74(1): 234-241.
- Engel, R.; Nunez, L.D.; Roem, D.; Mierlo, G. van; Holst, S.; Oers, M.H.J. van; Wuhrer, M.; Wouters, D. & Zeerleder, S. (2015), Alpha1-Antichymotrypsin Present in Therapeutic C1-Inhibitor Products Competes with Selectin - Sialyl Lewis(X) Interaction, Blood 126(23).
- Holst, S.; Wuhrer, M.; Rombouts, Y.; Drake, R.R. & Ball, L.E. (2015), Glycosylation Characteristics of Colorectal Cancer, Advances in Cancer Research 126: 203-256.
- Powers, T.W.; Holst, S.; Wuhrer, M.; Mehta, A.S. & Drake, R.R. (2015), Two-Dimensional N-Glycan Distribution Mapping of Hepatocellular Carcinoma Tissues by MALDI-Imaging Mass Spectrometry, Biomolecules 5(4): 2554-2572.
- Stavenhagen, K.; Plomp, R. & Wuhrer, M. (2015), Site-Specific Protein N- and O-Glycosylation Analysis by a C18-Porous Graphitized Carbon-Liquid Chromatography-Electrospray Ionization Mass Spectrometry Approach Using Pronase Treated Glycopeptides, Analytical Chemistry 87(23): 11691-11699.
- Wuhrer, M.; Selman, M.H.J.; McDonnell, L.A.; Kumpfel, T.; Derfuss, T.; Khademi, M.; Olsson, T.; Hohlfeld, R.; Meinl, E. & Krumbholz, M. (2015), Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid.
- Jansen, B.C.; Reiding, K.R.; Bondt, A.; Ederveen, A.L.H.; Palmblad, M.; Falck, D. & Wuhrer, M. (2015), MassyTools: A High-Throughput Targeted Data Processing Tool for Relative Quantitation and Quality Control Developed for Glycomic and Glycoproteomic MALDI-MS, Journal of Proteome Research 14(12): 5088-5098.
- Bladergroen, M.R.; Reiding, K.R.; Ederveen, A.L.H.; Vreeker, G.C.M.; Clerc, F.; Holst, S.; Bondt, A.; Wuhrer, M. & Burgt, Y.E.M. van der (2015), Automation of High-Throughput Mass Spectrometry-Based Plasma N-Glycome Analysis with Linkage-Specific Sialic Acid Esterification, Journal of Proteome Research 14(9): 4080-4086.
- Fokkink, W.J.R.; Falck, D.; Santbergen, T.C.M.; Huizinga, R.; Wuhrer, M. & Jacobs, B.C. (2015), Comparison of Fc N-Glycosylation of Pharmaceutical Products of Intravenous Immunoglobulin G, PLoS ONE 10(10).
- Krumpochova, P.; Bruyneel, B.; Molenaar, D.; Koukou, A.; Wuhrer, M.; Niessen, W.M.A. & Giera, M. (2015), Amino acid analysis using chromatography-mass spectrometry: An inter platform comparison study, Journal of Pharmaceutical and Biomedical Analysis 114: 398-407.
- Falck, D.; Jansen, B.C.; Plomp, R.; Reusch, D.; Haberger, M. & Wuhrer, M. (2015), Glycoforms of Immunoglobulin G Based Biopharmaceuticals Are Differentially Cleaved by Trypsin Due to the Glycoform Influence on Higher-Order Structure, Journal of Proteome Research 14(9): 4019-4028.
- Borelli, V.; Vanhooren, V.; Lonardi, E.; Reiding, K.R.; Capri, M.; Libert, C.; Garagnani, P.; Salvioli, S.; Franceschi, C. & Wuhrer, M. (2015), Plasma N-Glycome Signature of Down Syndrome, Journal of Proteome Research 14(10): 4232-4245.
- Dotz, V.; Haselberg, R.; Shubhakar, A.; Kozak, R.P.; Falck, D.; Rombouts, Y.; Reusch, D.; Somsen, G.W.; Fernandes, D.L. & Wuhrer, M. (2015), Mass spectrometry for glycosylation analysis of biopharmaceuticals, Trends in Analytical Chemistry 73: 1-9.
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- Smit, C.H.; Diepen, A. van; Nguyen, D.L.; Wuhrer, M.; Hoffmann, K.F.; Deelder, A.M. & Hokke, C.H. (2015), Glycomic Analysis of Life Stages of the Human Parasite Schistosoma mansoni Reveals Developmental Expression Profiles of Functional and Antigenic Glycan Motifs, Molecular and Cellular Proteomics 14(7): 1750-1769.
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- Carlsson, M.C.; Balog, C.I.A.; Kilsgard, O.; Hellmark, T.; Bakoush, O.; Segelmark, M.; Ferno, M.; Olsson, H.; Malmstrom, J.; Wuhrer, M. & Leffler, H. (2012), Different fractions of human serum glycoproteins bind galectin-1 or galectin-8, and their ratio may provide a refined biomarker for pathophysiological conditions in cancer and inflammatory disease, BBA - General Subjects 1820(9): 1366-1372.
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- Pacchiarotta, T.; Hensbergen, P.J.; Wuhrer, M.; Nieuwkoop, C. van; Nevedomskaya, E.; Derks, R.J.E.; Schoenmaker, B.; Koeleman, C.A.M.; Dissel, J. van; Deelder, A.M. & Mayboroda, O.A. (2012), Fibrinogen alpha chain O-glycopeptides as possible markers of urinary tract infection, Journal of Proteomics 75(3): 1067-1073.
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- Wang, J.; Bax, M.; Balog, C.I.A.; Stavenhagen, K.; Koeleman, C.A.M.; Scherer, H.U.; Deelder, A.M.; Huizinga, T.W.J.; Toes, R.E.M. & Wuhrer, M. (2011), FC-GLYCOSYLATION OF IGG1 IS MODULATED BY B CELL STIMULI, Annals of the Rheumatic Diseases 70.
- Taganna, J.; Boer, A.R. de; Wuhrer, M. & Bouckaert, J. (2011), Glycosylation changes as important factors for the susceptibility to urinary tract infection, Biochemical Society Transactions 39: 349-354.
- Huffman, J.E.; Knezevic, A.; Vitart, V.; Kattla, J.; Adamczyk, B.; Novokmet, M.; Igl, W.; Pucic, M.; Zgaga, L.; Johannson, A.; Redzic, I.; Gornik, O.; Zemunik, T.; Polasek, O.; Kolcic, I.; Pehlic, M.; Koeleman, C.A.M.; Campbell, S.; Wild, S.H.; Hastie, N.D.; Campbell, H.; Gyllensten, U.; Wuhrer, M.; Wilson, J.F.; Hayward, C.; Rudan, I.; Rudd, P.M.; Wright, A.F. & Lauc, G. (2011), Polymorphisms in B3GAT1, SLC9A9 and MGAT5 are associated with variation within the human plasma N-glycome of 3533 European adults, Human Molecular Genetics 20(24): 5000-5011.
- Pucic, M.; Knezevic, A.; Vidic, J.; Adamczyk, B.; Novokmet, M.; Polasek, O.; Gornik, O.; Supraha-Goreta, S.; Wormald, M.R.; Redzic, I.; Campbell, H.; Wright, A.; Hastie, N.D.; Wilson, J.F.; Rudan, I.; Wuhrer, M.; Rudd, P.M.; Josic, D. & Lauc, G. (2011), High Throughput Isolation and Glycosylation Analysis of IgG-Variability and Heritability of the IgG Glycome in Three Isolated Human Populations.
- Zauner, G.; Deelder, A.M. & Wuhrer, M. (2011), Recent advances in hydrophilic interaction liquid chromatography (HILIC) for structural glycomics, ELECTROPHORESIS 32(24): 3456-3466.
- Wuhrer, M.; Deelder, A.M. & Burgt, Y.E.M. van der (2011), MASS SPECTROMETRIC GLYCAN REARRANGEMENTS.
- Selman, M.H.J.; Jong, S.E. de; Soonawala, D.; Kroon, F.P.; Adegnika, A.A.; Deelder, A.M.; Hokke, C.H.; Yazdanbakhsh, M. & Wuhrer, M. (2011), Changes in antigen-specific IgG1 Fc N-glycosylation upon influenza and tetanus vaccination., Molecular & Cellular Proteomics.
- Guhr, T.; Bloem, J.; Derksen, N.I.L.; Wuhrer, M.; Koenderman, A.H.L.; Aalberse, R.C. & Rispens, T. (2011), Enrichment of Sialylated IgG by Lectin Fractionation Does Not Enhance the Efficacy of Immunoglobulin G in a Murine Model of Immune Thrombocytopenia, PLoS ONE 6(6): -.
- Carlsson, M.C.; Cederfur, C.; Schaar, V.; Balog, C.I.A.; Lepur, A.; Touret, F.; Salomonsson, E.; Deelder, A.M.; Ferno, M.; Olsson, H.; Wuhrer, M. & Leffler, H. (2011), Galectin-1-Binding Glycoforms of Haptoglobin with Altered Intracellular Trafficking, and Increase in Metastatic Breast Cancer Patients, PLoS ONE 6(10): -.
- Selman, M.H.J.; Niks, E.H.; Titulaer, M.J.; Verschuuren, J.J.G.M.; Wuhrer, M. & Deelder, A.M. (2011), IgG Fc N-Glycosylation Changes in Lambed-Eaton Myasthenic Syndrome and Myasthenia Gravis, Journal of Proteome Research 10(1): 143-152.
- Geijn, F.E. van de; Man, Y.A. de; Wuhrer, M.; Willemsen, S.P.; Deelder, A.M.; Hazes, J.M.W. & Dolhain, R.J.E.M. (2011), Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis, Arthritis Research and Therapy 13(1).
- Wang, J.; Balog, C.I.A.; Stavenhagen, K.; Koeleman, C.A.M.; Scherer, H.U.; Selman, M.H.J.; Deelder, A.M.; Huizinga, T.W.J.; Toes, R.E.M. & Wuhrer, M. (2011), Fc-Glycosylation of IgG1 is Modulated by B-cell Stimuli, Molecular and Cellular Proteomics 10(5).
- Selman, M.H.J.; Hemayatkar, M.; Deelder, A.M. & Wuhrer, M. (2011), Cotton HILIC SPE Microtips for Microscale Purification and Enrichment of Glycans and Glycopeptides, Analytical Chemistry 83(7): 2492-2499.
- Meevissen, M.H.J.; Balog, C.I.A.; Koeleman, C.A.M.; Doenhoff, M.J.; Schramm, G.; Haas, H.; Deelder, A.M.; Wuhrer, M. & Hokke, C.H. (2011), Targeted Glycoproteomic Analysis Reveals That Kappa-5 is a Major, Uniquely Glycosylated Component of Schistosoma mansoni Egg Antigens, Molecular and Cellular Proteomics 10(5).
- Bruggink, C.; Poorthuis, B.J.H.M.; Piraud, M.; Froissart, R.; Deelder, A.M. & Wuhrer, M. (2010), Glycan profiling of urine, amniotic fluid and ascitic fluid from galactosialidosis patients reveals novel oligosaccharides with reducing end hexose and aldohexonic acid residues, FEBS Journal 277(14): 2970-2986.
- Ruhaak, L.R.; Zauner, G.; Huhn, C.; Bruggink, C.; Deelder, A.M. & Wuhrer, M. (2010), Glycan labeling strategies and their use in identification and quantification, Analytical and Bioanalytical Chemistry 397(8): 3457-3481.
- Ruhaak, L.R.; Steenvoorden, E.; Koeleman, C.A.M.; Deelder, A.M. & Wuhrer, M. (2010), 2-Picoline-borane: A non-toxic reducing agent for oligosaccharide labeling by reductive amination, Proteomics 10(12): 2330-2336.
- Wuhrer, M.; Remoortere, A. van; Balog, C.I.A.; Deelder, A.M. & Hokke, C.H. (2010), Ligand identification of carbohydrate-binding proteins employing a biotinylated glycan binding assay and tandem mass spectrometry, Analytical Biochemistry 406(2): 132-140.
- Huhn, C.; Ramautar, R.; Wuhrer, M. & Somsen, G.W. (2010), Relevance and use of capillary coatings in capillary electrophoresis-mass spectrometry, Analytical and Bioanalytical Chemistry 396(1): 297-314.
- Selman, M.H.J.; McDonnell, L.A.; Palmblad, M.; Ruhaak, L.R.; Deelder, A.M. & Wuhrer, M. (2010), Immunoglobulin G Glycopeptide Profiling by Matrix-Assisted Laser Desorption Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Analytical Chemistry 82(3): 1073-1081.
- Scherer, H.U.; Woude, D. van der; Ioan-Facsinay, A.; Bannoudi, H. el; Trouw, L.A.; Wang, J.; Haupl, T.; Burmester, G.R.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M. & Toes, R.E.M. (2010), Glycan profiling of anti-citrullinated protein antibodies (ACPA) isolated from human serum and synovial fluid., Arthritis and Rheumatism.
- Lonardi, E.; Balog, C.I.A.; Deelder, A.M. & Wuhrer, M. (2010), Natural glycan microarrays., Expert Review of Proteomics 7(5): 761-74.
- Balog, C.I.A.; Mayboroda, O.A.; Wuhrer, M.; Hokke, C.H.; Deelder, A.M. & Hensbergen, P.J. (2010), Mass Spectrometric Identification of Aberrantly Glycosylated Human Apolipoprotein C-III Peptides in Urine from Schistosoma mansoni-infected Individuals, Molecular and Cellular Proteomics 9(4): 667-681.
- Scherer, H.U.; Woude, D. van der; Ioan-Facsinay, A.; Bannoudi, H. el; Trouw, L.A.; Wang, J.; Haupl, T.; Burmester, G.R.; Deelder, A.M.; Huizinga, T.W.J.; Wuhrer, M. & Toes, R.E.M. (2010), Glycan Profiling of Anti-Citrullinated Protein Antibodies Isolated From Human Serum and Synovial Fluid, Arthritis and Rheumatism 62(6): 1620-1629.
- Eggink, D.; Melchers, M.; Wuhrer, M.; Montfort, T. van; Dey, A.K.; Naaijkens, B.A.; David, K.B.; Douce, V. le; Deelder, A.M.; Kang, K.; Olson, W.C.; Berkhout, B.; Hokke, C.H.; Moore, J.P. & Sanders, R.W. (2010), Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function, Virology 401(2): 236-247.
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Koeleman, C.A.M.; Hokke, C.H.; Westendorp, R.G.J.; Wuhrer, M.; Houwing-Duistermaat, J.J.; Slagboom, P.E. & Deelder, A.M. (2010), Decreased Levels of Bisecting GlcNAc Glycoforms of IgG Are Associated with Human Longevity, PLoS ONE 5(9).
- Ruhaak, L.R.; Uh, H.W.; Beekman, M.; Hokke, C.H.; Westendorp, R.G.J.; Houwing-Duistermaat, J.; Wuhrer, M.; Deelder, A.M. & Sagboom, P.E. (2010), Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health., Journal of Proteome Research.
- Zauner, G.; Koeleman, C.A.M.; Deelder, A.M. & Wuhrer, M. (2010), Protein glycosylation analysis by HILIC-LC-MS of Proteinase K-generated N- and O-glycopeptides, Journal of Separation Science 33(6-7): 903-910.
- Eggink, D.; Melchers, M.; Wuhrer, M.; Montfort, T. van; Dey, A.K.; Naaijkens, B.A.; David, K.B.; Douce, V. le; Deelder, A.M.; Kang, K.; Olson, W.C.; Berkhout, B.; Hokke, C.H.; Moore, J.P. & Sanders, R.W. (2010), Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function (vol 401, pg 236, 2010), Virology 406(1): 162-163.
- Ruhaak, L.R.; Hennig, R.; Huhn, C.; Borowiak, M.; Dolhain, R.J.E.M.; Deelder, A.M.; Rapp, E. & Wuhrer, M. (2010), Optimized Workflow for Preparation of APTS-Labeled N-Glycans Allowing High-Throughput Analysis of Human Plasma Glycomes using 48-Channel Multiplexed CGE-LIF, Journal of Proteome Research 9(12): 6655-6664.
- Meevissen, M.H.J.; Wuhrer, M.; Doenhoff, M.J.; Schramm, G.; Haas, H.; Deelder, A.M. & Hokke, C.H. (2010), Structural Characterization of Glycans on Omega-1, a Major Schistosoma mansoni Egg Glycoprotein That Drives Th2 Responses, Journal of Proteome Research 9(5): 2630-2642.
- Wuhrer M, de Boer AR & Deelder AM (2009), STRUCTURAL GLYCOMICS USING HYDROPHILIC INTERACTION CHROMATOGRAPHY (HILIC) WITH MASS SPECTROMETRY, Mass Spectrometry Reviews 28(2): 192-206.
- Wuhrer M, Porcelijn L, Kapur R, Koeleman CAM, Deelder AM, de Haas M & Vidarsson G (2009), Regulated Glycosylation Patterns of IgG during Alloimmune Responses against Human Platelet Antigens, Journal of Proteome Research 8(2): 450-456.
- Ruhaak LR, Deelder AM & Wuhrer M (2009), Oligosaccharide analysis by graphitized carbon liquid chromatography-mass spectrometry, Analytical and Bioanalytical Chemistry 394(1): 163-174.
- Huhn C, Selman MHJ, Ruhaak LR, Deelder AM & Wuhrer M (2009), IgG glycosylation analysis, Proteomics 9(4): 882-913.
- Schramm G, Hamilton JV, Balog CIA, Wuhrer M, Gronow A, Beckmann S, Wippersteg V, Grevelding CG, Goldmann T & Weber E (2009), Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs, Molecular and Biochemical Parasitology 166(1): 4-14.
- Wuhrer M, Koeleman CA & Deelder AM (2009), Two-dimensional HPLC separation with reverse-phase-nano-LC-MS/MS for the characterization of glycan pools after labeling with 2-aminobenzamide., Methods in Molecular Biology 534: 79-91.
- Wuhrer M, Koeleman CAM & Deelder AM (2009), Hexose Rearrangements upon Fragmentation of N-Glycopeptides and Reductively Aminated N-Glycans, Analytical Chemistry 81(11): 4422-4432.
- Heiskanen A, Hirvonen T, Salo H, Impola U, Olonen A, Laitinen A, Tiitinen S, Natunen S, Aitio O, Miller-Podraza H, Wuhrer M, Deelder AM, Natunen J, Laine J, Lehenkari P, Saarinen J, Satomaa T & Valmu L (2009), Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage, Glycoconjugate Journal 26(3): 367-384.
- Scherer HU, Wang J, Toes REM, van der Woude D, Koeleman CAM, de Boer AR, Huizinga TWJ, Deelder AM & Wuhrer M (2009), Immunoglobulin 1 (IgG1) Fc-glycosylation profiling of anti-citrullinated peptide antibodies from human serum, PROTEOMICS - Clinical Applications 3(1): 106-115.
- van de Geijn FE, Wuhrer M, Selman MHJ, Willemsen SP, de Man YA, Deelder AM, Hazes JMW & Dolhain RJEM (2009), Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study.
- Johswich, A.; Kraft, B.; Wuhrer, M.; Berger, M.; Deelder, A.M.; Hokke, C.H.; Gerardy-Schahn, R. & Bakker, H. (2009), Golgi targeting of Drosophila melanogaster beta 4GalNAcTB requires a DHHC protein family-related protein as a pilot, Journal of Cell Biology 184(1): 173-183.
- de Geijn FEV, Wuhrer M, Willemsen SP, de Man YA, Deelder AM, Hazes JMW & Dolhain RJEM (2008), IgG galactosylation is associated with pregnancy-induced improvement of RA and the postpartum flare, Arthritis and Rheumatism 58(9).
- Scherer HU, van der Woude D, Koeleman CA, de Boer AR, Huizinga TWJ, Deelder AM, Wuhrer M & Toes REM (2008), Glycan profiling of anti-citrullinated protein antibodies (ACPA) reveals profound differences in glycosylation between ACPA and serum, Arthritis and Rheumatism 58(9).
- Bakker H, Johswich A, Kraft B, Wuhrer M, Hokke CH & Gerardy-Schahn R (2008), Mechanism of Interaction between Drosophila beta 4GalNAcTB and the beta 4GalNAcTB Pilot Protein (GABPI), Glycobiology 18(11): 993-993.
- Niks EH, de Boer AR, Titulaer MJ, Jol-van der Zijde CM, Wuhrer M & Verschuuren JJGM (2008), Glycosylation of IgG in three autoimmune myasthenic syndromes, Journal of Neuroimmunology 203(2): 178-179.
- Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M & Bakker H (2008), Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis, Glycoconjugate Journal 25(2).
- de Geijn FEV, Wuhrer M, de Man YA, Deelder AM, Colin E, Lubberts E, Hazes JMW & Dolhain RJEM (2008), Preliminary results on IgG glycosylation profiles in rheumatoid arthritis patients during pregnancy and postpartum, Annals of the Rheumatic Diseases 67.
- van Alphen LB, Wuhrer M, Bleumink-Pluym NMC, Hensbergen PJ, Deelder AM & van Putten JPM (2008), A functional Campylobacter jejuni maf4 gene results in novel glycoforms on flagellin and altered autoagglutination behaviour, Microbiology 154.
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2008), Serum antibody screening by surface plasmon resonance using a natural glycan microarray, Glycoconjugate Journal 25(1).
- Ruhaak LR, Huhn C, Waterreus WJ, de Boer AR, Neususs C, Hokke CH, Deelder AM & Wuhrer M (2008), Hydrophilic interaction chromatography-based high-throughput sample preparation method for N-glycan analysis from total human plasma glycoproteins, Analytical Chemistry 80(15).
- Wuhrer M, Catalina MI, Deelder AM & Hokke CH (2007), Glycoproteomics based on tandem mass spectrometry of glycopeptides, Journal of Chromatography B 849(1-2).
- Wuhrer M, Stam JC, van de Geijn FE, Koeleman CAM, Verrips CT, Dolhain RJEM, Hokke CH & Deelder AM (2007), Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum, Proteomics 7(22).
- Robijn MLM, Koeleman CAM, Wuhrer M, Royle L, Geyer R, Dwek RA, Rudd PM, Deelder AM & Hokke CH (2007), Targeted identification of a unique glycan epitope of Schistosoma mansoni egg antigens using a diagnostic antibody, Molecular and Biochemical Parasitology 151(2).
- Hokke CH, Deelder AM, Hoffmann KF & Wuhrer M (2007), Glycomics-driven discoveries in schistosome research, Experimental Parasitology 117(3).
- de Boer AR, Hokke CH, Deelder AM & Wuhrer M (2007), General microarray technique for immobilization and screening of natural glycans, Analytical Chemistry 79(21).
- Wuhrer M (2007), Glycosylation profiling in clinical proteomics: heading for glycan biomarkers, Expert Review of Proteomics 4(2).
- Catalina MI, Koeleman CAM, Deelder AM & Wuhrer M (2007), Electron transfer dissociation of N-glycopeptides: loss of the entire N-glycosylated asparagine side chain, Rapid Communications in Mass Spectrometry 21(6).
- Rouwendal GJA, Wuhrer M, Florack DEA, Koeleman CAM, Deelder AM, Bakker H, Stoopen GM, van Die I, Helsper JPFG, Hokke CH & Bosch D (2007), Efficient introduction of a bisecting GlcNAc residue in tobacco N-glycans by expression of the gene encoding human N-acetylglucosaminyltransferase III, Glycobiology 17(3).
- Van Riet E, Wuhrer M, Wahyuni S, Retra K, Deelder AM, Tielens AGM, Van der Kleij D & Yazdanbakhsh M (2006), Antibody responses to Ascaris-derived proteins and glycolipids: the role of phosphorylcholine, Parasite Immunology 28(8).
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CH (2006), Repeats of LacdiNAc and fucosylated LacdiNAc on N-glycans of the human parasite Schistosoma mansoni, FEBS Journal 273(2).
- Wuhrer M, Koeleman CAM, Fitzpatrick JM, Hoffmann KF, Deelder AM & Hokke CH (2006), Gender-specific expression of complex-type N-glycans in schistosomes, Glycobiology 16(10).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2006), Mass spectrometry of proton adducts of fucosylated N-glycans: fucose transfer between antennae gives rise to misleading fragments, Rapid Communications in Mass Spectrometry 20(11).
- Wuhrer M, Balog CIA, Catalina MI, Jones FM, Schramm G, Haas H, Doenhoff MJ, Dunne DW, Deelder AM & Hokke CH (2006), IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans, FEBS Journal 273(10).
- Wuhrer M & Deelder AM (2006), Matrix-assisted laser desorption/ionization in-source decay combined with tandem time-of-flight mass spectrometry of permethylated oligosaccharides: targeted characterization of specific parts of the glycan structure, Rapid Communications in Mass Spectrometry 20(6).
- Bruggink C, Wuhrer M, Koeleman CAM, Barreto V, Liu Y, Pohl C, Ingendoh A, Hokke CH & Deelder AM (2005), Oligosaccharide analysis by capillary-scale high-pH anion-exchange chromatography with on-line ion-trap mass spectrometry, Journal of Chromatography B 829(1-2).
- Wuhrer M & Deelder AM (2005), Negative-mode MALDI-TOF/TOF-MS of oligosaccharides labeled with 2-aminobenzamide, Analytical Chemistry 77(21).
- Wuhrer M, Deelder AM & Hokke CH (2005), Protein glycosylation analysis by liquid chromatography-mass spectrometry, Journal of Chromatography B 825(2).
- Wuhrer M, Balog CIA, Koeleman CAM, Deelder AM & Hokke CH (2005), New features of site-specific horseradish peroxidase (HRP) glycosylation uncovered by nano-LC-MS with repeated ion-isolation/fragmentation cycles, BBA - General Subjects 1723(1-3).
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2005), Protein glycosylation analyzed by normal-phase nano-liquid chromatography-mass spectrometry of glycopeptides, Analytical Chemistry 77(3).
- Robijn MLM, Wuhrer M, Kornelis D, Deelder AM, Geyer R & Hokke CH (2005), Mapping fucosylated epitopes on glycoproteins and glycolipids of Schistosoma mansoni cercariae, adult worms and eggs, Parasitology 130.
- Fitzsimmons CM, Schramm G, Jones FM, Chalmers IW, Hoffmann KE, Grevelding CG, Wuhrer M, Hokke CH, Haas H, Doenhoff MJ & Dunne DW (2005), Molecular characterization of omega-1: A hepatotoxic ribonuclease from Schistosoma mansoni eggs, Molecular and Biochemical Parasitology 144(1).
- Geyer H, Wuhrer M, Resemann A & Geyer R (2005), Identification and characterization of keyhole limpet hemocyanin N-glycans mediating cross-reactivity with Schistosoma mansoni, Journal of Biological Chemistry 280(49).
- Wuhrer M, Koeleman CAM, Deelder AM & Hokke CN (2004), Normal-phase nanoscale liquid chromatography - Mass spectrometry of underivatized oligosaccharides at low-femtomole sensitivity, Analytical Chemistry 76(3).
- Wuhrer M, Hokke CH & Deelder AM (2004), Glycopeptide analysis by matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry reveals novel features of horseradish peroxidase glycosylation, Rapid Communications in Mass Spectrometry 18(15).
- Wuhrer M, Robijn MLM, Koeleman CAM, Balog CIA, Geyer R, Deelder AM & Hokke CH (2004), A novel Gal(beta 1-4)Gal(beta 1-4)Fuc(alpha 1-6)-core modification attached to the proximal N-acetylglucosamine of keyhole limpet haemocyanin (KLH) N-glycans, Biochemical Journal 378.
- Wuhrer M, Koeleman CAM, Hokke CH & Deelder AM (2004), Nano-scale liquid chromatography-mass spectrometry of 2-aminobenzamide-labeled oligosaccharides at low femtomole sensitivity, International Journal of Mass Spectrometry 232(1).
- Member of ExCom European Journal of Immunology