Lu Su
Assistant professor
- Name
- Dr. L. Su
- Telephone
- +31 71 527 4219
- l.su@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-8207-756X
Lu Su is an assistant professor at the Division of BioTherapeutics at the Leiden Academic Center for Drug Research
PhD candidates
Lu Su studied Polymer Chemistry and Physics and obtained her Ph.D. in 2014 at Fudan University under the supervision of Prof. Ming Jiang and Prof. Guosong Chen. Her Ph.D. research was on glycopolymer-based self-assembly. Then she moved to Texas A&M University as a postdoctoral fellow under the direction of Prof. Karen L. Wooley, where she worked on the functional and degradable poly(glucose carbonate)s and polyphosphoesters towards biomedical applications. Switching to supramolecular chemistry, she joined TU Eindhoven in 2017 as a postdoctoral fellow to work with Prof. Bert Meijer and discovered the dilution-induced gel-sol-gel-sol transition in the multicomponent supramolecular system.
In 2022, she was appointed as Assistant Professor at Leiden university where her research focusses on the development of (supramolecular) polymeric droplets for the delivery of biotherapeutics. Up to now, Lu Su has contributed over 30 research papers and reviews in journals such as Science, Nature, JACS, and Chemical Reviews
Assistant professor
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Drug Delivery Technology
- Bi D., Hal A. van, Aschmann D., Shen M., Zhang H., Su L., Arias Alpizar G., Kros A., Barz M. & Bussmann J. (2024), Deconvolving passive and active targeting of liposomes bearing LDL receptor binding peptides using the zebrafish embryo model, Small 20(32): 2310781.
- Horvat N.K., Chocarro S., Marques O., Bauer T.A., Qiu R., Diaz-Jimenez A., Helm B., Chen Y., Sawall S., Sparla R., Su L., Klingmüller U., Barz M., Hentze M.W., Sotillo R. & Muckenthaler M.U. (2024), Superparamagnetic iron oxide Nanoparticles reprogram the tumor microenvironment and reduce lung cancer regrowth after crizotinib treatment, ACS Nano 18(17): 11025-11041.
- Schwiertz D.T., Heck A., Muhl C., Su L. & Barz M. (2024), Design of cross-linkable polypept(o)ide-based AB3 miktoarm star polymers through advances in PeptoMiktoStar synthesis, European Polymer Journal 210: 112989.
- Fu H., Huang J., Tol J.J.B. van der, Su L., Wang Y., Dey S., Zijlstra P., Fytas G., Vantomme G., Dankers P.Y.W. & Meijer E.W. (2024), Supramolecular polymers form tactoids through liquid-liquid phase separation, Nature 626(8001): 1011-1018.
- Rijns L., Duijs H., Lafleur R.P.M., Cardinaels R., Palmans A.R.A., Dankers P.Y.W. & Su L. (2024), Molecularly engineered supramolecular thermoresponsive hydrogels with tunable mechanical and dynamic properties, Biomacromolecules 25(8): 4686-4696.
- Duijs H., Kumar M., Dhiman S. & Su L. (2024), Harnessing competitive interactions to regulate supramolecular "Micelle-Droplet-Fiber" transition and reversibility in water, Journal of the American Chemical Society 146(43): 29759-29766.
- Rijns L., Su L., Maxeiner K., Morgese G., Ng D.Y.W., Weil T. & Dankers P.Y.W. (2023), Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels, Chemical Communications 59(15): 2090-2093.
- Su L., Dalby K.S., Luehmann H., Elkassih S.A., Cho S., He X., Detering L., Lin Y.N., Kang N., Moore D.A, Laforest R., Sun G., Liu Y. & Wooley K.L. (2023), Ultrasmall, elementary and highly translational nanoparticle X-ray contrast media from amphiphilic iodinated statistical copolymers, Acta Pharmaceutica Sinica B 13(4): 1660-1670.
- Su L., Mosquera J., Mabesoone M.F.J., Schoenmakers S.M.C., Muller C., Vleugels M.E.J., Dhiman S., Wijker S., Palmans A.R.A. & Meijer E.W. (2022), Dilution-induced gel-sol-gel-sol transitions by competitive supramolecular pathways in water, Science 377(6602): 213-218.
- Su L., Hendrikse S.I.S. & Meijer E.W. (2022), Supramolecular glycopolymers: how carbohydrates matter in structure, dynamics, and function, Current Opinion in Chemical Biology 69: 102171.
- Su L., Feng Y.L., Wei K.C., Xu X.Y., Liu R.Y. & Chen G.S. (2021), Carbohydrate-based macromolecular biomaterials, Chemical Reviews 121(18): 10950-11029.
- Schoenmakers S.M.C., Bersselaar B.W.L. van den, Dhiman S., Su L. & Palmans A.R.A. (2021), Facilitating functionalization of benzene-1,3,5-tricarboxamides by switching amide connectivity, Organic and Biomolecular Chemistry 19(38): 8281-8294.
- Varela-Aramburu S., Su L., Mosquera J., Morgese G., Schoenmakers S.M.C., Cardinaels R., Palmans A.R.A. & Meijer E.W. (2021), Introducing Hyaluronic Acid into Supramolecular Polymers and Hydrogels, Biomacromolecules 22(11): 4633-4641.
- Song Y., Elsabahy M., Collins C.A., Khan S., Li R.C., Hreha T.N., Shen Y.D., Lin Y.N., Letteri R.A., Su L., Dong M., Zhang F.W., Hunstad D.A. & Wooley K.L. (2021), Morphologic design of silver-bearing sugar-based polymer nanoparticles for uroepithelial cell binding and antimicrobial delivery, Nano Letters 21(12): 4990-4998.
- Nguyen T.P., Easley A.D., Kang N.A., Khan S., Lim S.M., Rezenom Y.H., Wang S.Y., Tran D.K., Fan J.W., Letteri R.A., He X., Su L., Yu C.H., Lutkenhaus J.L. & Wooley K.L. (2021), Polypeptide organic radical batteries, Nature 593(7857): 61-66.
- Lin Y.N., Elsabahy M., Khan S., Zhang F.W., Song Y., Dong M., Li R.C., Smolen J., Letteri R.A., Su L. & Wooley K.L. (2020), Erythrocyte-membrane-camouflaged nanocarriers with tunable paclitaxel release kinetics via macromolecular stereocomplexation, ACS Materials Letters 2(6): 595-601.
- Varela-Aramburu S., Morgese G., Su L., Schoenmakers S.M.C., Perrone M., Leanza L., Perego C., Pavan G.M., Palmans A.R.A. & Meijer E.W. (2020), Exploring the potential of benzene-1,3,5-tricarboxamide supramolecular polymers as biomaterials, Biomacromolecules 21(10): 4105-4115.
- Lafleur R.P.M., Herziger S., Schoenmakers S.M.C., Keizer A.D.A., Jahzerah J., Thota B.N.S., Su L., Bomans P.H.H., Sommerdijk N.A.J.M., Palmans A.R.A., Haag R., Friedrich H., Bottcher C. & Meijer E.W. (2020), Supramolecular double helices from small C-3-symmetrical molecules aggregated in water, Journal of the American Chemical Society 142(41): 17644-17652.
- Dong M., Song Y., Wang H., Su L., Shen Y., Tran D.K., Letteri R.A., Flores J.A., Lin Y., Li J. & Wooley K.L. (2020), Degradable sugar-based magnetic hybrid nanoparticles for recovery of crude oil from aqueous environments, Polymer Chemistry 11(30): 4895--4903.
- Hendrikse S.I.S., Su L., Hogervorst T.P., Lafleur R.P.M., Lou X., Marel G.A. van der, Codee J.D.C. & Meijer E.W. (2019), Elucidating the Ordering in Self-Assembled Glycocalyx Mimicking Supramolecular Copolymers in Water, Journal of the American Chemical Society 141(35): 13877-13886.
- Dong M., Wessels M.G., Lee J.Y., Su L., Wang H., Letteri R.A., Song Y., Lin Y. Chen Y., Li R., Pochan D.J., Jayaraman A. & Wooley K.L. (2019), Experiments and simulations of complex sugar-based coil−brush block polymer nanoassemblies in aqueous solution, ACS Nano 13(5): 5147−5162.
- Li R., Elsabahy M., Song Y., Wang H., Su L., Letteri R.A., Khan S., Heo G.S., Sun G., Liu Y. & Wooley K.L. (2019), Functional, degradable zwitterionic polyphosphoesters as biocompatible coating materials for metal nanostructures, Langmuir 35(5): 1503-1512.
- Li R., Wang H., Song Y., Lin Y., Dong M., Shen Y., Khan S., Zhang S., Fan J., Zhang F., Su L & Wooley K.L. (2019), In Situ production of Ag/Polymer asymmetric nanoparticles via a powerful light-driven technique, Journal of the American Chemical Society 141(50): 19542-19545.
- Wang H., Dong M., Khan S., Su L., Li R., Song Y., Lin Y., Kang N., Komatsu C.H., Elsabahy M. & Wooley K.L. (2018), Acid-triggered polymer backbone degradation and disassembly to achieve release of camptothecin from functional polyphosphoramidate nanoparticles, ACS Macro Letters 7(7): 783-788.
- Su.L., Li R., Khan S., ClantonR., Zhang F., Lin Y-N, Song Y., Wang H., Fan J., Hernandez S., Butters A.S., Akabani G., MacLoughlin R., Smolen J. & Wooley K.L. (2018), Chemical design of both a glutathione-sensitive dimeric drug guest and a glucose-derived nanocarrier host to achieve enhanced osteosarcoma lung metastatic anticancer selectivity, Journal of the American Chemical Society 140(4): 1438-1446.
- Lin Y., Su L., Smolen J., Li R., Song Y., Wang H., Dong M. & Wooley K.L. (2018), Co-assembly of sugar-based amphiphilic block polymers to achieve nanoparticles with tunable morphology, size, surface charge, and acid-responsive behavior, Materials Chemistry Frontiers 2(12): 2230-2238.
- Song Y., Chen Y., Su L., Li R., Letteri R.A. & Wooley K.L. (2017), Crystallization-driven assembly of fully degradable, natural product-based poly(l-lactide)-block-poly(α-d-glucose carbonate)s in aqueous solution, Polymer 122: 270-279.
- Zhang F., Khan S., Li R., Smolen J.A., Zhang S., Zhu G., Su L., Jahnke A.A., Elsabahy M., Chen X. & Wooley K.L. (2017), Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading, Nanoscale 9(41): 15773--15777.
- Su L., Khan S., Fan J., Lin Y., Wang H., Gustafson T., Zhang F. & Wooley K.L. (2017), Functional sugar-based polymers and nanostructures comprised of degradable poly(d-glucose carbonate)s, Polymer Chemistry 8(10): 1699-1707.
- Kristufek S.L., Wacker K.T., Tsao Y.T., Su L. & Wooley K.L. (2017), Monomer design strategies to create natural product-based polymer materials, Natural Product Reports 34(4): 433-459.
- Wang H., Su L., Li R., Zhang S., Fan J., Zhang F., Nguyen T.P. & Wooley K.L. (2017), Polyphosphoramidates that undergo acid-triggered backbone degradation, ACS Macro Letters 6(3): 219-223.
- Su L., Heo G.S., Lin Y., Dong M., Zhang S., Chen Y., Sung G. & Wooley K.L. (2017), Syntheses of triblock bottlebrush polymers through sequential ROMPs: expanding the functionalities of molecular brushes, Journal of Polymer Science 55(18): 2966-2970.
- Fan J., Borguet Y.P., Su L., Nguyen T.P., Wang H., He X., Zou J. & Wooley K.L. (2017), Two-dimensional controlled syntheses of polypeptide molecular brushes via N-carboxyanhydride ring-opening polymerization and ring-opening metathesis polymerization, ACS Macro Letters 6(9): 1031-1035.
- Wu X., Su L., Chen G. & Jiang M. (2015), Deprotection-induced micellization of glycopolymers: control of kinetics and morphologies, Macromolecules 48(11): 3705-3712.
- Su L., Zhang W., Wu X., Zhang Y., Chen X., Liu G., Chen G. & Jiang M. (2015), Glycocalyx-mimicking nanoparticles for stimulation and polarization of macrophages via specific interactions, Small 11(33): 4191-4200.
- Zhang Q., Su L., Collins J., Chen G., Wallis R., Mitchell D.A., Haddleton D.M. & Becer C.R. (2014), Dendritic cell lectin-targeting sentinel-like unimolecular glycoconjugates to release an anti-HIV drug, Journal of the American Chemical Society 136(11): 4325-4332.
- Su L., Wang C., Polzer F., Lu Y., Chen G. & Jiang M. (2014), Glyco-inside micelles and vesicles directed by protection–deprotection chemistry, ACS Macro Letters 3(6): 534-539.
- Zhao Y., Sakai F., Su L., Liu Y., Wei K., Chen G. & Jiang M. (2013), Progressive macromolecular self-assembly: from biomimetic chemistry to bio-inspired materials, Advanced Materials 25(37): 5215-5256.
- Su L., Zhao Y., Chen G. & Jiang M. (2012), Polymeric vesicles mimicking glycocalyx (PV-Gx) for studying carbohydrate–protein interactions in solution, Polymer Chemistry 3(6): 1560-1566.
- Wei K., Su L., Chen G. & Jiang M. (2011), Does PNIPAM block really retard the micelle-to-vesicle transition of its copolymer?, Polymer 52(16): 3647-3654.