Lisa den Hollander
PhD candidate / internal
- Name
- L.S. den Hollander MSc
- Telephone
- +31 71 527 2727
- l.s.den.hollander@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-8954-3460
In 2013, I started my bachelor Pharmaceutical Sciences at Leiden University with a minor in pharmacy. During my internship at the Department of Medicinal Chemistry in 2015, I worked on finding new intracellular allosteric antagonists for CC chemokine receptor 5. I expanded on my bachelor project during my 9 months internship for my Master’s in Biopharmaceutical Sciences. In addition, I explored the possibilities of the compound’s probe dependent characteristics. My second internship I performed at the Department of Clinical Chemistry and Hematology, where I was involved in the development of an experimental model for extracellular vesicle transfer in cancer cells. After obtaining my Master’s degree, I decided to further explore my interests in chemical pharmacology and joined the lab of Prof. Dr. Ad IJzerman in the Dr. Laura Heitman group. During my PhD, I will again focus on CC chemokine receptors and explore concepts in drug discovery such as allosteric modulation, precision medicine and functional selectivity in combination with drug binding kinetics.
PhD candidate / internal
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
- Hollander L.S. den, IJzerman A.P. & Heitman L.H. (2024), Pharmacological characterization of allosteric modulators: a case for chemokine receptors, Medicinal Research Reviews : 1-16.
- Hollander L.S. den (25 September 2024), From every angle: novel insights into CC chemokine receptor 2 pharmacology (Dissertatie. Leiden Academic Centre for Drug Research (LACDR), Faculty of Science, Leiden University). Supervisor(s): Heitman A.P. & Heitman L.H.
- Hollander L.S. den, Béquignon O.J.M., Wang X., Wezel K. van, Broekhuis J., Gorostiola González M., Visser K.E. de, IJzerman A.P., Westen G.J.P. van & Heitman L.H. (2022), Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism, Biochemical Pharmacology 208: 115399.
- Ortiz Zacarías N.V., Veldhoven J.P.D. van, Hollander L.S. den, Dogan B., Openy J., Hsiao Y.Y., Lenselink E.B., Heitman L.H. & IJzerman A.P. (2019), Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5, Journal of Medicinal Chemistry 62(24): 11035-11053.