Linde Schoenmaker
PhD candidate
- Name
- L. Schoenmaker MSc
- Telephone
- +31 71 527 4607
- l.schoenmaker@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0001-9879-1004
In 2016, because of my interest in biology and chemistry, I started with the Bio-Pharmaceutical Sciences Bachelor at Leiden University. After completing the bachelor and having found that I really enjoyed the computational research side of drug discovery I decided to focus my master's program on this field, doing the Bio-Pharmaceutical Sciences Master at Leiden University. During the master's, I performed a 9-month research internship at the LACDR with the group of Prof.dr. Gerard van Westen developing a new tool for de novo drug design. Afterward, I also did an internship at the LIACS under the supervision of Dr. Lu Cao, working on image analysis methods for the characterization of cardiotoxicity. After finishing my master’s degree, I decided to start a Ph.D. position at the LACDR under the supervision of the aforementioned Prof.dr. Gerard van Westen. I will be working on the Virtual Human Platform for safety assessment. This project aims to do animal-free predictions of the toxicity of novel chemicals using computational methods. I will specifically be looking into modeling ligand-target interactions, in order to bridge the gap between the exposure in the body to a chemical and potential adverse outcomes.
PhD candidate
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Medicinal Chemistry
- Maagdenberg H.W. van den, Šícho Martin A.D.A., Luukkonen S., Schoenmaker L., Jespers M., Béquignon O.J.M., Gorostiola González M.G., Broek R.L van den, Bernatavicius R., Hasselt J.G.C.van, Graaf P.H. van der & Westen G.J.P. van (2024), QSPRpred: a flexible open-source quantitative structure-property relationship modelling tool, Journal of Cheminformatics 16: 128.
- Cao L., Schoenmaker L., Den S.A. ten, Passier R., Schwach V. & Verbeek F.J. (2023), Automated sarcomere structure analysis for studying cardiotoxicity in human pluripotent stem cell-derived cardiomyocytes, Microscopy and Microanalysis 29(1): 254-264.
- Schoenmaker L., Béquignon O.J.M., Jespers W. & Westen G.J.P. van (2023), UnCorrupt SMILES: a novel approach to de novo design, Journal of Cheminformatics 15(1): 22.
- Sicho M., Luukkonena S., Maagdenberg H.W. van den, Schoenmaker L., Bequignon O.J.M. & Westen G.J.P. van (2023), DrugEx: deep learning models and tools for exploration of drug-like chemical space. [working paper].