Kim Bonger
Associate professor
- Name
- Dr. K.M. Bonger
- Telephone
- +31 71 527 2727
- k.m.bonger@lic.leidenuniv.nl
- ORCID iD
- 0000-0001-9498-2620
The research of Kim Bonger combines organic chemistry with molecular biology and biochemistry to target and answer biological questions related to autoimmune- and protein misfolding diseases.
Associate professor
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Chemische Biologie & Immunologie
- Weijsten M.J. van, Venrooij K.R., Lelieveldt L.P.W.M., Kissel T., Buijtenen E. van, Dalen F.J. van, Verdoes M., Toes R.E.M. & Bonger K.M. (2024), Effect of antigen valency on autoreactive B-Cell targeting, Molecular Pharmaceutics 21(2): 481-490.
- Bartels Y.L., Lent P.L.E.M. van, Kraan P.M. van der, Blom A.B, Bonger K.M. & Bosch M.H.J. van den (2024), Inhibition of TLR4 signalling to dampen joint inflammation in osteoarthritis, Rheumatology 63(3): 608-618.
- Ramos Caceres E., Kemperman L. & Bonger K.M. (2024), Environment-sensitive turn-on fluorescent probe enables live cell imaging of myeloperoxidase activity during NETosis, Communications Chemistry 7(1): 262.
- Venrooij K.R., Bondt L. de & Bonger K.M. (2024), Mutually orthogonal bioorthogonal eeactions: selective chemistries for labeling multiple biomolecules simultaneously, Topics in Current Chemistry 382(3): 24.
- Joosten J., Sluijs B. van, Egberts W.V., Emmaneel M., Jansen P.W.T.C., Vermeulen M., Boelens W., Bonger K.M. & Spruijt E. (2023), Dynamics and composition of small heat shock protein condensates and aggregates, Journal of Molecular Biology 435(13): 168139.
- Sondag D., Maartense L., Jong H. de, Kleijne F.F.J. de, Bonger K.M., Lowik D.W.P.M., Boltje T.J., Dommerholt J., White P.B., Blanco-Ania D. & Rutjes F.P.J.T. (2023), Readily accessible strained difunctionalized trans-cyclooctenes with fast click and release capabilities, Chemistry: a European Journal 29(6): e202203375.
- Ignacio B.J., Dijkstra J., Mora N., Slot E.F.J., Weijsten M.J. van, Storkebaum E., Vermeulen M. & Bonger K.M. (2023), THRONCAT: metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog, Nature Communications 14: 3367.
- Holborough-Kerkvliet M.D., Mucignato G., Moons S.J., Psomiadou V., Konada R.S.R., Pedowitz N.J., Pratt M.R., Kissel T., Koeleman C.A.M., Tjokrodirijo R.T.N., Veelen P.A. van, Huizinga T., Schie K.A.J. van, Wuhrer M., Kohler J.J., Bonger K.M., Boltje T.J. & Toes R.E.M. (2023), A photoaffinity glycan-labeling approach to investigate immunoglobulin glycan-binding partners, Glycobiology 33(9): 732-744.
- Kristyanto H., Holborough-Kerkvliet M.D., Lelieveldt L., Bartels Y., Hammink R., Schie K.A.J. van, Toes R.E.M., Bonger K.M. & Scherer H.U. (2022), Multifunctional, multivalent PIC polymer scaffolds for targeting antigen-specific, autoreactive B cells, ACS Biomaterials Science and Engineering 8(4): 1486-1493.
- Le Gall C.M., Schoot J.M.S. van der, Ramos-Tomillero I., Khalily M.P., Dalen F.J. van, Wijfjes Z., Smeding L., Dalen D. van, Cammarata A., Bonger K.M., Figdor C.G., Scheeren F.A & Verdoes M. (2021), Dual site-specific chemoenzymatic antibody fragment conjugation using CRISPR-based hybridoma engineering, Bioconjugate Chemistry 32(2): 301-310.
- Smeenk M.L.W.J., Agramunt J. & Bonger K.M. (2021), Recent developments in bioorthogonal chemistry and the orthogonality within, Current Opinion in Chemical Biology 60: 79-88.
- Ignacio B.J., Bakkum T., Bonger K.M., Martin N.I. & Kasteren S.I. van (2021), Metabolic labeling probes for interrogation of the host-pathogen interaction, Organic and Biomolecular Chemistry 19(13): 2856-2870.
- Jong H. de, Bonger K.M. & Loewik D.W.P.M. (2020), Activatable cell-penetrating peptides: 15 years of research, RSC Chemical Biology 1(4): 192-203.
- Kissel T., Reijm S., Slot L.M., Cavallari M., Wortel C.M., Vergroesen R.D., Stoeken-Rijsbergen G., Kwekkeboom J.C., Kampstra A.S.B., Levarht E.W.N., Drijfhout J.W., Bang H., Bonger K.M., Janssen G.M.C., Veelen P.A. van, Huizinga T.W.J., Scherer H.U., Reth M. & Toes R.E.M. (2020), Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications, Annals of the Rheumatic Diseases 79(4): 472-480.
- Verhelst S.H.L., Bonger K.M. & Willems L.I. (2020), Bioorthogonal reactions in activity-based protein profiling, Molecules 25(24): 5994.
- Bode S.A., Timmermans S.B.P.E., Eising S., Gemert S.P.W. van, Bonger K.M. & Lowik D.W.P.M. (2019), Click to enter: activation of oligo-arginine cell-penetrating peptides by bioorthogonal tetrazine ligations, Chemical Science 10(3): 701-705.
- Lelieveldt L.P.W.M., Eising S., Wijen A. & Bonger K.M. (2019), Vinylboronic acid-caged prodrug activation using click-to-release tetrazine ligation, Organic and Biomolecular Chemistry 17(39): 8816-8821.
- Eising S., Engwerda A.H.J., Riedijk X., Bickelhaupt F.M. & Bonger K.M. (2018), Highly stable and selective tetrazines for the coordination-assisted bioorthogonal ligation with vinylboronic acids, Bioconjugate Chemistry 29(9): 3054-3059.
- Schoonen L., Eising S., Eldijk M.B. van, Bresseleers J., Pijl M. van der, Nolte R.J.M., Bonger K.M. & Hest J.C.M. van (2018), Modular, bioorthogonal strategy for the controlled loading of cargo into a protein nanocage, Bioconjugate Chemistry 29(4): 1186-1193.
- Lelieveldt L.P.W.M., Kristyanto H., Pruijn G.J.M., Scherer H.U., Toes R.E.M. & Bonger K.M. (2018), Sequential prodrug strategy to target and eliminate ACPA-selective autoreactive B cells, Molecular Pharmaceutics 15(12): 5565-5573.
- Kleinpenning F., Eising S., Berkenbosch T., Garzero V., Schaart J.M. & Bonger K.M. (2018), Subcellular protein labeling by a spatially restricted arylamine N-acetyltransferase, ACS Chemical Biology 13(8): 1932-1937.
- Eising S., Linden N.G.A. van der, Kleinpenning F. & Bonger K.M. (2018), Vinylboronic acids as efficient bioorthogonal reactants for tetrazine labeling in living cells, Bioconjugate Chemistry 29(4): 982-986.
- Gracht A.M.F. van der, Geus M.A.R. de, Camps M.G.M., Ruckwardt T.J., Sarris A.J.C., Bremmers J., Maurits E., Pawlak J.B., Posthoorn M.M., Bonger K.M., Filippov D.V., Overkleeft H.S., Robillard M.S., Ossendorp F. & Kasteren S.I. van (2018), Chemical control over T-cell activation in vivo using deprotection of trans-cyclooctene-modified epitopes, ACS Chemical Biology 13(6): 1569-1576.
- Eising S., Xin B., Kleinpenning F., Heming J.J.A., Florea B.I., Overkleeft H.S. & Bonger K.M. (2018), Coordination-Assisted Bioorthogonal Chemistry: Orthogonal Tetrazine Ligation with Vinylboronic Acid and a Strained Alkene, ChemBioChem 19(15): 1648-1652.
- Buggenum J.A.G.L. van, Gerlach J.P., Eising S., Schoonen L., Eijl R.A.P.M. van, Tanis S.E.J., Hogeweg M., Hubner N.C., Hest J.C. van, Bonger K.M. & Mulder K.W. (2016), A covalent and cleavable antibody-DNA conjugation strategy for sensitive protein detection via immuno-PCR, Scientific Reports 6: 22675.
- Eising S., Lelivelt F. & Bonger K.M. (2016), Vinylboronic acids as fast reacting, synthetically accessible, and stable bioorthogonal reactants in the Carboni-Lindsey reaction, Angewandte Chemie (International Edition) 55(40): 12243-12247.
- Hensen S.M.M., Boelens W.C., Bonger K.M., Cruchten R.T.P. van, Delft F.L. van & Pruijn G.J.M. (2015), Phenylglyoxal-based visualization of citrullinated proteins on western blots, Molecules 20(4): 6592-6600.
- Collins S.R., Yang H.W., Bonger K.M., Guignet E.G., Wandless T.J. & Meyer T. (2015), Using light to shape chemical gradients for parallel and automated analysis of chemotaxis, Molecular Systems Biology 11(4): 804.
- Berg R.J.B.H.N. van der, Rijssel E.R. van, Ferraz M.J., Houben J., Strijland A., Donker-Koopman W.E., Wennekes T., Bonger K.M., Ghisaidoobe A.B.T., Hoogendoorn S., Marel G.A. van der, Codee J.D.C., Overkleeft H.S. & Aerts J.M.F.G. (2015), Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors, ChemMedChem 10(12): 2042-2062.
- Bonger K.M., Rakhit R., Payumo A.Y., Chen J.K. & Wandless T.J. (2014), General method for regulating protein stability with light, ACS Chemical Biology 9(1): 111-115.
- Wennekes T., Bonger K.M., Vogel K., Van den Berg R.J.B.H.N., Strijland A., Donker-Koopman W.E., Aerts J.M.F.G., Van der Marel G.A. & Overkleeft H.S. (2012), The Development of an Aza-C-Glycoside Library Based on a Tandem Staudinger/Aza-Wittig/Ugi Three-Component Reaction, European Journal of Organic Chemistry (32): .
- Bonger K.M., Chen L.-C., Liu C.W. & Wandless T.J. (2011), Small-molecule displacement of a cryptic degron causes conditional protein degradation, Nature Chemical Biology 7(8): 531-537.
- Bonger K.M., Hoogendoorn S., Van Koppen C.J., Timmers C.M., Van der Marel G.A. & Overkleeft H.S. (2011), Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor Antagonist, ACS Medicinal Chemistry Letters 2(1): .
- Bonger K.M., Kapoerchan V.V., Grotenbreg G.M., Van Koppen C.J., Timmers C.M., Van der Marel G.A. & Overkleeft H.S. (2010), Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands, Organic and Biomolecular Chemistry 8(8): .
- Bonger K.M., Hoogendoorn S., Van Koppen C.J., Timmers C., Overkleeft H.S. & Van der Marel G.A. (2009), Synthesis and Pharmacological Evaluation of Dimeric Follicle-Stimulating Hormone Receptor Antagonists, ChemMedChem 4(12): 2098-2102.
- Bonger K.M., Van den Berg R., Knijnenburg A.D., Heitman L.H., Van Koppen C.J., Timmers C., Overkleeft H.S. & Marel G.A. van der (2009), Discovery of Selective Luteinizing Hormone Receptor Agonists Using the Bivalent Ligand Method, ChemMedChem 4(7): 1189-1195.
- Wennekes T., Van den Berg R., Bonger K.M., Donker-Koopman W.E., Ghisaidoobe A., Van der Marel G.A., Strijland A., Aerts J. & Overkleeft H.S. (2009), Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism, Tetrahedron Asymmetry 20(6-8): 836-846.
- Bonger K.M., Wennekes T., Filippov D.V., Lodder G., Marel G.A. van der & Overkleeft H.S. (2008), The effect of Lewis acids on the stereochemistry in the Ugi three-component reaction with D-lyxo pyrroline, European Journal of Organic Chemistry : 3678-3688.
- Bonger K.M., Berg R.J.B.H.N. van den, Heitman L.H., IJzerman A.P., Oosterom J., Timmers C.M., Overkleeft H.S. & Marel G.A. van der (2007), Synthesis and evaluation of homo-bivalent GnRHR ligands, Bioorganic & Medicinal Chemistry 15(14): 4841-4856.