Ken Kok
PhD candidate/ guest
- Name
- Dr. K. Kok
- Telephone
- +31 71 527 3575
- k.kok@lic.leidenuniv.nl
PhD candidate/ guest
- Science
- Leiden Institute of Chemistry
- LIC/Chemical Biology
- LIC/CB/Medical Biochemistry
- Dam D., Lagerweij N.R., Janmaat K.M., Kok K., Bouwman E. & Codee J.D.C. (2024), Organic dye-sensitized nitrene generation: intermolecular aziridination of unactivated alkenes, Journal of Organic Chemistry (JOC) 89(5): 3251-3258.
- Kok K. (2 October 2024), Design, synthesis and application of sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases (Dissertatie. Leiden Institute of Chemistry (LIC), Faculty of Science, Leiden University). Supervisor(s): Overkleeft H.S. & Artola Perez de Azanza M.E.
- Ofman T.P., Heming J.J.A., Nin-Hill A., Küllmer F., Moran E., Bennett M., Steneker R., Klein A.M., Ruijgrok G., Kok K., Armstrong Z.W.B., Aerts J.M.F.G., Marel G.A. van der, Rovira C., Davies G.J., Artola M.E., Codée J.D.C. & Overkleeft H.S. Rovira Carme Davies Gideon J. Artola Marta Codée Jeroen D. C. Overkleeft Herman S. (2024), Conformational and electronic variations in 1,2‐ and 1,5a‐Cyclophellitols and their impact on retaining α‐glucosidase inhibition, Chemistry: a European Journal 30(31): e202400723.
- Thaler M., Ofman T.P., Kok K., Heming J.J.A., Moran E., Pickles I., Leijs A.A., Nieuwendijk A.M.C.H. van den, Berg R.J.B.H.N. van den, Ruijgrok G., Armstrong Z., Salgado-Benvindo C., Ninaber D.K., Snijder E.J., Boeckel C.A.A. van, Artola M., Davies G.J., Overkleeft H.S. & Hemert M.J. van (2024), Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses, ACS Central Science 10(8): 1594-1608.
- Males A., Kok K., Nin-Hill A., Koster N. de, Beukel S. van den, Beenakker T.J.M., Marel G.A. van der, Codée J.D.C., Aerts J.M.F.G., Overkleeft H.S., Rovira C., Davies G. & Artola Perez de Azanza M.E. (2023), Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump–hole strategy, Chemical Science 14(46): 13581-13586.
- Kok K., Kuo C.L., Katzy R.E., Lelieveld L.T., Wu L., Roig-Zamboni V., Marel G.A. van der, Codee J.D.C., Sulzenbacher G., Davies G.J., Overkleeft H.S., Aerts J.M.F.G. & Artola Perez de Azanza M.E. (2022), 1,6-epi-Cyclophellitol cyclosulfamidate is a bona fide lysosomal α-glucosidase stabilizer for the treatment of Pompe disease, Journal of the American Chemical Society 144(32): 14819-14827.
- Kok K., Zwiers K.C., Boot R.G., Overkleeft H.S., Aerts J.M.F.G. & Artola M. (2021), Fabry disease: molecular basis, pathophysiology, diagnostics and potential therapeutic directions, Biomolecules 11(2): 271.