Jeroen van Smeden
Assistant professor / guest
- Name
- Dr. J. van Smeden
- Telephone
- 071 7516320
- j.van_smeden@lumc.nl
Assistant professor / guest
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Onderwijs
Contact
- Rousel J., Mergen C., Schoones J.W., Niemeyer-van der Kolk T., Doorn M.B.A. van, Bouwstra J.A., Smeden J. van & Rissmann R. (2024), Similar alterations of the stratum corneum ceramide profile in atopic dermatitis, psoriasis, and ichthyosis: results from a systematic review and meta-analysis, Journal of Investigative Dermatology : .
- Boiten W.A., Smeden J. van & Bouwstra J.A. (2020), The cornified envelope-bound ceramide fraction is altered in patients with atopic dermatitis, Journal of Investigative Dermatology 140(5): 1097-1100.e4.
- Boer D.E.C., Smeden J. van, Al-Khakany H., Melnik E., Dijk R. van, Absalah S., Vreeken R.J., Haenen C.C.P., Lavrijsen A.P.M., Overkleeft H.S., Aerts J.M.F.G. & Bouwstra J.A. (2020), Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865(6): 158673.
- Smeden J. van, Al-Khakany H., Wang Y., Visscher D., Stephens N., Absalah S., Overkleeft H.S., Aerts J.M.F.G., Hovnanian A. & Bouwstra J.A. (2020), Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities, Journal of Lipid Research 61(6): 859-869.
- Boer D.E.C. Smeden J. van Bouwstra J.A Aerts J.M.F.G. (2020), Glucocerebrosidase: Functions in and Beyond the Lysosome, Journal of Clinical Medicine 9(3): 736-766.
- Boer D.E.C., Mirzaian M., Ferraz M.J., Nadaban A., Schreuder A., Hovnanian A., Smeden J. van, Bouwstra J.A. & Aerts J.M.F.G. (2020), Glucosylated cholesterol in skin: synthetic role of extracellular glucocerebrosidase, Clinica Chimica Acta 510: 707-710.
- Berkers M.A.J., Boiten W.A., Absalah S., Smeden J. van, Lavrijsen A.P.M. & Bouwstra J.A. (2019), Compromising human skin in vivo and ex vivo to study skin barrier repair, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(8): 1103-1108.
- Boiten W.A., Helder R.W.J., Smeden J. van & Bouwstra J.A. (2019), Selectivity in cornified envelop binding of ceramides in human skin and the role of LXR inactivation on ceramide binding, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864(9): 1206-1213.
- Boiten W.A., Berkers M.A.J., Absalah S., Smeden J. van, Lavrijsen A.P.M. & Bouwstra J.A. (2018), Applying a vernix caseosa based formulation accelerates skin barrier repair by modulating lipid biosynthesis, Journal of Lipid Research 59(2): 250-260.
- Berkers T., Van Dijk .L., Absalah S., Smeden J. van & Bouwstra J.A. (2017), Topically applied fatty acids are elongated before incorporation in the stratum corneum lipid matrix in compromised skin, Experimental Dermatology 26(1): 36-43.
- Mieremet A., Rietveld M., Absalah S., Smeden J. van, Bouwstra J.A. & El Ghalbzouri A. (2017), Improved epidermal barrier formation in human skin models by chitosan modulated dermal matrices, 12(3): e0174478.
- Danso M.O., Boiten W., Drongelen V. van, Meijling K.G., Gooris G., Ghalbzouri A. El, Absalah S., Vreeken R., Kezic S., Smeden J. van, Lavrijsen A.P.M. & Bouwstra J.A. (2017), Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition, Journal of Dermatological Science 88(1): 57-66.
- Boiten W., Absalah .S, Vreeken R, Bouwstra J. & Van Smeden J. (2016), Quantitative analysis of ceramides using a novel lipidomics approach with three dimensional response modelling, Biochimica et Biophysica Acta 1861(11): 1652-1661.
- Danso M.O., Drongelen V. van, Mulder A., Gooris G.S., Smeden J. van, El Ghalbzouri A. & Bouwstra J.A. (2015), Exploring the potentials of nurture: 2nd and 3rd generation explant human skin equivalents, Journal of Dermatological Science 77(2): 102-109.
- Thakoersing V.S., Smeden J. van, Boiten W.A., Gooris G.S., Mulder A.A., Vreeken R.J., El Ghalbzouri A. & Bouwstra J.A. (2015), Modulation of stratum corneum lipid composition and organization of human skin equivalents by specific medium supplements, Experimental Dermatology 24(9): 669-74.
- Van Smeden Jeroen, Janssens Michelle, Kaye Edward C.J., Caspers Peter J., Lavrijsen Adriana P., Vreeken Rob J. & Bouwstra Joke A. (2014), The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients, Experimental Dermatology 23(1): 45-52.
- Smeden J. van, Boiten W.A., Hankemeier T., Rissmann R., Bouwstra J.A. & Vreeken R.J. (2014), Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841(1): 70-79.
- Van Smeden J., Janssens M., Gooris G.S. & Bouwstra J.A. (2014), The important role of stratum corneum lipids for the cutaneous barrier function, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1841(3): 295-313.
- Janssens M., Van Smeden J., Puppels G.J., Lavrijsen A.P.M., Caspers P.J. & Bouwstra J.A. (2014), Lipid to protein ratio plays an important role in the skin barrier function in patients with atopic eczema, British Journal of Dermatology 170(6): 1248-1255.
- Van Drongelen Vincent, Danso Mogbekeloluwa O., Mulder Aat, Mieremet Arnout, Van Smeden Jeroen, Bouwstra Joke A. & El Ghalbzouri Abdoelwaheb (2014), Barrier Properties of an N/TERT-Based Human Skin Equivalent, Tissue Engineering Part B: Reviews 20(21-22): 3041-3049.
- Van Smeden Jeroen, Janssens Michelle, Boiten Walter A., Van Drongelen Vincent, Furio Laetitia, Vreeken Rob J., Hovnanian Alain & Bouwstra Joke A. (2014), Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients, 134(5): 1238-1245.
- Danso Mogbekeloluwa O., Van Drongelen Vincent, Mulder Aat, Van Esch Jeltje, Scott Hannah, Van Smeden Jeroen, El Ghalbzouri Abdoelwaheb & Bouwstra Joke A. (2014), TNF-alpha and Th2 Cytokines Induce Atopic Dermatitis-Like Features on Epidermal Differentiation Proteins and Stratum Corneum Lipids in Human Skin Equivalents, 134(7): 1941-1950.
- Janssens M., Mulder A.A., Van Smeden J., Pilgram G.S.K., Wolterbeek R., Lavrijsen A.P.M., Koning R.I., Koster A.J. & Bouwstra J.A. (2013), Electron diffraction study of lipids in non-lesional stratum corneum of atopic eczema patients, Biochimica et Biophysica Acta (BBA) - Biomembranes 1828(8): 1814-1821.
- Van Smeden Jeroen, Janssens Michelle, Lavrijsen Adriana P., Kezic Sanja, Vreeken Rob J. & Bouwstra Joke A. (2013), Skin barrier dysfunction in non-lesional atopic eczema: the role of stratum corneum lipids, European Journal of Dermatology 23: 39-42.
- Van Drongelen Vincent, Alloul-Ramdhani Mariam, Danso Mogbekeloluwa O., Mieremet Arnout, Mulder Aat, Van Smeden Jeroen, Bouwstra Joke A. & El Ghalbzouri Abdoelwaheb (2013), Knock-down of filaggrin does not affect lipid organization and composition in stratum corneum of reconstructed human skin equivalents, Experimental Dermatology 22(12): 807-812.
- Thakoersing Varsha S., Van Smeden Jeroen, Mulder Aat A., Vreeken Rob J., El Ghalbzouri Abdoelwaheb & Bouwstra Joke A. (2013), Increased Presence of Monounsaturated Fatty Acids in the Stratum Corneum of Human Skin Equivalents, 133(1): 59-67.
- Van Smeden J., Hoppel L., Van der Heijden R., Hankemeier T., Vreeken R.J. & Bouwstra J.A. (2012), LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery, 52(6): .
- Janssens M., Van Smeden J., Gooris G.S., Bras W., Portale G., Caspers P.J., Vreeken R.J., Kezic S., Lavrijsen A.P. & Bouwstra J.A. (2012), Lamellar lipid organization and ceramide composition in the stratum corneum of patients with atopic eczema, 131(10): .
- Janssens M., Smeden J. van, Gooris G.S., Bras W., Portale G., Caspers P.J., Vreeken R.J., Hankemeier T., Kezic S., Wolterbeek R., Lavrijsen A.P. & Bouwstra J.A. (2012), Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients, Journal of Lipid Research 53(12): 2755-2766.
- Van Smeden J., Hankemeijer T., Vreeken R.J. & Bouwstra J.A. (2010), The detailed lipid composition in human stratum corneum, 62(6): .
- Ackaert O.W., Van Smeden J., De Graan J., Dijkstra D., Danhof M. & Bouwstra J.A. (2010), Mechanistic studies of the transdermal iontophoretic delivery of 5-OH-DPAT in vitro, JOURNAL OF PHARMACEUTICAL SCIENCES 99(1): .