Jan van der Greef
Professor emeritus of Analytical chemistry, in particular bio-analysis
- Name
- Prof.dr. J. van der Greef
- Telephone
- +31 71 527 4220
- j.vandergreef@lacdr.leidenuniv.nl
Jan van der Greef is Professor of Analytical Biosciences at Leiden University within the Leiden/Amsterdam Centre for Drug Research (LACDR) and director of the Sino-Dutch Center for preventive and personalized Medicine (SD-PPM), a joint initiative of the CAS, Netherlands Metabolomics Center, Leiden University and TNO. He is currently focusing on Systems Biology as a way to innovate and scientifically bridge different health care concepts. In addition he is co-founder of several start-up companies in Life Sciences : Screentec/Kiadis BG Medicine Inc (founded 2000, NASDAQ BGMD)and SU BioMedicine. His PhD was completed at the University of Amsterdam in the field of mass spectrometry in 1980. He has published over 400 papers in international journals, supervised more than 25 PhD thesis projects and has given opening, plenary and keynote lectures (> 300) at major life sciences, analytical and pharmaceutical based conferences. He is co-inventor of several patents in Life Sciences. He is considered as a pioneer in the field of liquid chromatography coupled to mass spectrometry, the field of metabolomics in the biomedical domain (since 1980) , among the first to develop single cell profiling by mass spectrometry and early pioneer (2000) and in the field of Systems Biology in Medicine. He received an award for major contributions in drug analysis by the Belgium Society of Pharmaceutical sciences in 1998. He became doctor honoris causa at Ghent University in 2000 and received an AAPS award as one of the authors of the best analytical paper in 2002. He was chosen as Lilly distinguished lecturer in the area of Analytical Chemistry in 2004 and granted the prestigious Scheele award by the Swedish Academy for Pharmaceutical Sciences in 2005. He also received a honorary professorship from the Chinese Academy of Sciences at the Dalian Institute of Chemical Physics and visiting professorship’s from the Chinese Academy of Engineering at the Jiao Tong university in Shanghai in 2005 and from the Hangzhou Medical university and Westminster university in London in 2010. His research was recognized among the top-ten innovations in China in 2012.
Professor emeritus of Analytical chemistry, in particular bio-analysis
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Analytical Biosciences
- Draper C.F., Duisters K.L.W., Weger B., Chakrabarti A., Harms A.C., Brennan L., Hankemeier T., Goulet L., Konz T., Martin F.P., Moco S. & Greef J. van der (2019), Publisher Correction: Menstrual cycle rhythmicity: metabolic patterns in healthy women, Scientific Reports 9: 5797.
- He M., Sun M.M., Koval S., Wijk R. van, Hankemeier T., Greef J. van der, Wijk E.P.A. van der & Wang M. (2019), Traditional Chinese Medicine-Based Subtyping of Early-Stage Type 2 Diabetes Using Plasma Metabolomics Combined with Ultra-Weak Photon Emission, Engineering 5(5): 916-923.
- He M., Harms A.C., Wijk E.P.A. van, Wang M., Berger R., Koval V.V., Hankemeier T. & Greef J. van der (2019), Role of amino acids in rheumatoid arthritis studied by metabolomics, International Journal of Rheumatic Diseases 22(1): 38-46.
- Draper C.F., Duisters K.L.W., Weger B., Chakrabarti A., Harms A.C., Brennan L., Hankemeier T., Goulet L., Konz T., Martin F.P., Moco S. & Greef J. van der (2018), Menstrual cycle rhythmicity: metabolic patterns in healthy women, Scientific Reports 8: 14568.
- Rossetto Burgos R.C., Ramautar R., Wijk E.P.A. van, Hankemeier T., Greef J. van der & Mashaghi Tabari A. (2018), Pharmacological targeting of ROS reaction network in myeloid leukemia cells monitored by ultra-weak photon emission, OncoTarget 9(2): 2028-2034.
- Sun M., Wijk E.P.A. van, Koval V.V., Wijk R. van, He M., Wang M., Hankemeier T. & Greef J. van der (2017), Measuring ultra-weak photon emission as a non-invasive diagnostic tool for detecting early-stage type 2 diabetes: A step toward personalized medicine, Journal of Photochemistry and Photobiology B: Biology 166: 86-93.
- Rossetto Burgos R.C., Schoeman J.C., Van Winden L.J., Červinková K., Ramautar R., Van Wijk E.P.A., Cifra M., Berger R., Hankemeier T. & Van der Greef J. (2017), Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism, Scientific Reports 7: 1229.
- Sun M., Chang Wen-Te, Wijk E.P.A. van, He M., Koval V.V., Lin M.K., Wijk R. van, Hankemeier T., Greef J. van der & Wang M. (2017), Characterization of the therapeutic properties of Chinese herbal materials by measuring delayed luminescence and dendritic cell-based immunomodulatory response, Journal of Photochemistry and Photobiology B: Biology 168: 1-11.
- He M., Wijk E. van, Wietmarschen H. van, Wang M., Sun M., Koval V.V., Wijk R. van, Hankemeier T. & Greef J. van der (2017), Spontaneous ultra-weak photon emission correlates with inflammatory metabolism and oxidative stress in the collagen induced arthritis mice model, Journal of Photochemistry and Photobiology B: Biology 168: 98-106.
- Rossetto Burgos R.C., Zhang W., Wijk E.P.A. van., Hankemeier T., Ramautar R. & Greef J. van der (2017), Cellular glutathione levels in HL-60 cells during respiratory burst are not correlated with ultra-weak photon emission, Journal of Photochemistry and Photobiology B: Biology 175: 291-296.
- He M., Wijk E.P.A. van, Wietmarschen H.A. van, Wang M., Sun M., Koval V.V., Wijk E.P.A. van, Hankemeier T. & Greef J. van der (2017), Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis, Journal of Photochemistry and Photobiology B: Biology 168: 98-106.
- Sun M., Li L., Wang M., Wijk E.P.A. van, He M., Wijk R. van, Koval S., Hankemeier T., Greef J. van der & Wei S. (2016), Effects of growth altitude on chemical constituents and delayed luminescence properties in medicinal rhubarb, Journal of Photochemistry and Photobiology B: Biology 162: 24-33.
- He M., Sun M., Wijk E.P.A. van, Wietmarschen H.A. van, Wijk R., Wang Z., Wang M., Hankemeier T. & Greef J. van der (2016), A Chinese literature overview on ultra-weak photon emission as promising technology for studying system-based diagnostics, Complementary therapies in medicine 25: 20-26.
- Fu J., Schoeman J.C., Harms A.C., Van Wietmarschen H.A., Vreeken R.J., Berger R., Cuppen B.V., Lafeber F.P., Van der Greef J. & Hankemeier T. (2016), Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis, Analytical and Bioanalytical Chemistry 408(23): 6307–6319.
- Sun M., Wijk R. van, Wijk E.P.A. van, Wang M., Wietmarschen H.A. van, Hankemeier T. & Greef J. van der (2016), Delayed luminescence: an experimental protocol for Chinese herbal medicines, Luminescence 31(6): 1220-1228.
- Fu J., Cuppen B.V.J., Welsing P.M.J., Wietmarschen H.A. van, Harms A.C., Berger R., Koval V.V., Fritsch-Stork R.D.E., Bijlsma J.W.J., Hankemeier T., Greef J. van der & Lafeber F.P.J.G. (2016), Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment, Inflammopharmacology 24(6): 397-402.
- Cuppen B.V.J., Fu J., Wietmarschen H.A. van, Harms A.C., Koval V.V., Marijnissen A.C.A., Peeters J.J.W., Bijlsma J.W.J., Tekstra J., Laar J.M., Hankemeier T., Lafeber F.P.J.G. & Greef J. van der (2016), Exploring the Inflammatory Metabolomic Profile to Predict Response to TNF-alpha Inhibitors in Rheumatoid Arthritis, 11(9): e0163087.
- Rossetto-Burgoss R.C., Cervinkova K., Laan T. van der, Ramautar R., Wijk E.P.A., Cifra M., Koval V.V., Berger R., Hankemeier T. & Greef J. van der (2016), Tracking biochemical changes correlated with ultra-weak photon emission using metabolomics, Journal of Photochemistry and Photobiology B: Biology 163: 237-245.
- Rossetto Burgos R.C., Wijk E.P.A. van, Wijk R. van, He M. & Greef J. van der (2016), Crossing the Boundaries of Our Current Healthcare System by Integrating Ultra-Weak Photon Emissions with Metabolomics, Frontiers in Physiology 7: 611.
- Schroen Y., Wang M., Wietmarschen H.A. van, Witkamp R., Hankemeier T., Fan T.-P. & Greef J. van der (2015), Bridging the seen and the unseen: a systems pharmacology view of herbal medicine, Science 350(6262): S66-S69.
- He M., Wijk E.P.A. van, Berger R., Wang M., Strassburg K., Schoeman J.C., Vreeken R.J., Wietmarschen H.A. van, Harms A.C., Kobayashi M., Hankemeier T. & Greef J. van der (2015), Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma, Mediators of Inflammation 2015: 543541.
- Schroen Y. van, Wietmarschen H.A., Wang M., Wijk E.P. van, Hankemeier T., Xu G. & Greef J. van der (2014), East is East and West is West, and never the twain shall meet?, Science 346(6216): S10-S12.
- Vis D.J., Westerhuis J.A., Hoefsloot H.C.J., Roelfsema F., Greef J. van der, Hendriks M.M.W.B. & Smilde A.K. (2014), Network Identification of Hormonal Regulation, PLoS ONE 9(5): e96284.
- Schalkwijk D.B. van, Graaf A.A. de, Tsivtsivadze E., Parnell L.D., Werff-Van der Vat B.J.C. van der, Ommen B. van, Greef J. van der & Ordovas J.M. (2014), Lipoprotein Metabolism Indicators Improve Cardiovascular Risk Prediction, PLoS ONE 9(3): 92840.
- Saccenti E., Tenori L., Verbruggen P., Timmerman M.E., Bouwman J., Greef J. van der, Luchinat C. & Smilde A.K. (2014), Of Monkeys and Men: A Metabolomic Analysis of Static and Dynamic Urinary Metabolic Phenotypes in Two Species, PLoS ONE 9(9): e106077.
- Aschbacher K., Rodriguez-Fernandez M., Jain S., Wietmarschen H. van, Doyle F. & Greef J. van der (2014), A personalized medicine approach to subtype identification in obesity: ae circadian leptin-cortisol interactions a vulnerability factor?, Psychosomatic Medicine 76(3): A18-A18.
- Kaduk M., Hoefsloot H.C.J., Vis D.J., Reijmers T., Greef J. van der, Smilde A.K. & Hendriks M.M.W.B. (2014), Correlated measurement error hampers association network inference, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 966: 93-99.
- Ommen B. van, Greef J. van der, Ordovas J.M. & Daniel H. (2014), Phenotypic flexibility as key factor in the human nutrition and health relationship, Genes & Nutrition 9(5): 423.
- Aschbacher K., Rodriguez-Fernandez M., Wietmarschen H. van, Tomiyama A.J., Jain S., Epel E., Doyle III F.J. & Greef J. van der (2014), The hypothalamic-pituitary-adrenal-leptin axis and metabolic health: a systems approach to resilience, robustness and control, Interface Focus 4(5): 20140020.
- Wijk R., Wijk E.P.A. van, Wietmarschen H.A. van & Greef J. van der (2014), Towards whole-body ultra-weak photon counting and imaging with a focus on human beings: A review, Journal of Photochemistry and Photobiology B: Biology 139: 39-46.
- Fan T.-P., Briggs J., Liu L., Aiping L., Greef J. van der & Anlong X. (2014), Integrating traditional medicine into modern health care, Science 346(6216): S4-S4.
- Ives J.A., Wijk E.P.A. van, Namuun B., Crawford C., Avi W., Wayne J.B., Wijk R. van & Greef J. van der (2014), Ultraweak Photon Emission as a Non-Invasive Health Assessment: A Systematic Review, PLoS ONE 9(2): 87401.
- Bajpai Rajendra P., Van Wijk Eduard P.A., Van Wijk Roeland & Van der Greef Jan (2013), Attributes characterizing spontaneous ultra-weak photon signals of human subjects, Journal of Photochemistry and Photobiology B: Biology 129: 6-16.
- Draisma H.H., Reijmers T.H., Meulman J.J., Greef J. van der, Hankemeier T. & Boomsma D.I. (2013), Hierarchical clustering analysis of blood plasma lipidomics profiles from mono- and dizygotic twin families, European Journal of Human Genetics 21(1): 95-101.
- Ramautar Rawi, Berger Ruud, Greef Jan van der & Hankemeier Thomas (2013), Human metabolomics: strategies to understand biology, Current Opinion in Chemical Biology 17(5): 841-846.
- Van Wietmarschen Herman A., Van der Greef Jan, Schroen Yan & Wang Mei (2013), Evaluation of symptom, clinical chemistry and metabolomics profiles during Rehmannia six formula (R6) treatment: An integrated and personalized data analysis approach, 150(3): 851-859.
- Greef Jan van der, Wietmarschen Herman van, Ommen Ben van & Verheij Elwin (2013), Looking back into the future: 30 years of metabolomics at TNO, Mass spectrometry reviews 32(5): 399-415.
- Wijk E.P.A. van, Kobayashi M., Wijk R. van & Greef J. van der (2013), Imaging of Ultra-Weak Photon Emission in a Rheumatoid Arthritis Mouse Model, PLoS ONE 8(12): e84579.
- Wei H., Hu C., Wang M., Hoek A.M. van den, Reijmers T.H., Wopereis S., Bouwman J., Ramaker R., Korthout H.A.A.J., Vennik M., Hankemeier T., Havekes L.M., Witkamp R.F., Verheij E.R., Xu G. & Greef J. van der (2012), Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice, PLoS ONE 7(1): e30332.
- Wietmarschen H.A. van, Dai W., Kooij A.J. van der, Reijmers T.H., Schroën Y., Wang M., Xu Z., Wang X., Kong H., Xu G., Hankemeier T., Meulman J.J. & Greef J. van der (2012), Characterization of rheumatoid arthritis subtypes using symptom profiles, clinical chemistry and metabolomics measurements, PLoS ONE 7(9): e44331.
- Kloet F.M. van der, Tempels F.W.A., Ismail N., Heijden R. van der, Kasper P.T., Rojas-Cherto M., Doorn R. van, Spijksma G., Koek M., Greef J. van der, Mäkinen V.P., Forsblom C., Holthöfer H., Groop P.H., Reijmers T.H. & Hankemeier T. (2012), Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study), Metabolomics 2012(8): 109-119.
- Lindenburg P.W., Tempels F.W.A., Tjaden U.R., Greef J. van der & Hankemeier T. (2012), On-line large-volume electroextraction coupled to liquid chromatography-mass spectrometry to improve detection of peptides, Journal of Chromatography A 1249: 17-24.
- Lindenburg P.W., Tjaden U.R., Greef J. van der & Hankemeier T. (2012), Feasibility of electroextraction as versatile sample preconcentration for fast and sensitive analysis of urine metabolites, demonstrated on acylcarnitines, Electrophoresis 33(19-20): 2987-2995.
- Koek M.M., Jellema R.H., Van der Greef J., Tas A.C. & Hankemeier T. (2012), Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives, METABOLOMICS 7(3): .
- Wei Heng, Pasman Wilrike, Rubingh Carina, Wopereis Suzan, Tienstra Marc, Schroen Jan, Wang Mei, Verheij Elwin & Greef Jan van der (2012), Urine metabolomics combined with the personalized diagnosis guided by Chinese medicine reveals subtypes of pre-diabetes, Molecular Biosystems 8(5): 1482-1491.
- Zhu C., Dane A., Spijksma G.K., Wang M., Greef J. van der, Luo G.A., Hankemeier T. & Vreeken R.J. (2012), An efficient hydrophilic interaction liquid chromatography separation of 7 phospholipid classes based on a diol column, Journal of Chromatography A 1220: 26-34.
- Van der Greef J. (2012), The 27th Montreux Symposium on LC-MS, Bioanalysis 3(10): .
- Draisma H.H., Reijmers T.H., Meulman J.J., Greef J. van der, Hankemeijer T. & Boomsma D.I. (2012), Hierarchical clustering analysis of blood plasma lipidomics profiles from mono- and dizygotic twin families, European Journal of Human Genetics 21: 95-101.
- Hu C., Wei H., Kong H., Bouwman J., Gonzalez-Covarrubias V., Van der Heijden R., Reijmers T.H., Bao X., Verheij E.R., Hankemeier T., Xu G., Van der Greef J. & Wang M. (2012), Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats, Molecular Biosystems 7(11): .
- Chan W.T., Choi Y.H., Heijden R. van der, Lee M.S., Lin M.K., Kong H., Kim H.K., Verpoorte R., Hankemeier T. & Greef J. van der (2011), Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa Roots, Chemical and pharmaceutical bulletin 59: 546.
- Hu C., Wei H., Hoek A.M. van den, Wang M., Heijden R. van der, Spijksma G.K., Reijmers T.H., Bouwman J., Wopereis S., Havekes L.M., Verheij E., Hankemeier T., Xu G. & Greef J. van der (2011), Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice, PLoS ONE 6(5): e19423.
- Rubingh Carina M., Van Erk Marjan J., Wopereis Suzan, Van Vliet Trinette, Verheij Elwin R., Cnubben Nicole H.P., Van Ommen Ben, Van der Greef Jan, Hendriks Henk F.J. & Smilde Age K. (2011), Discovery of subtle effects in a human intervention trial through multilevel modeling, Chemometrics and Intelligent Laboratory Systems 106(1): 108-114.
- Greef J. van der (2011), Perspective: All systems go, Nature 480(7378): S87.
- Wietmarschen H.A. van, Reijmers T.H., Kooij A.J. van der, Schroen J., Wei H., Hankemeier T., Meulman J.J. & Greef J. van der (2011), Sub-typing of rheumatic diseases based on a systems diagnosis questionnaire, PLoS ONE 6(9): e24846.
- Lindenburg P.W., Seitzinger R., Tempels F.W.A., Tjaden U.R., Van der Greef J. & Hankemeier T. (2010), Online capillary liquid-liquid electroextraction of peptides as fast pre-concentration prior to LC-MS, Electrophoresis 31(23-24): .
- Vis D.J., Westerhuis J.A., Hoefsloot H.C., Pijl H., Roelfsema F., Greef J. van der & Smilde A.K. (2010), Endocrine pulse identification using penalized methods and a minimum set of assumptions, AJP - Endocrinology and Metabolism 298(2): E146-515.
- Van Schalkwijk Daniel B., Van Bochove Kees, Van Ommen Ben, Freidig Andreas P., Van Someren Eugene P., Van der Greef Jan & De Graaf Albert A. (2010), Developing computational model-based diagnostics to analyse clinical chemistry data, Briefings in Bioinformatics 11(4): 403-416.
- Van der Greef J., Van Wietmarschen H., Schroen J., Wang M., Hankemeier T. & Xu G.W. (2010), Systems Biology-Based Diagnostic Principles as Pillars of the Bridge between Chinese and Western Medicine, Planta Medica 76(17): .
- Van Wijk E.P.A., Van Wijk R., Bajpai R.P. & Van der Greef J. (2010), Statistical analysis of the spontaneously emitted photon signals from palm and dorsal sides of both hands in human subjects, Journal of Photochemistry and Photobiology B: Biology 99(3): .
- Van Schalkwijk D.B., Van Ommen B., Freidig A.A., Van der Greef J. & De Graaf A.A. (2010), Introducing the VLDL performance diagnostic, Atherosclerosis Supplements 11(2): 220-220.
- Huber Machteld, Vijver Lucy P.L. van de, Parmentier Henk, Savelkoul Huub, Coulier Leon, Wopereis Suzan, Verheij Elwin, Van der Greef Jan, Nierop Dre & Hoogenboom Ron A.P. (2010), Effects of organically and conventionally produced feed on biomarkers of health in a chicken model, The British Journal of Nutrition: an International Journal of Nutritional Science 103(5): 663-676.
- Smilde A.K., Westerhuis J.A., Hoefsloot H.C.J., Bijlsma S., Rubingh C.M., Vis D.J., Jellema R.H., Pijl H., Roelfsema F. & Van der Greef J. (2010), Dynamic metabolomic data analysis: a tutorial review, Metabolomics 6(1): 3-17.
- Erk M.J. van, Wopereis S., Rubingh C., Vliet T. van, Verheij E., Cnubben N.H., Pedersen T.L., Newman J.W., Smilde A.K., Greef J. van der, Hendriks H.F. & Ommen B. van (2010), Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study, BMC Medical Genomics 3: 5.
- Song G.S., Zhai H.L., Peng Y.G., Zhang L., Wei G., Chen X.Y., Xiao Y.G., Wang L., Chen Y.J., Wu B., Chen B., Zhang Y., Chen H., Feng X.J., Gong W.K., Liu Y., Yin Z.J., Wang F., Liu G.Z., Xu H.L., Wei X.L., Zhao X.L., Ouwerkerk P.B.F., Hankemeier T., Reijmers T., Heijden R.V., Lu C.M., Wang M., Greef J. van der & Zhu Z. (2010), Comparative Transcriptional Profiling and Preliminary Study on Heterosis Mechanism of Super-Hybrid Rice, Molecular Plant 3: 1012-1025.
- Kong H., Wang M., Venema K., Maathuis A., Heijden R. van der, Greef J. van der & Hankemeier T. (2009), Bioconversion of red ginseng saponines in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry, Journal of Chromatography A 1216(11): 2195-203.
- Hu C., Van der Heijden R., Wang M., Van der Greef J., Hankemeier T. & Xu G. (2009), Analytical strategies in lipidomics and applications in disease biomarker discovery, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 877(26): 2836-46.
- Wang J., Reijmers T., Chen L., Van der Heijden R., Wang M., Peng S., Hankemeier T., Xu G. & Van der Greef J. (2009), Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics, METABOLOMICS 5(4): 407-418.
- Verpoorte R., Crommelin D., Danhof M., Gilissen L.J., Schuitmaker H., Van der Greef J. & Witkamp R.F. (2009), Commentary: "A systems view on the future of medicine: inspiration from Chinese medicine?", Journal of Ethnopharmacology 121(3): 479-81.
- Kamphorst J.J., Tjaden U.R., Van der Heijden R., DeGroot J., Van der Greef J. & Hankemeier T. (2009), Feasibility of electrodialysis as a fast and selective sample preparation method for the profiling of low-abundant peptides in biofluids, Electrophoresis 30(13): 2284-92.
- Van Wietmarschen H., Yuan K., Lu C., Gao P., Wang J., Xiao C., Yan X., Wang M., Schroen J., Lu A., Xu G. & Van der Greef J. (2009), Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients, JCR: Journal of Clinical Rheumatology 15(7): 330-7.
- Wopereis S., Rubingh C.M., Erk M.J. van, Verheij E.R., Vliet T. van, Cnubben N.H.P., Smilde A.K., Greef J. van der, Ommen B. van & Hendriks H.F.J. (2009), Metabolic Profiling of the Response to an Oral Glucose Tolerance Test Detects Subtle Metabolic Changes, PLoS ONE 4(2): e4525.
- Wang J., Heijden R. van der, Spijksma G.K., Reijmers T., Wang M., Xu G., Hankemeier T. & Greef J. van der (2009), Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography-mass spectrometry, Journal of Chromatography A 1216(11): 2169-2178.
- Van Schalkwijk D.B., De Graaf A.A., Van Ommen B., Van Bochove K., Rensen P.C., Havekes L., Van de Pas N.C., Hoefsloot H.C., Van der Greef J. & Freidig A.P. (2009), Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size, 50(12): 2398-411.
- Draisma H.H., Reijmers T., Van der Kloet F.M., Bobeldijk-Pastorova I., Spies-Faber E., Vogels J., Meulman J.J., Boomsma D., Van der Greef J. & Hankemeier T. (2009), Equating, or correction for between-block effects with application to body fluid LC-MS and NMR metabolomics data sets, Analytical Chemistry 82(3): 1039-46.
- Adourian A., Jennings E., Balasubramanian R., Hines W.M., Damian D., Plasterer T.N., Clish C.B., Stroobant P., McBurney R.N., Verheij E.R., Bobeldijk I., Greef J. van der, Lindberg J., Kenne K., Andersson U., Hellmold H., Salter H. & Schuppe-Koistinen I. (2008), Correlation network analysis for data integration and biomarker selection, Mol. Biosyst. 4(3): 249-259.
- Hu C., Dommelen J., Heijden R. van der, Spijksma G., Reijmers T.H., Wang M., Slee E., Lu X., Xu G., Greef J. van der & Hankemeier T. (2008), RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model, Journal of Proteome Research 7(11): 4982-4991.
- Chang W.T., Choi Y.H., Heijden R. van der, Kong H., Kim H.K., Verpoorte R., Xu G., Hankemeier T., Greef J. van der & Wang M. (2008), Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa Roots, : .
- Bergheanu S.C., Reijmers T., Zwinderman A.H., Bobeldijk I., Ramaker R., Liem A.H., Greef J. van der, Hankemeier T. & Jukema J.G. (2008), Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: investigating differential effects among statins, Current Medical Research and Opinion 24: 2477-2487.
- Draisma H.H.M., Reijmers T.H., Bobeldijk-Pastorova I., Meulman J.J., Estourgie-Van Burk G.F., Bartels M., Ramaker R., Greef J. van der, Boomsma D.I. & Hankemeier T. (2008), Similarities and differences in lipidomics profiles among healthy monozygotic twin pairs, OMICS 12(1): 17-31.
- Verpoorte R., Crommelin D.J.A., Danhof M., Gilissen L.J., Schuitmaker H., Greef J. van der & Witkamp R.F. (2008), Commentary: "A systems view on the future of medicine: Inspiration from Chinese medicine?", : .
- Angelova N.S., Kong H.W., Heijden R. van der, Yang S.Y., Choi Y.H., Kim H.K., Wang M., Hankemeier T., Greef J. van der, Xu X. & Verpoorte R. (2008), Recent methodology in the phytochemical analysis of ginseng, Phytochemical Analysis 19: 2-16.
- Damian D., Oresic M., Verheij E.R., Meulman J.J., Friedman J., Adourian A., Morel N., Smilde A.K. & Greef J. van der (2007), Applications of a new subspace clustering algorithm (COSA) in medical systems biology, METABOLOMICS 3(1): 69-77.
- Doorn M. van, Vogels J., Tas A., Hoogdalem E.J. van, Burggraaf J., Cohen A.F. & Greef J. van der (2007), Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers, British Journal of Clinical Pharmacology 63(5): 562-574.
- Schalkwijk D.B. van, Freidig A.P., Ommen B. van & Greef J. van der (2007), Particle profiler: A model analysis of lipoprotein delipidation, Atherosclerosis 8(1): 36-37.
- Kamphorst J.J., Heijden R.V., DeGroot J., Lafeber F.P.J.G., Reijmers T.H., El B.V., Tjaden U.R., Greef J. van der & Hankemeier T. (2007), Profiling of Endogenous Peptides in Human Synovial Fluid by NanoLC-MS: Method Validation and Peptide Identification, Journal of Proteome Research 6: 4388-4396.
- Vis D.J., Westerhuis J.A., Smilde A.K. & Greef J. van der (2007), Statistical validation of megavariate effects in ASCA, BMC Bioinformatics 8(1): 322.
- Kleemann R., Verschuren L., Erk M.J. van, Nikolsky N., Cnubben N.H., Verheij E.R., Smilde A.K., Hendriks H.F., Zadelaar S., Smith G.J., Kaznacheev V., Nikolskaya T., Melnikov A., Hurt-Camejo E., Greef J. van der, Ommen B. van & Kooistra T. (2007), Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis, Genome Biology 8(9): R200.
- Greef J. van der (2007), Systems toxicology: A new perspective in drug discovery and development, Toxicology Letters 172: S1-S1.
- Benavente F., Sanz-Nebot V., Barbosa J., Heijden R. van der, Greef J. van der & Hankemeier T. (2007), Capillary electrophoresis electrospray mass spectrometry of anions in plastic capillaries at high pH, Electrophoresis 28(6): 944-949.
- Greef J. van der (2007), 23rd montreux symposium on liquid chromatography-mass spectrometry, supercritical fluid chromatography-mass spectrometry, capillary electrophoresis-mass spectrometry and tandem mass spectrometry - Foreword. [other].
- Muskulus M., Besozzi D., Brijder R., Cazzaniga P., Houweling S., Pescini D., Rozenberg G. & Greef J. van der (2007), Cycles and Communicating Classes in Membrane Systems and Molecular Dynamics, 372(2-3): 242-266.
- Ginneken V.J.T. van, Verhey E., Poelmann R.E., Ramakers R., Willems van Dijk K., Ham L., Voshol P.J., Havekes L.M., Eck M. van & Greef J. van der (2007), Metabolomics (liver and blood profiling) in a mouse model in response to fasting: A study of hepatic steatosis, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1771: 1263-1270.
- Greef J. van der, Martin S., Juhasz P., Adourian A., Plasterer T.N., Verheij E.R. & McBurney R.N. (2007), The art and practice of systems biology in medicine: mapping patterns of relationships, Journal of Proteome Research 6(4): 1540-1549.
- Wang M. & Greef J. van der (2006), Systems biology: scientific evidence and a novel quality control for traditional chinese medicine (TCM), Drug Safety 29: 369-369.
- Gaspari M., Verhoeckx K.C.M., Verheij E.R. & Greef J. van der (2006), Integration of two-dimensional LC-MS with multivariate statistics for comparative analysis of proteomic samples, Analytical Chemistry 78(7): 2286-2296.
- Verhoeckx K.C.M., Lagerweij T., Nagelkerken L.A.M., Korthout H.A., Wang M., Greef J. van der, Richard J.T., Rodenburg R.J.T. & Witkamp R.F. (2006), Unheated cannabis sativa extracts and its major compound THC-acid have potential anti-inflammatory properties not mediated by CB1 and CB2 receptor coupled pathways, International Immunopharmacology 6: 656-665.
- Greef J. van der, Hankemeier T. & McBurney R.N. (2006), Metabolomics-based systems biology and personalized medicine: moving towards n=1 clinical trials?, Pharmacogenomics 7(7): 1087-1094.
- Benavente F., Heijden R. van der, Tjaden U.R., Greef J. van der & Hankemeier T. (2006), Metabolite profiling of human urine by CE-ESI-MS using separation electrolytes at low pH, Electrophoresis 27(22): 4570-4584.
- Heijden R. van der, Hankemeier T. & Greef J. van der (2006), Pharmaceutical Applications: LC-MS: Core technology in metabolomics research. In: , Encyclopedia of Mass Spectrometry Volume 8: Hyphenated Methods. Oxford: Elsevier Science. 507-515.
- Verhoeckx K.C.M., Doornbos R.P., Witkamp R.F., Greef J. van der & Rodenburg R.J.T. (2006), Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages, International Immunopharmacology 6(1): 1-7.
- Storms H.F., Heijden R. van der, Tjaden U.R. & Greef J. van der (2006), Considerations for proteolytic labeling-optimization of (18)O incorporation and prohibition of back-exchange, Rapid Communications in Mass Spectrometry 20(23): 3491-3497.
- Chang W-T., Thissen U., Ehlert K.A., Koek M., Jellema R.H., Hankemeier T., Greef J. van der & Wang M. (2006), Effects of Growth Conditions and Processing on Rehmannia glutinosa L. Using Fingerprint Strategy, Planta Medica 72: 458-467.
- Verhoeckx K.C.M., Korthout H.A., Meeteren-Kreikamp A.P. van, Ehlert K.A., Wang M., Greef J. van der, Rodenburg R.J.T. & Witkamp R.F. (2006), Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways, International Immunopharmacology 6(4): 656-665.
- Lamers R.J., Nesselrooij J.H. van, Kraus V.B., Jordan J.M., Renner J.B., Dragomir A.D., Luta G., Greef J. van der & DeGroot J. (2005), Identification of an urinary metabolite profile associated with osteoarthritis, OSTEOARTHRITIS AND CARTILAGE 13: 762-768.
- Jacobs D.I., Gaspari M., Greef J. van der, Heijden R. van der & Verpoorte R. (2005), Proteome analysis of Catharanthus roseus cultured cells for the identification of proteins involved in alkaloid biosynthesis and finding of novel sequences, Planta 221: 690-704.
- Verhoeckx K.C.M., Doornbos R.P., Greef J. van der, Witkamp R.F. & Rodenburg R.J.T. (2005), Inhibitory effects of the beta(2)-adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-alpha in vitro and in vivo, 28: 531-537.
- Storms H.F., Heijden R. van der, Tjaden U.R. & Greef J. van der (2005), Optimization of protein identification from digests as analyzed by capillary isoelectric focusing-mass spectrometry, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 824(1-2): 189-200.
- Smilde A.K., Jansen J.J., Hoefsloot H.C., Lamers R.J., Greef J. van der & Timmerman M.E. (2005), ANOVA-Simultaneous component analysis (ASCA): a new tool for analyzing designed metabolomics data, BIOINFORMATICS 21(13): 3043-3048.
- Jansen J.J., Hoefsloot H.C., Greef J. van der, Timmerman M.E. & Smilde A.K. (2005), Multilevel component analysis of time-resolved metabolic fingerprinting data, Analytica Chimica Acta 530: 173-183.
- Greef J. van der & McBurney R.N. (2005), Rescuing Drug Discovery: In Vivo Systems Pathology and Systems Pharmacology, Nature Reviews Drug Discovery 4: 961-967.
- Jacobs D.I., Gaspari M., Greef J. van der, Heijden R. van der & Verpoorte R. (2005), Proteome analysis of the medicinal plant Catharanthus roseus, Planta 221: 690-704.
- Jansen J.J., Hoefsloot H.C.J., Greef J. van der, Timmerman M.E., Westerhuis J.A. & Smilde A.K. (2005), ASCA: analysis of multivariate data obtained from an experimental design, Journal of Chemometrics 19(9): 469-481.
- Verhoeckx K.C.M., Gaspari M., Bijlsma S., Greef J. van der, Witkamp R.F., Doornbos R.P. & Rodenburg R.J.T. (2005), In search of secreted protein biomarkers for the anti-inflammatory effect of beta(2)-adrenergic receptor agonists: Application of DIGE technology in combination with multivariate and univariate data analysis tools, Journal of Proteome Research 4(6): 2015-2023.
- Greef J. van der (2005), Systems biology, connectivity and the future of medicine, IEE Proceedings - Systems Biology 152(4): 174-178.
- Greef J. van der & Smilde A.K. (2005), Symbiosis of chemometrics and metabolomics: past, present, and future, Journal of Chemometrics 19(5-7): 376-386.
- Greef J. van der (2005), 21st Montreux symposium on liquid chromatography mass spectrometry, supercritical fluid chromatography - Mass spectrometry, capillary electrophoresis - Mass spectrometry and tandem mass spectrometry - Foreword. [other].
- Wang M., Lamers R.J., Korthout H.A., Nesselrooij J.H. van, Witkamp R.F., Heijden R. van der, Voshol P.J., Havekes L.M., Verpoorte R. & Greef J. van der (2005), Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology, Phytotherapy Research 19(3): 173-182.
- Wang M., Lamers R.J., Korthout H.A., Nesselrooij J.H. van, Witkamp R.F., Heijden R. van der, Voshol P.J., Havekes L.M., Verpoorte R. & Greef J. van der (2005), Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology, Phytotherapy Research 19(3): 173-182.
- Storms H.F., Heijden R. van der, Tjaden U.R. & Greef J. van der (2004), Capillary isoelectric focusing-mass spectrometry for shotgun approach in proteomics, Electrophoresis 25: 3461-3467.
- Verhoeckx K.C.M., Bijlsma S., Jespersen S., Ramaker R., Verheij E.R., Witkamp R.F., Greef J. van der & Rodenburg R.J. (2004), Characterization of anti-inflammatory compounds using transcriptomics, proteomics, and metabolomics in combination with multivariate data analysis, International Immunopharmacology 4: 1499-1514.
- Clish C.B., Davidov E., Oresic M., Plasterer T.N., Lavine G., Londo T., Meys M., Snell P., Stochaj W., Adourian A., Zhang X., Morel N., Neumann E., Verheij E.R., Vogels J.T., Havekes L., Afeyan N., Regnier F., Greef J. van der & Naylor S. (2004), Integrative biological analysis of the APOE*3-leiden transgenic mouse, OMICS 8: 3-13.
- Morel N.M., Holland J.M., Greef J. van der, Marple E.W., Clish C.B., Loscalzo J. & Naylor S. (2004), Primer on medical genomics. Part XIV: Introduction to systems biology - a new approach to understanding disease and treatment, Mayo Clinic Proceedings 79: 651-658.
- Verhoeckx K.C.M., Bijlsma S., Groene E.M. de, Witkamp R.F., Greef J. van der & Rodenburg R.J. (2004), A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line, Proteomics 4: 1014-1028.
- Greef J. van der, Heijden R. van der & Verheij E.R. (2004), The Role of Mass Spectrometry in Systems Biology: Data Processing and Identification Strategies in Metabolomics. In: Ashcroft A.E. & Brenton G. (Eds.), Advances in Mass Spectrometry. Amsterdam: Elsevier Science. 145-165.
- Davidov E., Clish C.B., Oresic M., Meys M., Stochaj W., Snell P., Lavine G., Londo T.R., Adourian A., Zhang X., Johnston M., Morel N., Marple E.W., Plasterer T.N., Neumann E., Verheij E., Vogels J.T.W.E., Havekes L.M., Greef J. van der & Naylor S. (2004), Methods for the differential integrative omic analysis of plasma from a transgenic disease animal model, OMICS: A Journal of Integrative Biology 8(4): 267-288.
- Jansen J.J., Hoefsloot H.C., Boelens H.F., Greef J. van der & Smilde A.K. (2004), Analysis of longitudinal metabolomics data, BIOINFORMATICS 12: 2438-2446.
- Elswijk D.A. van, Schobel U.P., Lansky E.P., Irth H. & Greef J. van der (2004), Rapid dereplication of estrogenic compounds in pomegranate (Punica granatum) using on-line biochemical detection coupled to mass spectrometry, Phytochemistry 65: 233-241.
- Kohli E., Gaspari M., Raj H.G., Parmar V.S., Sharma S.K., Greef J. van der, Kumari R., Gupta G., Khurana P., Tyagi Y.K., Watterson A.C. & Olsen C.E. (2004), Acetoxy drug: protein transacetylase of buffalo liver-characterization and mass spectrometry of the acetylated protein product, Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1698: 55-66.
- Greef J. van der, Stroobant P. & Heijden R. van der (2004), The role of analytical sciences in medical systems biology, Current Opinion in Chemical Biology 8: 559-565.
- Schenk T., Appels N., Elswijk D.A. van, Irth H., Tjaden U.R. & Greef J. van der (2003), A generic assay for phosphate-consuming or -releasing enzymes coupled on-line to liquid chromatography for lead finding in natural products, Analytical Biochemistry 316: 118-126.
- Greef J. van der, Davidov E., Verheij E.R., Vogels J.T., Heijden R. van der, Adourian A., Oresic M., Marple E.W. & Naylor S. (2003), The role of metabolomics in Systems Biology. In: Harrigan G.G. & Goodacre R. (Eds.), Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis. Boston/Dordrecht/London: Kluwer Academic Publishers. 170-198.
- Hart B.A. 't, Vogels J.T.W.E., Spijksma G., Brok H.P.M., Polman C. & Greef J. van der (2003), 1H-NMR spectroscopy combined with pattern recognition analysis reveals characteristic chemical patterns in urines of MS patients and non-human primates with MS-like disease, Journal of the Neurological Sciences 212(1-2): 21-30.
- Lamers R.J.A.N., Groot J. de, Spies-Faber E.J., Jellema R.H., Kraus V.B., Verzijl N., TeKoppele J.M., Spijksma G.K., Vogels J.T.W.E., Greef J. van der & Nesselrooij J.H.J. van (2003), Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigs, Journal of Nutrition 133(6): 1776-1780.
- Schenk T., Molendijk A., Irth H., Tjaden U.R. & Greef J. van der (2003), Liquid chromatography coupled on-line to flow cytometry for postcolumn homogeneous biochemical detection, Analytical Chemistry 75: 4272-4278.
- Elswijk D.A. van, Diefenbach O., Berg S.A. van den, Irth H., Tjaden U.R. & Greef J. van der (2003), Rapid detection and identification of angiotensin-converting enzyme inhibitors by on-line liquid chromatography-biochemical detection, coupled to electrospray mass spectrometry, Journal of Chromatography A 1020: 45-58.
- Lamers R.J.A.N., Wessels E.C.H.H., Sandt J.J.M. van de, Venema K., Schaafsma G., Greef J. van der & Nesselrooij J.H.J. van (2003), A pilot study to investigate effects of inulin on Caco-2 cells through in vitro metabolic fingerprinting, Journal of Nutrition 133(10): 3080-3084.
- Schenk T., Breel J., Koevoets P., Berg S.A. van den, Hogenboom A.C., Irth H., Tjaden U.R. & Greef J. van der (2003), Screening of natural products extracts for the presence of phosphodiesterase inhibitors using liquid chromatography coupled online to parallel biochemical detection and chemical characterization, J. Biomol. Screen. 8: 421-429.
- Schenk T., Breel G., Berg S.A. van den, Hogenboom A.C., Irth H., Tjaden U.R. & Greef J. van der (2003), The screening of natural product extracts for the presence of phosphodiesterase inhibitors using LC coupled on-line to parallel biochemical detection and chemical characterization, J. Biomol. Screen. 8(4): 421-429.
- Greef J. van der (2003), Foreword. 19th Montreux Symposium on Liquid Chromatography - Mass Spectrometry, Supercritical Fluid Chromatography - Mass Spectrometry, Capillary Electrophoresis - Mass Spectrometry and Tandem Mass Spectrometry, Journal of Chromatography A 1020(1): 1.
- Kohli E., Gaspari M., Raj H.G., Parmer V.S., Greef J. van der, Gupta G., Kumari R., Prasad A.K., Goel S., Pal G., Tyagi Y.K., Jain S.C., Ahmad N., Watterson A.C. & Olsen C.E. (2002), Establishment of the enzymatic protein acetylation independent of acetyl CoA: recombinant glutathine S-transferase 3-3 is acetylated by a novel membrane-bound transacetylase using 7,8-diacetoxy-4-methul cournarin as the acetyl donor, 530: 139-142.
- Kohli E., Gaspari M., Raj H.G., Parmar V.S., Greef J. van der, Gupta G., Kumari R., Prasad A.K., Goel S., Pal G., Tyagi Y.K., Jain S.C., Ahmad N., Watterson A.C. & Olsen C.E. (2002), Corrigendum to: Establishment of the enzymatic protein acetylation independent of acetyl CoA: recombinant glutathione S-transferase 3-3 is acetylated by a novel membrane-bound transacetylase using 7,8-diacetoxy-4-methyl coumarin as the acetyl donor (FEBS 26626) (vol 530, pg 139, 2002), FEBS Letters 531(3): 571-571.
- Chartogne A.K.M.M., Reeuwijk H.J.E.M., Hofte B., Heijden R. van der, Tjaden U.R. & Greef J. van der (2002), Capillary electrophoretic separations of proteins using carrier ampholytes, Journal of Chromatography A 959: 289-298.
- Chartogne A.K.M.M., Gaspari M., Jespersen S., Buscher B., Verheij E.R., Heiden R. van der, Tjaden U.R. & Greef J. van der (2002), On-target fraction collection for the off-line coupling of capillary isoelectric focusing with matrix assisted laser desorption/ionization mass spectrometry, Rapid Communications in Mass Spectrometry 16(3): 201-207.
- Schenk T., Irth H., Marko-Varga G., Edholm L.E., Tjaden U.R. & Greef J. van der (2001), Potential of on-line micro-LC immunochemical detection in the bioanalysis of cytokines, Journal of Pharmaceutical and Biomedical Analysis 26(5-6): 975-985.
- Gaspari M., Gucek M., Walhagen K., Vreeken R.J., Verheij E.R., Tjaden U.R. & Greef J. van der (2001), Ion trap mass spectrometry as detector for capillary electrochromatography of peptides: Possibilities and limitations, Journal of Microcolumn Separations 13(6): 243-249.
- Walhagen K., Gaspari M., Tjaden U.R., Rozing G.P. & Greef J. van der (2001), In-line coupling of low-pressure short capillary electrochromatography columns to electrospray ionisation mass spectrometry, Rapid Communications in Mass Spectrometry 15(11): 878-883.
- Warnke U., Gysler J., Hofte B., Tjaden U.R., Greef J. van der, Kloft C., Schunack W. & Jaehde U. (2001), Separation and identification of platinum adducts with DNA nucleotides by capillary zone electrophoresis and capillary zone electrophoresis coupled to mass spectrometry, Electrophoresis 22(1): 97-103.
- Aguilar C., Hofte A.J.P., Tjaden U.R. & Greef J. van der (2001), Analysis of histones by on-line capillary zone electrophoresis-electrospray ionisation mass spectrometry, Journal of Chromatography A 926(1): 57-67.
- Elswijk D.A. van, Tjaden U.R., Greef J. van der & Irth H. (2001), Mass Spectrometry-based bioassay for the screening of soluble orphan receptors, International Journal of Mass Spectrometry 210(1-3): 625-636.
- Greef J. van der (2001), 17th Montreux Symposium on Liquid Chromatography-Mass Spectrometry, Supercritical Fluid Chromatography-Mass Spectrometry, Capillary Electrophoresis-Mass Spectrometry and Tandem Mass Spectrometry Montreux Switzerland, 8-10 November 2000 - Foreword. [other].
- Greef J. van der (2001), Ion chemistry, mass spectrometry, and infectious enthusiasm: The career of a Dutch scientist, International Journal of Mass Spectrometry 210/211(1-3): xiii-xiv.
- Vrouwe E.X., Gysler J., Tjaden U.R. & Greef J. van der (2000), Chip-based capillary electrophoresis with an electrodeless nanospray interface, Rapid Communications in Mass Spectrometry 14(18): 1682-1688.
- Guetens G., Cauwenberghe K. van, Boeck G. de, Maes R., Tjaden U.R., Greef J. van der, Highley M., Oosterom A.T. van & Bruijn E.A. van (2000), Nanotechnology in bio/clinical analysis, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 739(1): 139-150.
- Chartogne A., Tjaden U.R. & Greef J. van der (2000), A free-flow electrophoresis chip device for interfacing capillary isoelectric focusing on-line with electrospray mass spectrometry, Rapid Communications in Mass Spectrometry 14(14): 1269-1274.
- Gucek M., Gaspari M., Walhagen K., Vreeken R.J., Verheij E.R. & Greef J. van der (2000), Capillary electrochromatography/nanoelectrospray mass spectrometry for attomole characterization of peptides, Rapid Communications in Mass Spectrometry 14(16): 1448-1454.
- Bommel M.R. van, Jong A.P.J.M. van, Tjaden U.R., Irth H. & Greef J. van der (2000), High-performance liquid chromatography coupled to enzyme-amplified biochemical detection for the analysis of hemoglobin after pre-column biotinylation, Journal of Chromatography A 886(1-2): 19-29.
- Mazereeuw M., Spikmans V., Tjaden U.R. & Greef J. van der (2000), On-line isotachophoretic sample focusing for loadability enhancement in capillary electrochromatography-mass spectrometry, Journal of Chromatography A 879(2): 219-233.
- Ingkaninan K., Hazekamp A., Best C.M. de, Irth H., Tjaden U.R., Heijden R. van der, Greef J. van der & Verpoorte R. (2000), The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from Narcissus 'Sir Winston Churchill', Journal of Natural Products 63(6): 803-806.
- Ingkaninan K., Best C.M. de, Heijden R. van der, Hofte A.J.P., Karabatak B., Irth H., Tjaden U.R., Greef J. van der & Verpoorte R. (2000), High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products, Journal of Chromatography A 872(1-2): 61-73.
- Mazereeuw M., Best C.M. de, Tjaden U.R., Irth H. & Greef J. van der (2000), Free flow electrophoresis device for continuous on-line separation in analytical systems. An application in biochemical detection, Analytical Chemistry 72(16): 3881-3886.
- Toussaint B., Hubert P., Tjaden U.R., Greef J. van der & Crommen J. (2000), Enantiomeric separation of clenbuterol by transient isotachophoresis-capillary zone electrophoresis-UV detection - New optimization technique for transient isotachophoresis, Journal of Chromatography A 871(1-2): 173-180.
- Bommel M.R. van, Jong A.P.J.M. de, Tjaden U.R., Irth H. & Greef J. van der (1999), Enzyme amplification as detection tool in continuous-flow systems II. On-line coupling of liquid chromatography to enzyme-amplified biochemical detection after pre-column derivatization with biotin, Journal of Chromatography A 855(2): 397-409.
- Jespersen S., Chaurand P., Strien F.J.C. van, Spengler B. & Greef J. van der (1999), Direct sequencing of neuropeptides in biological tissue by MALDI-PSD mass spectrometry, Analytical Chemistry 71(3): 660-666.
- Reeuwijk H.J.E.M., Tjaden U.R. & Greef J. van der (1999), Development and validation of a bioanalytical assay for (E)-5-(2-bromovinyl)-2 '-deoxyuridine in plasma by capillary zone electrophoresis, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 726(1-2): 269-276.
- Spikmans V., Lane S.J., Tjaden U.R. & Greef J. van der (1999), Automated capillary electrochromatography tandem mass spectrometry using mixed mode reversed-phase ion-exchange chromatography columns, Rapid Communications in Mass Spectrometry 13(3): 141-149.
- Bommel M.R. van, Jong A.P.J.M. de, Tjaden U.R., Irth H. & Greef J. van der (1999), Enzyme amplification as detection tool in continuous-flow systems I. Development of an enzyme-amplified biochemical detection system coupled on-line to flow-injection analysis, Journal of Chromatography A 855(2): 383-396.
- Gysler J., Helk B., Dambacher S., Tjaden U.R. & Greef J. van der (1999), Characterization of recombinant cytokine fragments using isotachophoresis-capillary zone electrophoresis, reversed-phase high performance liquid chromatography, and mass spectrometry, Pharmaceutical Research 16(5): 695-701.
- Gysler J., Mazereeuw M., Helk B., Heitzmann M., Jaehde U., Schunack W., Tjaden U.R. & Greef J. van der (1999), Utility of isotachophoresis-capillary zone electrophoresis, mass spectrometry and high-performance size-exclusion chromatography for monitoring of interleukin-6 dimer formation, Journal of Chromatography A 841(1): 63-73.
- Vazquez-Martinez R.M., Malagon M.M., Strien F.J.C. van, Jespersen S., Greef J. van der, Roubos E.W. & Gracia-Navarro F. (1999), Analysis by mass spectrometry of POMC-derived peptides in amphibian melanotrope subpopulations, Life Sciences 64(11): 923-930.
- Greef J. van der (1999), 15th Montreux Symposium on Liquid Chromatography-Mass Spectrometry, Supercritical Fluid Chromatography-Mass Spectrometry, Capillary Electrophoresis-Mass Spectrometry and Tandem Mass Spectrometry - Montreux (Switzerland), 11-13 November 1998 - Foreword. [other].
- Greef J. van der (1998), Development of micro-electroseparation systems focused on mass spectrometric detection. Symposium on Microseparations. Lund, Sweden. [lecture].
- Hoeven R.A.M. van der, Hofte A.J.P., Tjaden U.R., Greef J. van der, Torto N., Gorton L., Marko-Varga G. & Bruggink C. (1998), Sensitivity improvement in the analysis of oligosaccharides by high-performance anion-exchange chromatography/ion spray mass spectrometry, Rapid Communications in Mass Spectrometry 12: 69-74.
- Jespersen S., Niessen W.M.A., Tjaden U.R. & Greef J. van der (1998), Basic matrices in the analysis of non-covalent complexes by matrix-assisted laser desorption/ionization mass spectrometry, Journal of Mass Spectrometry 33: 1088-1093.
- Gysler J., Helk B., Tjaden U.R. & Greef J. van der (1998), Characterization of recombinant cytokine fragment using isotachophoresis-capillary zone electrophoresis, reversed-phase high performance liquid chromatography, and mass spectrometry, PHARMACEUTICAL RESEARCH : .
- Hoeven R.A.M. van der, Tjaden U.R., Greef J. van der, Casteren W.H.M. van, Schols H.A., Voragen A.G.J. & Bruggink C. (1998), Recent progress in high-performance anion-exchange chromatography/ion spray mass spectrometry for molecular mass determination and characterization of carbohydrates using static and scanning array detection, Journal of Mass Spectrometry 33: 377-386.
- Oosterkamp A.J., Hoeven R.A.M. van der, Glässgen W., König B., Tjaden U.R. & Greef J. van der (1998), Gradient reversed-phase liquid chromatography coupled on-line to receptor-affinity detection based on the urokinase receptor, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences : .
- Lamoree M.H., Hoeven R.A.M. van der, Tjaden U.R. & Greef J. van der (1998), Application of microdialysis for on-line coupling of capillary isoelectric focusing with electrospray mass spectrometry on a magnetic sector instrument, Journal of Mass Spectrometry 33: 453-460.
- Reeuwijk H.J.E.M., Tjaden U.R. & Greef J. van der (1998), Development and validation of a bioanalytical assay for (E)-5-(2-bromovinyl)-2'-deoxyuridine in plasma by capillary zone electrophoresis, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences : .
- Gysler J., Helk B., Heitzmann M., Tjaden U.R. & Greef J. van der (1998), Utility of isotachophoresis-capillary zone electrophoresis, mass spectrometry and high performance size exclusion chromatography for monitoring of inter leukin-6 dimer formation, Journal of Chromatography A : .
- Mazereeuw M., Spikmans V., Tjaden U.R. & Greef J. van der (1998), On-lne isotachophoretic sample focusing for loadability enhancement in capillary electrochromatography-mass spectrometry, Journal of Chromatography A : .
- Stol R., Mazereeuw M., Tjaden U.R. & Greef J. van der (1998), Pseudo-electrokinetic packing of high efficiency columns for capillary electrochromatography, Journal of Chromatography A : .
- Torto N., Hofte A., v Hoeven R. van der, Tjaden U., Gorton L., Marko-Varga G., Bruggink C. & Greef J. van der (1998), Microdialysis introduction high-performance anion-exchange chromatography ionspray mass spectrometry for monitoring of on-line desalted carbohydrate hydrolysates, Journal of Mass Spectrometry 33(4): 334-341.
- Hofte A.J.P., Hoeven R.A.M. van der, Fung S.Y., Verpoorte R., Tjaden U.R. & Greef J. van der (1998), Characterization of hop acids by liquid chromatography with negative electrospray ionization mass spectrometry, Journal American Society Brewing Chemists 56(3): 118-122.
- Kokkonen P., Greef J. van der, Niessen W.M.A., Tjaden U.R., Hove G.J. ten & Werken G. van der (1989), Separation and Identification of Intact Glucosinolates Using Direct Coupling of High-performance Liquid Chromatography with Frit to Fast-atom Bombardment Mass Spectrometry, Rapid Communications in Mass Spectrometry 3(4): 102-106.
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