Henricus Verspaget
Professor emeritus Biobanking
- Name
- Prof.dr.ir. H.W. Verspaget
- h.w.verspaget@umail.leidenuniv.nl
- ORCID iD
- 0000-0001-5769-6887
Hein W. Verspaget is professor in Biobanking at the Leiden University Medical Center (LUMC). Nowadays he is head of the centralized biobank facility in the LUMC, national and LUMC biobank-coordinator of the Parelsnoer Institute from the Netherlands Federation of University Medical Centres. He is also staff member of the department of Gastroenterology-Hepatology at the LUMC, member of the board of the Dutch Society of Gastroenterology, and member of the executive committee of the Netherlands Donor Feces Bank.
Biobank
Main goal of the centralized biobanking organisation and the professorship of Hein W. Verspaget is to implement a high standard uniform infrastructure for disease-related biobanking in the LUMC, as a best practice model and in accordance with (inter)national law, rules and regulations. The biobanking organisation as such does not have a direct impact on the patient care. However, the biobanking activities are indicated to patients, recognising the invaluable importance of biobanking biomaterials and clinical data in order to perform research to improve patient care. This is executed by using a clear and open access general informed consent for research application of the requested information and accountability through (web-based) reporting of research results. Finally, results obtained in research setting from biobanking is made accessible to further (cyclical) improvement of patient care. The inter-divisional biobanking organisation within the LUMC provides a sustainable, accountable, high standard biobanking organisation which supports the profiling research areas and contributes to the valorisation of the biomedical research efforts. This also contributes to an increased engagement and (public) awareness of patients, medical doctors and basic scientists towards biobanking as a pivotal tool for clinical innovation.
Academic career
As a trained cell-biologist Hein W. Verspaget started his research on gastrointestinal diseases in 1979. He performed cellular and biomedical research on Inflammatory Bowel Diseases at the department of Gastroenterology and Hepatology of the LUMC. He defended his thesis entitled: Cellular activity in Crohn's disease, abnormalities in the immune response, in Leiden in 1987. Later on he also performed and supervised research on Gastrointestinal Cancer and on Liver Diseases and Liver Transplantation in the same department, at present he is still involved in these research lines. In December 2014 he became professor in Biobanking at the Leiden University Medical Center. The title of his inaugural lecture was: Biobanking for translational research: valuables, rules and playing field.
Professor emeritus Biobanking
- Faculteit Geneeskunde
- Divisie 2
- Maag-, Darm- en Leverziekten
- Broekhoven, A.G.C.; Ostyn, T.; Melkebeke, L. van; Verspaget, H.W.; Merwe, S. van der; Verbeek, J.; Coenraad, M.J.; Roskams, T.A. & Nevens, F. (2024), Histological characteristics in patients admitted to the hospital with alcoholic hepatitis complicated by acute-on-chronic liver failure, Scandinavian Journal of Gastroenterology 59(5): 577-583.
- Lingen, E. van; Nooij, S.; Terveer, E.M.; Crossette, E.; Prince, A.L.; Bhattarai, S.K.; Watson, A.; Galazzo, G.; Menon, R.; Szabady, R.L.; Bucci, V.; Norman, J.M.; Woude, C.J. van der; Marel, S. van der; Verspaget, H.W.; Meulen-de Jong, A.E. van der & Keller, J.J. (2024), Faecal microbiota transplantation engraftment after budesonide or placebo in patients with active ulcerative colitis using pre-selected donors, Journal of Crohn's and Colitis 18(9): 1381-1393.
- Schaapman, J.; Shumbayawonda, E.; Castelo-Branco, M.; Alves, F.C.; Costa, T.; Fitzpatrick, E.; Tupper, K.; Dhawan, A.; Deheragoda, M.; Sticova, E.; French, M.; Beyer, C.; Rymell, S.; Tonev, D.; Verspaget, H.; Neubauer, S.; Banerjee, R.; Lamb, H. & Coenraad, M. (2024), MRI-serum-based score accurately identifies patients undergoing liver transplant without rejection avoiding the need for liver biopsy, Liver Transplantation.
- Ouboter, L.F.; Barnhoorn, M.C.; Verspaget, H.W.; Plug, L.; Pool, E.S.; Szuhai, K.; Hawinkels, L.J.A.C.; Pel, M. van; Zwaginga, J.J.; Roelen, D.; Koning, F.; Pascutti, M.F. & Meulen-de Jong, A.E. van der (2023), Local administration of mesenchymal stromal cells is safe and modulates the immune compartment in ulcerative proctitis, JCI Insight 8(9).
- Broekhoven, A.; Postma, R.; Boer, H.C. de; Verspaget, H.W.; Hankemeier, T.; Coenraad, M.J.; Zonneveld, A.J. van & Duinen, V. van (2022), NOVEL MORPHOLOGICAL PROFILING ASSAY TO STUDY THE ROLE OF ENDOTHELIAL CELLS IN THE DISEASE TRAJECTORY OF LIVER CIRRHOSIS IN VITRO., Hepatology 76: S143-S144.
- Barnhoorn, M.C.; Meulen-de Jong, A.E. van der; Schrama, E.C.L.M.; Plug, L.G.; Verspaget, H.W.; Fibbe, W.E.; Pel, M. van; Hawinkels, L.J.A.C. & Schepers, K. (2022), Cytokine mixtures mimicking the local milieu in patients with inflammatory bowel disease impact phenotype and function of mesenchymal stromal cells, Stem Cells Translational Medicine 11(9).
- Groenewegen, B.; Lingen, E. van; Ooijevaar, R.E.; Wessels, E.; Feltkamp, M.C.W.; Boeije-Koppenol, E.; Verspaget, H.W.; Kuijper, E.J.; Prehn, J. van; Keller, J.J.; Terveer, E.M. & Study Grp Netherlands Donor Feces (2022), How to prepare stool banks for an appropriate response to the ongoing COVID-19 pandemic, PLoS ONE 17(3).
- Broekhoven, A.; Ostyn, T.; Melkebeke, L. van; Verspaget, H.W.; Merwe, S. van der; Verbeek, J.; Coenraad, M.; Roskams, T. & Nevens, F. (2022), Ductular bilirubinostasis is a diagnostic biomarker for acute-on-chronic liver failure: results from a well-defined cohort of patients with alcoholic steatohepatitis, Journal of Hepatology 77: S144-S144.
- Vendrik, K.E.W.; Terveer, E.M.; Kuijper, E.J.; Nooij, S.; Boeije-Koppenol, E.; Sanders, I.M.J.G.; Lingen, E. van; Verspaget, H.W.; Berssenbrugge, E.K.L.; Keller, J.J.; Prehn, J. van & Netherlands Donor Faeces Bank Stud (2021), Periodic screening of donor faeces with a quarantine period to prevent transmission of multidrug-resistant organisms during faecal microbiota transplantation: a retrospective cohort study, The Lancet Infectious Diseases 21(5): 711-721.
- Karkampouna, S.; Helm, D. van der; Scarpa, M.; Hoek, B. van; Verspaget, H.W.; Goumans, M.J.; Coenraad, M.J.; Kruithof, B.P.T. & Julio, M.K.D. (2021), Oncofetal protein CRIPTO is involved in wound healing and fibrogenesis in the regenerating liver and is associated with the initial stages of cardiac fibrosis, Cells 10(12).
- Nooij, S.; Ducarmon, Q.R.; Laros, J.F.J.; Zwittink, R.D.; Norman, J.M.; Smits, W.K.; Verspaget, H.W.; Keller, J.J.; Terveer, E.M.; Kuijper, E.J. & Netherlands Donor Feces Bank (2021), Fecal microbiota transplantation influences procarcinogenic Escherichia coli in recipient recurrent Clostridioides difficile patients, Gastroenterology 161(4): 1218-+.
- Ouboter, L.; Barnhoorn, M.; Plug, L.; Pel, M. van; Zwaginga, J.J.; Roelen, D.; Pascutti, E.; Koning, F.; Hawinkels, L.; Verspaget, H. & Meulen-de Jong, A. van der (2021), Endoscopically injected allogeneic mesenchymal stromal cells alter the mucosal immune cell compartment in patients with ulcerative proctitis, Journal of Crohn's and Colitis 15: S098-S099.
- Schaapman, J.; Ostyn, T.; Helm, D. van der; Haele, M. van; Reijden, J. van der; Nevens, F.; Verspaget, H.W.; Roskams, T. & Coenraad, M. (2021), Systemic and hepatic endothelial cell activation biomarkers expression are associated with inflammation and disease progression in patients with cirrhosis, Journal of Hepatology 75: S336-S337.
- Ooijevaar, R.E.; Nood, E. van; Goorhuis, A.; Terveer, E.M.; Prehn, J. van; Verspaget, H.W.; Beurden, Y.H. van; Dijkgraaf, M.G.W. & Keller, J.J. (2021), Ten-Year Follow-Up of Patients Treated with Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection from a Randomized Controlled Trial and Review of the Literature, Microorganisms 9(3).
- Ooijevaar, R.E.; Nood, E. van; Goorhuis, A.; Terveer, E.M.; Prehn, J. van; Verspaget, H.W.; Beurden, Y.H. van; Dijkgraaf, M.G.W. & Keller, J.J. (2021), Ten-Year Follow-Up of Patients Treated with Fecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection from a Randomized Controlled Trial and Review of the Literature, Microorganisms 9(3).
- Broekhoven, A.G.C.; Fiocco, M.; Sprengers, D.; Takkenberg, R.B.; Meer, S. van; Erpecum, K.J. van; Ramsoekh, D.; Verspaget, H.W.; Burgmans, M.C.; Osanto, S.; Baranski, A.G.; Hoek, B. van & Coenraad, M.J. (2021), Real-life data on the impact of successful downstaging in patients with hepatocellular carcinoma, European Journal of Internal Medicine 97.
- Drs, L.O.; Barnhoorn, M.; Pel, M. van; Zwaginga, J.J.; Hawinkels, L.; Maljaars, J.; Koning, F.; Verspaget, H. & Meulen-de de Jong, A. van der (2021), Locally injected allogeneic bone marrow-derived mesenchymal stromal cells for the treatment of refractory proctitis: clinical results of a phase IIa trial, Journal of Crohn's and Colitis 15: S381-S381.
- Keller, J.J.; Ooijevaar, R.E.; Hvas, C.L.; Terveer, E.M.; Lieberknecht, S.C.; Hogenauer, C.; Arkkila, P.; Sokol, H.; Gridnyev, O.; Megraud, F.; Kump, P.K.; Nakov, R.; Goldenberg, S.D.; Satokari, R.; Tkatch, S.; Sanguinetti, M.; Cammarota, G.; Dorofeev, A.; Gubska, O.; Laniro, G.; Mattila, E.; Arasaradnam, R.P.; Sarin, S.K.; Sood, A.; Putignani, L.; Alric, L.; Baunwall, S.M.D.; Kupcinskas, J.; Link, A.; Goorhuis, A.G.; Verspaget, H.W.; Ponsioen, C.; Hold, G.L.; Tilg, H.; Kassam, Z.; Kuijper, E.J.; Gasbarrini, A.; Mulder, C.J.J.; Williams, H.R.T. & Vehreschild, M.J.G.T. (2021), A standardised model for stool banking for faecal microbiota transplantation, United European Gastroenterology Journal 9(2).
- Bruckner, R.S.; Spalinger, M.R.; Barnhoorn, M.C.; Feakins, R.; Fuerst, A.; Jehle, E.C.; Rickenbacher, A.; Turina, M.; Niechcial, A.; Lang, S.; Hawinkels, L.J.A.C.; Meulen-de Jong, A.E. van der; Verspaget, H.W.; Rogler, G. & Scharl, M. (2021), Contribution of CD3(+)CD8(-) and CD3(+)CD8(+) T cells to TNF-alpha overexpression in crohn disease-associated perianal fistulas and induction of epithelial-mesenchymal transition in HT-29 cells, Inflammatory Bowel Diseases 27(4): 538-549.
- Ooijevaar, R.E.; Nood, E. van; Goorhuis, A.; Terveer, E.M.; Prehn, J. van; Verspaget, H.W.; Beurden, Y.H. van; Dijkgraaf, M.G.W. & Keller, J.J. (2021), Ten-year follow-up of patients treated with fecal microbiota transplantation for recurrent Clostridioides difficile infection from a randomized controlled trial and review of the literature, Microorganisms 9(3).
- Schaapman, J.J.; Amoros, A.; Reijden, J.J. van der; Laleman, W.; Zeuzem, S.; Banares, R.; Jalan, R.; Arroyo, V.; Claria, J.; Verspaget, H.W. & Coenraad, M.J. (2020), Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection, Liver International 40(3).
- Terveer, E.M.; Gool, T. van; Ooijevaar, R.E.; Sanders, I.M.J.G.; Boeije-Koppenol, E.; Keller, J.J.; Bart, A.; Kuijper, E.J. & Netherlands Donor Feces Bank NDFB (2020), Human transmission of blastocystis by fecal microbiota transplantation without development of gastrointestinal symptoms in recipients, Clinical Infectious Diseases 71(10): 2630-2636.
- Terveer, E.M.; Vendrik, K.E.W.; Ooijevaar, R.E.; Lingen, E. van; Boeije-Koppenol, E.; Nood, E. van; Goorhuis, A.; Bauer, M.P.; Beurden, Y.H. van; Dijkgraaf, M.G.W.; Mulder, C.J.J.; Vandenbroucke-Grauls, C.M.J.E.; Seegers, J.F.M.L.; Prehn, J. van; Verspaget, H.W.; Kuijper, E.J. & Keller, J.J. (2020), Faecal microbiota transplantation for Clostridioides difficile infection, United European Gastroenterology Journal 8(10): 1236-1247.
- Polytarchou, C.; Hatziapostolou, M.; Koutsioumpa, M.; Christodoulou, N.; Yau, T.O.; Birli, E.; Pomenya, O.; Montiel-Duarte, C.; Joshi, S.M.; Hommes, D.W.; Verspaget, H.W.; Yu, J. & Iliopoulos, D. (2020), A lncRNA-histone acetyltransferase complex induces colorectal oncogenesis through regulation of a metabolic kinase network, Cancer Research 80(16).
- Drs, L.O.; Barnhoorn, M.C.; Hawinkels, L.J.A.C.; Pel, M. van; Zwaginga, J.J.; Verspaget, H.W.; Koning, F.; Pascutti, M.F. & Meulen-de Jong, A.E. van der (2020), High-dimensional mass cytometry after local MSC treatment in patients with refractory proctitis shows an effect on the myeloid compartment: preliminary data, Journal of Crohn's and Colitis 14: S174-S175.
- Barnhoorn, M.C.; Plug, L.; Muller-De Jonge, E.S.M.; Molenkamp, D.; Bos, E.; Schoonderwoerd, M.J.A.; Corver, W.E.; Meulen-De Jong, A.E. van der; Verspaget, H.W. & Hawinkels, L.J.A.C. (2020), Mesenchymal stromal cell-derived exosomes contribute to epithelial regeneration in experimental inflammatory bowel disease.
- Barnhoorn, M.C.; Wasser, M.N.J.M.; Roelofs, H.; Maljaars, P.W.J.; Molendijk, I.; Bonsing, B.A.; Oosten, L.E.M.; Dijkstra, G.; Woude, C.J. van der; Roelen, D.L.; Zwaginga, J.J.; Verspaget, H.W.; Fibbe, W.E.; Hommes, D.W.; Peeters, K.C.M.J. & Meulen-de Jong, A.E. van der (2020), Long-term evaluation of allogeneic bone marrow-derived mesenchymal stromal cell therapy for Crohn's disease perianal fistulas, Journal of Crohn's and Colitis 14(1): 64-70.
- Barnhoorn, M.; Plug, L.; Muller-de Jonge, E.; Bos, E.; Meulen-de Jong, A. van der; Verspaget, H. & Hawinkels, L. (2019), Mesenchymal stromal cell-derived exosomes stimulate epithelial regeneration in vitro and reduce experimental colitis, Journal of Crohn's and Colitis 13: S15-S15.
- Ooijevaar, R.E.; Terveer, E.M.; Verspaget, H.W.; Kuijper, E.J.; Keller, J.J. & Klotman, M.E. (2019), Clinical Application and Potential of Fecal Microbiota Transplantation, Annual Review of Medicine 70: 335-351.
- Barnhoorn, M.C.; Halteren, A.G.S. van; Pel, M. van; Molendijk, I.; Struijk, A.C.; Jansen, P.M.; Verspaget, H.W.; Dijkstra, G.; Oosten, L.E.M. & Meulen-de Jong, A.E. van der (2019), Lymphoproliferative Disease in the Rectum 4 Years After Local Mesenchymal Stromal Cell Therapy for Refractory Perianal Crohn's Fistulas: A Case Report, Journal of Crohn's and Colitis 13(6): 807-811.
- Schaapman, J.; Alex, A.; Reijden, J. van der; Laleman, W.; Zeuzem, S.; Banares, R.; Jalan, R.; Arroyo, V.; Verspaget, H.W. & Coenraad, M. (2019), Genetic variants of innate immunity receptors are associated with mortality but not with bacterial infections in liver cirrhosis, Journal of Hepatology 70(1): E182-E182.
- Keller, J.J.; Vehreschild, M.J.G.T.; Hvas, C.L.; Jorgensen, S.M.D.; Kupciskas, J.; Link, A.; Mulder, C.J.J.; Goldenberg, S.D.; Arasaradnam, R.; Sokol, H.; Gasbarrini, A.; Hoegenauer, C.; Terveer, E.M.; Kuijper, E.J.; Arkkila, P.; Gasbarrini, A.; Gridnyev, O.; Megraud, F.; Kump, P.K.; Nakov, R.; Goldenberg, S.D.; Satokari, R.; Tkatch, S.; Sanguinetti, M.; Sokol, H.; Cammarota, G.; Dorofeev, A.; Keller, J.J.; Hoegenauer, C.; Gubska, O.; Ianiro, G.; Mattila, E.; Ooijevaar, R.E.; Arasaradnam, R.; Sarin, S.K.; Sood, A.; Putignani, L.; Alric, L.; Arkkila, P.; Hvas, C.L.; Jorgensen, S.M.D.; Kuijper, E.J.; Kupciskas, J.; Link, A.; Mulder, C.J.J.; Williams, H.R.T.; Goorhuis, A.; Verspaget, H.W.; Terveer, E.M.; Hold, G.L.; Tilg, H.; Ponsioen, C.Y. & Standards Guidelines Initiative (2019), Stool for fecal microbiota transplantation should be classified as a transplant product and not as a drug.
- Barnhoorn, M.; Schepers, K.; Verspaget, H.; Fibbe, W.; Hawinkels, L.; Pel, M. van & Meulen-de Jong, A. van der (2019), The cytokine milieu in patients with inflammatory bowel disease impacts the phenotype of mesenchymal stromal cells, Journal of Crohn's and Colitis 13: S106-S107.
- Helm, D. van der; Barnhoorn, M.C.; Jonge-Muller, E.S.M. de; Molendijk, I.; Hawinkels, L.J.A.C.; Coenraad, M.J.; Hoek, B. van & Verspaget, H.W. (2019), Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers, Journal of Cellular and Molecular Medicine 23(9): 6238-6250.
- Terveer, E.M.; Beurden, Y.H. van; Goorhuis, A.; Mulder, C.J.J.; Kuijper, E.J.; Keller, J.J. & Working Grp Netherlands Donor Fece (2018), Faecal microbiota transplantation in clinical practice, Gut 67(1): 196-196.
- Molendijk, I.; Meulen-de Jong, A.E. van der; Verspaget, H.W.; Veenendaal, R.A.; Hommes, D.W.; Bonsing, B.A. & Peeters, K.C.M.J. (2018), Standardization of mesenchymal stromal cell therapy for perianal fistulizing Crohn's disease, European Journal of Gastroenterology and Hepatology 30(10): 1148-1154.
- Strijker, M.; Gerritsen, A.; Hilst, J. van; Bijlsma, M.F.; Bonsing, B.A.; Brosens, L.A.; Bruno, M.J.; Dam, R.M. van; Dijk, F.; Eijck, C.H. van; Sarasqueta, A.F.; Fockens, P.; Gerhards, M.F.; Koerkamp, B.G.; Harst, E. van der; Hingh, I.H. de; Hooft, J.E. van; Huysentruyt, C.J.; Kazemier, G.; Klaase, J.M.; Laarhoven, C.J. van; Laarhoven, H.W. van; Liem, M.S.; Meijer, V.E. de; Rijssen, L.B. van; Santvoort, H.C. van; Suker, M.; Verhagen, J.H.; Verheij, J.; Verspaget, H.W.; Wennink, R.A.; Wilmink, J.W.; Molenaar, I.Q.; Boermeester, M.A.; Busch, O.R. & Besselink, M.G. (2018), The Dutch Pancreas Biobank Within the Parelsnoer Institute: A Nationwide Biobank of Pancreatic and Periampullary Diseases, Pancreas 47(4): 495-501.
- Helm, D. van der; Groenewoud, A.; Jonge-Muller, E.S.M. de; Barnhoorn, M.C.; Schoonderwoerd, M.J.A.; Coenraad, M.J.; Hawinkels, L.J.A.C.; Snaar-Jagalska, B.E.; Hoek, B. van & Verspaget, H.W. (2018), Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model, Scientific Reports 8.
- Strijker, M.; Gerritsen, A.; Hilst, J. van; Bijlsma, M.F.; Bonsing, B.A.; Brosens, L.A.; Bruno, M.J.; Dam, R.M. van; Dijk, F.; Eijck, C.H. van; Sarasqueta, A.F.; Fockens, P.; Gerhards, M.F.; Koerkamp, B.G.; Harst, E. van der; Hingh, I.H. de; Hooft, J.E. van; Huysentruyt, C.J.; Kazemier, G.; Klaase, J.M.; Laarhoven, C.J. van; Laarhoven, H.W. van; Liem, M.S.; Meijer, V.E. de; Rijssen, L.B. van; Santvoort, H.C. van; Suker, M.; Verhagen, J.H.; Verheij, J.; Verspaget, H.W.; Wennink, R.A.; Wilmink, J.W.; Molenaar, I.Q.; Boermeester, M.A.; Busch, O.R. & Besselink, M.G. (2018), The Dutch Pancreas Biobank Within the Parelsnoer Institute: A Nationwide Biobank of Pancreatic and Periampullary Diseases, Pancreas 47(4): 495-501.
- Dulk, A.C. den; Shi, X.L.; Verhoeven, C.J.; Dubbeld, J.; Claas, F.H.J.; Wolterbeek, R.; Brand-Schaaf, S.H.; Verspaget, H.W.; Sarasqueta, A.F.; Laan, L.J.W. van der; Metselaar, H.J.; Hoek, B. van; Kwekkeboom, J. & Roelen, D.L. (2018), Donor-specific anti-HLA antibodies are not associated with nonanastomotic biliary strictures but both are independent risk factors for graft loss after liver transplantation, Clinical Transplantation 32(2).
- Karkampouna, S.; Helm, D. van der; Gray, P.C.; Chen, L.P.; Klima, I.; Grosjean, J.; Burgmans, M.C.; Farina-Sarasqueta, A.; Snaar-Jagalska, E.B.; Stroka, D.M.; Terracciano, L.; Hoek, B. van; Schaapherder, A.F.; Osanto, S.; Thalmann, G.N.; Verspaget, H.W.; Coenraad, M.J. & Kruithof-de Julio, M. (2018), CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma, Journal of Pathology 245(3): 297-310.
- Kerbert, A.J.C.; Reverter, E.; Verbruggen, L.; Tieleman, M.; Navasa, M.; Mertens, B.J.A.; Rodriguez-Tajes, S.; Vree, M. de; Metselaar, H.J.; Chiang, F.W.T.; Verspaget, H.W.; Hoek, B. van; Bosch, J. & Coenraad, M.J. (2018), Impact of hepatic encephalopathy on liver transplant waiting list mortality in regions with different transplantation rates, Clinical Transplantation 32(11).
- Barnhoorn, M.; Jonge-Muller, E. de; Molendijk, I.; Gulijk, M. van; Lebbink, O.; Janson, S.; Schoonderwoerd, M.; Helm, D. van der; Meulen-de Jong, A. van der; Hawinkels, L. & Verspaget, H. (2018), Endoscopic Administration of Mesenchymal Stromal Cells Reduces Inflammation in Experimental Colitis, Inflammatory Bowel Diseases 24(8): 1755-1767.
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- Roos A, Bouwman LH, Terpstra OT, de Knijff P, van Hoek B, Verspaget HW, Berger SP, Daha MR, Frolich M, van der Slik AR, Doxiadis II, Roep BO & Schaapherder AFM (2006), Mannose-binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation, Molecular Immunology 43(1-2).
- Verspaget HW, Kuyvenhoven JP & van Hoek B (2005), Preanalytical conditions and circulating matrix metalloproteinases, Transplantation 79(6).
- Bouwman LH, Terpstra OT, Schaapherder AFM, Roos A, Berger SP, Daha MR, De Knijff P, Van Hoek B, Verspaget HW, Frolich M, Van der Slik AR, Doxiadis II & Roep BO (2005), Mannose-binding lectin and liver transplantation - Reply, Gastroenterology 129(5).
- van der Veek PPJ, van den Berg M, de Kroon YE, Verspaget HW & Masclee AAM (2005), Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome, American Journal of Gastroenterology 100(11).
- Gao Q, Meijer MJW, Kubben FJGM, Sier CFM, Kruidenier L, van Duijn W, van den Berg M, van Hogezand RA, Lamers CBHW & Verspaget HW (2005), Expression of matrix metalloproteinases-2 and-9 in intestinal tissue of patients with inflammatory bowel diseases, Digestive and Liver Disease 37(8).
- Bouwman LH, Roos A, Terpstra OT, De Knijff P, Van Hoek B, Verspaget HW, Berger SP, Daha MR, Frolich M, Van Der Slik AR, Doxiadis II, Roep BO & Schaapherder AFM (2005), Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation, Gastroenterology 129(2).
- Gao Q, Van Hogezand RA, Lamers CBHW & Verspaget HW (2004), Basic fibroblast growth factor as a response parameter to infliximab in fistulizing Crohn's disease, Alimentary Pharmacology and Therapeutics 20(5).
- Kuyvenhoven JP, Verspaget HW, Gao Q, Ringers J, Smit VTHBM, Lamers CBHW & Van Hoek B (2004), Assessment of serum matrix metalloproteinases MMP-2 and MMP-9 after human liver transplantation: Increased serum MMP-9 level in acute rejection, Transplantation 77(11).
- Kuyvenhoven JP, Molenaar IQ, Verspaget HW, Veldman MG, Palareti G, Legnani C, Moolenburgh SE, Terpstra O, Lamers CBHW, van Hoek B & Porte RJ (2004), Plasma MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 during human orthotopic liver transplantation - The effect of aprotinin and the relation to ischemia/reperfusion injury, Thrombosis and Haemostasis 91(3).
- Kruidenier L, Kuiper I, van Duijn W, Marklund SL, van Hogezand RA, Lamers CBHW & Verspaget HW (2003), Differential mucosal expression of three superoxide dismutase isoforms in inflammatory bowel disease, Journal of Pathology 201(1).
- Kruidenier L, Kuiper I, van Duijn W, Mieremet-Ooms MAC, van Hogezand RA, Lamers CBHW & Verspaget HW (2003), Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease, Journal of Pathology 201(1).
- Kruidenier L, Kulper I, Lamers CBHW & Verspaget HW (2003), Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants, Journal of Pathology 201(1).
- Kruidenier L, Van Meeteren ME, Kuiper I, Jaarsma D, Lamers CBHW, Zijlstra FJ & Verspaget HW (2003), Attenuated mild colonic inflammation and improved survival from severe DSS-colitis of transgenic Cu/Zn-SOD mice, Free Radical Biology and Medicine 34(6).
- Kuyvenhoven JP, Ringers J, Verspaget HW, Lamers CBHW & van Hoek B (2003), Serum matrix metalloproteinase MMP-2 and MMP-9 in the late phase of ischemia and reperfusion injury in human orthotopic liver transplantation, Transplantation Proceedings 35(8).
- Kuyvenhoven JP, van Hoek B, Blom E, van Duijn W, Hanemaaijer R, Verheijen JH, Lamers CBHW & Verspaget HW (2003), Assessment of the clinical significance of serum matrix metalloproteinases MMP-2 and MMP-9 in patients with various chronic liver diseases and hepatocellular carcinoma, Thrombosis and Haemostasis 89(4).
- Mourad-Baars PEC, Verspaget HW, Verhoeff JDBM, Mertens BJA, Verloove-Vanhorick PS & Mearin LM (2002), The prevalence of Helicobacter pylori (Hp) infection in young children in the Netherlands, Gut 51.
- Kruidenier L & Verspaget HW (2002), Review article: oxidative stress as a pathogenic factor in inflammatory bowel disease - radicals or ridiculous?, Alimentary Pharmacology and Therapeutics 16(12).
- Janssen AML, van Duijn W, Kubben FJGM, Griffioen G, Lamers CBHW, van Krieken JHJM, van de Velde CJH & Verspaget HW (2002), Prognostic significance of metallothionein in human gastrointestinal cancer, Clinical Cancer Research 8(6).
- Verspaget HW, van der Zon AM, Gao Q & van Hogezand RA (2001), Infliximab for Crohn's disease, Alimentary Pharmacology and Therapeutics 15(12).
- Jaarsma D, Rognoni F, van Duijn W, Verspaget HW, Haasdijk ED & Holstege JC (2001), CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations, Acta Neuropathologica 102(4).
- Wagtmans MJ, Verspaget HW, Lamers CBHW & van Hogezand RA (2001), Gender-related differences in the clinical course of Crohn's disease, American Journal of Gastroenterology 96(5).
- Bus PJ, Verspaget HW, Lamers CBHW & Griffioen G (2000), Chemoprevention of colorectal cancer by non-steroidal anti-inflammatory drugs, Scandinavian Journal of Gastroenterology 35.
- Jaarsma D, Haasdijk ED, Grashorn JAC, Hawkins R, van Duijn W, Verspaget HW, London J & Holstege JC (2000), Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1, Neurobiology of Disease 7(6).
- Smoot DT, Elliott TB, Verspaget HW, Jones D, Allen CR, Vernon KG, Bremner T, Kidd LR, Kim GS, Groupman JD & Ashktorab H (2000), Influence of Helicobacter pylori on reactive oxygen-induced gastric epithelial cell injury, Carcinogenesis 21(11).
- Janssen AML, van Duijn W, Oostendorp-van de Ruit MM, Kruidenier L, Bosman CB, Griffioen G, Lamers CBHW, van Krieken JHJM, van de Velde CJH & Verspaget HW (2000), Metallothionein in human gastrointestinal cancer, Journal of Pathology 192(3).
- Wrigley E, Verspaget HW, Jayson GC & McGown AT (2000), Metallothionein expression in epithelial ovarian cancer: effect of chemotherapy and prognostic significance, Journal of Cancer Research and Clinical Oncology 126(12).
- Janssen AML, Bosman CB, van Duijn W, Oostendorp-van de Ruit MM, Kubben FJGM, Griffioen G, Lamers CBHW, van Krieken JHJM, van de Velde CJH & Verspaget HW (2000), Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer.
- Bestuurslid
- Landelijk biobankcoördinator en lid Centraal team
- Lid VENI-selectiecommissie