Helga van der Heul
Research Analyst
- Name
- Dr. H.U. van der Heul
- Telephone
- +31 71 527 4294
- h.u.van.der.heul@biology.leidenuniv.nl
- ORCID iD
- 0000-0002-4401-9585
I am a PhD student working on the novel natural product lugdunomycin, which is produced by Streptomyces sp. QL37. The goal of my PhD will be to improve the production of this molecule in order to obtain sufficient material to determine the functionality of the molecule as an antibiotic or anti-cancer agent. This goal will be reached by gaining insight in the transcriptional regulation of the biosynthetic gene cluster and the biosynthetic pathway involved in lugdunomycin production. I am using techniques such as Streptomyces culturing, molecular cloning, heterologous expression, natural products extractions and the input of liquid chromatography- mass spectrometry (LC-MS) data to identify and quantify the production of lugdunomycin. This project is one of the projects of the Centre for Antimicrobial Research (CARES).
Supervisor(s)
Research Analyst
- Science
- Instituut Biologie Leiden
- IBL Microbial Sciences
- Nuutila A., Xiao X., Heul H.U. van der, Wezel G.P. van Dinis P., Elsayed S.S.M.A. & Metsä-Ketelä M. (2024), Divergence of classical and C-Ring-Cleaved Angucyclines: Elucidation of early tailoring steps in Lugdunomycin and Thioangucycline biosynthesis, ACS Chemical Biology 19(5): 1131-1141.
- Elsayed S.S.M.A., Heul H.U. van der, Xiao X., Nuutila A., Baars L.R., Wu C., Metsä-Ketelä M. & Wezel G.P. van (2023), Unravelling key enzymatic steps in C-ring cleavage during angucycline biosynthesis, Communications Chemistry 6: 281.
- Heul H.U. van der (21 December 2022), Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production (Dissertatie. Institute of Biology Leiden (IBL), Faculty of Science, Leiden University). Supervisor(s) and Co-supervisor(s): Wezel G.P. van, Elsayed S.S.
- Xiao X., Elsayed S.S.M.A., Wu C., Heul H.U. van der, Metsä-Ketelä M., Du C., Prota A.E., Chen C.C., Liu W., Guo R.T., Abrahams J.P. & Wezel G.P. van (2020), Functional and structural insights into a novel promiscuous ketoreductase of the lugdunomycin biosynthetic pathway, ACS Chemical Biology 15(9): 2529-2538.
- Uiterweerd M.T., Nuñez Santiago I., Heul H.U. van der, Wezel G.P. van & Minnaard A.J. (2020), Iso‐maleimycin, a constitutional isomer of maleimycin, from streptomyces sp. QL37, European Journal of Organic Chemistry (32): 5145-5152.
- Heul H.U. van der, Byly B.L., McDowall K.J. & Seipke R.F. Wezel G.P. van (2018), Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era: new perspectives from the post-genomic era, Natural Product Reports 35: 575-604.