Douwe Breimer
Professor emeritus Pharmacology
- Name
- Prof.dr. D.D. Breimer
- Telephone
- +31 71 527 2727
- ddbreimer@lacdr.leidenuniv.nl
Douwe Breimer is Professor of Pharmacology and was both rector magnificus and president of the Executive Board of Leiden University. His research focusses on pharmacokinetics, pharmacodynamics and drug metabolism.
Breimer studied pharmacology at the University of Groningen (1962–1970) and obtained his Ph.D. from the Catholic University of Nijmegen. In 1975, he was appointed professor of pharmacology at Leiden University. Breimer co-authored over 500 scientific papers and supervised more than 50 Ph.D. students.
Breimer holds honorary doctorates from Ghent University, Uppsala University(1992), Semmelweis University (Budapest), the University of Navarra (Pamplona), Hoshi University (Tokyo), the University of London and the Université de Montréal.
Professor emeritus Pharmacology
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Pharmacology
- Loryan I., Smith D.E., Artursson P., Breimer D.D., Deguchi Y., Paalzow L., Sugiyama Y., Terasaki T. & Lange E.C.M. de (2022), Professor Margareta Hammarlund-Udenaes: humbled scientist shaping modern neuropharmacokinetics, Pharmaceutical Research 39(7): 1283-1289.
- Burggraaf J., Breimer D.D., Graaf P.H. van der. & Lange E.C.M. de (2017), Editorial Special Supplement of the European Journal of Pharmaceutical Sciences on the occasion of the retirement of Professor Meindert Danhof as Professor of Pharmacology at Leiden University, European Journal of Pharmaceutical Sciences 109(Supplement): S1.
- Gaillard P.J., Boer A.G. de & Breimer D.D. (2002), Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro, Microvasc. Res. 65(1): 24-31.
- Boer A.G de, Lange E.C.M. de, Sandt I.C.J. van der & Breimer D.D. (2000), The application of microdialysis techniques to the study of drug transport across the blood-brain-barrier. In: Begley D.J., Bradbury M.W. & Kreuter J. (Eds.), The blood-brain barrier and drug delivery to the CNS: CRC Press.
- Steveninck A.L. van, Berckel B.N.M. van, Schoemaker R.C., Breimer D.D., Gerven J.M.A. van & Cohen A.F. (1999), The sensitivity of pharmacodynamic tests for central nervous system effects of drugs on the effects of sleep deprivation, Journal of Psychopharmacology 3: 10-17.
- Lange E.C.M. de, Boer A.G. de & Breimer D.D. (1999), Microdialysis for pharmacokinetic analysis of drug transport to the brain, Advanced Drug Delivery Reviews 36(2,3): 211-228.
- Hesselink M.B., Smolders H., Breimer D.D., Boer A.G. de & Danysz W. (1999), Modifications of the behavioral profile of non-competitive NMDA receptor antagonists, memantine, amantadine and (+)MK-801 after chronic administration, BEHAVIOURAL PHARMACOLOGY 10(1): 85-98.
- Boer A.G. de, Lange E.C.M. de, Sandt I.C.J. van der & Breimer D.D. (1998), Transporters and the blood-brain barrier (BBB), International Journal of Clinical Pharmacology and Therapeutics 36(1): 14-15.
- Breimer D.D. (1998), Het transport van geneesmiddelen over de Bloedhersenbarrière, Verhandelingen van de Kon. Academie voor Geneeskunde in België LX-1: 47-61.
- Desrayaud S., Lange E.C.M. de, Lemaire M., Bruelisauer A., Boer A.G. de & Breimer D.D. (1998), Effect of the Mdr1a P-glycoprotein gene disruption on the tissue distribution of SDZ PSC 833, a multidrug resistance-reversing agent, in mice, Journal of Pharmacology and Experimental Therapeutics 285(2): 438-443.
- Breimer D.D. (1998), Future challenges for drug delivery. In: , Second Yugoslav Congress of Pharmacy with International Participation. Belgrade, Yugoslav: Arhiv za Farmaciju. 380-384.
- Lange E.C.M. de, Boer A.G. de & Breimer D.D. (1998), Intracerebral microdialysis. In: Pardridge W.M. (Ed.), An introduction to the blood-brain-barrier. Cambridge, USA: Cambridge University Press. 94-112.
- Boer A.G. de & Breimer D.D. (1998), Cytokines and Blood-Brain Barrier permeability. In: Sharma H.S. & Westman J. (Eds.), Progress in Brain Research: Elsevier Science BV. 425-451.
- Meijer O.C., Lange E.C.M. de, Boer A.G. de, Workel J.O., Breimer D.D. & Kloet E.R. de (1998), Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice, Endocrinology 139: 1789-1793.
- Breimer D.D. (1998), Future challenges for drug delivery research, Advanced Drug Delivery Reviews 33: 265-268.
- Breimer D.D. (1998), Over de bloedhersenbarrière: transport van geneesmiddelen naar de hersenen. In: , Afdeling Natuurkunde KNAW. Amsterdam: KNAW. 82-86.
- Lange E.C.M. de, Bock G.H. de, Schinkel G., Boer A.G. de & Breimer D.D. (1998), BBB Transport and P-glycoprotein functionality using mdr1A (-/-) and Wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123, PHARMACEUTICAL RESEARCH 15(11): 1657-1665.
- Sandt I.C.J. van der, Boer A.G. de, Danhof M. & Breimer D.D. (1998), Selectivity of P-glycoprotein substrates rhodamine-123 and doxorubicin in wild-type and MDR1 cDNA transfected LLC-PK1 cells, British Journal of Pharmacology : 130P.
- Boer A.G. de, Gaillard P.J., Lange E.C.M. de, Danhof M., Vries H.E. de, Kuiper J. & Breimer D.D. (1997), Drug transport across blood-brain barriers: in vitro vs. in vivo models, Developments in animal and veterinary sciences 27: 873-879.
- Lange E.C.M. de, Boer A.G. de & Breimer D.D. (1997), Monitoring in vivo blood-brain barrier drug transport: Cerebrospinal fluid sampling, the unit impulse response method and, with special reference, intracerebral microdialysis, S.T.P. Pharma Sciences 7(1): 17-27.
- Lange E.C.M. de, Danhof M., Boer A.G. de & Breimer D.D. (1997), Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier, Brain research reviews 25(1): 27-49.
- Lange E.C.M. de (1997), Effect of perfusate tonicity and temperature on microdialysate AUC values of acetaminophen and atenolol obtained from rat cortical brain. In: Boer A.G. de & Sutanto W. (Eds.), Drug transport across the blood-brain-barrier. In vitro and in vivo techniques. Amsterdam: Harwood Academic Publishers. 157-163.
- Lange E.C.M. de, Vries J.D. de, Zurcher C., Danhof M., Boer A.G. de & Breimer D.D. (1995), The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain, 12(12): 1924-1931.
- Lange E.C.M. de, Hesselink M.B., Danhof M., Boer A.G. de & Breimer D.D. (1995), The use of intracerebral microdialysis to determine changes in blood-brain-barrier transport, 12(1): 129-133.
- Lange E.C.M. de, Danhof M., Zurcher C., Boer A.G. de & Breimer D.D. (1995), Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability, Brain Research 702(1-2): 261-265.
- Lange E.C.M. de, Bouw M.R., Mandema J.W., Danhof M., Boer A.G. de & Breimer D.D. (1995), Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat-brain, British Journal of Pharmacology 116(5): 2538-2544.
- Boer A.G. de, Vries H.E. de, Lange E.C.M. de, Danhof M., Kuiper J. & Breimer D.D. (1994), Drug transport to the brain: in-vitro versus in-vivo approaches, 28(1-3): 259-263.
- Lange E.C.M. de, Danhof M., Boer A.G. de & Breimer D.D. (1994), Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brain, Brain Research 666(1): 1-8.
- Lange E.C.M. de, Danhof M., Boer A.G. de & Breimer D.D. (1993), The use of intracerebral microdialysis to study blood-brain-barrier transport in health, after modification and in disease. In: Drewes L.R. & Betz A.L. (Eds.), Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology no. 331. New York: Springer. 257-262.
- Lange E.C.M. de, Danhof M., Boer A.G. de & Breimer D.D. (1991), The use of intracerebral microdialysis for the characterization of drug transport into the brain. Rollema H., Westerink B.H.C. & Drijfhout W.J. (Eds.), 5th International Conference on In Vivo Methods. Monitoring molecules in neuroscience 21 September 1991 - 24 September 1991: International Society for Monitoring Molecules in Neuroscience. 74-75.
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