Dennis Hetterscheid
Associate professor
- Name
- Dr. D.G.H. Hetterscheid
- Telephone
- +31 71 527 4545
- d.g.h.hetterscheid@chem.leidenuniv.nl
- ORCID iD
- 0000-0001-5640-4416
Dennis Hetterscheid tries to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. The research of Dennis Hetterscheid is carried out both in the MCBIM and CASC research groups of Leiden University.
More information about Dennis Hetterscheid
PhD candidates
News
Teaching
Former PhD Candidates
Curriculum Vitae
Personal information
Nationality: Dutch
Date of birth: 6 October 1978
Education
2007 PhD, Faculty of Science, Radboud University Nijmegen, the Netherlands, 15 March 2007.
Thesis title: "The chemistry of organometallic RhII and IrII complexes"
Advisors: Prof. B. de Bruin and Prof. A.E. Rowan
2002 MSc in Chemistry, Faculty of Science, Radboud University Nijmegen
Current and previous research positions
2018 – now Associate professor, Leiden Institute of Chemistry, Leiden University the Netherlands
2013 – 2018 Tenure Track Assistant professor, Leiden Institute of Chemistry, Leiden University the Netherlands
2009 – 2012 Post-doctoral Researcher, Van ‘t Hoff Institute for Molecular Sciences, University of Amsterdam, the Netherlands, supported by a Veni fellowship (Prof. J.N.H. Reek)
2007 – 2008 Post-doctoral Researcher, Department of Inorganic Chemistry, Massachusetts Institute of Technology, United States, supported by a Rubicon Fellowship (Prof. R.R. Schrock)
Grants, awards, recognitions
2019 EU ERC Proof of Concept grant (k€ 150)
2018 NWO Mat4Sus grant (k€ 700) in collaboration with Prof. Jarl Ivar van der Vlugt (Oldenburg) and Dr. Stefania Grecea (University of Amsterdam)
2014 FOM ‘CO2 neutral fuels’ programme grant with M.T.M. Koper and E. Bouwman (k€ 464)
2014 NWO-CW ECHO-STIP grant (k€ 260)
2014 EU ERC Starting Grant (k€ 1,500)
Contribution to teaching and supervision
- Teaching the courses “Statistische Thermodynamica en Spectroscopie” (BSc), “Bioinorganic Catalysis” (MSc), “Anthropocene, the Era of Man” (BSc), and “the Group Project on Sustainable Chemistry and Biotechnology” (BSc)
- Content coordinator of the minor on Sustainable Chemistry and Biotechnology
- Member of the Education boards of the Holland Research School of Molecular Chemistry (HRSMC) and the Netherlands Institute for Catalysis Research (NIOK)
- Member of the Chemistry MSc Program committee until 2022
- Member of the Molecular Science and Technology exam committee since 2022, and chair from November 2023 onwards
Supervision of 15 PhD students since 2013.
Other responsibilities
- Chair of the Advisory Board of the Wiley journal ChemistrySelect
- Member of the Advisory board of EurJIC
- Guest editor of the EurJIC special issue on Inorganic Reaction Mechanisms
- Co-organizer of the Kroese-Duijsters Symposium 2023 on “Reaction mechanisms in heterogeneous, inorganic and biological electro(photo)catalysis”
Publication record including five recent representative publications
>60 papers with >3000 citations, H-index 27 (Web of Science)
Full publication record: ResearcherID
- Den Boer, D., Hetterscheid, D. G. H. Correlations between the electronic structure and energetics of the catalytic steps in homogeneous water oxidation catalysis. J. Am. Chem. Soc. 2023. DOI: 10.1021/jacs.3c05741
- Langevelde P.H. van, Engbers S., Buda F., Hetterscheid D.G.H. Elucidation of the Electrocatalytic Nitrite Reduction Mechanism by Bio-Inspired Copper Complexes. ACS Catalysis, 2023, 13, 10094-10103. DOI: 10.1021/acscatal.3c01989
- Langevelde, P.H. van, Kounalis, E., Killian, L., Monkcom, E.C., Broere, D.L.J., Hetterscheid, D.G.H. Mechanistic Investigations into the Selective Reduction of Oxygen by a Multicopper Oxidase T3 Site-Inspired Dicopper Complex. ACS Catalysis, 2023, 13, 5712-5722. DOI: 10.1021/acscatal.3c01143
- D’Agostini, S., Kottrup, K.G., Casadevall, C., Gamba, I., Dantignana, V., Bucci,A., Costas,M., Lloret-Fillol, J., Hetterscheid, D.G.H. Electrocatalytic Water Oxidation with α-[Fe(mcp)(OTf)2] and Analogues. ACS Catal. 2021, 11, 2583–2595. DOI: 10.1021/acscatal.0c05439
- Langerman, M., Hetterscheid, D.G.H. Fast Oxygen Reduction Catalyzed by a Copper(II) Tris(2-pyridylmethyl)amine Complex through a Stepwise Mechanism. Angew. Chem. Int. Ed. 2019, 58, 12974–12978. DOI: 10.1002/anie.201904075
Presentations including five presentations at international conferences
Several invited presentations at universities, institutes, and invited lectures at international conferences.
- 44th International Conference on Coordination Chemistry, August 28th – September 2nd 2022, Rimini, Italy
- nanoGe Materials for Sustainable Development Conference, March 6th – March 10th 2023, Valencia, Spain
- 240th Meeting of the Electrochemical Society, October 10th – October 14th 2021, Digital Meeting
- QBIC Society Award Symposium, July 5th and 7th 2021, Digital Meeting
- International Solar Fuels Conference 2021, July 26th – July 29th 2021, Digital Meeting
Associate professor
- Science
- Leiden Institute of Chemistry
- LIC/Energy & Sustainability
- Rademaker D., Tanase S., Kang H., Hofmann J.P. & Hetterscheid D.G.H. (2024), Selective electrochemical oxygen reduction to hydrogen peroxide by confinement of cobalt porphyrins in a metal-organic framework, Chemistry - A European Journal 30(45): e202401339.
- Jeuken L.J.C., Hetterscheid D.G.H., Koper M.T.M., Casadevall C., Léger C., Llobet A., Milton R.D., Nakamura R. & Tschulik K. (2024), Toward an informative comparison of heterogeneous, synthetic, and biological electrocatalysis in energy conversion, Chem Catalysis : 101098.
- Langevelde P.H. van & Hetterscheid D.G.H. (2024), Selective electrochemical H2O2 production by a molecular copper catalyst: a crucial relation between reaction rate and mass transport, Chem Catalysis 4(8): 101069.
- Langevelde P.H. van, Kounalis E., Killian L., Monkcom E.C., Broere D.L.J. & Hetterscheid D.G.H. (2023), Mechanistic investigations into the selective reduction of oxygen by a multicopper oxidase T3 site-inspired dicopper complex, ACS Catalysis 13(8): 5712-5722.
- Langevelde P.H. van, Engbers S., Buda F. & Hetterscheid D.G.H. (2023), Elucidation of the electrocatalytic nitrite reduction mechanism by bio-inspired copper complexes, ACS Catalysis 13(15): 10094-10103.
- Hoefnagel M.E., Rademaker D. & Hetterscheid D.G.H. (2023), Directing the selectivity of oxygen reduction to water by confining a Cu catalyst in a metal organic framework, ChemSusChem 16(20): e202300392.
- Langerman M., Dorth M. van & Hetterscheid D.G.H. (2023), Dioxygen reduction in acetonitrile with copper pyridylalkylamine complexes: the influence of acid strength on the catalytic performance, European Journal of Inorganic Chemistry 26(24): e202300218.
- Boer D. den, Konovalov A., Siegler M.A. & Hetterscheid D.G.H. (2023), Unusual water oxidation mechanism via a redox-active copper polypyridyl complex, Inorganic Chemistry 62(14): 5303-5314.
- Budhija V., Langevelde P.H. van, Krause K.B., Cula B., Hetterscheid D.G.H. & Schwalbe M. (2023), Synthesis, properties and reactivity studies of a hetero‐dicopper complex consisting of a porphyrin and a bispyridylamine moiety connected by a xanthene backbone, European Journal of Inorganic Chemistry 26(14): e202200743.
- Langerman M., Langevelde P.H. van, Vijver J.J. van de & Siegler M.A. Hetterscheid D.G.H. (2023), Scaling relation between the reduction potential of copper catalysts and the turnover frequency for the oxygen and hydrogen peroxide reduction reactions, Inorganic Chemistry 62(48): 19593-19602.
- Wu X.F., Oropeza F.E., Boer D. den, Kleinschmidt P., Hannappel T., Hetterscheid D.G.H., Hensen E.J.M. & Hofmann J.P. (2023), Thermally induced oxygen vacancies in BiOCl nanosheets and their impact on photoelectrochemical performance, ChemPhotoChem 7(3): e202200192.
- Jiang L., Dijk van B., Wu L., Maheu C., Hofmann J.P., Tudor V., Koper M.T.M., Hetterscheid D.G.H. & Schneider G.F. (2022), Predoped oxygenated defects activate nitrogen-doped graphene for the oxygen reduction reaction, ACS Catalysis 12: 173-182.
- Boer D. den, Heer H.C. de, Buda F. & Hetterscheid D.G.H. (2022), Challenges in elucidating the free energy scheme of the laccase catalyzed reduction of oxygen, ChemCatChem 15(1): e202200878.
- Boer D. den, Siberie Q., Siegler M.A., Ferber T.H., Moritz D.C., Hofmann J.P. & Hetterscheid D.G.H. (2022), On the homogeneity of a cobalt-based water oxidation catalyst, ACS Catalysis 12(8): 4597-4607.
- Ham C.J.M. van der, Zwagerman D.N.H., Wu L., Hofmann J.P. & Hetterscheid D.G.H. (2022), A heterogenized copper phenanthroline system to catalyze the oxygen reduction reaction, ChemElectroChem 9(3): e202101365.
- Dijk B. van, Kinders R., Ferber T.H., Hofmann J.P. & Hetterscheid D.G.H. (2022), A selective copper based oxygen reduction catalyst for the electrochemical synthesis of H2O2 at neutral pH, ChemElectroChem 9(3): e202101692.
- Smits N.W.G., Rademaker D., Konovalov A.I., Siegler M.A. & Hetterscheid D.G.H. (2022), Influence of the spatial distribution of copper sites on the selectivity of the oxygen reduction reaction, Dalton Transactions 51(3): 1206-1215.
- Boer D. den & Hetterscheid D.G.H. (2022), Design principles for homogeneous water oxidation catalysts based on first–row transition metals, Current Opinion in Electrochemistry 35: 101064 (101064).
- D'Agostini S., Kottrup K.G., Casadevall C., Gamba I., Dantignana V., Bucci A., Costas M., Lloret-Fillol J. & Hetterscheid D.G.H. (2021), Electrocatalytic water oxidation with alpha-[Fe(mcp)(OTf)(2)] and analogues, ACS Catalysis 11(5): 2583-2595.
- Langerman M. & Hetterscheid D.G.H. (2021), Mechanistic study of the activation and the electrocatalytic reduction of hydrogen peroxide by Cu-tmpa in neutral aqueous solution, ChemElectroChem 8(15): 2783 –2791.
- Olivares M., Ham C.J.M. van der, Mdluli V., Schmidtendorf M., Müller-Bunz H., Verhoeven T.W.G.M., Li M., Niemantsverdriet J.W., Hetterscheid D.G.H., Bernhard S. & Albrecht M. (2020), Relevance of Chemical vs. Electrochemical Oxidation of Tunable Carbene Iridium Complexes for Catalytic Water Oxidation, European Journal of Inorganic Chemistry 2020(10): 801-812.
- Van Dijk B., Rodriguez G.M., Wu L., Hofmann J.P., Macchioni A. & Hetterscheid D.G.H. (2020), The influence of the ligand in the iridium mediated electrocatalyic water oxidation, ACS Catalysis 10(7): 4398-4410.
- Wu L., Dzade N.Y., Chen N., Dijk B. van, Balasubramanyam S., Sharma A., Gao Lu., Hetterscheid D.G.H., Hensen E.J.M., Bol A.A., Leeuw N.H. de & Hofmann J.P. (2020), Cu electrodeposition on nanostructured MoS2 and WS2 and implications for HER active site determination, Journal of The Electrochemical Society 167(11): 116517.
- Yang S. & Hetterscheid D.G.H. (2020), Redefinition of the active species and the mechanism of the oxygen evolution reaction on gold oxide, ACS Catalysis 10(21): 12582-12589.
- Smits N.W.G., Dijk B. van, Bruin I. de, Groeneveld S.L.T., Siegler M.A. & Hetterscheid D.G.H. (2020), Influence of ligand denticity and flexibility on the molecular copper mediated oxygen reduction reaction, Inorganic Chemistry 59(22): 16398-16409.
- Smits N.W.G., Boer D. den, Wu L., Hofmann J.P. & Hetterscheid D.G.H. (2019), Elucidation of the Structure of a Thiol Functionalized Cu-tmpa Complex Anchored to Gold via a Self-Assembled Monolayer, Inorganic Chemistry 58(19): 13007-13019.
- Langerman M. & Hetterscheid D.G.H. (2019), Fast Oxygen Reduction Catalyzed by a Copper(II) Tris(2-pyridylmethyl)amine Complex through a Stepwise Mechanism, Angewandte Chemie (International Edition) 58(37): 12974-12978.
- Kottrup K.G., D'Agostini S., Langevelde P.H. van, Siegler M.A. & Hetterscheid D.G.H. (2018), Catalytic Activity of an Iron-Based Water Oxidation Catalyst: Substrate Effects of Graphitic Electrodes, ACS Catalysis 8(2): 1052-1061.
- Dijk B. van, Hofmann J.P. & Hetterscheid D.G.H. (2018), Pinpointing the active species of the Cu(DAT) catalyzed oxygen reduction reaction, Physical Chemistry Chemical Physics 20: 19625-19634.
- Ham C.J.M. van der, Isik F., Verhoeven T.W.G.M., Niemantsverdriet J.W. & Hetterscheid D.G.H. (2017), Activation pathways taking place at molecular copper precatalysts for the oxygen evolution reaction, Catalysis Today 290: 33-38.
- Hetterscheid D.G.H. & Smith W.A. (Eds.) (2017), Electrochemical and photochemical water oxidation. Catalysis Today: Elsevier B.V..
- Hetterscheid D.G.H. (2017), In operando studies on the electrochemical oxidation of water mediated by molecular catalysts, Chemical Communications 53(77): 10622-10631.
- Ruiter J.M. de, Purchase R.L., Monti A., Ham C.J.M. van der, Gullo M.P., Joya K.S., D'Angelantonio M., Barbieri A., Hetterscheid D.G.H., Groot H.J.M. de & Buda F. (2016), Electrochemical and Spectroscopic Study of Mononuclear Ruthenium Water Oxidation Catalysts: A Combined Experimental and Theoretical Investigation, ACS Catalysis 6(11): 7340-7349.
- Hetterscheid D.G.H., Ham C.J. van der, Diaz Morales O.A., Verhoeven M.W.G.M., Longo A., Banerjee D., Niemantsverdriet J.W., Reek J.N.H. & Feiters M.C. (2016), Early stages of catalyst aging in the iridium mediated water oxidation reaction, Physical Chemistry Chemical Physics 18(16): 10931-10940.
- Abril P., Rio M.P. del, Tejel C., Verhoeven T.W.G.M., Niemantsverdriet J.W., Ham C.J.M., Kottrup K.G. & Hetterscheid D.G.H. (2016), Detangling catalyst modification reactions from the oxygen evolution reaction by online mass spectrometry, ACS Catalysis 6(11): 7872-7875.
- Kottrup K.G. & Hetterscheid D.G.H. (2016), Evaluation of iron-based electrocatalysts for water oxidation : an on-line mass spectrometry approach, Chemical Communications 52(12): 2643-2646.
- Chen H.C., Hetterscheid D.G.H., Williams R.M., Vlugt J.I. van der, Reek J.N.H. & Brouwer A.M. (2015), Platinum(II)-porphyrin as a sensitizer for visible-light driven water oxidation in neutral phosphate buffer, Energy & Environmental Science 8(3): 975-982.
- Hetterscheid D.G.H. & Sun Licheng (2014), Water Oxidation, European Journal of Inorganic Chemistry (4): 571-572.
- Ham C.J.M. van der, Koper M.T.M. & Hetterscheid D.G.H. (2014), Challenges in reduction of dinitrogen by proton and electron transfer, Chemical Society Reviews 43(15): 5183-5191.
- Venturini A., Barbieri A., Reek J.N.H. & Hetterscheid D.G.H. (2014), Catalytic water splitting with an iridium carbene complex: a theoretical study, Chemistry: a European Journal 20(18): 5358-5368.
- Diaz Morales O., Hersbach T.J.P., Hetterscheid D.G.H., Reek J.N.H. & Koper M.T.M. (2014), Electrochemical and spectroelectrochemical characterization of an iridium-based molecular catalyst for water splitting: turnover frequencies, stability, and electrolyte effects, Journal of the American Chemical Society 136(29): 10432-10439.
- Hetterscheid D.G.H. & Reek J.N.H. (2014), Periodate as an oxidant for catalytic water oxidation: oxidation via electron transfer or O-atom transfer?, European Journal of Inorganic Chemistry 2014(4): 742-749.
- Hetterscheid D.G.H., Chikkali S.H., Bruin B. de & Reek J.N.H. (2013), Binuclear Cooperative Catalysts for the Hydrogenation and Hydroformylation of Olefins, ChemCatChem 5(10): 2785-2793.
- Hetterscheid D.G.H. & Reek J.N.H. (2012), Mononuclear Water Oxidation Catalysts, Angewandte Chemie (International Edition) 51(39): 9740-9747.
- Tejel C., Pilar del Rio M., Asensio L., Bruele F.J. van den, Ciriano M.A., Tsichlis i Spithas N., Hetterscheid D.G.H. & Bruin B. de (2011), Cooperative Double Deprotonation of Bis(2-picolyl)amine Leading to Unexpected Bimetallic Mixed Valence (M-1, M-1) Rhodium and Iridium Complexes, Inorganic Chemistry 50(16): 7524-7534.
- Dzik W.I., Calvo S.E., Reek J.N.H., Lutz M., Ciriano M.A., Tejel C., Hetterscheid D.G.H. & Bruin B. de (2011), Binuclear [(cod)(Cl)Ir(bpi)Ir(cod)](+) for Catalytic Water Oxidation, Organometallics 30(3): 372-374.
- Hetterscheid D.G.H. & Reek J.N.H. (2011), Me-2-NHC based robust Ir catalyst for efficient water oxidation, Chemical Communications 47(9): 2712-2714.
- Kinney R.A., Hetterscheid D.G.H., Hanna B.S., Schrock R.R. & Hoffman B.M. (2010), Formation of {[HIPTN3N]Mo(III)H}(-) by Heterolytic Cleavage of H-2 as Established by EPR and ENDOR Spectroscopy, Inorganic Chemistry 49(2): 704-713.
- Tejel C., Pilar del Rio M., Ciriano M.A., Reijerse E.J., Hartl F., Zalis S., Hetterscheid D.G.H., Tsichlis i Spithas N. & Bruin B. de (2009), Ligand-Centred Reactivity of Bis(picolyl)amine Iridium: Sequential Deprotonation, Oxidation and Oxygenation of a "Non-Innocent" Ligand, Chemistry: a European Journal 15(44): 11878-11889.
- Hetterscheid D.G.H., Hanna B.S. & Schrock R.R. (2009), Molybdenum Triamidoamine Systems. Reactions Involving Dihydrogen Relevant to Catalytic Reduction of Dinitrogen, Inorganic Chemistry 48(17): 8569-8577.
- Hetterscheid D.G.H., Vlugt J.I. van der, Bruin B. de & Reek J.N.H. (2009), Water Splitting by Cooperative Catalysis, Angewandte Chemie (International Edition) 48(44): 8178-8181.
- Tejel C., Ciriano M.A., Pilar del Rio M., Hetterscheid D.G.H., Tsichlis i Spithas N., Smits J.M.M. & Bruin B. de (2008), Ligand Oxidation of a Deprotonated Bis(picolyl)amine Ir-I(cod) Complex, Chemistry: a European Journal 14(35): 10932-10936.
- Tejel C., Ciriano M.A., Del Rio M. Pilar, Bruele F.J. van den, Hetterscheid D.G.H., Spithas Nearchos Tsichlis I. & Bruin B. de (2008), Deprotonation induced ligand-to-metal electron transfer: Synthesis of a mixed-valence Rh(-I,I) dnuclear compound and its reaction with dioxygen, Journal of the American Chemical Society 130(18): 5844-5845.
- Bruin B. de & Hetterscheid D.G.H. (2007), Paramagnetic (alkene)Rh and (alkene)Ir complexes: Metal or ligand radicals?, European Journal of Inorganic Chemistry (2): 211-230.
- Hetterscheid D.G.H., Mop M., Kicken R.J.N.A.M., Smits J.M.M., Reijerse E.J. & Bruin B. de (2007), Hydrogen-atom transfer in open-shell organometallic chemistry: The reactivity of Rh-II(cod) and Ir-II(cod) radicals, Chemistry: a European Journal 13(12): 3386-3405.
- Bruin B. de, Hetterscheid D.G.H., Koekkoek A.J.J. & Gruetzmacher H. (2007), The Organometallic Chemistry of Rh-, Ir-, Pd-, and Pt-Based Radicals: Higher Valent Species. In: Karlin K.D. (Ed.), Progress in Inorganic Chemistry. Progress in Inorganic Chemistry no. 55. Hoboken, NJ: John Wiley & Sons, Inc.. 247-354.
- Hetterscheid D.G.H., Hendriksen C., Dzik W.I., Smits J.M.M., Eck E.R.H. van, Rowan A.E., Busico V., Vacatello M., Axel Castelli V. van, Segre A., Jellema E., Bloemberg T.G. & Bruin B. de (2006), Rhodium-mediated stereoselective polymerization of "carbenes", Journal of the American Chemical Society 128(30): 9746-9752.
- Hetterscheid D.G.H. & Bruin B. de (2006), Open-shell rhodium and iridium species in (catalytic) oxygenation reactions, Journal of Molecular Catalysis A: Chemical 251(1-2): 291-296.
- Knijnenburg Q., Horton A.D., Heijden H. van der, Kooistra T.M., Hetterscheid D.G.H., Smits J.M.M., Bruin B. de, Budzelaar P.H.M. & Gal A.W. (2005), Olefin hydrogenation using diimine pyridine complexes of Co and Rh, Journal of Molecular Catalysis A: Chemical 232(1-2): 151-159.
- Hetterscheid D.G.H., Bens M. & Bruin B. de (2005), Ir-II(ethene): Metal or carbon radical? Part II: Oxygenation via iridium or direct oxygenation at ethene?, Dalton Transactions (5): 979-984.
- Hetterscheid D.G.H., Kaiser J., Reijerse E., Peters T.P.J., Thewissen S., Blok A.N.J., Smits J.M.M., Gelder R. de & Bruin B. de (2005), Ir-II(ethene): Metal or carbon radical?, Journal of the American Chemical Society 127(6): 1895-1905.
- Knijnenburg Q., Hetterscheid D., Kooistra T.M. & Budzelaar P.H.M. (2004), The electronic structure of (diiminopyridine)cobalt(I) complexes, European Journal of Inorganic Chemistry (6): 1204-1211.
- Hetterscheid D.G.H., Smits J.M.M. & Bruin B. de (2004), Chloride-triggered disproportionation of a mononuclear Rh-II(nbd) species to Rh-I(nbd) and Rh-III(eta(1)-norbornenyl) complexes: Possibilities for Wacker type mono-oxygenation of norbornadiene to norbornenone, Organometallics 23(18): 4236-4246.
- Kooistra T.M., Hetterscheid D.G.H., Schwartz E., Knijnenburg Q., Budzelaar P.H.M. & Gal A.W. (2004), Chemical ligand non-innocence in pyridine diimine Rh complexes, Inorganica Chimica Acta 357(10): 2945-2952.
- Beusker P.H., Veldhuis H., Brinkhorst J., Hetterscheid D.G.H., Feichter N., Bugaut A. & Scheeren H.W. (2003), Semisynthesis of 7-deoxypaclitaxel derivatives devoid of an oxetane D-ring, starting from taxine B, European Journal of Organic Chemistry 2003(4): 689-705.
- Hetterscheid D.G.H., Bruin B. de, Smits J.M.M. & Gal A.W. (2003), Disproportionation of Rh-II(cod) to Rh-I(cod) and Rh-III(cycloocta-2,5-dien-1-yl): Hydrogen atom transfer vs electron and proton transfer, Organometallics 22(15): 3022-3024.