Bregje Brinkmann
Postdoc
- Name
- Dr. B.W. Brinkmann
- Telephone
- +31 71 527 7475
- b.w.brinkmann@cml.leidenuniv.nl
- ORCID iD
- 0000-0002-0985-0066
Bregje investigates the impacts of microbiome and host interactions on nanomaterial toxicity in aquatic ecosystems
Professional experience
Bregje obtained a BSc degree in Biology at Leiden University and a MSc degree in Limnology & Oceanography (Biological Sciences) at the University of Amsterdam (UvA).
In two MSc research projects, Bregje developed a growing interest in the impacts of microbial activity on water quality and ecosystem functioning. In a first project at the research group of Aquatic Microbiology (UvA), she studied the role of cyanotoxin microcystin in the sensitivity of cyanobacteria to strong oxidative stress. In a second project at the research group of Aquatic Environmental Ecology (UvA) and Deltares, she studied limnetic aggregates in relation to algae survival in the turbid water column of large and shallow delta lake Markermeer (the Netherlands). By way of a literature study, she also investigated the role of microbiome and host interactions in the adaptive potential of coral calcification to ocean acidification. During her MSc education, Bregje was awarded the Professor Kees Bakker prijs 2014 and an ISME16 travel grant, supporting her visit to the 16th International Symposium on Microbial Ecology in Montreal (Canada).
In October 2017, she returned to Leiden University as PhD candidate at the department of Conservation Biology of the Institute of Environmental Sciences.
Research topic
Bregje investigates the impacts of microbiome and host interactions on nanomaterial toxicity in aquatic ecosystems. Her research aims to contribute to understanding potential effects of realistic (long-term and low dose) nanomaterial exposure to ecosystems.
Bregje’s PhD project is part of the EU funded H2020 project PATROLS (‘Physiologically Anchored Tools for Realistic nanOmateriaL hazard aSsessment’) awarded to Martina Vijver and research partners
PATROLS - Role of microbiota in nanotoxicity
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- Science
- Centrum voor Milieuwetenschappen Leiden
- CML/Environmental Biology
- Nederstigt T.A.P., Brinkmann B.W., Peijnenburg W.J.G.M. & Vijver M.G. (2024), Sustainability claims of nanoenabled pesticides require a more thorough evaluation, Environmental Science and Technology 58(5): 2163-2165.
- Pol R.W.I. van der, Brinkmann B.W. & Sevink G.J.A. (2024), Analyzing lipid membrane defects via a coarse-grained to triangulated surface map: the role of lipid order and local curvature in molecular binding, Journal of Chemical Theory and Computation 20(7): 2888-2900.
- Brinkmann B.W. (12 September 2023), Recent progress towards microbiota-inclusive nanosafety research. Nanopinion: European Union Observatory for Nanomaterials (European Chemicals Agency). [blog entry].
- Brinkmann B.W., Koch B.E.V., Peijnenburg W.J.G.M. & Vijver M.G. (2022), Microbiota-dependent TLR2 signaling reduces silver nanoparticle toxicity to zebrafish larvae, Ecotoxicology and Environmental Safety 237: 113522.
- Brinkmann B.W., Singhal A., Sevink G.J.A., Neeft L., Vijver M.G. & Peijnenburg W.J.G.M. (2022), Predicted adsorption affinity for enteric microbial metabolites to metal and carbon nanomaterials, Journal of Chemical Information and Modeling 62(15): 3589-3603.
- Brinkmann B.W. (8 December 2022), Nanomaterial safety for microbially-colonized hosts: Microbiota-mediated physisorption interactions and particle-specific toxicity (Dissertatie. Institute of Environmental Sciences (CML), Faculty of Science, Leiden University). Supervisor(s): Vijver M.G. & Peijnenburg W.J.G.M.
- Brinkmann B.W., Beijk W.F., Vlieg R.C., Noort S.J.T. van, Mejia J., Colaux J.L., Lucas S., Lamers G.E.M., Peijnenburg W.J.G.M. & Vijver M.G. (2021), Adsorption of titanium dioxide nanoparticles onto zebrafish eggs affects colonizing microbiota, Aquatic Toxicology 232: 105744.
- Dovidat L.C., Brinkmann B.W., Vijver M.G. & Bosker T. (2020), Plastic particles adsorb to the roots of freshwater vascular plant Spirodela polyrhiza but do not impair growth, Limnology and Oceanography Letters 5(1): 37-45.
- Brinkmann B.W., Koch B.E.V., Spaink H.P., Peijnenburg W.J.G.M. & Vijver M.G. (2020), Colonizing microbiota protect zebrafish larvae against silver nanoparticle toxicity, Nanotoxicology 14(6): 725-739.
- Schuurmans J.M., Brinkmann B.W., Makower A.K., Dittmann E., Huisman J. & Mathijs H.C.P. (2018), Microcystin interferes with defense against high oxidative stress in harmful cyanobacteria, Harmful Algae 76: 47-55.