Bram Slütter
Associate Professor
- Name
- Dr. B.A. Slütter
- Telephone
- +31 71 527 6208
- b.a.slutter@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0003-3996-0503
Dr. Bram Slütter is associate professor at the Division of BioTherapeutics.
More information about Bram Slütter
News
-
Arteriosclerosis and drug discovery: two young researchers win Krijn Rietveld Award for innovative research -
Atherosclerosis resembles an autoimmune disease. Marie Depuydt graduated on this topic, with honours -
Preventing heart attacks by earlier detection of cardiovascular disease -
EIC Pathfinder Challenge grant for research into autoreactive B cells in cardiovascular disease -
Why arteriosclerosis looks like an autoimmune disease -
Steering the immune system with liposomes
Associate Professor
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Biopharmaceutics
- Lee J., Neustrup M.A., Slütter B.A., O'Mahony C., Bouwstra J.A. & Maaden K. van der (2024), Intradermal vaccination with PLGA nanoparticles via dissolving microneedles and classical injection needles, Pharmaceutical Research 41: 305–319.
- Strien J. van, Makurat D.M.M., Zeng Y., Olsthoorn R.R.C.L., Schneider G.F., Slutter B.A., MacKay J.A., Jiskoot W. & Kros A. (2024), Noncovalent conjugation of OVA323 to ELP micelles increases immune response, Biomacromolecules 25(2): 1027-1037.
- Mulholland M., Depuydt M.A.C., Jakobsson G., Ljungcrantz I., Grentzmann A., To F., Bengtsson E., Jaensson Gyllenbäck E., Grönberg C., Rattik S., Liberg D., Schiopu A., Björkbacka H., Kuiper J., Bot I., Slütter B.A. & Engelbertsen D. (2024), Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation, Cardiovascular Research 120(6): 581-595.
- Jong M.J.M. de, Schaftenaar F.H., Depuydt M.A.C., Lozano Vigario F., Janssen G.M.C., Peeters J.A.H.M., Goncalves L., Wezel A., Smeets H.J., Kuiper J., Bot I., Veelen P. van & Slütter B.A. (2024), Virus-associated CD8+T-cells are not activated through antigen-mediated interaction inside atherosclerotic lesions, Arteriosclerosis, Thrombosis, and Vascular Biology 44: 1302-1314.
- Schaftenaar F.H., Dam A.D. van, Bruin G. de, Depuydt M.A.C., Mol J., Amersfoort J., Douna H., Meijer M., Kröner M.J., Santbrink P.J. van, Bernabé Kleijn M.N.A., Puijvelde G.H.M. van, Florea B.I., Slütter B., Foks A.C., Bot I., Rensen P.C.N. & Kuiper J. (2024), Immunoproteasomal inhibition with ONX-0914 attenuates atherosclerosis and reduces white adipose tissue mass and metabolic syndrome in mice, Arteriosclerosis, Thrombosis, and Vascular Biology 44(6): 1346–1364.
- Jong M.J.M. de, Depuydt M.A.C., Schaftenaar F.H., Liu K., Maters D., Wezel A., Smeets H.J., Kuiper J., Bot I., Gisbergen K. van & Slütter B.A. (2024), Resident memory T cells in the atherosclerotic lesion associate with reduced macrophage content and increased lesion stability, Arteriosclerosis, Thrombosis, and Vascular Biology 44(6): 1318–1329.
- Coban B., Wang Z., Liao C., Beslmüller K., Timmermans M.A.M., Martens J.W.M., Hunscheid J.H.M., Slütter B.A., Zweemer A.J.M., Neubert E. & Danen E.H.J. (2024), GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment, iScience 27(5): 109738.
- Depuydt M.A.C., Smit V., Schaftenaar F.H., Hemme E., Delfos L., Vlaswinkel F.D., Simpson C., Kovanen P.T., Slütter B.A., Kuiper J., Bot I. & Foks A.C. (2024), Aging promotes mast cell activation and antigen presenting capacity in atherosclerosis, Cardiovascular Research 120(Supplement 1): cvae088.201.
- Ge X., Slütter B.A., Lambooij J.M., Zhou E., Ying Z., Agirman C., Heijink M., Rimbert A., Guigas B., Kuiper J., Muller C., Bracher F., Giera M., Kooijman S., Rensen P.C.N., Wang Y. & Schonke M. (2024), DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice, iScience 27(6): 109830.
- Prange K., Bel-Bordes G., Depuydt M.A.C., Kempkes R.W.M., Jong M.D.M. de, Mol B.M., Slütter B., Bot I., Neele A.E., Kleijn D.P.V. de, Borst G.J. de, Kuiper J., Pasterkamp. G., Mokry M. & Winther M.P.J. de (2024), Human atherosclerotic plaque macrophages associate with clinical presentation and follow diverse lineage differentiation routes, Cardiovascular Research 120(Supplement 1): cvae088.168.
- Warmenhoven H., Leboux R.J.T., Bethanis A., Strien J. van, Logiantara A., Schijndel H. van, Aglas L., Rijt L. van, Slütter B.A., Kros A., Jiskoot W. & Ree R. van (2023), Cationic liposomes bearing Bet v 1 by coiled coil-formation are hypo-allergenic and induce strong immunogenicity in mice, Frontiers in allergy 3: 1092262.
- Zeng Y., Escalona-Rayo O., Knol R.A., Kros A. & Slütter B.A. (2023), Lipid nanoparticle-based mRNA candidates elicit potent T cell responses, Biomaterials Science 11(3): 964-974.
- Nagy N.A., Lozano Vigario F., Sparrius R., Capel T.M.M. van, Ree R. van, Tas S.W., Vries I.J.M. de, Geijtenbeek T.B.H., Slütter B.A. & Jong E.C. de (2023), Liposomes loaded with vitamin D3 induce regulatory circuits in human dendritic cells, Frontiers in Immunology 14: 1137538.
- Bauer T.A., Alberg I., Zengerling L.A., Besenius P., Koynov K., Slütter B.A., Zentel R., Que I., Zhang H. & Barz M. (2023), Tuning the cross-linking density and cross-linker in core cross-linked polymeric micelles and its effects on the particle stability in human blood plasma and mice, Biomacromolecules 24(8): 3545-3556.
- Escalona Rayo O., Zeng Y., Knol R.A., Kock T.J.F., Aschmann D., Slütter B.A. & Kros A. (2023), In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy, Biomedicine & Pharmacotherapy 165: 115065.
- Lozano Vigario F., Simo Vesperinas I., Depuydt M.A.C., Bot I., Veelen P. van, Bouwstra J.A., Kros A. & Slutter B. (2023), Immunopeptidomic analysis of human atherosclerosis identifies novel ApoB100-derived antigenic drivers of atherosclerosis, Atherosclerosis 379: S8-S9.
- Depuydt M.A.C., Schaftenaar F.H., Prange H.H.M., Boltjes A., Hemme E., Delfos L., Mol J. de, Jong M.J.M. de, Bernabé Kleijn M.N.A., Peeters J.A.H.M., Goncalves L., Wezel A., Smeets H.J., Borst G.J. de, Foks A.C., Pasterkamp G., Winther M.P.J. de, Kuiper J., Bot I. & Slütter B. (2023), Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells, Nature Cardiovascular Research 2: 112-125.
- Lozano Vigario F., Nagy N.A., The M.H., Sparrius R., Bouwstra J.A., Kros A., Jiskoot W., Jong E.C. de & Slütter B.A. (2022), The use of a staggered herringbone micromixer for the preparation of rigid liposomal formulations allows efficient encapsulation of antigen and adjuvant, Journal of Pharmaceutical Sciences 111(4): 1050-1057.
- Depuydt M.A.C., Smit V., Lozano Vigario F., Bernabé Kleijn M.N.A., Vries M.R. de, Quax P.H.A., Wezel A., Smeets H.J., Kuiper J., Foks A.C., Bot I. & Slütter B.A. (2022), Granzyme B+CD4+T cells associate with an unstable plaque phenotype in advanced human atherosclerosis, Cardiovascular Research 118(Supplement_1): cvac066.229.
- Nagy N.A., Castenmiller C., Lozano Vigario F., Sparrius R., Capel T.M.M. van, Haas A.M. de, Kooy Y. van, Ree R. van, Tas S.W., Geijtenbeek T.B.H., Jiskoot W., Slütter B.A. & Jong E.C. de (2022), Uptake kinetics of liposomal formulations of differing charge influences development of in vivo dendritic cell immunotherapy, Journal of Pharmaceutical Sciences 111(4): 1081-1091.
- Egorova E., Lamers G.E.M., Abdolahpur Monikh F., Boyle A.L., Slütter B.A. & Kros A. (2022), Gold nanoparticles decorated with ovalbumin-derived epitopes: effect of shape and size on T-cell immune responses, RSC Advances 12(31): 19703-19716.
- Depuydt M.A.C., Vlaswinkel F.D., Hemme E., Delfos L., Bernabe Kleijn M.N.A., Santbrink P.J. van, Foks A.C., Slütter B., Kuiper J. & Bot I. (2022), Blockade of the BLT1-LTB4 axis does not affect mast cell migration towards advanced atherosclerotic lesions in LDLr-/- mice, Scientific Reports 12(1): 18362.
- Strien J. van, Escalona-Rayo O.,Jiskoot W., Slütter B. & Kros A. (2022), Elastin-like polypeptide-based micelles as a promising platform in nanomedicine, Journal of Controlled Release 353: 713-726.
- Amersfoort J., Schaftenaar F.H., Douna H., Santbrink P.J. van, Puijvelde G.H.M. van, Slütter B., Foks A.C., Harms A., Moreno-Gordaliza E., Wang Y., Hankemeier T., Bot I., Chi H. & Kuiper J. (2021), Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells, Cardiovascular Research 117(5): 1309-1324.
- Duijn J. van, Jong M.J.M. de, Benne N., Leboux R.J.T., Ooijen M.E. van, Kruit N., Foks A.C., Jiskoot W., Bot I., Kuiper J. & Slütter B. (2021), Tc17 CD8+ T-cells accumulate in murine atherosclerotic lesions, but do not contribute to early atherosclerosis development, Cardiovascular Research 117(14): 2755-2766.
- Leboux RJ.T., Benne N., Os W.A. van, Bussmann J., Kros A., Jiskoot W. & Slütter B.A. (2021), High-affinity antigen association to cationic liposomes via coiled coil-forming peptides induces a strong antigen-specific CD4+ T-cell response, European Journal of Pharmaceutics and Biopharmaceutics 158: 96-105.
- Guzelj S., Nabergoj S.: Gobec M., Pajk S., Klancic V., Slütter B.A., Frkanec R., Stimac A., Sket P., Plavec J., Mlinaric-Rascan I. & Jakopin Z. (2021), Structural fine-tuning of desmuramylpeptide NOD2 agonists defines their in vivo adjuvant activity, Journal of Medicinal Chemistry 64(11): 7809-7838.
- Kijanka G., Bee J.S., Schenerman M.A., Korman S.A., Wu Y., Slütter B. & Jiskoot W. (2020), Monoclonal Antibody Dimers Induced by Low pH, Heat, or Light Exposure Are Not Immunogenic Upon Subcutaneous Administration in a Mouse Model, Journal of Pharmaceutical Sciences 109(1): 730-738.
- Douna H., Amersfoort J., Schaftenaar F.H., Kröner M.J., Kiss M.B., Slütter B.A., Depuydt M.A.C., Bernabé Kleijn M.N.A., Wezel A., Smeets H., Yagita H., Binder C.J., Bot I., Puijvelde G.H.M. van, Kuiper J. & Foks A.C. (2020), BTLA stimulation protects against atherosclerosis by regulating follicular B cells, Cardiovascular Research 116(2): 295-305.
- Benne N., Martins Cardoso R., Boyle A.L., Kros A., Jiskoot W., Kuiper J., Bouwstra J., Eck M. van & Slütter B.A. (2020), Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques, Advanced Healthcare Materials 9(10): 2000043.
- Lozano Vigario F. Kuiper J. Slütter B.A. (2020), Tolerogenic vaccines for the treatment of cardiovascular diseases, EBioMedicine 57: 102827.
- Leone M., Romeijn S., Slütter B., O'Mahony C., Kersten G. & Bouwstra J.A. (2020), Hyaluronan molecular weight: Effects on dissolution time of dissolving microneedles in the skin and on immunogenicity of antigen, European Journal of Pharmaceutical Sciences 146: 105269.
- Depuydt M.A.C., Prange K.H.M., Slenders L., Örd T., Elbersen D., Boltjes A., Jager S.C.A. de, Asselbergs F.W., Borst G.J. de, Aavik E., Lönnberg T., Lutgens E., Glass C.K., Ruijter H.M. den, Kaikkonen M.U., Bot I., Slütter B., Laan S.W. van der, Yla-Herttuala S., Mokry M., Kuiper J., Winther M.P.J. de & Pasterkamp G. (2020), Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics, Circulation Research 127(11): 1437-1455.
- Kritikou E., Depuydt M.A.C., Vries M.R. de, Mulder K.E., Govaert A.M., Smit M.D., Duijn J. van, Foks A.C., Wezel A., Smeets H.J., Slütter B., Quax P.H.A., Kuiper J. & Bot I. (2019), Flow Cytometry-Based Characterization of Mast Cells in Human Atherosclerosis, Cells 8(4): 334.
- Duijn J. van, Elsas M. van, Benne N., Depuydt M.A.C., Wezel A., Smeets H., Bot I., Jiskoot W., Kuiper J. & Slütter B.A. (2019), CD39 identifies a microenvironment-specific anti-inflammatory CD8+ T-cell population in atherosclerotic lesions, Atherosclerosis 285: 71-78.
- Douna H., Amersfoort J., Schaftenaar F.H., Kröner M.J., Kiss M.B., Slütter B., Depuydt M.A.C., Kleijn M.N.A.B., Wezel A., Smeets H., Yagita H., Binder C.J., Bot I., Puijvelde G.H.M. van, Kuiper J. & Foks A.C. (2019), B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells, Cardiovascular Research 116(2): 295-305.
- Slütter B. & Kuiper J. (2019), Immune Responses in Context, Circulation 139(22): 2567-2569.
- Benne N., Duijn J. van, Lozano Vigario F., Leboux R., Veelen P. van, Jiskoot W., Kuiper J. & Slütter B. (2019), Vaccination with a regulatory t-cell inducing vaccine formulation containing apob100 peptides, reduces atherosclerosis in mice, Atherosclerosis 287: e99-e100.
- Duijn J. van, Elsas M. van, Benne N., Depuydt M., Wezel A., Smeets H., Bot I., Jiskoot W., Kuiper J. & Slutter B. (2019), Continuous Tcr signaling in the atherosclerotic environment induces immunomodulatory Cd8+ T-cells expressing Cd39, Atherosclerosis 287: e17-e18.
- Laan S.W. van der, Slenders L., Depuydt M., Prange K., Granneman L., Elbersen D., Boltjes A., Jager S. de, Slutter B., Bot I., Winther M., Kuiper J., Mokry M., Asselbergs F. & Pasterkamp G. (2019), Mapping genes to cardiovascular susceptibility loci at a single-cell resolution, Atherosclerosis 287: E21-E21.
- Depuydt M., Prange K.H.M., Slenders L., Elbersen D., Boltjes A., De Jager S.C.A., Slutter B.A., Bot I., Laan S.W. van der, Mokry M., Pasterkamp G., Winther M.P.J. de & Kuiper J. (2019), Microanatomy of advanced human atherosclerotic plaques through single-cell transcriptomics, Atherosclerosis 287: E5-E5.
- Mokry M., Depuydt M.A.C., Prange K.H.M., Slenders L., Elbersen D., Granneman L.E.C., Jager S.C.A. de, Slutter B.A., Bot I., Winther M.P.J. de, Kuiper J., Asselbergs F.W., Laan S.W. van der & Pasterkamp G. (2019), Single cell Rna-sequencing identifies numerous cell sub-types and suggests lineage plasticity in human atherosclerotic plaques, Atherosclerosis 287: E96-E97.
- Benne N., Leboux R.J.T., Glandrup M., Duijn J. van, Lozano Vigario F., Neustrup M.A., Romeijn S., Galli F., Kuiper J., Jiskoot W. & Slütter B. (2019), Atomic force microscopy measurements of anionic liposomes reveal the effect of liposomal rigidity on antigen-specific regulatory T cell responses, Journal of Controlled Release 318: 246-255.
- Schaftenaar F.H., Amersfoort J., Douna H., Kröner M.J., Foks A.C., Bot I., Slütter B.A., Puijvelde G.H.M. van, Drijfhout J.W. & Kuiper J. (2019), Induction of HLA-A2 restricted CD8 T cell responses against ApoB100 peptides does not affect atherosclerosis in a humanized mouse model, Scientific Reports 9(1): 17391.
- Kritikou E., Heijden T. van der, Swart M., Duijn J. van, Slütter B., Wezel A., Smeets H.J., Maffia P., Kuiper J. & Bot I. (2019), Hypercholesterolemia induces a mast cell-CD4+ T cell interaction in atherosclerosis, Journal of Immunology 202(5): 1531-1539.
- Seijkens T.T.P., Tiel C.M. van, Kusters P.J.H., Atzler D., Soehnlein O., Zarzycka B., Aarts S.A.B.M., Lameijer M., Gijbels M.J., Beckers L., Toom M. den, Slütter B.A., Kuiper J., Duchene J., Aslani M., Megens R.T.A., Veer C. van 't, Kooij G., Schrijver R., Hoeksema M.A., Boon L., Fay F., Tang J., Baxter S., Jongejan A., Moerland P.D., Vriend G., Bleijlevens B., Fisher E.A., Duivenvoorden R., Gerdes N., Winther M.P.J. de, Nicolaes G.A., Mulder W.J.M., Weber C. & Lutgens E. (2018), Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis, Journal of the American College of Cardiology 71(5): 527-542.
- Mönkare J., Pontier M.J., Kampen E.E.M. van, Du G., Leone M., Romeijn S.G., Nejadnik M.R., O'Mahony C., Slütter B.A., Jiskoot W. & Bouwstra J.A. (2018), Development of PLGA nanoparticle loaded dissolving microneedles and comparison with hollow microneedles in intradermal vaccine delivery, European Journal of Pharmaceutics and Biopharmaceutics 129: 111-121.
- Duijn J. van, Kritikou E., Benne N., Heijden T. van der, Puijvelde G.H. van, Kröner M.J., Schaftenaar F.H., Foks A.C., Wezel A., Smeets H., Yagita H., Bot I., Jiskoot W., Kuiper J. & Slütter B. (2018), CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses, Cardiovascular Research 115(4): 729-738.
- Benne N., Duijn J. van, Lozano Vigario F.L., Leboux R.J.T., Veelen P. van, Kuiper J., Jiskoot W. & Slütter B. (2018), Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice, Journal of Controlled Release 291: 135-146.
- Seijkens T.T.P., Poels K., Meiler S., Tiel C.M. van, Kusters P.J.H., Reiche M., Atzler D., Winkels H., Tjwa M., Poelman H., Slütter B., Kuiper J., Gijbels M., Kuivenhoven J.A., Matic L.P., Hedin U., Paulsson-Berne G., Nicolaes G.A.F., Hansson G.K., Weber C., Daemen M.J.A.P., Winther M.P.J. de, Gerdes N. & Lutgens E. (2018), Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death, European Heart Journal 40(4): 372-382.
- Slütter B.A., Depuydt M.A.C., Duijn J. van, Bot I., Wezel A., Koppejan H., Toes R. & Kuiper J. (2018), Masscytometry identifies CD8 T-cell diversity in human atherosclerotic lesions, Atherosclerosis 275: e8.
- Schaftenaar F.H., Amersfoort J., Douna H., Kroner M.J., Slutter B.A., Bot I., Puijvelde G.H.M. van & Kuiper J. (2018), Vaccination with APOB100 derived HLA-A2 restricted CD8 T cell epitopes did not reduce atherosclerosis in male LDLRKO HAPOB100TG HLA-A2TG mice, Atherosclerosis Supplements 32: 100-101.
- Duijn J. van, Kuiper J. & Slütter B.A. (2018), The many faces of CD8+ T cells in atherosclerosis, Current Opinion in Lipidology 29(5): 411-416.
- Heijden T. van der, Kritikou E., Venema W., Duijn J. van, Santbrink P.J. van, Slütter B., Foks A.C., Bot I. & Kuiper J. (2017), NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mice-Brief Report, Arteriosclerosis, Thrombosis, and Vascular Biology 37(8): 1457-1461.
- Du G., Mohammed Hafez Mohammed Hathout R., Nasr Sayed Aly M., Nejadnik M.R., Tu J., Koning R.I., Koster A.J., Slütter B.A., Kros A., Jiskoot W., Bouwstra J.A. & Monkare J.T. (2017), Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles, Journal of Controlled Release 266: 109-118.
- Benne N., Duijn J. van, Kuiper J., Jiskoot W. & Slütter B. (2016), Orchestrating immune responses: How size, shape and rigidity affect the immunogenicity of particulate vaccines, Journal of Controlled Release 234: 124-134.
- Silva A.L., Soema P.C., Slütter B., Ossendorp F. & Jiskoot W. (2016), PLGA particulate delivery systems for subunit vaccines: linking particle properties to immunogenicity, Human Vaccines and Immunotherapeutics 12(4): 1056-1069.
- Duijn J. van, Jiskoot W., Kuiper J. & Slutter B.A. (2016), A tissue-specific phenotype for CD8+T cells in atherosclerotic lesions: role of the arterial microenvironment, Journal of Immunology 196(1): 186.10.
- Benne N., Jiskoot W., Kuiper J. & Slutter B.A. (2016), Stimulating antigen-specific regulatory T cells for an atherosclerosis vaccine, Journal of Immunology 196(1): 70.18.
- Slütter B.A. & Jiskoot W. (2015), Sizing the optimal dimensions of a vaccine delivery system: a particulate matter, Expert Opinion on Drug Delivery 13(2): 167-170.
- Amorij J.P., Kersten G.F.A., Saluja V., Tonnis W.F., Hinrichs W.L.J., Slutter B., Bal S.M., Bouwstra J.A., Huckriede A. & Jiskoot W. (2012), Towards tailored vaccine delivery: Needs, challenges and perspectives, 161(2): 363-376.
- Slütter B.A. (27 January 2011), Challenges and opportunities in nasal subunt vaccine delivery : mechanistic studies using ovalbumin as a model antigen (Dissertatie. Leiden/Amsterdam Center for Drug Research (LACDR), Faculty of Science, Leiden University). Supervisor(s): Jiskoot W. & Bouwstra J.A.