Bas ter Braak
Postdoc
- Name
- Dr. S.J. ter Braak
- Telephone
- +31 71 527 2727
- s.j.ter.braak@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-7290-4119
Bas ter Braak is postdoctoral researcher at the Division of Drug Discovery & Safety.
More information about Bas ter Braak
PhD Candidates
Biography:
Bas ter Braak obtained both his BSc and MSc degrees in Biotechnology at Wageningen University. During his studies he completed three graduation Master projects (at Wageningen University, at Lisbon Technical University in Portugal and at Emory University in the United States). Directly after completing his studies in 2010 he started working as a PhD student at the Leiden Academic Center for Drug Research at Leiden University, on the project “Carcinogenicity of insulin analogues.” Bas defended his thesis on June 18th 2015. Since then he is employed as post-doctoral researcher at Leiden University on a project in which cell signalling reporter stem cell models are established for the mechanistic understanding of liver disease.
Project:
We are currently developing a new models for the mechanistic understanding of Drug Induced Liver Injury (DILI) using multiple fluorescent tagged human induced pluripotent stem cells (hiPSC) using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system. With this system we can tag the endogenous stress-gene. Once we have developed these hiPSC-reporter cells we can differentiate these cells towards hepatocyte-like cells and use these for High Throughput drug Screens (HTS). We anticipate that our cellular stress response reporters in combination with High Content Imaging (HCI) may play a key role in future safety assessment of chemicals.
Postdoc
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Toxicology
- Danilyuk T.Y., Niemeijer M.C., Wijaya L.S., Snijders K., Berk L. van der, Braak S.J. ter, Callegaro G., Bouwman R.J.P., Le Dévédec S.E. & Water B. van de (2023), Human-induced pluripotent stem cell reporters for high-content screening of stress response activation identifying target organ-specific toxicities, Toxicology Letters 384: S192.
- Braak S.J. ter, Niemeijer M.C., Wolters L., Le Dévédec S.E., Bouwman R.J.P. & Water B. van de (2022), Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters, Mutagenesis 37(2): 130-142.
- Braak S.J. ter, Klip J.E., Wink S., Hiemstra S.W., Cooper S.L., Middleton A., White A. & Water B. van de (2022), Mapping the dynamics of Nrf2 antioxidant and NFκB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses, Toxicology In Vitro 84: 105419.
- Gupta R., Schrooders Y., Hauser D., Herwijnen M. van, Albrecht W., Braak B. ter, Brecklinghaus T., Castell J.V., Elenschneider L., Escher S., Guye P., Hengstler J.G., Ghallab A., Hansen T., Leist M., Maclennan R., Moritz W., Tolosa L., Tricot T., Verfaillie C., Walker P., Water B. van de, Kleinjans J. & Caiment F. (2021), Comparing in vitro human liver models to in vivo human liver using RNA-Seq, Archives of Toxicology 95: 573-589.
- Braak B. ter, Niemeijer M., Boon R., Parmentier C., Baze A., Richert. L., Huppelschoten S., Wink S., Verfaillie C. & Water B. van de (2021), Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes, Toxicology In Vitro 73: 105107.
- Liu T., Berk L. van den, Wondergem J.A.J., Tong C., Kwakernaak M.C., Braak B. ter, Heinrich D., Water B. van de & Kieltyka R.E. (2021), Squaramide‐based supramolecular materials Drive hepG2 spheroid differentiation, Advanced Healthcare Materials 10(11): 2001903.
- Tolosa L., Martínez-Sena T., Schimming J.P., Moro E., Escher S.E., Braak S.J. ter, Water B. van de, Miranda M.A., Vugt-Lussenburg B.M.A. van & Castell J.V. (2021), The in vitro assessment of the toxicity of volatile, oxidisable, redox-cycling compounds: phenols as an example, Archives of Toxicology 95(6): 2109-2121.
- Krebs A. Vugt-Lussenburg B.M.A. van Waldmann T. Albrecht W. Boei J. Braak B. ter Brajnik M. Braunbeck T. Brecklinghaus T. Busquet F. Dinnyes A. Dokler J. Dolde X. Exner T.E. Fisher C. Fluri D. Forsby A. Hengstler J.G. Holzer A.K. Janstova Z. Jennings P. Kisitu J. Kobolak J. Kumar M. Limonciel A. Lundqvist J. Mihalik B. Moritz W. Pallocca G. Ulloa A.P.C. Pastor M. Rovida C. Sarkans U. Schimming J.P. Schmidt B.Z. Stöber R. Strassfeld T. Water B. van de Wilmes A. Burg B. van der Verfaillie C.M. von Hellfeld R. Vrieling H. Vrijenhoek N.G. Leist M. (2020), The EU-ToxRisk method documentation, data processing and chemical testing pipeline for the regulatory use of new approach methods, Archives of Toxicology 94(7): 2435-2461.
- Gräpel R., Braak B. ter, Escher S.E., Fisher C., Gardner I., Kamp H., Kroese D., Leist M., Moné M.J., Pastor M. & Water B. van de (2019), Paradigm shift in safety assessment using new approach methods: The EU-ToxRisk strategy, Current Opinion in Toxicology 15: 33-39.
- Schimming J.P., Braak B. ter, Niemeijer M., Wink S. & Water B. van de (2019), System Microscopy of Stress Response Pathways in Cholestasis Research. In: Vinken M. (Ed.), Experimental Cholestasis Research. Methods in Molecular Biology no. 1981. New York, NY, U.S.A.: Humana Press. 187-202.
- Bischoff L.J.M., Kuijper I.A., Schimming J.P., Wolters L., Braak B. ter, Langenberg J.P., Noort D., Beltman J.B. & Water B. van de (2019), A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure, Archives of Toxicology 93(2): 435-451.
- Niemeijer M.C., Hiemstra S.W., Wink S., Hollander W. den, Braak S.J. ter & Water B. van de (2018), Systems microscopy approaches in unraveling and predicting Drug-Induced Liver Injury (DILI). In: Chen M. & Will Y. (Eds.), Drug-Induced Liver Toxicity. Methods in Pharmacology and Toxicology. New York: Humana Press. 611-625.
- Bronsveld H.K., Bruin M.L. de, Wesseling J., Sanders J., Hofland I., Jensen V., Bazelier M.T., Braak S.J. ter, Boer A. de, Vestergaard P. & Schmidt M.K. (2018), The association of diabetes mellitus and insulin treatment with expression of insulin-related proteins in breast tumors, BMC Cancer 18(1): 224.
- Braak S.J. ter, Siezen C.L., Lee J.S., Rao P., Voorhoeve C., Ruppin E., Laan J.W. van der & Water B. van de (2017), Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production, Breast cancer research 19: 14.
- Braak S.J. ter, Siezen C.L.E., Speksnijder E.N., Koedoot E., Steeg H. ter, Salvatori D.C.F., Water B. van de & Laan J.W. van der (2015), Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53(R270H/+)WAPCre mouse model, Breast cancer research 17: 14.
- Dempster M., Siezen K., Braak S.J. ter, Brink W.J. van den, Emerenciana A., Bellanti F., Duijnhoven R.G., Kwa M. & Laan J.W. van der (2015), Carcinogenicity of Biopharmaceuticals. In: Graziano M.J. & Jacobson-Kram D. (Eds.), Genotoxicity and Carcinogenicity Testing of Pharmaceuticals. Cham: Springer International Publishing. 125-157.
- Bronsveld H.K., Braak B. ter, Karlstad O., Vestergaard P., Starup-Linde J., Bazelier M.T., Bruin M.L. de, Boer A. de, Siezen C.L.E., Water B. van de, Laan J.W. van der & Schmidt M.K. (2015), Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence, Breast cancer research 17: 100.
- Braak B. ter, Wink S., Koedoot E., Pont C., Siezen C., Laan J.W. van der & Water B. van de (2015), Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells, Breast cancer research 17: 97.
- Braak S.J. ter, Siezen C.L.E., Kannegieter N., Koedoot E., Water B. van de & Laan J.W. van der (2014), Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel, Archives of Toxicology 88(4): 953-966.
- Braak S.J. ter, Laughton A.M., Altincicek B., Parker B.J. & Gerardo N.M. (2013), Exposure to bacterial signals does not alter pea aphids' survival upon a second challenge or investment in production of winged offspring, 8(8): e73600.
- De La Vega J., Braak S.J. ter, Azzoni A.R., Monteiro G.A. & Prazeres D.M. (2013), Impact of plasmid quality on lipoplex-mediated transfection, Journal of Pharmaceutical Sciences 102(11): 3932-3941.