Amy Harms
Assistant professor
- Name
- Dr. A.C. Harms
- Telephone
- +31 71 527 6326
- a.c.harms@lacdr.leidenuniv.nl
- ORCID iD
- 0000-0002-2931-4295
Amy Harms joined Analytical Biosciences group in 2010 and manages the metabolomics core facility embedded in the Analytical Biosciences division of the LACDR. She received her PhD in chemistry from Penn State in 1994 and did post-doctoral research in the field of biological mass spectrometry at Pacific Northwest National Lab.
Amy Harms joined Analytical Biosciences group in 2010 and manages the metabolomics core facility embedded in the Analytical Biosciences division of the LACDR. She received her PhD in chemistry from Penn State in 1994 and did post-doctoral research in the field of biological mass spectrometry at Pacific Northwest National Lab. After working as a mass spectrometry facility manager in the University of Kentucky, she moved to Wisconsin and in 1998 became the director of the Mass Spectrometry/ proteomics/ metabolomics facility at the University of Wisconsin Biotechnology Center and ran the core facility for the University of Wisconsin Comprehensive Cancer Center until moving to the Netherlands.
Amy’s interests include instrumentation, data processing strategies, and quality control. As research support, she hopes to contribute to the experimental design, the actual collecting of data, evaluation and interpretation of data, and integration of metabolomics into the larger goals of the proposed projects.
Assistant professor
- Science
- Leiden Academic Centre for Drug Research
- LACDR/Analytical Biosciences
- Pandian K., Huang L., Junaid A.O., Harms A.C., Zonneveld A.J. van & Hankemeier T. (2024), Tracer‐based metabolomics for profiling nitric oxide metabolites in a 3D microvessels‐on‐chip model, The FASEB Journal 38(16): e70005.
- Singh M., Kiyuna L.A., Odendaal C., Bakker B.M., Harms A.C. & Hankemeier T. (2024), Development of targeted hydrophilic interaction liquid chromatography-tandem mass spectrometry method for acyl-Coenzyme A covering short- to long-chain species in a single analytical run, Journal of Chromatography A 1714: 464524.
- Bonanini F., Singh M., Yang H., Kurek D., Harms A.C., Mardinoglu A. & Hankemeier T. (2024), A comparison between different human hepatocyte models reveals profound differences in net glucose production, lipid composition and metabolism in vitro, Experimental Cell Research 437(1): 114008.
- Abyar S., Huang L., Husiev Y., Bretin L.R., Chau B., Vadde R., Wildeman J.H., Belfor K., Wijyay L.S., Noord V.E. van der, Harms A.C., Siegler M.A., Le Dévédec S.E. & Bonnet S.A. (2024), Oxygen-dependent interactions between the ruthenium cage and the photoreleased inhibitor in NAMPT-targeted photoactivated chemotherapy, Journal of Medicinal Chemistry 67(13): 11086–11102.
- Zhang Z., Karu N., Kindt A.S.D., Singh M., Lamont L., Gammeren A.J. van, Ermens A.A.M., Harms A.C., Lutzen P., Vermeulen R.C.H, Dik W.A., Langerak A.W. , Velden V.H.J. van der & Hankemeier T. (2024), Association of altered plasma lipidome with disease severity in COVID-19 patients, Biomolecules 14(3): 296.
- Pandian K., Matos L.D. de, Hetzel L A., Zwier R.C.T., Veldhuizen P.J. van, Schubert C., Karuppusamy J., Harms A.C., Ali A. & Hankemeier T. (2024), Enabling high-sensitivity live single-cell mass spectrometry using an integrated electrical lysis and nano electrospray ionization interface, Analytica Chimica Acta 1324: 343068.
- Zhang Z., Duri K., Duisters K.L.W., Schoeman J.C., Chandiwana P., Lindenburg P., Jaeger J., Ziegler S., Altfeld M., Kohler I., Harms A., Gumbo F.Z., Hankemeier T. & Bunders M.J. (2023), Altered methionine-sulfone levels are associated with impaired growth in HIV-exposed-uninfected children, AIDS 37(9): 1367-1376.
- Onderwater G.L.J., Dongen R.M. van, Harms A.C., Zielman R., Oosterhout W.P.J. van, Klinken J.B. van, Goeman J.J., Terwindt G.M., Maagdenberg A.M.J.M. van den, Hankemeier T. & Ferrari M.D. (2023), Cerebrospinal fluid and plasma amine profiles in interictal migraine, Annals of Neurology 93(4): 715-728.
- Zhang Z., Singh M., Kindt A.S.D., Wegrzyn A.B., Pearson M.J., Ali A.M.A.M., Harms A.C., Baker P. & Hankemeier T. (2023), Development of a targeted hydrophilic interaction liquid chromatography-tandem mass spectrometry based lipidomics platform applied to a coronavirus disease severity study, Journal of Chromatography A 1708: 464342.
- Hubers N., Hagenbeek F.A., Pool R., Déjean S., Harms A.C. Roetman P.J., Beijsterveldt C.E.M. van, Fanos V., Ehli E.A., Vermeiren R.R.J.M., Bartels M., Hottenga J.J., Hankemeier T., Dongen J. van & Boomsma D.I. (2023), Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 195(2): e32955.
- Singh M., Elfrink H.L., Harms A.C. & Hankemeier T. (2023), Recent developments in the analytical approaches of acyl-CoAs to assess their role in mitochondrial fatty acid oxidation disorders, Molecular Genetics and Metabolism 140(1-2): 107711.
- Hagenbeek F.A., Dongen J. van, Roetman P.J., Harms A.C., Hottenga J.J., Kluft C., Colins O.F., Beijsterveldt C.E.M. van, Fanos V., Ehli E.A., Hankemeier T., Vermeiren R.R.J.M., Bartels M., Dejean S. & Boomsma D.I. (2023), Integrative multi-omics analysis of childhood aggressive behavior, Behavior Genetics 53: 101-117.
- Yin C., Harms A.C., Hankemeier T., Kindt A.S.D. & Lange E.C.M. de (2023), Status of metabolomic measurement for insights in Alzheimer’s disease progression—what is missing?, International Journal of Molecular Sciences 24(5): 4960.
- Huang L., Drouin N.F.P., Causon J., Wegrzyn A.B., Castro-Perez J., Fleming R.M., Harms A.C. & Hankemeier T. (2023), Reconstruction of glutathione metabolism in the neuronal model of rotenone-induced neurodegeneration using mass isotopologue analysis with hydrophilic interaction liquid chromatography-Zeno high-resolution multiple reaction monitoring, Analytical Chemistry 95(6): 3255-3266.
- Jurado-Fasoli L., Di X., Sanchez-Delgado G., Yang W., Osuna-Prieto F.J., Ortiz-Alvarez L., Krekels E., Harms A.C., Hankemeier T., Schonke C., Aguilera C.M., Llamas-Elvira J.M., Kohler I., Rensen P.C.N., Ruiz J.R. & Martinez-Tellez B. (2022), Acute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial, EBioMedicine 85: 104313.
- Hagenbeek F., Hubers N., Dongen J. van, Pool R., Roetman P., Harms A.C., Hottenga J.J., Hankemeier T., Veremeiren R., Bartels M., Dejean S. & Boomsma D. (2022), Integrative multi-omics approaches to child-hood aggression and attention-deficit/hyper-activity disorder, European Neuropsychopharmacology 63: e4.
- Kanhai K.M.S., Goulooze S.C., Grond J. van der, Harms A.C., Hankemeier T., Verma A., Dent G., Chavez J., Meijering H. & Groeneveld G.J. (2022), Kinetics of myelin breakdown products: a labeling study in patients with progressive multiple sclerosis, Clinical and Translational Science 15(3): 638-648.
- Jurado-Fasoli L., Di X.Y., Kohler I., Osuna-Prieto F.J., Hankemeier T., Krekels E.H.J., Harms A.C., Yang W., Garcia-Lario J.V., Fernandez-Veledo S., Ruiz J.R., Rensen P.C.N. & Martinez-Tellez B. (2022), Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults, Obesity 30(1): 50-61.
- Hosseinkhani F., Huang L., Dubbelman A.C., Guled F., Harms A.C. & Hankemeier T. (2022), Systematic evaluation of HILIC stationary phases for global metabolomics of human plasma, Metabolites 12(2): 165.
- Karu N., Kindt A., Lamont L., Gammeren A.J. van, Ermens A.A.M., Harms A.C., Portengen L., Vermeulen R.C.H. Dik W.A., Langerak A.W., Velden V.H.J. van der & Hankemeier T. (2022), Plasma oxylipins and their precursors are strongly associated with COVID-19 severity and with immune response markers, Metabolites 12(7): 619.
- Karu N., Kindt A., Gammeren A.J. van, Ermens A.A.M., Harms A.C., Portengen L., Vermeulen R.C.H., Dik W.A., Langerak A.W., Velden V.H.J. van der & Hankemeier T. (2022), Severe COVID-19 is characterised by perturbations in plasma amines correlated with immune response markers, and linked to inflammation and oxidative stress, Metabolites 12(7): 618.
- Ding Y., Haks M.C., Eeden S.J.F. van den, Ottehoff T.H.M., Harms A.C., Hankemeier T., Eeza M.N.H., Matysik J., Alia A. & Spaink H.P. (2022), Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome, Metabolomics 18(8): 67.
- He Y., Mever M. van, Yang W., Huang L.: Ramautar R., Rijksen Y., Vermeij W.P., Hoeijmakers J.H.J., Harms A.C., Lindenburg P.W. & Hankemeier T. (2022), A sample preparation method for the simultaneous profiling of signaling lipids and polar metabolites in small quantities of muscle tissues from a mouse model for sarcopenia, Metabolites 12(8): 742.
- Wouters B., Miggiels A.L.W., Bezemer R.P., Cruijsen E.A.W. van der, Leeuwen E. van, Gauvin J., Houben K., Sai Sankar Gupta K.B., Zuijdwijk P., Harms A.C., Carvalho de Souza A. & Hankemeier T. (2022), Automated segmented-flow analysis: NMR with a novel fluoropolymer flow cell for high-throughput screening, Analytical Chemistry 94(44): 15350-15358.
- Jurado-Fasoli L., Yang W., Kohler I., Dote-Montero M., Osuna-Prieto F.J., Di X., Hankemeier T., Krekels E.H.J., Harms A.C., Castillo M.J., Amaro-Gahete F.J. & Martinez-Tellez B. (2022), Effect of different exercise training modalities on fasting levels of oxylipins and endocannabinoids in middle-aged sedentary adults: a randomized controlled trial, International Journal of Sport Nutrition and Exercise Metabolism 32(4): 275-284.
- Hagenbeek F.A., Dongen J. van, Pool R., Harms A.C., Roetman P.J., Fanos V., Keulen B.J. van, Walker B.R., Karu N., Hulshoff P.H.E., Rotteveel J., Finken M.J.J., Vermeiren R.R.J.M., Kuft C., Bartels M. & Hankemeier T. Boomsma D.I. (2022), Heritability of urinary amines, organic acids, and steroid hormones in children, Metabolites 12(6): 474.
- Leygeber S., Grossmann J.L., Diez-Simon C., Karu N., Dubbelman A.C., Harms A.C., Westerhuis J.A., Jacobs D.M., Lindenburg P.W., Hendriks M.M.W.B., Ammerlaan B.C., Berg M.A. van den, Doorn R. van, Mumm R., Hall R.D., Smilde A.K. & Hankemeier T. (2022), Flavor profiling using comprehensive mass spectrometry analysis of metabolites in tomato soups, Metabolites 12(12): 1194.
- He B.S., Di X., Gulded F., Harder A.V.E., Maagdenberg A.M.J.M. van den, Terwindt G.M., Krekels E.H.J., Kohler I., Harms A.C., Ramautar R. & Hankemeier T. (2022), Quantification of endocannabinoids in human cerebrospinal fluid using a novel micro-flow liquid chromatography-mass spectrometry method, Analytica Chimica Acta 1210: 339888.
- Laan T. van der, Elfrink H.L., Azadi-Chegeni F., Dubbelman A.C., Harms A.C., Jacobs D.M., Braumann U., Velders A.H., Duynhoven J. & Hankemeier T. (2021), Fractionation platform for target identification using off-line directed two-dimensional chromatography, mass spectrometry and nuclear magnetic resonance, Analytica Chimica Acta 1142: 28-37.
- Hosseinkhani F., Heinken A., Thiele I., Lindenburg P.W. Harms A.C. & Hankemeier T. (2021), The contribution of gut bacterial metabolites in the human immune signaling pathway of non-communicable diseases, Gut Microbes 13(1): 1-22.
- Ding Y., Haks M.C., Forn Cuní G., He J., Nowik N., Harms A.C., Hankemeier T., Eeza M.N.H., Matysik J., Alia A. & Spaink H.P. (2021), Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways, Cell & Bioscience 11(1): 126.
- Puyvelde B. van, Uytfanghe K. van, Tytgat O., Oudenhove L., Gabriels R., Bouwmeester R., Daled S., Bossche T. van den, Ramasamy P., Verhelst S., Clerck L. de, Corveleyn L., Willems S., Debunne N., Wynendaele E., Spiegeleer B. de, Judak P, Roels K., Wilde L. de, Eenoo P. van, Reyns T., Cherlet M., Dumont E., Debyser G.,'Kindt R. 't, Sandra K., Gupta S., Drouin N., Harms A., Hankemeier T., Jones D.J.L., Gupta P., Lane D., Lane C.S., El Ouadi S., Vincendet J.B., Morrice N., Oehrle S., Tanna N., Silvester S., Hannam S., Sigloch F.C., Bhangu-Uhlmann A., Claereboudt J., Anderson N.L., Razavi M., Degroeve S., Cuypers L., Stove C., Lagrou K., Martens G.A., Deforce D., Martens L., Vissers J.P.C. & Dhaenens M. (2021), Cov-MS: A Community-Based Template Assay for Mass-Spectrometry-Based Protein Detection in SARS-CoV-2 Patients: a community-based template assay for mass-spectrometry-based protein detection in SARS-CoV-2 patients, JACS Au 1(6): 750-765.
- Arykbaeva A.S., Vries D.K. de, Doppenberg J.B., Engelse M.A., Hankemeier T., Harms A.C., Wijermars L.G., Schaapherder A.F., Bakker J.A., Ploeg R.J., Alwayn I.P.J. & Lindeman J.H.N. (2021), Metabolic needs of the kidney graft undergoing normothermic machine perfusion, Kidney International 100(2): 301-310.
- Hartog I. den, Zwep L.B., Vestjens S.M.T., Harms A.C., Voorn G.P., Lange D.W. de, Bos W.J.W., Hankemeier T., Garde E.M.W. & Hasselt J.G.C. van (2021), Metabolomic profiling of microbial disease etiology in community-acquired pneumonia, PLoS ONE 16(6): e0252378.
- Hosseinkhani F., Dubbelman A.C., Karu N., Harms A.C. & Hankemeier T. (2021), Towards standards for human fecal sample preparation in targeted and untargeted LC-HRMS studies, Metabolites 11(6): 364.
- He B.S., Zhang W., Guled F., Harms A.C., Ramautar R. & Hankemeier T. (2021), Analytical techniques for biomass-restricted metabolomics: an overview of the state-of-the-art, Microchemical Journal 171: 106794.
- Jurado-Fasoli L., Di X.Y., Kohler I., Osuna-Prieto F.J., Hankemeier T., Krekels E.H.J., Harms A.C., Yang W., Garcia-Lario J.V., Fernendez-Veledo S., Ruiz J.R., Rensen P.C.N. & Martinez-Tellez B. (2021), Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic risk in young adults, Obesity 30(1): 50-61.
- Mever M. van, Willacey C.C.W., Zhang W., Drouin N.F.P., Christina A.E., Lindenburg P.W., Veldhoven J.P. D. van, Es D. van der, Harms A.C., Hankemeier T. & Ramautar R. (2021), Profiling acidic metabolites by capillary electrophoresis‐mass spectrometry in low numbers of mammalian cells using a novel chemical derivatization approach, Analytical Science Advances 3(1-2): 3-13.
- Ding Y., Raterink R., Marín Juez R., Veneman W.J., Egbers K., Eeden S. van den, Haks M.C., Joosten S.A., Ottenhoff T.H.M., Harms A.C., Alia A., Hankemeier T. & Spaink H.P. (2020), y Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae, Scientific Reports 10(1): 11635.
- Duisters K.L.W., Ogino S., Andou T., Ito K., Akabane T., Harms A.C., Moerland M., Hashimoto Y., Ando A., Ohtsu Y., Wada N., Yukinaga H., Meulman J., Kobayashi H., Kobayashi N., Suzumura K. & Hankemeier T. (2020), Intersubject and intrasubject variability of potential plasma and urine metabolite and protein biomarkers in healthy human volunteers, Clinical Pharmacology & Therapeutics 107(2): 397-405.
- Ding Y. Raterink R. Marín‑Juez R. Veneman W.J. Egbers K. Eeden S. van den Haks M.C. Joosten S.A. Ottenhof T.H.M. Harms A.C. Alia A. Hankemeier T. Spaink H.P. (2020), Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria‑infected mice and zebrafish larvae, Scientific Reports 10: 11635.
- Hagenbeek F.A., Pool R., Dongen J. van, Draisma H.M., Hottenga J.J., Willemsen G., Abdellaoui A., Fedko I.O., Braber A. den , Visser P.J., Geus E.J.C.N. de, Duijn C.M. van, Harms A.C., Bartels M. Nivard M.G., Boomsma D.I., Hankemeier T., Beulens J.W., Rutters F., Flier W.M. van der, Hart L.M., Bom J.A. van der, Kloppenburg M., Harst P. van der, Bomer N., Hilten J.A. van, So-Osman C., Meessen J.M.T.A., Fu J., Wijmenga C., Zhernikova A., Slofstra M., Swertz M., Onderwater G.L.J., Terwindt G.M., Heijden A.A.W.A. van der, Asselbergs F.W., Boersma E., Elders P.M., Geleijnse J.M., Ikram M.A., Mooijaart S.P., Nelissen R.G.H.H., Netea M.G., Penninx B.W.J.H., Stehouwer C.D.A., Kallen C.J.H. van der, Greevenbroek M.M.J. van, Teunissen C.E., Maagdenberg A.M.J.M. van den, Horst I.C.C. van der, Spil W.E. van, Zwinderman A.H., Jukema J.W., Mei H., Akker E.B. van den, Reinders M.J.T., Deelen J. & Abdel Abdellaoui (2020), Correction to: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (vol 11, 39, 2020), Nature Communications 11: 1702.
- Di Zazzo A., Yang W., Coassin M., Micera A., Antonini M., Piccinni F., De Piano M., Kohler I., Harms A.C., Hankemeier T., Boinini S. & Mashaghi A. (2020), Signaling lipids as diagnostic biomarkers for ocular surface cicatrizing conjunctivitis, Journal of Molecular Medicine 98: 751-760.
- Di Zazzo A., Yang W., Coassin M., Micera A., Antonini M., Piccinni F., Piano M. de, Kohler I., Harms A.C., Hankemeier T., Bonini S. & Mashaghi A. (2020), Correction to: Signaling lipids as diagnostic biomarkers for ocular surface cicatrizing conjunctivitis , Journal of Molecular Medicine 98: 1049-1049.
- Hagenbeek F.A., Roetman P.J., Pool R., Kluft C., Harms A.C., Dongen J. van, Colins O.F., Talens S., Beijsterveldt C.E.M. van, Vandenbosch M.M.L.J.Z., Zeeuw E.L. de, Dejean S., Fanos V., Ehli E.A., Davies G.E., Hottenga J.J., Hankemeier T., Bartels M., Vermeiren R.R.J.M. & Boomsma D.I. (2020), Urinary Amine and Organic Acid Metabolites Evaluated as Markers for Childhood Aggression: The ACTION Biomarker Study, Frontiers in Psychiatry 11: 165.
- Laan T. van der, Dubbelman A.C., Duisters K.L.W., Kindt A.S.D., Harms A.C. & Hankemeier T. (2020), High-throughput fractionation coupled to mass spectrometry for improved quantitation in metabolomics, Analytical Chemistry 92(21): 14330-14338.
- Hubers N., Hagenbeek F.A., Dongen J. van, Dejean S., Roetman P.J., Harms A.C., Hottenga J.J., Kluft C., Colins O.F., Beijsterveldt C.E.M., Vandenbosch M.M.L.J.Z., Zeeuw E.L., Talens S., Fanos V., Ehli E.A., Davies G.E., Vermeiren R.R.J.M., Hankemeier T., Bartels M., Pool R. & Boomsma D.I. (2020), Integrative multi-omics analysis of epigenomic and metabolomic data for attention-deficit/ hyperactivity disorder. The 50th BGA Meeting 26 June 2020 - 26 June 2020. Behavior Genetics: Springer. 459.
- Hagenbeek F.A., Dongen J. van, Pool R., Roetman P.J., Harms A.C., Hottenga J.J., Kluft C., Colins O.F., Beijsterveldt C.E.M. van, Vandenbosch M.M.L.J.Z., Zeeuw E.L., Talens S., Fanos V., Ehli E.A., Davies G.E., Vermeiren R.R.J.M., Hankemeier T., Bartels M., Dejean S. & Boomsma D.I. (2020), Integrative multi-omics analysis of genomic, epigenomic, and metabolomic data for childhood aggressive behavior, Behavior Genetics 50(6): 457-458.
- Willacey C.C.W., Karu N., Harms A.C. & Hankemeier T. (2020), Metabolic profiling of material-limited cell samples by dimethylaminophenacyl bromide derivatization with UPLC-MS/MS analysis, 159: 105445.
- Laan T. van der, Boom I., Maliepaard J., Dubbelman A.C., Harms A.C. & Hankemeier T. (2020), Data-independent acquisition for the quantification and identification of metabolites in plasma, Metabolites 10(12): 514.
- Wijk R.C. van, Krekels E.H.J., Kantae V., Harms A.C., Hankemeier T., Graaf P.H. van der & Spaink H.P. (2019), Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae, Scientific Reports 9: 2149.
- Wijk R.C. van, Krekels E.H.J., Kantae V., Ordas A., Kreling T., Harms A.C., Hankemeier T., Spaink H.P. & Graaf P.H. van der (2019), Mechanistic and quantitative understanding of pharmacokinetics in zebrafish larvae through nanoscale blood sampling and metabolite modelling of paracetamol, Journal of Pharmacology and Experimental Therapeutics 371(1): 15-24.
- Laan T. van der, Kloots T.N., Beekman M., Kindt A.S.D., Dubbelman A.C., Harms A.C., Duijn C.M. van, Slagboom P.E. & Hankemeier T. (2019), Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum, Scientific Reports 9: 12370.
- Nickels S.L., Walter J., Bolognin S., Gerard D., Jaeger C., Qing X.B., Tisserand J., Jarazo J., Hemmer K., Harms A.C., Halder R., Lucarelli P., Berger E., Antony P.M.A., Glaab E., Hankemeier T., Klein C., Sauter T., Sinkkonen L. & Schwamborn J.C. (2019), Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients, Parkinsonism & Related Disorders 67: 48-55.
- Hertel J., Harms A.C., Heinken A., Baldini F., Thinnes C.C., Glaab E., Vasco D.A., Pietzner M., Stewart I.D., Wareham N.J., Langenberg C., Trenkwalder C., Kruger R., Hankemeier T., Fleming R.M.T., Mollenhauer B. & Thiele I. (2019), Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson's Disease, Cell Reports 29(7): 1767-1777.
- Willacey C.C.W., Naaktgeboren M., Moreno E.L., Wegrzyn A.B., Es D. van der, Karu N., Fleming R.M.T., Harms A.C. & Hankemeier T. (2019), LC-MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide, Journal of Chromatography A 1608: 460413.
- Draper C.F., Duisters K.L.W., Weger B., Chakrabarti A., Harms A.C., Brennan L., Hankemeier T., Goulet L., Konz T., Martin F.P., Moco S. & Greef J. van der (2019), Publisher Correction: Menstrual cycle rhythmicity: metabolic patterns in healthy women, Scientific Reports 9: 5797.
- Vrieling F., Alisjahbana B., Sahiratmadja E., Crevel R. van, Harms A.C., Hankemeier T., Ottenhoff T.H.M. & Joosten S.A. (2019), Plasma metabolomics in tuberculosis patients with and without concurrent type 2 diabetes at diagnosis and during antibiotic treatment, Scientific Reports 9: 18669.
- Gomez-Cabrero D., Tarazona S., Ferreiros-Vidal I., Ramirez R.N., Company C., Schmidt A., Reijmers T., Saint Paul V.V., Marabita F., Rodriguez-Ubreva J., Garcia-Gomez A., Carroll T., Cooper L., Liang Z.W., Dharmalingam G., Kloet F. van der, Harms A.C., Balzano-Nogueira L., Lagani V., Tsamardinos I., Lappe M., Maier D., Westerhuis J.A., Hankemeier T., Imhof A., Ballestar E., Mortazavi A., Merkenschlager M., Egner J.T. & Conesa A. (2019), STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse, Scientific Data 6: 256.
- Boomsma D., Pool R., Hagenbeek F., Hankemeier T., Kluft C., Fanos V., Nivard M., Bartels M., Harms A.C. & Slagboom P. (2019), Twin studies of metabolomics traits and metabo-phenotype associations, Behavior Genetics 49(6): 494.
- Drouin N.F.P., Kloots T.N., Schappler J., Rudaz S., Kohler I., Harms A.C., Lindenburg P.W. & Hankemeier T. (2019), Electromembrane Extraction of Highly Polar Compounds: Analysis of Cardiovascular Biomarkers in Plasma, Metabolites 10(1): 4.
- He M., Harms A.C., Wijk E.P.A. van, Wang M., Berger R., Koval V.V., Hankemeier T. & Greef J. van der (2019), Role of amino acids in rheumatoid arthritis studied by metabolomics, International Journal of Rheumatic Diseases 22(1): 38-46.
- Teitsma X.M., Yang W., Jacobs J.W.G., Petho-Schramm A., Borm M.E.A., Harms A.C., Hankemeier T., Laar J.M. van, Bijlsma J.W.J. & Lafeber F.P.J.G. (2018), Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology, Arthritis Research & Therapy 20: 230.
- Peltenburg N.C., Schoeman J.C., Hou J., Mora F., Harms A.C., Lowe S.H., Bierau J., Bakker J.A., Verbon A., Hankemeier T. & Boonstra A. (2018), Persistent metabolic changes in HIV-infected patients during the first year of combination antiretroviral therapy, Scientific Reports 8: 16947.
- Buijink M.R., Weeghel M. van, Gulersonmez M.C., Harms A.C., Rohling J.H.T., Meijer J.H., Hankemeier T. & Michel S. (2018), The influence of neuronal electrical activity on the mammalian central clock metabolome, Metabolomics 14: 122.
- Eyk H.J. van, Schinkel L.D. van, Kantae V., Dronkers C.E.A., Westenberg J.J.M., Roos A. de, Lamb H.J., Jukema J.W., Harms A.C., Hankemeier T., Stelt M. van der, Jazet I.M., Rensen P.C.N. & Smit J.W.A. (2018), Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes, Nutrition and Diabetes 8(1): 6.
- Fu J., Chang L., Harms A.C., Jia Z., Wang H., Wei C., Qiao L., Tian S., Hankemeier T., Wu Y. & Wang M. (2018), A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach, Scientific Reports 8(1): 3688.
- Schoeman J.C., Harms A.C., Weeghel M. van, Berger R., Vreeken R.J. & Hankemeier T. (2018), Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress, Analytical and Bioanalytical Chemistry 410(10): 2551-2568.
- Nahon K.J., Kantae V., Haan R. den, Hanssen M.J.W., Harms A.C., Stelt M. van der, Hankemeier T., Jazet I.M., Marken Lichtenbelt W.D. van, Rensen P.C.N. & Boon M.R. (2018), Gene expression of endocannabinoid system components in skeletal muscle and adipose tissue of South Asians and White Caucasians with overweight, Obesity 26(8): 1332-1337.
- Aart L.T. van der, Spijksma G.K., Harms A.C., Vollmer W., Hankemeier T. & Wezel G.P. van (2018), High-Resolution analysis of the Peptidoglycan composition in Streptomyces coelicolor, Journal of Bacteriology 200(20): e00290.
- Draper C.F., Duisters K.L.W., Weger B., Chakrabarti A., Harms A.C., Brennan L., Hankemeier T., Goulet L., Konz T., Martin F.P., Moco S. & Greef J. van der (2018), Menstrual cycle rhythmicity: metabolic patterns in healthy women, Scientific Reports 8: 14568.
- Kaddurah-Daouk R., Hankemeier T., Scholl E.H., Baillie R., Harms A.C., Stage C., Dalhoff K.P., Jűrgens G., Taboureau O., Nzabonimpa G.S., Motsinger-Reif A.A., Thomsen R., Linnet K. & Rasmussen H.B. (2018), Pharmacometabolomics Informs about pharmacokinetic profile of Methylphenidate, CPT: Pharmacometrics and Systems Pharmacology 7(8): 525-533.
- Noga M.J., Zielman R., Dongen R.M. van, Bos S., Harms A.C., Terwindt G.M., Maagdenberg A.M.J.M. van den, Hankemeier T. & Ferrari M.D. (2018), Strategies to assess and optimize stability of endogenous amines during cerebrospinal fluid sampling, Metabolomics 14: 44.
- Kuipers E.N., Kantae V., Maarse B.C.E., Berg S.M. van den, Eenige R. van, Nahon K.J., Reifel-Miller A., Coskun T., Winther M.P.J. de, Lutgens E., Kooijman S., Harms A.C., Hankemeier T., Stelt M. van der, Rensen P.C.N. & Boon M.R. (2018), High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue, Frontiers in Physiology 9: 1913.
- Kantae V., Krekels E.H.J., Esdonk M.J. van, Lindenburg P.W., Harms A.C., Knibbe C.A.J., Graaf P.H. van der & Hankemeier T. (2017), Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy, Metabolomics 13(1): 9.
- Kantae V., Nahon K.J., Straat M.E., Bakker L.E.H., Harms A.C., Stelt M. van der, Hankemeier T., Jazet I.M., Boon M.R. & Rensen P.C.N. (2017), Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men, Scientific Reports 7(1): 7558.
- Kantae V., Krekels E.H.J., Esdonk M.J. van, Lindenburg P.W., Harms A.C., Knibbe C.A.J., Graaf P.H. van der & Hankemeier T. (2017), Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy: an addition to the topical collection "Recent Advances in Pharmacometabolomics: Enabling Tools for Precision Medicine", Metabolomics 13(5): 58.
- Liu J., Semiz S., Lee S.J. van der, Spek A. van der, Verhoeven A., Klinken J.B., Sijbrands E., Harms A.C., Hankemeier T., Willems van Dijk J.A.P., Duijn C.M. van & Demirkan A. (2017), Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study, Metabolomics 13(9): 104.
- Leeuw F.A., Peeters C.F.W., Kester M.I., Harms A.C., Struys E.A., Hankemeier T., Vlijmen H. van, Lee S.J. van der, Duijn C.M. van, Scheltens P., Demirkan A., Wiel M.A. van der, Flier W.M. van der & Teunissen C.E. (2017), Blood-based metabolic signatures in Alzheimer's disease, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 8: 196-207.
- Brink W.J. van den, Elassaiss J., Gonzalez Amoros B., Harms A.C., Graaf P.H. van der, Hankemeier T. & Lange E.C.M. de (2017), Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats, European Journal of Pharmaceutical Sciences 109: 431-440.
- Liu J., Klinken J.B. van, Semiz S., Willems van Dijk K., Verhoeven A., Hankemeier T., Harms A.C., Sijbrands E., Sheehan N.A., Duijn C.M. van & Demirkan A. (2017), A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes, Diabetes 66(11): 2915-2926.
- Schoeman J.C., Moutloatse G.P., Harms A.C., Vreeken R.J., Scherpbier H.J., Leeuwen L. van, Kuijpers T.W., Reinecke C.J., Berger R., Hankemeier T. & Bunders M.J. (2017), Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1-and Combination Antiretroviral Therapy-Exposed Infants, The Journal of Infectious Diseases 216(4): 436-446.
- Kantae V., Krekels E.H.J., Ordas A.K., Gonzalez O., Wijk R.C. van, Harms A.C., Racz P.I., Graaf P.H. van der, Spaink H.P. & Hankemeier T. (2016), Pharmacokinetic modeling of paracetamol uptake and clearance in zebrafish larvae: expanding the allometric scale in vertebrates with five orders of magnitude, Zebrafish 13(6): 504-510.
- Hankemeier T., Kaddurah-Daouk R., Koval V.V., Harms A.C., Moon I., Kuwahara H., Bos S., Marin S., Cascante M., Weinshilboum R. & Wang L. (2016), Studying individual differences in cancer drug efficacy using cell lines derived from patients, Clinical Pharmacology & Therapeutics 99: S103-S103.
- Bojic L.A., McLaren D.G., Harms A.C., Hankemeier T., Dane A.D., Wang S.-P., Rosa R., Previs S.F., Johns D.G. & Castro-Perez J.M. (2016), Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits, Analytical and Bioanalytical Chemistry 408(1): 97-105.
- Breitenstein M.K., Berger R., Bos S., Cascante M., Hankemeier T., Harms A.C., Kaddurah-Daouk R.F., Kalari K.R., Koval V.V., Marin S., Moon I., Nair K.S., Persson M., Weinshilboum R.M. & Wang L. (2016), A metformin metabolomic expression profile study utilizing an electronic health record (ehr)-linked biorepository and integrative molecular epidemiology approaches, Clinical Pharmacology & Therapeutics 99: S30-S30.
- Schoeman J.C., Hou J., Harms A.C., Vreeken R.J., Berger R., Hankemeier T. & Boonstra A. (2016), Metabolic characterization of the natural progression of chronic hepatitis B, Genome Medicine 8(1): 64.
- Fu J., Schoeman J.C., Harms A.C., Van Wietmarschen H.A., Vreeken R.J., Berger R., Cuppen B.V., Lafeber F.P., Van der Greef J. & Hankemeier T. (2016), Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis, Analytical and Bioanalytical Chemistry 408(23): 6307–6319.
- Fu J., Cuppen B.V.J., Welsing P.M.J., Wietmarschen H.A. van, Harms A.C., Berger R., Koval V.V., Fritsch-Stork R.D.E., Bijlsma J.W.J., Hankemeier T., Greef J. van der & Lafeber F.P.J.G. (2016), Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment, Inflammopharmacology 24(6): 397-402.
- Cuppen B.V.J., Fu J., Wietmarschen H.A. van, Harms A.C., Koval V.V., Marijnissen A.C.A., Peeters J.J.W., Bijlsma J.W.J., Tekstra J., Laar J.M., Hankemeier T., Lafeber F.P.J.G. & Greef J. van der (2016), Exploring the Inflammatory Metabolomic Profile to Predict Response to TNF-alpha Inhibitors in Rheumatoid Arthritis, 11(9): e0163087.
- Hagenbeek F., Nivard M., Pool R., Dongen J. van, Hottenga J.-J., Abdellaoui A., Willemsen G., Vink J., Ligthart L., Harms A.C., Hankemeier T., Bartels M. & Boomsma D. (2016), Genome-wide pleiotropy of adult aggression and blood metabolites, Behavior Genetics 46(6): 785-786.
- Zhang Y., Blasco-Colmenares E., Harms A.C., London B., Halder I., Singh M., Dudley S.C., Gutmann R., Guallar E., Hankemeier T., Tomaselli G.F. & Cheng A. (2016), Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients, Europace 18(9): 1383-1390.
- Zhang Y., Guallar E., Blasco-Colmenares E., Harms A.C., Vreeken R.J., Hankemeier T., Tomaselli G.F. & Cheng A. (2016), Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients, 11(6): e0157035.
- He M., Wijk E.P.A. van, Berger R., Wang M., Strassburg K., Schoeman J.C., Vreeken R.J., Wietmarschen H.A. van, Harms A.C., Kobayashi M., Hankemeier T. & Greef J. van der (2015), Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma, Mediators of Inflammation 2015: 543541.
- Alves R.D.A.M., Dane A.D., Harms A.C., Strassburg K, Seifar R.M, Verdijk L.B., Kersten S., Berger R., Hankemeier T. & Vreeken R.J. (2015), Global profiling of the muscle metabolome: method optimization, validation and application to determine exercise-induced metabolic effects, Metabolomics 11(2): 271-285.
- Koster M.P.H., Vreeken R.J., Harms A.C., Dane A.D., Kuc S., Schielen Peter C.J.I., Hankemeier T., Berger R., Visser G.H.A. & Pennings J.L.A. (2015), First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach, Disease Markers 2015(857108): .
- Ellero-Simatos S., Beitelshees A.L., Lewis J.P., Yerges-Armstrong L.M., Georgiades A., Dane A., Harms A.C., Strassburg K., Guled F., Hendriks M.M., Horenstein R.B., Shuldiner A.R., Hankemeier T. & Kaddurah-Daouk R. (2015), Oxylipid profile of low-dose exposure: a pharmacometabolomics study, Clinical Pharmacology & Therapeutics 97(S1): S22-S22.
- Rueda-Rincon N., Bloch K., Derua R., Vyas R., Harms A.C., Hankemeier T., Khan Niamat A., Dehairs J., Bagadi M., Binda M.M., Waelkens E., Marine J.-C. & Swinnen J.V. (2015), p53 attenuates AKT signaling by modulating membrane phospholipid composition, OncoTarget 6(25): 21240-21254.
- Kuc S., Koster M.P.H., Pennings J.L.A., Hankemeier T., Berger R., Harms A.C., Dane A.D., Schielen P.C.J.L., Visser G.H.A. & Vreeken R.J. (2014), Metabolomics profiling for identification of novel potential markers in early prediction of preeclampsia, PLoS ONE 9(5): e98540.
- Ellero-Simatos S., Lewis J.P., Georgiades A., Yerges-Armstrong L.M., Beitelshees A.L., Horenstein R.B., Dane A.D., Harms A.C., Ramaker R., Vreeken R.J., Perry C.G., Zhu H., Sànchez C.L., Kuhn C., Ortel T.L., Shuldiner A.R., Hankemeier T. & Kaddurah-Daouk R. (2014), Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability, CPT: Pharmacometrics and Systems Pharmacology 2014(3): e125.
- Lips M.A., Klinken J.B. van, Harmelen V. van, Dharuri H.K., Hoen P.A. 't, Laros J.F., Ommen G.J. van, Janssen I.M., Ramshorst B. van, Wagensveld B.A. van, Swank D.J., Dielen F. van, Dane A.D., Harms A.C., Vreeken R.J., Hankemeier T., Smit J.W.A., Pijl H. & Willems van Dijk K. (2014), Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes, Diabetes Care 37(12): 3150-3156.
- Dane A.D., Hendriks M.M., Reijmers T.H., Harms A.C., Troost J., Vreeken R.J., Boomsma D.I., Duijn C.M. van, Slagboom E.P. & Hankemeier T. (2014), Integrating metabolomics profiling measurements across multiple biobanks, Analytical Chemistry 86(9): 4110-4.