Alexander Gorbalenya
Professor emeritus Applied bioinformatics in virology
- Name
- Prof.dr. A.E. Gorbalenya
- Telephone
- +31 71 526 3931
- a.e.gorbalenya@lumc.nl
- ORCID iD
- 0000-0002-4967-7341
Alexander E. Gorbalenya is Professor of Medical Microbiology, in particular virus bioinformatics and Head of Virus Evolution and Bioinformatics lab in the Research Section. He is also visiting Professor at the Faculty of Bioengineering & Bioinformatics, Lomonosov Moscow State University, Moscow, Russia. He held Leiden University Fund Chair in Applied Bioinformatics in Virology (2009-2017) and was Vice-President of the International Committee on the Virus Taxonomy (2011-2017).
More information about Alexander Gorbalenya
Alexander E. Gorbalenya is Professor of Medical Microbiology, in particular virus bioinformatics and Head of Virus Evolution and Bioinformatics lab in the Research Section. He is also visiting Professor at the Faculty of Bioengineering & Bioinformatics, Lomonosov Moscow State University, Moscow, Russia. He held Leiden University Fund Chair in Applied Bioinformatics in Virology (2009-2017) and was Vice-President of the International Committee on the Virus Taxonomy (2011-2017).
Infections
Humans suffer from different diseases caused by viruses that range from common cold to fatal. However, virus infection may also do no harm or be even beneficial to host. Some pathogenic viruses circulating in the human population are host-restricted, while others emerge(d) from benign viruses infecting humans or other animals (emerging infections). The ability to evolve very fast is the key to both the pathogenicity and the remarkable adaptability of viruses to different hosts. The enormous natural diversity of viruses, which researchers only start to describe, is the biggest challenge in our quest for understanding the Virosphere and to control virus infections.
Gorbalenya pursues these goals by applying bioinformatics to genomic sequences which is the most reliable, comprehensive, and up-to-the-date source of information about viruses. These studies benefit from steady advancements in computing as well as the exponential accumulation of virus genome sequences. We develop and employ genomics-based computational approaches to differentiate viruses, and to gain insight into their function, structure, and evolution. Results of these analyses guide experimental studies and facilitate development of virus diagnostics and antivirals.
Academic career
A.E. (Alexander/Sasha) Gorbalenya (1952), PhD, DSci received training in genetics at Novosibirsk State University, Russia, (M.Sc, 1974) and virus biochemistry at the Institute of Poliomyelitis, Moscow and Institute of Molecular Biology, Koltsovo, (Ph.D, 1984), and was awarded D.Sci degree in molecular biology from Lomonosov Moscow State University, Russia (1991). He was lead research scientist at the Institute of Poliomyelitis before moving to the National Cancer Institute, Frederick, USA, as visiting scientist in 1998. Alexander Gorbalenya joined Leiden University Medical Center (2001), as tenured associate professor and group leader at the Department of Medical Microbiology, where he was extraordinary professor (2009-2017) and continue serving as part-time professor. He leads Collaborative Program in Bioinformatics between LUMC and Moscow State University (Moscow-Bioinformatics-Leiden, MoBiLe Program).
While conducting PhD project, Gorbalenya started using nascent comparative sequence analysis to study the structure, function and evolution of viruses, which became his calling in virology. He pursues analysis of the natural variation of virus genomes to advance understanding biology of virus-host interactions and its applications to managing virus infections. These studies have been supported by various national and EU grants. Its results have been published in more than 200 papers and book chapters.
His inauguration lecture (In English) on June 20, 2011 was entitled “Could we live in peace with viruses?”.
Prizes and honourable appointments
Gorbalenya is Editor of Virology (on Virus Evolution) since 2013, and serves on the Editorial Boards of J. of Virology and Virus Research. He was Guest Editor of Proc.Natl.Acad.Sci. USA and PLoS Pathogens, and Editorial Board Member of J. of General Virology. He served on the Advisory Panel for the Virus Genomes Database of NCBI (USA), the Advisory Board for the XVth and XVIth International Congresses of Virology (2011 and 2014), and several other international committees and boards concerned with viruses and bioinformatics. He was an ad-hoc reviewer for dozens of international journals as well as for grant agencies in the Netherlands, EU, France, Israel, UK and Russia. From 2005 till 2011 he served as an Elected Member of the Executive Committee and from 2011 to 2017 as Vice-President of the International Committee for Taxonomy of Viruses.
Professor emeritus Applied bioinformatics in virology
- Faculteit Geneeskunde
- Divisie 4
- Medische Microbiologie
- Squarr, J.; Kirk, R.; Gorbalenya, A.E. & Malim, M. (2024), PLOS Pathogens expanding horizons, PLoS Pathogens 20(6).
- Lauber, C.; Zhang, X.Y.; Vaas, J.; Klingler, F.; Mutz, P.; Dubin, A.; Pietschmann, T.; Roth, O.; Neuman, B.W.; Gorbalenya, A.E.; Bartenschlager, R. & Seitz, S. (2024), Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates, PLoS Pathogens 20(4).
- Gorbalenya, A.E. & Perlman, S. (2023), What's what in a pandemic? Virus, disease, and societal disaster must be differentiated, PLoS Biology 21(5).
- Gorbalenya, A.E. & Anisimova, M. (2022), Editorial overview: Virus bioinformatics - empowering genomics of pathogens, viromes, and the virosphere across divergence scales, Current Opinion in Virology 52: 161-165.
- Pan, R.G.; Kindler, E.; Cao, L.; Zhou, Y.; Zhang, Z.; Liu, Q.Y.; Ebert, N.; Zust, R.; Sun, Y.; Gorbalenya, A.E.; Perlman, S.; Thiel, V.; Chen, Y. & Guo, D.Y. (2022), N7-methylation of the coronavirus RNA cap Is required for maximal virulence by preventing innate immune recognition, mBio 13(1).
- Seabra, S.G.; Libin, P.J.K.; Theys, K.; Zhukova, A.; Potter, B.I.; Nebenzahl-Guimaraes, H.; Gorbalenya, A.E.; Sidorov, I.A.; Pimentel, V.; Pingarilho, M.; Vasconcelos, A.T.R. de; Dellicour, S.; Khouri, R.; Gascuel, O.; Vandamme, A.M.; Baele, G.; Cuypers, L. & Abecasis, A.B. (2022), Genome-wide diversity of Zika virus, Virus Evolution 8(1).
- Kamminga, S.; Sidorov, I.A.; Tadesse, M.; Meijden, E. van der; Brouwer, C. de; Zaaijer, H.L.; Feltkamp, M.C.W. & Gorbalenya, A.E. (2022), Translating genomic exploration of the family Polyomaviridae into confident human polyomavirus detection, iScience 25(1).
- Gorbalenya, A.E. & Lauber, C. (2022), Bioinformatics of virus taxonomy: foundations and tools for developing sequence-based hierarchical classification, Current Opinion in Virology 52: 48-56.
- Calisher, C.H.; Carroll, D.; Colwell, R.; Corley, R.B.; Daszak, P.; Drosten, C.; Enjuanes, L.; Farrar, J.; Field, H.; Golding, J.; Gorbalenya, A.E.; Haagmans, B.; Hughes, J.M.; Keusch, G.T.; Lam, S.K.; Lubroth, J.; Mackenzie, J.S.; Madoff, L.; Mazet, J.K.; Perlman, S.M.; Poon, L.; Saif, L.; Subbarao, K. & Turner, M. (2021), Science, not speculation, is essential to determine how SARS-CoV-2 reached humans.
- Konings, F.; Perkins, M.D.; Kuhn, J.H.; Pallen, M.J.; Alm, E.J.; Archer, B.N.; Barakat, A.; Bedford, T.; Bhiman, J.N.; Caly, L.; Carter, L.L.; Cullinane, A.; Oliveira, T. de; Druce, J.; Masry, I. el; Evans, R.; Gao, G.F.; Gorbalenya, A.E.; Hamblion, E.; Herring, B.L.; Hodcroft, E.; Holmes, E.C.; Kakkar, M.; Khare, S.; Koopmans, M.P.G.; Korber, B.; Leite, J.; MacCannell, D.; Marklewitz, M.; Maurer-Stroh, S.; Rico, J.A.M.; Munster, V.J.; Neher, R.; Munnink, B.O.; Pavlin, B.I.; Peiris, M.; Poon, L.; Pybus, O.; Rambaut, A.; Resende, P.; Subissi, L.; Thiel, V.; Tong, S.X.; Werf, S. van der; Gottberg, A. von; Ziebuhr, J. & Kerkhove, M.D. van (2021), SARS-CoV-2 variants of interest and concern naming scheme conducive for global discourse, Nature Microbiology 6(7): 821-823.
- Gorbalenya, A.E. & Siddell, S.G. (2021), Recognizing species as a new focus of virus research, PLoS Pathogens 17(3).
- Slanina, H.; Madhugiri, R.; Bylapudi, G.; Schultheiss, K.; Karl, N.; Gulyaeva, A.; Gorbalenya, A.E.; Linne, U. & Ziebuhr, J. (2021), Coronavirus replication-transcription complex, Proceedings of the National Academy of Sciences 118(6).
- Jungreis, I.; Nelson, C.W.; Ardern, Z.; Finkel, Y.; Krogan, N.J.; Sato, K.; Ziebuhr, J.; Stern-Ginossar, N.; Pavesi, A.; Firth, A.E.; Gorbalenya, A.E. & Kellis, M. (2021), Conflicting and ambiguous names of overlapping ORFs in the SARS-CoV-2 genome, Virology 558: 145-151.
- Gulyaeva, A.A. & Gorbalenya, A.E. (2021), A nidovirus perspective on SARS-CoV-2, Biochemical and Biophysical Research Communications 538: 24-34.
- Gorbalenya, A.E.; Krupovic, M.; Mushegian, A.; Kropinski, A.M.; Siddell, S.G.; Varsani, A.; Adams, M.J.; Davison, A.J.; Dutilh, B.E.; Harrach, B.; Harrison, R.L.; Junglen, S.; King, A.M.Q.; Knowles, N.J.; Lefkowitz, E.J.; Nibert, M.L.; Rubino, L.; Sabanadzovic, S.; Sanfa?on, H.; Simmonds, P.; Walker, P.J.; Zerbini, F.M.; Kuhn, J.H. & Viruses Executive Comm (2020), The new scope of virus taxonomy, Nature Microbiology 5(5): 668-674.
- Zell, R.; Gorbalenya, A.E.; Knowles, N.J.; Simmonds, P. & Skern, T. (2020), How to recognise and deal with dubious virus sequences?
- Gulyaeva, A.A.; Sigorskih, A.I.; Ocheredko, E.S.; Samborskiy, D.V. & Gorbalenya, A.E. (2020), LAMPA, LArge Multidomain Protein Annotator, and its application to RNA virus polyproteins, Bioinformatics 36(9): 2731-2739.
- Simmonds, P.; Gorbalenya, A.E.; Harvala, H.; Hovi, T.; Knowles, N.J.; Lindberg, A.M.; Oberste, M.S.; Palmenberg, A.C.; Reuter, G.; Skern, T.; Tapparel, C.; Wolthers, K.C.; Woo, P.C.Y. & Zell, R. (2020), Recommendations for the nomenclature of enteroviruses and rhinoviruses, Archives of Virology 165(3): 793-797.
- Calisher, C.; Carroll, D.; Colwell, R.; Corley, R.B.; Daszak, P.; Drosten, C.; Enjuanes, L.; Farrar, J.M.; Field, H.; Golding, J.; Gorbalenya, A.; Haagmans, B.; Hughes, J.M.; Karesh, W.B.; Keusch, G.T.; Lam, S.K.; Lubroth, J.; Mackenzie, J.S.; Madoff, L.; Mazet, J.; Palese, P.; Perlman, S.; Poon, L.; Roizman, B.; Sail, L.; Subbarao, K. & Turner, M. (2020), Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19.
- Gorbalenya, A.E.; Baker, S.C.; Baric, R.S.; Groot, R.J. de; Drosten, C.; Gulyaeva, A.A.; Haagmans, B.L.; Lauber, C.; Leontovich, A.M.; Neuman, B.W.; Penzar, D.; Perlman, S.; Poon, L.L.M.; Samborskiy, D.V.; Sidorov, I.A.; Sola, I.; Ziebuhr, J. & Coronaviridae Study Grp (2020), The species Severe acute respiratory syndrome-related coronavirus, Nature Microbiology 5(4): 536-544.
- Kanitz, M.; Blanck, S.; Heine, A.; Gulyaeva, A.A.; Gorbalenya, A.E.; Ziebuhr, J. & Diederich, W.E. (2019), Structural basis for catalysis and substrate specificity of a 3C-like cysteine protease from a mosquito mesonivirus, Virology 533: 21-33.
- Romette, J.L.; Prat, C.M.; Gould, E.A.; Lamballerie, X. de; Charrel, R.; Coutard, B.; Fooks, A.R.; Bardsley, M.; Carroll, M.; Drosten, C.; Drexler, J.F.; Gunther, S.; Klempa, B.; Pinschewer, D.; Klimkait, T.; Avsic-Zupanc, T.; Capobianchi, M.R.; Dicaro, A.; Ippolito, G.; Nitsche, A.; Koopmans, M.; Reusken, C.; Gorbalenya, A.; Raoul, H.; Bourhy, H.; Mettenleiter, T.; Reiche, S.; Batten, C.; Sabeta, C.; Paweska, J.T.; Eropkin, M.; Zverev, V.; Hu, Z.; Mac Cullough, S.; Mirazimi, A.; Pradel, F. & Lieutaud, P. (2018), The European Virus Archive goes global: A growing resource for research, Antiviral Research 158: 127-134.
- Gorbalenya, A.E. (2018), Increasing the number of available ranks in virus taxonomy from five to ten and adopting the Baltimore classes as taxa at the basal rank, Archives of Virology 163(10): 2933-2936.
- Saberi, A.; Gulyaeva, A.A.; Brubacher, J.L.; Newmark, P.A. & Gorbalenya, A.E. (2018), A planarian nidovirus expands the limits of RNA genome size, PLoS Pathogens 14(11).
- Nijhuis, R.H.T.; Sidorov, I.A.; Chung, P.K.; Wessels, E.; Gulyaeva, A.A.; Vries, J.J. de; Claas, E.C.J. & Gorbalenya, A.E. (2018), PCR assays for detection of human astroviruses: In silico evaluation and design, and in vitro application to samples collected from patients in the Netherlands, Journal of Clinical Virology 108: 83-89.
- King, A.M.Q.; Lefkowitz, E.J.; Mushegian, A.R.; Adams, M.J.; Dutilh, B.E.; Gorbalenya, A.E.; Harrach, B.; Harrison, R.L.; Junglen, S.; Knowles, N.J.; Kropinski, A.M.; Krupovic, M.; Kuhn, J.H.; Nibert, M.L.; Rubino, L.; Sabanadzovic, S.; Sanfacon, H.; Siddell, S.G.; Simmonds, P.; Varsani, A.; Zerbini, F.M. & Davison, A.J. (2018), Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018), Archives of Virology 163(9): 2601-2631.
- Gulyaeva, A.; Dunowska, M.; Hoogendoorn, E.; Giles, J.; Samborskiy, D. & Gorbalenya, A.E. (2017), Domain Organization and Evolution of the Highly Divergent 5' Coding Region of Genomes of Arteriviruses, Including the Novel Possum Nidovirus, Journal of Virology 91(6).
- Simmonds, P.; Adams, M.J.; Benko, M.; Breitbart, M.; Brister, J.R.; Carstens, E.B.; Davison, A.J.; Delwart, E.; Gorbalenya, A.E.; Harrach, B.; Hull, R.; King, A.M.Q.; Koonin, E.V.; Krupovic, M.; Kuhn, J.H.; Lefkowitz, E.J.; Nibert, M.L.; Orton, R.; Roossinck, M.J.; Sabanadzovic, S.; Sullivan, M.B.; Suttle, C.A.; Tesh, R.B.; Vlugt, R.A. van der; Varsani, A. & Zerbini, M. (2017), Virus taxonomy in the age of metagenomics, Nature Reviews Microbiology 15(3): 161-168.
- Zell, R.; Delwart, E.; Gorbalenya, A.E.; Hovi, T.; King, A.M.Q.; Knowles, N.J.; Lindberg, A.M.; Pallansch, M.A.; Palmenberg, A.C.; Reuter, G.; Simmonds, P.; Skern, T.; Stanway, G.; Yamashita, T. & ICTV Report Consortium (2017), ICTV Virus Taxonomy Profile: Picornaviridae, Journal of General Virology 98(10): 2421-2422.
- Adams, M.J.; Lefkowitz, E.J.; King, A.M.Q.; Harrach, B.; Harrison, R.L.; Knowles, N.J.; Kropinski, A.M.; Krupovic, M.; Kuhn, J.H.; Mushegian, A.R.; Nibert, M.L.; Sabanadzovic, S.; Sanfacon, H.; Siddell, S.G.; Simmonds, P.; Varsani, A.; Zerbini, F.M.; Orton, R.J.; Smith, D.B.; Gorbalenya, A.E. & Davison, A.J. (2017), 50 years of the International Committee on Taxonomy of Viruses: progress and prospects, Archives of Virology 162(5): 1441-1446.
- Adams, M.J.; Lefkowitz, E.J.; King, A.M.Q.; Harrach, B.; Harrison, R.L.; Knowles, N.J.; Kropinski, A.M.; Krupovic, M.; Kuhn, J.H.; Mushegian, A.R.; Nibert, M.; Sabanadzovic, S.; Sanfacon, H.; Siddell, S.G.; Simmonds, P.; Varsani, A.; Zerbini, F.M.; Gorbalenya, A.E. & Davison, A.J. (2017), Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2017), Archives of Virology 162(8): 2505-2538.
- Lehmann, K.C.; Gorbalenya, A.E.; Snijder, E.J. & Posthuma, C.C. (2016), Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive, Virology 487: 68-74.
- Kazem, S.; Lauber, C.; Meijden, E. van der; Kooijman, S.; Kravchenko, A.A.; Feltkamp, M.C.W.; Gorbalenya, A.E. & TrichSpin Network (2016), Limited variation during circulation of a polyomavirus in the human population involves the COCO-VA toggling site of Middle and Alternative T-antigen(s), Virology 487: 129-140.
- Adams, M.J.; Lefkowitz, E.J.; King, A.M.Q.; Harrach, B.; Harrison, R.L.; Knowles, N.J.; Kropinski, A.M.; Krupovic, M.; Kuhn, J.H.; Mushegian, A.R.; Nibert, M.; Sabanadzovic, S.; Sanfacon, H.; Siddell, S.G.; Simmonds, P.; Varsani, A.; Zerbini, F.M.; Gorbalenya, A.E. & Davison, A.J. (2016), Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2016), Archives of Virology 161(10): 2921-2949.
- Dorobantu, C.M.; Albulescu, L.; Lyoo, H.; Kampen, M. van; Francesco, R. de; Lohmann, V.; Harak, C.; Schaar, H.M. van der; Strating, J.R.P.M.; Gorbalenya, A.E. & Kuppeveld, F.J.M. van (2016), Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase III alpha and Oxysterol-Binding Protein, mSphere 1(3).
- Lehmann, K.C.; Snijder, E.J.; Posthuma, C.C. & Gorbalenya, A.E. (2015), What we know but do not understand about nidovirus helicases, Virus Research 202: 12-32.
- Lauber, C.; Kazem, S.; Kravchenko, A.A.; Feltkamp, M.C.W. & Gorbalenya, A.E. (2015), Interspecific adaptation by binary choice at de novo polyomavirus T antigen site through accelerated codon-constrained Val-Ala toggling within an intrinsically disordered region, Nucleic Acids Research 43(10): 4800-4813.
- Adams, M.J.; Lefkowitz, E.J.; King, A.M.Q.; Bamford, D.H.; Breitbart, M.; Davison, A.J.; Ghabrial, S.A.; Gorbalenya, A.E.; Knowles, N.J.; Krell, P.; Lavigne, R.; Prangishvili, D.; Sanfacon, H.; Siddell, S.G.; Simmonds, P. & Carstens, E.B. (2015), Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2015), Archives of Virology 160(7): 1837-1850.
- Lehmann, K.C.; Hooghiemstra, L.; Gulyaeva, A.; Samborskiy, D.V.; Zevenhoven-Dobbe, J.C.; Snijder, E.J.; Gorbalenya, A.E. & Posthuma, C.C. (2015), Arterivirus nsp12 versus the coronavirus nsp16 2 '-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins, Journal of General Virology 96: 2643-2655.
- Dorobantu, C.M.; Albulescu, L.; Harak, C.; Feng, Q.; Kampen, M. van; Strating, J.R.P.M.; Gorbalenya, A.E.; Lohmann, V.; Schaar, H.M. van der & Kuppeveld, F.J.M. van (2015), Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus, PLoS Pathogens 11(9).
- Lehmann, K.C.; Gulyaeva, A.; Zevenhoven-Dobbe, J.C.; Janssen, G.M.C.; Ruben, M.; Overkleeft, H.S.; Veelen, P.A. van; Samborskiy, D.V.; Kravchenko, A.A.; Leontovich, A.M.; Sidorov, I.A.; Snijder, E.J.; Posthuma, C.C. & Gorbalenya, A.E. (2015), Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses, Nucleic Acids Research 43(17): 8416-8434.
- Subissi, L.; Posthuma, C.C.; Collet, A.; Zevenhoven-Dobbe, J.C.; Gorbalenya, A.E.; Decroly, E.; Snijder, E.J.; Canard, B. & Imbert, I. (2014), One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities, Proceedings of the National Academy of Sciences 111(37): E3900-E3909.
- Deng, Z.Q.; Lehmann, K.C.; Li, X.R.; Feng, C.; Wang, G.Q.; Zhang, Q.; Qi, X.X.; Yu, L.; Zhang, X.L.; Feng, W.H.; Wu, W.; Gong, P.; Tao, Y.; Posthuma, C.C.; Snijder, E.J.; Gorbalenya, A.E. & Chen, Z.Z. (2014), Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase, Nucleic Acids Research 42(5): 3464-3477.
- Bailey-Elkin, B.A.; Knaap, R.C.M.; Johnson, G.G.; Dalebout, T.J.; Ninaber, D.K.; Kasteren, P.B. van; Bredenbeek, P.J.; Snijder, E.J.; Kikkert, M. & Mark, B.L. (2014), Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression, Journal of Biological Chemistry 289(50): 34667-34682.
- Saiyasombat, R.; Carrillo-Tripp, J.; Miller, W.A.; Bredenbeek, P.J. & Blitvich, B.J. (2014), Substitution of the premembrane and envelope protein genes of Modoc virus with the homologous sequences of West Nile virus generates a chimeric virus that replicates in vertebrate but not mosquito cells, Virology Journal 11.
- Zlateva, K.T.; Coenjaerts, F.E.J.; Crusio, K.M.; Lammens, C.; Leus, F.; Viveen, M.; Ieven, M.; Spaan, W.J.M.; Claas, E.C.J. & Gorbalenya, A.E. (2013), No novel coronaviruses identified in a large collection of human nasopharyngeal specimens using family-wide CODEHOP-based primers, Archives of Virology 158(1): 251-255.
- Feltkamp, M.C.W.; Kazem, S.; Meijden, E. van der; Lauber, C. & Gorbalenya, A.E. (2013), From Stockholm to Malawi: recent developments in studying human polyomaviruses, Journal of General Virology 94: 482-496.
- Kazem, S.; Lauber, C.; Meijden, E. van der; Kooijman, S.; Bialasiewicz, S.; Wang, R.C.; Gorbalenya, A.E.; Feltkamp, M.C.W. & TrichSpin Network (2013), Global circulation of slowly evolving trichodysplasia spinulosa-associated polyomavirus and its adaptation to the human population through alternative T antigens, Journal of NeuroVirology 19(3): 298-299.
- Lauber, C.; Goeman, J.J.; Parquet, M.D.; Nga, P.T.; Snijder, E.J.; Morita, K. & Gorbalenya, A.E. (2013), The Footprint of Genome Architecture in the Largest Genome Expansion in RNA Viruses, PLoS Pathogens 9(7).
- Groot, R.J. de; Baker, S.C.; Baric, R.S.; Brown, C.S.; Drosten, C.; Enjuanes, L.; Fouchier, R.A.M.; Galiano, M.; Gorbalenya, A.E.; Memish, Z.A.; Perlman, S.; Poon, L.L.M.; Snijder, E.J.; Stephens, G.M.; Woo, P.C.Y.; Zaki, A.M.; Zambon, M. & Ziebuhr, J. (2013), Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group, Journal of Virology 87(14): 7790-7792.
- Knetsch, C.W.; Terveer, E.M.; Lauber, C.; Gorbalenya, A.E.; Harmanus, C.; Kuijper, E.J.; Corver, J. & Leeuwen, H.C. van (2012), Comparative analysis of an expanded Clostridium difficile reference strain collection reveals genetic diversity and evolution through six lineages, Infection, Genetics and Evolution 12(7): 1577-1585.
- Zhao, L.; Jha, B.K.; Wu, A.; Elliott, R.; Ziebuhr, J.; Gorbalenya, A.E.; Silverman, R.H. & Weiss, S.R. (2012), Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology, Cell Host and Microbe 11(6): 607-616.
- Lauber, C. & Gorbalenya, A.E. (2012), Partitioning the Genetic Diversity of a Virus Family: Approach and Evaluation through a Case Study of Picornaviruses, Journal of Virology 86(7): 3890-3904.
- Lauber, C. & Gorbalenya, A.E. (2012), Toward Genetics-Based Virus Taxonomy: Comparative Analysis of a Genetics-Based Classification and the Taxonomy of Picornaviruses, Journal of Virology 86(7): 3905-3915.
- Lauber, C.; Ziebuhr, J.; Junglen, S.; Drosten, C.; Zirkel, F.; Nga, P.T.; Morita, K.; Snijder, E.J. & Gorbalenya, A.E. (2012), Mesoniviridae: a proposed new family in the order Nidovirales formed by a single species of mosquito-borne viruses, Archives of Virology 157(8): 1623-1628.
- Lauber, C. & Gorbalenya, A.E. (2012), Genetics-Based Classification of Filoviruses Calls for Expanded Sampling of Genomic Sequences, VIRUSES-BASEL 4(9): 1425-1437.
- Jha, B.K.; Zhao, L.; Wu, A.; Elliot, R.; Ziebuhr, J.; Gorbalenya, A.E.; Weiss, S.R. & Silverman, R.H. (2012), Evasion of the OAS-RNase L pathway by murine coronavirus ns2 protein is required for viral replication and hepatitis, Cytokine 59(3): 511-511.
- Horst, D.; Burmeister, W.P.; Boer, I.G.J.; Leeuwen, D. van; Buisson, M.; Gorbalenya, A.E.; Wiertz, E.J.H.J. & Ressing, M.E. (2012), The "Bridge" in the Epstein-Barr Virus Alkaline Exonuclease Protein BGLF5 Contributes to Shutoff Activity during Productive Infection, Journal of Virology 86(17): 9175-9187.
- Boheemen, S. van; Graaf, M. de; Lauber, C.; Bestebroer, T.M.; Raj, V.S.; Zaki, A.M.; Osterhaus, A.D.M.E.; Haagmans, B.L.; Gorbalenya, A.E.; Snijder, E.J. & Fouchier, R.A.M. (2012), Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans, mBio 3(6): -.
- Zlateva, K.T.; Crusio, K.M.; Leontovich, A.M.; Lauber, C.; Claas, E.; Kravchenko, A.A.; Spaan, W.J.M. & Gorbalenya, A.E. (2011), Design and validation of consensus-degenerate hybrid oligonucleotide primers for broad and sensitive detection of corona- and toroviruses, Journal of Virological Methods 177(2): 174-183.
- Costenaro, L.; Kaczmarska, Z.; Arnan, C.; Janowski, R.; Coutard, B.; Sola, M.; Gorbalenya, A.E.; Norder, H.; Canard, B. & Coll, M. (2011), Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93, Journal of Virology 85(20): 10764-10773.
- Nga, P.T.; Parquet, M.D.; Lauber, C.; Parida, M.; Nabeshima, T.; Yu, F.X.; Thuy, N.T.; Inoue, S.; Ito, T.; Okamoto, K.; Ichinose, A.; Snijder, E.J.; Morita, K. & Gorbalenya, A.E. (2011), Discovery of the First Insect Nidovirus, a Missing Evolutionary Link in the Emergence of the Largest RNA Virus Genomes, PLoS Pathogens 7(9): -.
- Norder, H.; Palma, A.M. de; Selisko, B.; Costenaro, L.; Papageorgiou, N.; Arnan, C.; Coutard, B.; Lantez, V.; Lamballerie, X. de; Baronti, C.; Sola, M.; Tan, J.; Neyts, J.; Canard, B.; Coll, M.; Gorbalenya, A.E. & Hilgenfeld, R. (2011), Picornavirus non-structural proteins as targets for new anti-virals with broad activity, Antiviral Research 89(3): 204-218.
- Kuppeveld, F. van; Snijder, E.; Gorbalenya, A.; Canard, B.; Bartenschlager, R.; Neyts, J.; Brancale, A. & McGuigan, C. (2011), European Training Network on (+)RNA Virus Replication and Antiviral Drug Development, Antiviral Research 90(2): A64-A64.
- Teterina, N.L.; Lauber, C.; Jensen, K.S.; Levenson, E.A.; Gorbalenya, A.E. & Ehrenfeld, E. (2011), Identification of tolerated insertion sites in poliovirus non-structural proteins, Virology 409(1): 1-11.
- Assenberg, R.; Delmas, O.; Morin, B.; Graham, S.C.; Lamballerie, X. de; Laubert, C.; Coutard, B.; Grimes, J.M.; Neyts, J.; Owens, R.J.; Brandt, B.W.; Gorbalenya, A.; Tucker, P.; Stuart, D.I.; Canard, B. & Bourhy, H. (2010), Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription, Antiviral Research 87(2): 149-161.
- Papageorgiou, N.; Coutard, B.; Lantez, V.; Gautron, E.; Chauvet, O.; Baronti, C.; Norder, H.; Lamballerie, X. de; Heresanu, V.; Ferte, N.; Veesler, S.; Gorbalenya, A.E. & Canard, B. (2010), The 2C putative helicase of echovirus 30 adopts a hexameric ring-shaped structure, Acta Crystallographica Section D: Biological Crystallography 66: 1116-1120.
- Meijden, E. van der; Janssens, R.W.A.; Lauber, C.; Bavinck, J.N.B.; Gorbalenya, A.E. & Feltkamp, M.C.W. (2010), Discovery of a New Human Polyomavirus Associated with Trichodysplasia Spinulosa in an Immunocompromized Patient, PLoS Pathogens 6(7).
- Gould, E.A.; Coutard, B.; Malet, H.; Morin, B.; Jamal, S.; Weaver, S.; Gorbalenya, A.; Moureau, G.; Baronti, C.; Delogu, I.; Forrester, N.; Khasnatinov, M.; Gritsun, T.; Lamballerie, X. de & Canard, B. (2010), Understanding the alphaviruses: Recent research on important emerging pathogens and progress towards their control, Antiviral Research 87(2): 111-124.
- Nedialkova, D.D.; Gorbalenya, A.E. & Snijder, E.J. (2010), Arterivirus Nsp1 Modulates the Accumulation of Minus-Strand Templates to Control the Relative Abundance of Viral mRNAs, PLoS Pathogens 6(2).
- Wojdyla, J.A.; Manolaridis, I.; Kasteren, P.B. van; Kikkert, M.; Snijder, E.J.; Gorbalenya, A.E. & Tucker, P.A. (2010), Papain-like protease 1 from transmissible gastroenteritis virus: crystal structure and enzymatic activity toward viral and cellular substrates, Journal of Virology 84(19): 10063-10073.
- Zeddam, J.L.; Gordon, K.H.J.; Lauber, C.; Alves, C.A.F.; Luke, B.T.; Hanzlik, T.N.; Ward, V.K. & Gorbalenya, A.E. (2010), Euprosterna elaeasa virus genome sequence and evolution of the Tetraviridae family: Emergence of bipartite genomes and conservation of the VPg signal with the dsRNA Birnaviridae family, Virology 397(1): 145-154.
- Gorbalenya, A.E.; Lieutaud, P.; Harris, M.R.; Coutard, B.; Canard, B.; Kleywegt, G.J.; Kravchenko, A.A.; Samborskiy, D.V.; Sidorov, I.A.; Leontovich, A.M. & Jones, T.A. (2010), Practical application of bioinformatics by the multidisciplinary VIZIER consortium, Antiviral Research 87(2): 95-110.
- Wojdyla JA, Manolaridis I, Snijder EJ, Gorbalenya AE, Coutard B, Piotrowski Y, Hilgenfeld R & Tucker PA (2009), Structure of the X (ADRP) domain of nsp3 from feline coronavirus, Acta Crystallographica Section D: Biological Crystallography 65: 1292-1300.
- Manolaridis I, Wojdyla JA, Panjikar S, Snijder EJ, Gorbalenya AE, Berglind H, Nordlund P, Coutard B & Tucker PA (2009), Structure of the C-terminal domain of nsp4 from feline coronavirus, Acta Crystallographica Section D: Biological Crystallography 65: 839-846.
- Piotrowski Y, Hansen G, Zanden ALBVD, Snijder EJ, Gorbalenya AE & Hilgenfeld R (2009), Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property, Protein Science 18(1): 6-16.
- Nedialkova DD, Ulferts R, van den Born E, Lauber C, Gorbalenya AE, Ziebuhr J & Snijder EJ (2009), Biochemical Characterization of Arterivirus Nonstructural Protein 11 Reveals the Nidovirus-Wide Conservation of a Replicative Endoribonuclease, Journal of Virology 83(11): 5671-5682.
- Malet H, Coutard B, Jamal S, Dutartre H, Papageorgiou N, Neuvonen M, Ahola T, Forrester N, Gould EA & Lafitte D (2009), The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket, Journal of Virology 83(13): 6534-6545.
- Sidorov IA, Reshetov DA & Gorbalenya AE (2009), SNAD: sequence name annotation-based designer, BMC Bioinformatics 10.
- Sabanadzovic S, Abou Ghanem-Sabanadzovic N & Gorbalenya AE (2009), Permutation of the active site of putative RNA-dependent RNA polymerase in a newly identified species of plant alpha-like virus, Virology 394(1): 1-7.
- Roth-Cross JK, Stokes H, Chang GH, Chua MM, Thiel V, Weiss SR, Gorbalenya AE & Siddell SG (2009), Organ-Specific Attenuation of Murine Hepatitis Virus Strain A59 by Replacement of Catalytic Residues in the Putative Viral Cyclic Phosphodiesterase ns2, Journal of Virology 83(8): 3743-3753.
- Robel V, Gebhardt J, Mesters JR, Gorbalenya A, Coutard B, Canard B, Hilgenfeld R & Rohayem J (2008), Functional characterization of the cleavage specificity of the sapovirus chyrnotrypsin-like protease, Journal of Virology 82(16).
- Decroly E, Imbert I, Coutard B, Bouvet ML, Selisko B, Alvarez K, Gorbalenya AE, Snijder EJ & Canard B (2008), Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity, Journal of Virology 82(16).
- van Hemert MJ, de Wilde AH, Gorbalenya AE & Snijder EJ (2008), The in vitro RNA synthesizing activity of the isolated arterivirus replication/transcription complex is dependent on a host factor, Journal of Biological Chemistry 283(24).
- van Hemert Martijn J., van den Worm Sjoerd H. E., Knoops Kevin, Mommaas A. Mieke, Gorbalenya Alexander E. & Snijder Eric J. (2008), SARS-coronavirus replication/transcription complexes are membrane-protected and need a host factor for activity in vitro, PLoS Pathogens 4(5).
- Coutard B, Gorbalenya AE, Snijder EJ, Leontovich AM, Poupon A, De Lamballerie X, Charrel R, Gould EA, Gunther S, Norder H, Klempa B, Bourhy H, Rohayem J, L'hermite E, Nordlund P, Stuart DI, Owens RJ, Grimes JM, Tucker PA, Bolognesi M, Mattevi A, Coll M, Jones TA, Aqvist J, Unge T, Hilgenfeld R, Bricogne G, Neyts J, La Colla P, Puerstinger G, Gonzalez JP, Leroy E, Cambillau C, Romette JL & Canard B (2008), The VIZIER project: Preparedness against pathogenic RNA viruses, Antiviral Research 78(1).
- Le Gall O, Christian P, Fauquet CM, King AMQ, Knowles NJ, Nakashima N, Stanway G & Gorbalenya AE (2008), Picornavirales, a proposed order of positive-sense single-stranded RNA viruses with a pseudo-T=3 virion architecture, Archives of Virology 153(4).
- Carugo O., Djinovic-Carugo K., Gorbalenya A.E.L. & Tucker P. (2007), Likelihood of crystallization: experimental and computational approaches, Journal for Applied Crystallography 40: 392-393.
- Tijms MA, Nedialkova DD, Zevenhoven-Dobbe JC, Gorbalenya AE & Snijder EJ (2007), Arterivirus subgenomic mRNA synthesis and virion biogenesis depend on the multifunctional nsp1 autoprotease, Journal of Virology 81(19).
- Ziebuhr J, Schelle B, Karl N, Minskaia E, Bayer S, Siddell SG, Gorbalenya AE & Thiel V (2007), Human coronavirus 229E papain-like proteases have overlapping specificities but distinct functions in viral replication, Journal of Virology 81(8).
- Carugo O, Djinovic-Carugo K, Gorbalenya AE & Tucker P (2007), Workshop on the definition of protein domains and their likelihood of crystallization - Editorial, Current Protein and Peptide Science 8(2).
- Fullerton SWB, Blaschke M, Coutard B, Gebhardt J, Gorbalenya A, Canard B, Tucker PA & Rohayem J (2007), Structural and functional characterization of sapovirus RNA-dependent RNA polymerase, Journal of Virology 81(4).
- Letzel T, Mundt E & Gorbalenya AE (2007), Evidence for functional significance of the permuted C motif in CO2+-stimulated RNA-dependent RNA polymerase of infectious bursal disease virus, Journal of General Virology 88.
- Jiang P, Faase JAJ, Toyoda H, Paul A, Wimmer E & Gorbalenya AE (2007), Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication, Proceedings of the National Academy of Sciences 104(22).
- van Aken D, Snijder EJ & Gorbalenya AE (2006), Mutagenesis analysis of the nsp4 main proteinase reveals determinants of arterivirus replicase polyprotein autoprocessing, Journal of Virology 80(7).
- Imbert I, Guillemot JC, Bourhis JM, Bussetta C, Coutard B, Egloff MP, Ferron F, Gorbalenya AE & Canard B (2006), A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus, EMBO Journal 25(20).
- van Aken D, Zevenhoven-Dobbe J, Gorbalenya AE & Snijder EJ (2006), Proteolytic maturation of replicase polyprotein pp1a by the nsp4 main proteinase is essential for equine arteritis virus replication and includes internal cleavage of nsp7, Journal of General Virology 87.
- Putics A, Slaby J, Filipowicz W, Gorbalenya AE & Ziebuhr J (2006), ADP-ribose-1 ''-phosphatase activities of the human coronavirus 229E and SARS coronavirus X domains, Advances in Experimental Medicine and Biology 581.
- van Aken D, Benckhuijsen WE, Drijfhout JW, Wassenaar ALM, Gorbalenya AE & Snijder EJ (2006), Expression, purification, and in vitro activity of an arterivirus main proteinase, Virus Research 120(1-2).
- Teterina NL, Gorbalenya AE, Egger D, Bienz K, Rinaudo MS & Ehrenfeld E (2006), Testing the modularity of the N-terminal amphipathic helix conserved in picornavirus 2C proteins and hepatitis CNS5A protein, Virology 344(2).
- Teterina NL, Levenson E, Rinaudo MS, Egger D, Bienz K, Gorbalenya AE & Ehrenfeld E (2006), Evidence for functional protein interactions required for poliovirus RNA replication, Journal of Virology 80(11).
- Gorbalenya AE, Enjuanes L, Ziebuhr J & Snijder EJ (2006), Nidovirales: Evolving the largest RNA virus genome, Virus Research 117(1).
- Minskaia E, Hertzig T, Gorbalenya AE, Campanacci V, Cambillau C, Canard B & Ziebuhr J (2006), Discovery of an RNA virus 3 '-> 5 ' exoribonuclease that is critically involved in coronavirus RNA synthesis, Proceedings of the National Academy of Sciences 103(13).
- Posthuma CC, Nedialkova DD, Zevenhoven-Dobbe JC, Blokhuis JH, Gorbalenya AE & Snijder EJ (2006), Site-directed mutagenesis of the nidovirus replicative endoribonuclease NendoU exerts pleiotropic effects on the arterivirus life cycle, Journal of Virology 80(4).
- Putics A, Gorbalenya AE & Ziebuhr J (2006), Identification of protease and ADP-ribose 1 ''-monophosphatase activities associated with transmissible gastroenteritis virus non-structural protein 3, Journal of General Virology 87.
- Putics A, Filipowicz W, Hall J, Gorbalenya AE & Ziebuhr J (2005), ADP-ribose-1 ''-monophosphatase: That is dispensable for viral a conserved coronavirus enzyme replication in tissue culture, Journal of Virology 79(20).
- Seybert A, Posthuma CC, van Dinten LC, Snijder EJ, Gorbalenya AE & Ziebuhr J (2005), A complex zinc finger controls the enzymatic activities of nidovirus helicases, Journal of Virology 79(2).
- Lackner T, Muller A, Pankraz A, Becher P, Thiel HJ, Gorbalenya AE & Tautz N (2004), Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus, Journal of Virology 78(19): 10765-10775.
- Egloff MP, Ferron F, Campanacci V, Longhi S, Rancurel C, Dutartre H, Snijder EJ, Gorbalenya AE, Cambillau C & Canard B (2004), The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world, Proceedings of the National Academy of Sciences 101(11): 3792-3796.
- Ivanov KA, Hertzig T, Rozanov M, Bayer S, Thiel V, Gorbalenya AE & Ziebuhr J (2004), Major genetic marker of nidoviruses encodes a replicative endoribonuclease, Proceedings of the National Academy of Sciences 101(34).
- Fernandez-Vega V, Sosnovtsev SV, Belliot G, King AD, Mitra T, Gorbalenya A & Green KY (2004), Norwalk virus N-terminal nonstructural protein is associated with disassembly of the Golgi complex in transfected cells, Journal of Virology 78(9).
- Gorbalenya AE, Snijder EJ & Spaan WJM (2004), Severe acute respiratory syndrome coronavirus phylogeny: toward consensus, Journal of Virology 78(15).
- von Einem UI, Gorbalenya AE, Schirrmeier H, Behrens SE, Letzel T & Mundt E (2004), VP1 of infectious bursal disease virus is an RNA-dependent RNA polymerase, Journal of General Virology 85.
- Tellinghuisen TL, Marcotrigiano J, Gorbalenya AE & Rice CM (2004), The NS5A protein of hepatitis C virus is a zinc metalloprotein, Journal of Biological Chemistry 279(47).
- Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LLM, Guan Y, Rozanov M, Spaan WJM & Gorbalenya AE (2003), Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage, Journal of Molecular Biology 331(5): 991-1004.
- Ziebuhr J, Bayer S, Cowley JA & Gorbalenya AE (2003), The 3C-like proteinase of an invertebrate nidovirus links coronavirus and potyvirus homologs, Journal of Virology 77(2).
- Gonzaalez JM, Gomez-Puertas P, Cavanagh D, Gorbalenya AE & Enjuanes L (2003), A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae, Archives of Virology 148(11).
- Thiel V, Ivanov KA, Putics A, Hertzig T, Schelle B, Bayer S, Weissbrich B, Snijder EJ, Rabenau H, Doerr HW, Gorbalenya AE & Ziebuhr J (2003), Mechanisms and enzymes involved in SARS coronavirus genome expression.
- Hegyi A, Friebe A, Gorbalenya AE & Ziebuhr J (2002), Mutational analysis of the active centre of coronavirus 3C-like proteases.
- Johansson S, Niklasson B, Maizel J, Gorbalenya AE & Lindberg AM (2002), Molecular analysis of three Ljungan virus isolates reveals a new, close-to-root lineage of the Picornaviridae with a cluster of two unrelated 2A proteins, Journal of Virology 76(17).
- Barrette-Ng IH, Ng KKS, Mark BL, van Aken D, Cherney MM, Garen C, Kolodenko Y, Gorbalenya AE, Snijder EJ & James MNG (2002), Structure of arterivirus nsp4 - The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole, Journal of Biological Chemistry 277(42).
- Gorbalenya AE, Pringle FM, Zeddam JL, Luke BT, Cameron CE, Kalmakoff J, Hanzlik TN, Gordon KHJ & Ward VK (2002), The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage, Journal of Molecular Biology 324(1).
- Ziebuhr J, Thiel V & Gorbalenya AE (2001), The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond, Journal of Biological Chemistry 276(35): 33220-33232.
- Tijms MA, van Dinten LC, Gorbalenya AE & Snijder EJ (2001), A zinc finger-containing papain-like protease couples subgenomic mRNA synthesis to genome translation in a positive-stranded RNA virus, Proceedings of the National Academy of Sciences 98(4).
- van Dinten LC, van Tol H, Gorbalenya AE & Snijder EJ (2000), The predicted metal-binding region of the arterivirus helicase protein is involved in subgenomic mRNA synthesis, genome replication, and virion biogenesis.
- Ziebuhr J, Snijder EJ & Gorbalenya AE (2000), Virus-encoded proteinases and proteolytic processing in the Nidovirales.
- Herold J., Siddell S.G. & Gorbalenya A.E. (1999), A human RNA viral cysteine proteinase that depends upon a unique Zn2+ -binding finger connecting the two domains of a papain-like fold, Journal of Biological Chemistry 274: 14918-14925.
- Herold J, Siddell SG & Gorbalenya AE (1999), A human RNA viral cysteine proteinase that depends upon a unique Zn2+-binding finger connecting the two domains of a papain-like fold, Journal of Biological Chemistry 274(21): 14918-14925.
- van Dinten LC, Rensen S, Gorbalenya AE & Snijder EJ (1999), Proteolytic processing of the open reading frame 1b-encoded part of arterivirus replicase is mediated by nsp4 serine protease and is essential for virus replication, Journal of Virology 73(3): 2027-2037.
- Reed KE, Gorbalenya AE & Rice CM (1998), The NS5A/NS5 proteins of viruses from three genera of the family Flaviviridae are phosphorylated by associated serine/threonine kinases, Journal of Virology 72(7): 6199-6206.
- Herold J, Gorbalenya AE, Thiel V, Schelle B & Siddell SG (1998), Proteolytic processing at the amino terminus of human coronavirus 229E gene 1-encoded polyproteins: Identification of a papain-like proteinase and its substrate, Journal of Virology 72(2): 910-918.
- Gorbalenya AE (1998), Non-canonical inteins, Nucleic Acids Research 26(7): 1741-1748.
- Wassenaar ALM, Spaan WJM, Gorbalenya AE & Snijder EJ (1997), Alternative proteolytic processing of the arterivirus replicase ORF1a polyprotein: Evidence that nsp2 acts as a cofactor for the nsp4 serine protease, Journal of Virology 71(12): 9313-9322.
- Snijder EJ, Wassenaar ALM, vanDinten LC, Spaan WJM & Gorbalenya AE (1996), The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases, Journal of Biological Chemistry 271(9): 4864-4871.
- Gorbalenya AE & Snijder EJ (1996), Viral cysteine proteinases, Perspectives in Drug Discovery and Design 6: 64-86.
- vanDinten LC, Wassenaar ALM, Gorbalenya AE, Spaan WJM & Snijder EJ (1996), Processing of the equine arteritis virus replicase ORF1b protein: Identification of cleavage products containing the putative viral polymerase and helicase domains, Journal of Virology 70(10): 6625-6633.
- den Boon JA, Faaberg KS, Meulenberg JJM, Wassenaar ALM, Plagemann PGW, Gorbalenya AE & Snijder EJ (1995), Processing and evolution of the N-terminal region of the arterivirus replicase ORF1a protein - identification of 2 papainlike cysteine proteases, Journal of Virology 69(7): 4500-4505.
- Snijder EJ, Wassenaar ALM, Spaan WJM & Gorbalenya AE (1995), The arterivirus nsp2 protease - An unusual cysteine protease with primary structure similarities to both papain-like and chymotrypsin-like proteases, Journal of Biological Chemistry 270(28): 16671-16676.
- LEE HJ, SHIEH CK, GORBALENYA AE, KOONIN EV, LAMONICA N, TULER J, BAGDZHADZHYAN A & LAI MMC (1991), THE COMPLETE SEQUENCE (22 KILOBASES) OF MURINE CORONAVIRUS GENE-1 ENCODING THE PUTATIVE PROTEASES AND RNA-POLYMERASE, Virology 180(2): 567-582.
- GORBALENYA AE & KOONIN EV (1990), SUPERFAMILY OF UVRA-RELATED NTP-BINDING PROTEINS - IMPLICATIONS FOR RATIONAL CLASSIFICATION OF RECOMBINATION REPAIR SYSTEMS, Journal of Molecular Biology 213(4): 583-591.
- KOONIN EV & GORBALENYA AE (1989), TALE OF 2 SERINES, Nature 338(6215): 467-468.
- KOONIN EV, GORBALENYA AE & CHUMAKOV KM (1989), TENTATIVE IDENTIFICATION OF RNA-DEPENDENT RNA-POLYMERASES OF DSRNA VIRUSES AND THEIR RELATIONSHIP TO POSITIVE STRAND RNA VIRAL POLYMERASES, FEBS Letters 252(1-2): 42-46.
- GORBALENYA AE & KOONIN EV (1989), VIRAL-PROTEINS CONTAINING THE PURINE NTP-BINDING SEQUENCE PATTERN, Nucleic Acids Research 17(21): 8413-8440.
- BLINOV VM, DONCHENKO AP & GORBALENIA AE (1985), INTERNAL HOMOLOGY IN THE PRIMARY STRUCTURE OF POLIO VIRUS POLYPROTEIN - THE POSSIBLE EXISTENCE OF 2 VIRUS-SPECIFIC PROTEINASES, Doklady Akademii nauk SSSR 281(4): 984-987.
- BLINOV VM, GORBALENIA AE & DONCHENKO AP (1984), THE STRUCTURAL SIMILARITY BETWEEN POLIOVIRUS CYSTEINE PROTEINASE P3-7C AND CELLULAR SERINE PROTEINASE OF TRYPSIN, Doklady Akademii nauk SSSR 279(2): 502-505.
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- Founding Member
- Professor, Head of Moscow-Bioinformatics-Leiden (MoBiLe) Group
- Member of the Executive Committee; Vice-President
- Member of the Editorial Board
- Guest Editor
- Member of the Editorial Board; Editor
- Member of the Editorial Board
- Guest Editor
- Extraordinary Professor of Applied Bioinformatics in Virology
- Member
- member
- Member
- Member