Research project
GRIPonMASH
GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).
- Duration
- 2024 - 2028
- Contact
- Ahmed Ali-
- Funding
- Innovative Health Initiative Joint Undertaking (IHI JU) under grant agreement No 101132946
- Partners
The consortium consists of 27 parties from all over Europe. They will be working closely together for
the next four years to ensure the success of GRIPonMASH. The research was initiated by Julius
Clinical, a spin-out of the University Medical Center Utrecht (UMCU) in the Netherlands. Together with UMCU and Echosens, they will be coordinating the project.
The Metabolomics and Analytics Centre (MAC) at the Leiden Academic Centre for Drug Research (LACDR) at Leiden University will conduct metabolomics and lipidomics measurements of blood samples to develop metabolic and lipidomic biomarkers to diagnose MALSD and MASH. For the metabolomics and lipidomics MAC is using innovative technologies combined with advanced mass spectrometric methods and using automated sample preparation and robotics. MAC is miniaturizing the analytical methods to analyse liver-derived extracellular vesicles and samples obtained from the organ-on-a-chip model, even down to individual cells.
The 26-million-euro project will address the unmet public health need of reducing disease burden
and comorbidities associated with MASLD by designing and optimizing a sustainable and scalable
GRIPonMASH diagnostic platform.
The platform will provide:
- Screening, diagnosis, management and long-term follow-up of MASH high-risk patients to
ensure early detection - Development of decision support tools and testing of existing and novel biomarkers for the
detection of MASH patients through artificial intelligence-based decision support tools - Development of non-invasive alternatives to diagnostic liver biopsies
- Assessment and personalization of lifestyle advice based on factors like physical activity, diet,
sleep, smoking, alcohol consumption, and perception of stress
More about the project can be found here: https://griponmash.eu/