Advanced 2D Materials of Borophene for Mutationally Preserved Geno-sensing of Sexually Transmitted Disease

• Dipanjan Pan (The Pennsylvania State University)

Date

Thursday 24 October 2024

Time

14:45 - 15:15 hour

Address

Gorlaeus Building
Einsteinweg 55
2333 CC Leiden

Room

BM.1.23

Satheesh Natarajan, Ketan Dighe and Dipanjan Pan

^a Departments of Nuclear Engineering and Materials Science and Engineering
Huck Institutes for the Life Sciences and Materials Research Institute, 
The Pennsylvania State University, W205 Millenium Sciences Complex, State College, PA 16802

Abstract

Abstract-Text [1] Among the 2D nanomaterial portfolio, borophene demonstrates unique chemical and metallic properties along with a variety of structural polymorphisms. A second interesting aspect of this emerging boron allotrope is its anisotropic Dirac properties, which are thought to have a significant impact on biological interactions. In addition to its polymorphic nature, borophene also allows further customization of its properties due to the different bonding configurations between boron atoms. A growing concern is the difficulty of synthesizing these materials, as well as their solubility and stability. Recently, we developed a solution state synthesis procedure for preparing stable, functionalized borophene for biological applications. Our research focuses on molecular diagnostics. The global pandemic of coronavirus disease 2019 (COVID-19) highlights the shortcomings of the current testing paradigm for infectious disease diagnostics. We recently developed direct, amplification free nucleic acid assay for highly sensitive point of care testing of SARS-CoV-2 and other related pathogens. [1-10] Expanding our earlier works, we have now designed novel 2D nanomaterials from borophene [11] for highly sensitive detection of various sexually transmitted diseases, e.g., syphilis, chlamydia and gonorrhea, HIV-1, Mpox, HCV and others. Our talk will focus on material innovation as well as the development of advanced prototypes for translation, focusing on how borophene can be used to develop highly sensitive assays for syphilis.   

Acknowledgements

Funding from NIBIB (NIH) and CDC is gratefully acknowledged.

References

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