PhD defence
Targeting ocular malignancies using a novel light-activated virus-like particle conjugate
- S. Ma
- Date
- Wednesday 12 February 2025
- Time
- Location
-
Academy Building
Rapenburg 73
2311 GJ Leiden
Supervisor(s)
- Prof.dr. M.J. Jager
- Prof dr. F.A. Ossendorp
- dr. E. de los Pinos
Summary
The aim of my Ph.D. research is to develop a novel treatment strategy for ocular malignancies that preserves vision and the eye, while preventing metastases. This involves using a new form of photodynamic therapy (PDT). The core of this research is a virus-like particle-photosensitizer conjugate, known as Bel-sar (formerly AU-011), which is currently being tested in clinical trials for treating small choroidal melanomas or indeterminate pigmented lesions in the eye.
In my thesis, we investigated the anti-tumor efficacy of Bel-sar in ocular malignancies with varying genetic profiles and levels of pigmentation. The findings demonstrate that Bel-sar effectively targets tumors, enhances drug accumulation within the tumor, and reduces off-target effects. Importantly, this therapy also proved effective in treating pigmented tumors, which are often more challenging due to their protective pigmentation.
Our research further highlights the ability of Bel-sar PDT to induce immunogenic cell death. This process involves the exposure of damage-associated molecular patterns (DAMPs), which can trigger both local and systemic immune responses. The combination of Bel-sar PDT with immunotherapy has shown improved therapeutic outcomes compared to current treatments in preclinical models.
This innovative therapy offers a promising new option for patients with choroidal and conjunctival melanomas. By advancing the understanding and application of photodynamic therapy, my research contributes to the development of more effective and less invasive cancer treatments.
PhD dissertations
Approximately one week after the defence, PhD dissertations by Leiden PhD students are available digitally through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.
Press enquiries (journalists only)
General information
Beadle's Office
pedel@bb.leidenuniv.nl
+31 71 527 7211