Lecture
MCBIM Colloquium: Metal-Modified Nucleic Acids: From Silver(I)-Mediated Base Pairs to Phosphorescent Platinum(II)-Bearing DNA
- Date
- Monday 17 June 2024
- Time
- Location
-
Gorlaeus Building
Einsteinweg 55
2333 CC Leiden - Room
- CM.3.23
Abstract
Metal-mediated base pairs are conjugates of nucleic acids and metal complexes. They are formed by formally replacing hydrogen bonds within a base pair by coordinate bonds.
As a result, metal ions are introduced into the nucleic acid helix along its helical axis. The ability to decorate nucleic acids site-specifically with transition metal ions allows interesting applications in nucleic acid nanotechnology, in sensors, and in responsive nucleic acid systems.
This lecture will exemplify the design and characterization of metal-mediated base pairs, ranging from silver(I)-mediated base pairs to the first example of a phosphorescent platinum(II)-containing DNA oligonucleotide.
