PhD defence
Multimodality imaging in patients with valvular heart disease and systemic diseases
- T. Gegenava
- Date
- Tuesday 10 October 2023
- Time
- Location
-
Academy Building
Rapenburg 73
2311 GJ Leiden
Supervisor(s)
- Prof.dr. J.J. Bax
- dr. V. Delgado
Summary
Advances in multimodality cardiovascular imaging is crucial in the diagnosis of valvular heart disease and systemic disorders.
Results of the thesis can be summarized as follow: In our study we observed that thoracic aorta calcification burden influences survival and left ventricular recovery (measured by echocardiographic derived left ventricular ejection fraction-LVEF and left ventricular global longitudinal strain-LV GLS) in patients undergoing transcatheter aortic valve replacement (TAVI). This study results contributes to better selection of TAVI candidates.
We also observed that novel advanced technology, feature tracking multidetector row computed tomography (FT MDCT) derived left ventricular global longitudinal strain-LV GLS is feasible, shows good agreement with echocardiography derived LV GLS and is associated with prognosis in TAVI patients. This study shows that CT derived LV GLS can be measured in patients with poor echocardiographic window and can be useful in the risk-stratification of TAVI patients.
Our results in patients with connective tissue disorders showed, that in patients with Systemic lupus erythematosus (SLE), LV systolic function as measured by LV GLS is significantly impaired, compared to healthy controls, and is associated with cardiovascular events.
In patients with Systemic sclerosis (SSc) male sex
is associated with worse cardiovascular outcomes. LV GLS was more impaired in men SSc patients, as compared to women and this may potentially explain the sex differences in cardiovascular events. Implementation of advanced echocardiographic technique such as LV GLS contributes to early detection of subtle myocardial changes in these patients and provides better risk-stratification.
PhD dissertations
Approximately one week after the defence, PhD dissertations by Leiden PhD students are available digitally through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.
Press enquiries (journalists only)
General information
Beadle's Office
pedel@bb.leidenuniv.nl
+31 71 527 7211